Publications:

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Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome.

Biophysical Reviews

TeBay, Clifford C; Hill, Adam P AP; Windley, Monique J MJ

Publication Date: 2022-01-27

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PubMed Link: 35103080

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Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome.

Biophysical Reviews

TeBay, Clifford C; Hill, Adam P AP; Windley, Monique J MJ

Publication Date: 2022-02

Variant appearance in text: KCNH2: G628C

PubMed Link: 35103080

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Mechanism of C-type inactivation in the hERG potassium channel.

Science Advances

Li, Jing J; Shen, Rong R; Reddy, Bharat B; Perozo, Eduardo E; Roux, Benoît B

Publication Date: 2021-01

Variant appearance in text: HERG: G628C

PubMed Link: 33514547

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• abd6203.pdf

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Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Molecular Pharmacology

Gardner, Alison A; Wu, Wei W; Thomson, Steven S; Zangerl-Plessl, Eva-Maria EM; Stary-Weinzinger, Anna A; Sanguinetti, Michael C MC

Publication Date: 2017-10

Variant appearance in text: KCNH2: G628C

PubMed Link: 28705808

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The Link between Inactivation and High-Affinity Block of hERG1 Channels.

Molecular Pharmacology

Wu, Wei W; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2015-06

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PubMed Link: 25855787

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Getting to the heart of hERG K(+) channel gating.

The Journal Of Physiology

Perry, Matthew D MD; Ng, Chai-Ann CA; Mann, Stefan A SA; Sadrieh, Arash A; Imtiaz, Mohammad M; Hill, Adam P AP; Vandenberg, Jamie I JI

Publication Date: 2015-06-15

Variant appearance in text: HERG: G628C

PubMed Link: 25820318

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Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel.

British Journal Of Pharmacology

Mannikko, R R; Bridgland-Taylor, M H MH; Pye, H H; Swallow, S S; Abi-Gerges, N N; Morton, M J MJ; Pollard, C E CE

Publication Date: 2015-06

Variant appearance in text: Kv11.1: G628C

PubMed Link: 25684549

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Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.

The Journal Of Physiology

Wu, Wei W; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2014-10-15

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PubMed Link: 25063820

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Stoichiometry of altered hERG1 channel gating by small molecule activators.

The Journal Of General Physiology

Wu, Wei W; Sachse, Frank B FB; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2014-04

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PubMed Link: 24638994

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A molecular switch driving inactivation in the cardiac K+ channel HERG.

Plos One

Köpfer, David A DA; Hahn, Ulrike U; Ohmert, Iris I; Vriend, Gert G; Pongs, Olaf O; de Groot, Bert L BL; Zachariae, Ulrich U

Publication Date: 2012

Variant appearance in text: Kv11.1: G628C

PubMed Link: 22848423

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• pone.0041023.pdf

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Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.

Biophysical Journal

Es-Salah-Lamoureux, Zeineb Z; Xiong, Ping Yu PY; Goodchild, Samuel J SJ; Ahern, Christopher A CA; Fedida, David D

Publication Date: 2011-08-03

Variant appearance in text: LQT2: G628C

PubMed Link: 21806934

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

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PubMed Link: 21743002

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Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening.

Plos One

Es-Salah-Lamoureux, Zeineb Z; Fougere, Robert R; Xiong, Ping Yu PY; Robertson, Gail A GA; Fedida, David D

Publication Date: 2010-05-28

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PubMed Link: 20526358

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• pone.0010876.pdf

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PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Abbruzzese, Jennifer J; Sanguinetti, Michael C MC

Publication Date: 2009-11-24

Variant appearance in text: KCNH2: G628C

PubMed Link: 19892732

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Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Molecular Pharmacology

Wang, Lu L; Dennis, Adrienne T AT; Trieu, Phan P; Charron, Francois F; Ethier, Natalie N; Hebert, Terence E TE; Wan, Xiaoping X; Ficker, Eckhard E

Publication Date: 2009-04

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PubMed Link: 19139152

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Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.

British Journal Of Pharmacology

McPate, M J MJ; Duncan, R S RS; Hancox, J C JC; Witchel, H J HJ

Publication Date: 2008-11

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PubMed Link: 18724381

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Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).

Molecular Pharmacology

Xu, Xulin X; Recanatini, Maurizio M; Roberti, Marinella M; Tseng, Gea-Ny GN

Publication Date: 2008-06

Variant appearance in text: LQT2: G628C

PubMed Link: 18372399

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Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.

The Journal Of Physiology

Fernandez, David D; Ghanta, Azad A; Kinard, Krista I KI; Sanguinetti, Michael C MC

Publication Date: 2005-09-15

Variant appearance in text: HERG: G628C

PubMed Link: 15975984

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Gating charges in the activation and inactivation processes of the HERG channel.

The Journal Of General Physiology

Zhang, Mei M; Liu, Jie J; Tseng, Gea-Ny GN

Publication Date: 2004-12

Variant appearance in text: HERG: G628C

PubMed Link: 15545400

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Gating currents associated with intramembrane charge displacement in HERG potassium channels.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Piper, David R DR; Varghese, Anthony A; Sanguinetti, Michael C MC; Tristani-Firouzi, Martin M

Publication Date: 2003-09-02

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PubMed Link: 12928493

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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Chen, Jun J; Seebohm, Guiscard G; Sanguinetti, Michael C MC

Publication Date: 2002-09-17

Variant appearance in text: HERG: G628C

PubMed Link: 12209010

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Fast and slow voltage sensor movements in HERG potassium channels.

The Journal Of General Physiology

Smith, Paula L PL; Yellen, Gary G

Publication Date: 2002-03

Variant appearance in text: HERG: G628C

PubMed Link: 11865022

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A structural basis for drug-induced long QT syndrome.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Mitcheson, J S JS; Chen, J J; Lin, M M; Culberson, C C; Sanguinetti, M C MC

Publication Date: 2000-10-24

Variant appearance in text: HERG: G628C

PubMed Link: 11005845

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Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes.

The Journal Of Physiology

Heath, B M BM; Terrar, D A DA

Publication Date: 2000-02-01

Variant appearance in text: HERG: G628C

PubMed Link: 10713964

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

The Journal Of General Physiology

Mitcheson, J S JS; Chen, J J; Sanguinetti, M C MC

Publication Date: 2000-03

Variant appearance in text: HERG: G628C

PubMed Link: 10694252

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• GP-8134.pdf

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