Publications:

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome.

Heliyon

Butler, Andrew A; Zhang, Yihong Y; Stuart, A Graham AG; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2019-04

Variant appearance in text: LQT2: I560A

PubMed Link: 31049424

Variant Present in the following documents:

• Main text
• main.pdf

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Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.

The Journal Of Biological Chemistry

Ng, Chai-Ann CA; Gravel, Andrée E AE; Perry, Matthew D MD; Arnold, Alexandre A AA; Marcotte, Isabelle I; Vandenberg, Jamie I JI

Publication Date: 2016-08-12

Variant appearance in text: Kv11.1: I560A

PubMed Link: 27317659

Variant Present in the following documents:

• Main text

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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

The Journal Of General Physiology

Perry, Matthew D MD; Wong, Sophia S; Ng, Chai Ann CA; Vandenberg, Jamie I JI

Publication Date: 2013-09

Variant appearance in text: Kv11.1: I560A

PubMed Link: 23980196

Variant Present in the following documents:

• Main text
• JGP_201310975.pdf
• supp_jgp.201310975_JGP_201310975_sm.pdf

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Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating.

The Journal Of Biological Chemistry

Perry, Matthew D MD; Ng, Chai Ann CA; Vandenberg, Jamie I JI

Publication Date: 2013-04-19

Variant appearance in text: Kv11.1: I560A

PubMed Link: 23471968

Variant Present in the following documents:

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Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Molecular Pharmacology

Grunnet, Morten M; Abbruzzese, Jennifer J; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2011-01

Variant appearance in text: LQT2: I560A

PubMed Link: 20876384

Variant Present in the following documents:

• Main text

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