KCNH2 c.1367A>C ;(p.D456A)

Variant ID: 7-150649703-T-G

NM_000238.3(KCNH2):c.1367A>C;(p.D456A)

This variant was identified in 7 publications

View GRCh38 version.




Publications:


hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (IKr) in cardiomyocytes derived from hiPSCs.

The Journal Of Biological Chemistry
Ukachukwu, Chiamaka U CU; Jimenez-Vazquez, Eric N EN; Jain, Abhilasha A; Jones, David K DK
Publication Date: 2022-12-07

Variant appearance in text: KCNH2: D456A
PubMed Link: 36496073
Variant Present in the following documents:
  • Main text
  • main.pdf
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Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization.

Bmc Molecular And Cell Biology
Matsumura, Kazuki K; Shimomura, Takushi T; Kubo, Yoshihiro Y; Oka, Takayuki T; Kobayashi, Naohiro N; Imai, Shunsuke S; Yanase, Naomi N; Akimoto, Madoka M; Fukuda, Masahiro M; Yokogawa, Mariko M; Ikeda, Kazuyoshi K; Kurita, Jun-Ichi JI; Nishimura, Yoshifumi Y; Shimada, Ichio I; Osawa, Masanori M
Publication Date: 2021-01-07

Variant appearance in text: HERG: D456A
PubMed Link: 33413079
Variant Present in the following documents:
  • 12860_2020_Article_337.pdf
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Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Molecular Pharmacology
Gardner, Alison A; Wu, Wei W; Thomson, Steven S; Zangerl-Plessl, Eva-Maria EM; Stary-Weinzinger, Anna A; Sanguinetti, Michael C MC
Publication Date: 2017-10

Variant appearance in text: KCNH2: D456A
PubMed Link: 28705808
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Molecular Pharmacology
Dennis, Adrienne T AT; Wang, Lu L; Wan, Hanlin H; Nassal, Drew D; Deschenes, Isabelle I; Ficker, Eckhard E
Publication Date: 2012-02

Variant appearance in text: HERG: D456A
PubMed Link: 22046004
Variant Present in the following documents:
  • Main text
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Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Molecular Pharmacology
Wang, Lu L; Dennis, Adrienne T AT; Trieu, Phan P; Charron, Francois F; Ethier, Natalie N; Hebert, Terence E TE; Wan, Xiaoping X; Ficker, Eckhard E
Publication Date: 2009-04

Variant appearance in text: HERG: D456A
PubMed Link: 19139152
Variant Present in the following documents:
  • Main text
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Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating.

Channels (Austin, Tex.)
Lin, Meng Chin A MC; Papazian, Diane M DM
Publication Date: 2007

Variant appearance in text: HERG: D456A
PubMed Link: 18690045
Variant Present in the following documents:
  • Main text
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Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.

The Journal Of Physiology
Fernandez, David D; Ghanta, Azad A; Kinard, Krista I KI; Sanguinetti, Michael C MC
Publication Date: 2005-09-15

Variant appearance in text: HERG: D456A
PubMed Link: 15975984
Variant Present in the following documents:
  • Main text
View BVdb publication page