KCNH2 c.37A>G ;(p.T13A)

Variant ID: 7-150674965-T-C

NM_000238.3(KCNH2):c.37A>G;(p.T13A)

This variant was identified in 2 publications

View GRCh38 version.




Publications:


Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels.

The Journal Of General Physiology
Tan, Peter S PS; Perry, Matthew D MD; Ng, Chai Ann CA; Vandenberg, Jamie I JI; Hill, Adam P AP
Publication Date: 2012-09

Variant appearance in text: HERG: T13A
PubMed Link: 22891279
Variant Present in the following documents:
  • supp_jgp.201110761_JGP_201110761_sm.pdf
View BVdb publication page



The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

Plos One
Ng, Chai Ann CA; Hunter, Mark J MJ; Perry, Matthew D MD; Mobli, Mehdi M; Ke, Ying Y; Kuchel, Philip W PW; King, Glenn F GF; Stock, Daniela D; Vandenberg, Jamie I JI
Publication Date: 2011-01-13

Variant appearance in text: HERG: T13A
PubMed Link: 21249148
Variant Present in the following documents:
  • Main text
  • pone.0016191.pdf
View BVdb publication page