An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates.
Angewandte Chemie (International Ed. In English)
Merkul, Eugen E; Muns, Joey A JA; Sijbrandi, Niels J NJ; Houthoff, Hendrik-Jan HJ; Nijmeijer, Bart B; van Rheenen, Gerro G; Reedijk, Jan J; van Dongen, Guus A M S GAMS
Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment.
Molecular Oncology
Zoetemelk, Marloes M; Ramzy, George M GM; Rausch, Magdalena M; Koessler, Thibaud T; van Beijnum, Judy R JR; Weiss, Andrea A; Mieville, Valentin V; Piersma, Sander R SR; de Haas, Richard R RR; Delucinge-Vivier, Céline C; Andres, Axel A; Toso, Christian C; Henneman, Alexander A AA; Ragusa, Simone S; Petrova, Tatiana V TV; Docquier, Mylène M; McKee, Thomas A TA; Jimenez, Connie R CR; Daali, Youssef Y; Griffioen, Arjan W AW; Rubbia-Brandt, Laura L; Dietrich, Pierre-Yves PY; Nowak-Sliwinska, Patrycja P
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Science (New York, N.Y.)
Engle, Dannielle D DD; Tiriac, Hervé H; Rivera, Keith D KD; Pommier, Arnaud A; Whalen, Sean S; Oni, Tobiloba E TE; Alagesan, Brinda B; Lee, Eun Jung EJ; Yao, Melissa A MA; Lucito, Matthew S MS; Spielman, Benjamin B; Da Silva, Brandon B; Schoepfer, Christina C; Wright, Kevin K; Creighton, Brianna B; Afinowicz, Lauren L; Yu, Kenneth H KH; Grützmann, Robert R; Aust, Daniela D; Gimotty, Phyllis A PA; Pollard, Katherine S KS; Hruban, Ralph H RH; Goggins, Michael G MG; Pilarsky, Christian C; Park, Youngkyu Y; Pappin, Darryl J DJ; Hollingsworth, Michael A MA; Tuveson, David A DA