Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity.
Npj Precision Oncology
Yoshizawa, Takahiro T; Uchibori, Ken K; Araki, Mitsugu M; Matsumoto, Shigeyuki S; Ma, Biao B; Kanada, Ryo R; Seto, Yosuke Y; Oh-Hara, Tomoko T; Koike, Sumie S; Ariyasu, Ryo R; Kitazono, Satoru S; Ninomiya, Hironori H; Takeuchi, Kengo K; Yanagitani, Noriko N; Takagi, Satoshi S; Kishi, Kazuma K; Fujita, Naoya N; Okuno, Yasushi Y; Nishio, Makoto M; Katayama, Ryohei R
Publication Date: 2021-04-16
Variant appearance in text: EGFR: 748-49G>A; rs4947986
Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.
Acta Neuropathologica Communications
Jungwirth, Gerhard G; Warta, Rolf R; Beynon, Christopher C; Sahm, Felix F; von Deimling, Andreas A; Unterberg, Andreas A; Herold-Mende, Christel C; Jungk, Christine C
Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility.
Oncotarget
Adel Fahmideh, Maral M; Lavebratt, Catharina C; Schüz, Joachim J; Röösli, Martin M; Tynes, Tore T; Grotzer, Michael A MA; Johansen, Christoffer C; Kuehni, Claudia E CE; Lannering, Birgitta B; Prochazka, Michaela M; Schmidt, Lisbeth S LS; Feychting, Maria M
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
Computational dissection of human episodic memory reveals mental process-specific genetic profiles.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Luksys, Gediminas G; Fastenrath, Matthias M; Coynel, David D; Freytag, Virginie V; Gschwind, Leo L; Heck, Angela A; Jessen, Frank F; Maier, Wolfgang W; Milnik, Annette A; Riedel-Heller, Steffi G SG; Scherer, Martin M; Spalek, Klara K; Vogler, Christian C; Wagner, Michael M; Wolfsgruber, Steffen S; Papassotiropoulos, Andreas A; de Quervain, Dominique J-F DJ
Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.
Acta Neuropathologica Communications
Shankar, Ganesh M GM; Taylor-Weiner, Amaro A; Lelic, Nina N; Jones, Robert T RT; Kim, James C JC; Francis, Joshua M JM; Abedalthagafi, Malak M; Borges, Lawrence F LF; Coumans, Jean-Valery JV; Curry, William T WT; Nahed, Brian V BV; Shin, John H JH; Paek, Sun Ha SH; Park, Sung-Hye SH; Stewart, Chip C; Lawrence, Michael S MS; Cibulskis, Kristian K; Thorner, Aaron R AR; Van Hummelen, Paul P; Stemmer-Rachamimov, Anat O AO; Batchelor, Tracy T TT; Carter, Scott L SL; Hoang, Mai P MP; Santagata, Sandro S; Louis, David N DN; Barker, Fred G FG; Meyerson, Matthew M; Getz, Gad G; Brastianos, Priscilla K PK; Cahill, Daniel P DP
Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study.
Pharmacogenetics And Genomics
Kraus, Sarah S; Hummler, Simone S; Toriola, Adetunji T AT; Poole, Elizabeth M EM; Scherer, Dominique D; Kotzmann, Jana J; Makar, Karen W KW; Kazanov, Dina D; Galazan, Lior L; Naumov, Inna I; Coghill, Anna E AE; Duggan, David D; Gigic, Biljana B; Arber, Nadir N; Ulrich, Cornelia M CM