Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: EGFR: 988G>A; Glu330Lys

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Impact of EGFRA289T/V mutation on relapse pattern in glioblastoma.

Esmo Open

Noeuveglise, A A; Sarafan-Vasseur, N N; Beaussire, L L; Marguet, F F; Modzelewski, R R; Hanzen, C C; Alexandru, C C; Magne, N N; Langlois, O O; Di Fiore, F F; Clatot, F F; Thureau, S S; Fontanilles, M M

Publication Date: 2022-12-22

Variant appearance in text: EGFR: E330K

PubMed Link: 36566697

Variant Present in the following documents:

• Main text
• main.pdf

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: EGFR: E330K

PubMed Link: 36561320

Variant Present in the following documents:

• Table3.xlsx, sheet 1
• Table2.xlsx, sheet 4

View BVdb publication page

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Chinese expert consensus on the diagnosis and treatment of HER2-altered non-small cell lung cancer.

Thoracic Cancer

Zhang, Shirong S; Wang, Wenxian W; Xu, Chunwei C; Zhang, Yongchang Y; Cai, Xiuyu X; Wang, Qian Q; Song, Zhengbo Z; Li, Ziming Z; Yu, Jinpu J; Zhong, Wenzhao W; Wang, Zhijie Z; Liu, Jingjing J; Liu, Anwen A; Li, Wen W; Zhan, Ping P; Liu, Hongbing H; Lv, Tangfeng T; Miao, Liyun L; Min, Lingfeng L; Lin, Gen G; Huang, Long L; Yuan, Jingping J; Jiang, Zhansheng Z; Pu, Xingxiang X; Rao, Chuangzhou C; Lv, Dongqing D; Yu, Zongyang Z; Li, Xiaoyan X; Tang, Chuanhao C; Zhou, Chengzhi C; Zhang, Junping J; Guo, Hui H; Chu, Qian Q; Meng, Rui R; Liu, Xuewen X; Wu, Jingxun J; Zhou, Jin J; Zhu, Zhengfei Z; Pan, Weiwei W; Dong, Xiaowei X; Pang, Fei F; Wang, Kai K; Yao, Chao C; Lin, Guomin G; Li, Site S; Yang, Zhi Z; Luo, Jiancheng J; Jia, Hongtao H; Nie, Xiuqing X; Wang, Liping L; Zhu, Youcai Y; Hu, Xiao X; Xie, Yanru Y; Lin, Xinqing X; Cai, Jing J; Xia, Yang Y; Feng, Huijing H; Wang, Lin L; Du, Yingying Y; Yao, Wang W; Shi, Xuefei X; Niu, Xiaomin X; Yuan, Dongmei D; Yao, Yanwen Y; Kang, Jing J; Zhang, Jiatao J; Zhang, Chao C; Gao, Wenbin W; Huang, Jianhui J; Zhang, Yinbin Y; Sun, Pingli P; Wang, Hong H; Ye, Mingxiang M; Wang, Dong D; Wang, Zhaofeng Z; Wan, Bing B; Lv, Donglai D; Yu, Genhua G; Shi, Lin L; Xia, Yuanli Y; Gao, Feng F; Zhang, Xiaochen X; Xu, Tao T; Zhou, Wei W; Wang, Haixia H; Liu, Zhefeng Z; Yang, Nong N; Wu, Lin L; Wang, Qiming Q; Wang, Guansong G; Hong, Zhuan Z; Wang, Jiandong J; Fang, Meiyu M; Fang, Yong Y; Zhang, Yiping Y; Song, Yong Y; Ma, Shenglin S; Fang, Wenfeng W; Lu, Yuanzhi Y

Publication Date: 2022-11-28

Variant appearance in text: EGFR: E330K

PubMed Link: 36444143

Variant Present in the following documents:

• Main text
• TCA-14-91.pdf

View BVdb publication page

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Ultrasensitive tumour-agnostic non-invasive detection of colorectal cancer recurrence using ctDNA methylation.

Clinical And Translational Medicine

Xiao, Yu Y; Wang, Xiaodong X; Weng, Hong H; Ding, Zhao Z; Qian, Kaiyu K; Jin, Wan W; Lu, Sen S; Ju, Lingao L; He, Zhiwen Z; Wang, Gang G; Xie, Xiaoyu X; Liu, Dongmei D; Fan, Zhou Z; Wu, Kai K; Li, Sheng S; Guo, Huanhuan H; Qian, Guofeng G; Jiang, Wei W; Leng, Yunji Y; Zhao, Junpeng J; Cao, Xinyue X; Peng, Minsheng M; Jiang, Congqing C; Li, Li L; Zhang, Yi Y; Wang, Xinghuan X

Publication Date: 2022-09

Variant appearance in text: EGFR: 988G>A; E330K

PubMed Link: 36103400

Variant Present in the following documents:

• CTM2-12-e1015-s002.xlsx, sheet 1

View BVdb publication page

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Comprehensive germline and somatic genomic profiles of Chinese patients with biliary tract cancer.

Frontiers In Oncology

Yu, Haipeng H; Xu, Yan Y; Gao, Wei W; Li, Mei M; He, Ji'an J; Deng, Xiaoqian X; Xing, Wenge W

Publication Date: 2022

Variant appearance in text: EGFR: E330K

PubMed Link: 36072793

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

View BVdb publication page

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Are transient protein-protein interactions more dispensable?

Plos Computational Biology

Ghadie, Mohamed Ali MA; Xia, Yu Y

Publication Date: 2022-04

Variant appearance in text: EGFR: 988G>A; Glu330Lys

PubMed Link: 35404956

Variant Present in the following documents:

• pcbi.1010013.s002.xlsx, sheet 4

View BVdb publication page

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Longitudinal Circulating Tumor DNA Profiling in Metastatic Colorectal Cancer During Anti-EGFR Therapy.

Frontiers In Oncology

Yang, Wentao W; Zou, Jianling J; Li, Ye Y; Liu, Rujiao R; Yan, Zhengqing Z; Chen, Shiqing S; Zhao, Xiaoying X; Guo, Weijian W; Huang, Mingzhu M; Li, Wenhua W; Zhu, Xiaodong X; Chen, Zhiyu Z

Publication Date: 2022

Variant appearance in text: EGFR: E330K

PubMed Link: 35280779

Variant Present in the following documents:

• Main text
• fonc-12-830816.pdf

View BVdb publication page

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Efficacy and safety of pyrotinib in advanced lung adenocarcinoma with HER2 mutations: a multicenter, single-arm, phase II trial.

Bmc Medicine

Song, Zhengbo Z; Li, Yuping Y; Chen, Shiqing S; Ying, Shenpeng S; Xu, Shuguang S; Huang, Jianjin J; Wu, Dan D; Lv, Dongqing D; Bei, Ting T; Liu, Shuxun S; Huang, Xiaoping X; Xie, Congying C; Wu, Xiaoyu X; Fu, Jianfei J; Hua, Feng F; Wang, Wenxian W; Xu, Chunwei C; Gao, Chan C; Cai, Shangli S; Lu, Shun S; Zhang, Yiping Y

Publication Date: 2022-02-01

Variant appearance in text: EGFR: E330K

PubMed Link: 35101045

Variant Present in the following documents:

• Main text
• 12916_2022_Article_2245.pdf

View BVdb publication page

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Efficacy and safety of pyrotinib in advanced lung adenocarcinoma with HER2 mutations: a multicenter, single-arm, phase II trial.

Bmc Medicine

Song, Zhengbo Z; Li, Yuping Y; Chen, Shiqing S; Ying, Shenpeng S; Xu, Shuguang S; Huang, Jianjin J; Wu, Dan D; Lv, Dongqing D; Bei, Ting T; Liu, Shuxun S; Huang, Xiaoping X; Xie, Congying C; Wu, Xiaoyu X; Fu, Jianfei J; Hua, Feng F; Wang, Wenxian W; Xu, Chunwei C; Gao, Chan C; Cai, Shangli S; Lu, Shun S; Zhang, Yiping Y

Publication Date: 2022-02-01

Variant appearance in text: EGFR: E330K

PubMed Link: 35101045

Variant Present in the following documents:

• Main text
• 12916_2022_Article_2245.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: E330K

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (Cambridge (Mass.))

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: E330K

PubMed Link: 34557754

Variant Present in the following documents:

• Main text
• main.pdf

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (New York, N.Y.)

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: E330K

PubMed Link: 34557754

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Plasma Circulating Tumor DNA Sequencing Predicts Minimal Residual Disease in Resectable Esophageal Squamous Cell Carcinoma.

Frontiers In Oncology

Liu, Tao T; Yao, Qianqian Q; Jin, Hai H

Publication Date: 2021

Variant appearance in text: EGFR: E330K

PubMed Link: 34094900

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 6

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: EGFR: 988G>A; E330K

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer

Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY

Publication Date: 2020-10

Variant appearance in text: EGFR: E330K

PubMed Link: 33077514

Variant Present in the following documents:

• jitc-2020-001199supp002.pdf

View BVdb publication page

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Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Frontiers In Oncology

Wang, Shuhang S; Chen, Rongrong R; Tang, Yu Y; Yu, Yue Y; Fang, Yuan Y; Huang, Huiyao H; Wu, Dawei D; Fang, Hong H; Bai, Ying Y; Sun, Chao C; Yu, Anqi A; Fan, Qi Q; Gu, Dejian D; Yi, Xin X; Li, Ning N

Publication Date: 2020

Variant appearance in text: EGFR: 988G>A; E330K

PubMed Link: 32373528

Variant Present in the following documents:

• Table_6.xlsx, sheet 1

View BVdb publication page

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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer

Mack, Philip C PC; Banks, Kimberly C KC; Espenschied, Carin R CR; Burich, Rebekah A RA; Zill, Oliver A OA; Lee, Christine E CE; Riess, Jonathan W JW; Mortimer, Stefanie A SA; Talasaz, AmirAli A; Lanman, Richard B RB; Gandara, David R DR

Publication Date: 2020-07-15

Variant appearance in text: EGFR: E330K

PubMed Link: 32365229

Variant Present in the following documents:

• Main text
• CNCR-126-3219.pdf

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: E330K

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Importance of phosphorylation/dephosphorylation cycles on lipid-dependent modulation of membrane protein topology by posttranslational phosphorylation.

The Journal Of Biological Chemistry

Vitrac, Heidi H; Mallampalli, Venkata K P S VKPS; Dowhan, William W

Publication Date: 2019-12-06

Variant appearance in text: rs139429793

PubMed Link: 31645436

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naïve Patients With Advanced NSCLC.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Lisberg, A A; Cummings, A A; Goldman, J W JW; Bornazyan, K K; Reese, N N; Wang, T T; Coluzzi, P P; Ledezma, B B; Mendenhall, M M; Hunt, J J; Wolf, B B; Jones, B B; Madrigal, J J; Horton, J J; Spiegel, M M; Carroll, J J; Gukasyan, J J; Williams, T T; Sauer, L L; Wells, C C; Hardy, A A; Linares, P P; Lim, C C; Ma, L L; Adame, C C; Garon, Edward B EB

Publication Date: 2018-08

Variant appearance in text: EGFR: E330K

PubMed Link: 29874546

Variant Present in the following documents:

• Main text

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Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

McCoach, Caroline E CE; Blakely, Collin M CM; Banks, Kimberly C KC; Levy, Benjamin B; Chue, Ben M BM; Raymond, Victoria M VM; Le, Anh T AT; Lee, Christine E CE; Diaz, Joseph J; Waqar, Saiama N SN; Purcell, William T WT; Aisner, Dara L DL; Davies, Kurtis D KD; Lanman, Richard B RB; Shaw, Alice T AT; Doebele, Robert C RC

Publication Date: 2018-06-15

Variant appearance in text: EGFR: E330K

PubMed Link: 29599410

Variant Present in the following documents:

• Main text

View BVdb publication page

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: ERBB: 988G>A; rs139429793

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

View BVdb publication page

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Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell

Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R

Publication Date: 2015-09-24

Variant appearance in text: EGFR: E330K

PubMed Link: 26388441

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

View BVdb publication page

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Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation.

Cancers

Ymer, Susie I SI; Greenall, Sameer A SA; Cvrljevic, Anna A; Cao, Diana X DX; Donoghue, Jacqui F JF; Epa, V Chandana VC; Scott, Andrew M AM; Adams, Timothy E TE; Johns, Terrance G TG

Publication Date: 2011-04-18

Variant appearance in text: EGFR: E330K

PubMed Link: 24212795

Variant Present in the following documents:

• Main text
• cancers-03-02032.pdf
• cancers-03-02032-s001.pdf

View BVdb publication page

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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

Plos Medicine

Lee, Jeffrey C JC; Vivanco, Igor I; Beroukhim, Rameen R; Huang, Julie H Y JH; Feng, Whei L WL; DeBiasi, Ralph M RM; Yoshimoto, Koji K; King, Jennifer C JC; Nghiemphu, Phioanh P; Yuza, Yuki Y; Xu, Qing Q; Greulich, Heidi H; Thomas, Roman K RK; Paez, J Guillermo JG; Peck, Timothy C TC; Linhart, David J DJ; Glatt, Karen A KA; Getz, Gad G; Onofrio, Robert R; Ziaugra, Liuda L; Levine, Ross L RL; Gabriel, Stacey S; Kawaguchi, Tomohiro T; O'Neill, Keith K; Khan, Haumith H; Liau, Linda M LM; Nelson, Stanley F SF; Rao, P Nagesh PN; Mischel, Paul P; Pieper, Russell O RO; Cloughesy, Tim T; Leahy, Daniel J DJ; Sellers, William R WR; Sawyers, Charles L CL; Meyerson, Matthew M; Mellinghoff, Ingo K IK

Publication Date: 2006-12

Variant appearance in text: EGFR: E330K

PubMed Link: 17177598

Variant Present in the following documents:

• Main text
• pmed.0030485.pdf

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