Publications:

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance.

Nature Communications

Zhuang, Xinlei X; Wang, Zhe Z; Fan, Jiansheng J; Bai, Xuefei X; Xu, Yingchun Y; Chou, James J JJ; Hou, Tingjun T; Chen, Shuqing S; Pan, Liqiang L

Publication Date: 2022-07-30

Variant appearance in text: EGFR: I491M

PubMed Link: 35907884

Variant Present in the following documents:

• Main text
• 41467_2022_32159_MOESM2_ESM.pdf
• 41467_2022_32159_MOESM1_ESM.pdf
• 41467_2022_Article_32159.pdf

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Cross-Resistance Among Sequential Cancer Therapeutics: An Emerging Issue.

Frontiers In Oncology

Loria, Rossella R; Vici, Patrizia P; Di Lisa, Francesca Sofia FS; Soddu, Silvia S; Maugeri-Saccà, Marcello M; Bon, Giulia G

Publication Date: 2022

Variant appearance in text: EGFR: I491M

PubMed Link: 35814399

Variant Present in the following documents:

• Main text
• fonc-12-877380.pdf

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Ile491Met

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

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Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives.

Journal Of Cancer Metastasis And Treatment

Battaglin, Francesca F; Puccini, Alberto A; Naseem, Madiha M; Schirripa, Marta M; Berger, Martin D MD; Tokunaga, Ryuma R; McSkane, Michelle M; Khoukaz, Taline T; Soni, Shivani S; Zhang, Wu W; Lenz, Heinz-Josef HJ

Publication Date: 2018

Variant appearance in text: EGFR: I491M

PubMed Link: 34532592

Variant Present in the following documents:

• Main text

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A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models.

Signal Transduction And Targeted Therapy

Fan, Jiansheng J; Zhuang, Xinlei X; Yang, Xiaoyue X; Xu, Yingchun Y; Zhou, Zhan Z; Pan, Liqiang L; Chen, Shuqing S

Publication Date: 2021-09-03

Variant appearance in text: EGFR: I491M

PubMed Link: 34475375

Variant Present in the following documents:

• Main text
• 41392_2021_Article_666.pdf

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A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models.

Signal Transduction And Targeted Therapy

Fan, Jiansheng J; Zhuang, Xinlei X; Yang, Xiaoyue X; Xu, Yingchun Y; Zhou, Zhan Z; Pan, Liqiang L; Chen, Shuqing S

Publication Date: 2021-09-03

Variant appearance in text: EGFR: I491M

PubMed Link: 34475375

Variant Present in the following documents:

• Main text
• 41392_2021_Article_666.pdf

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Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope.

Scientific Reports

Makabe, Koki K; Yokoyama, Takeshi T; Uehara, Shiro S; Uchikubo-Kamo, Tomomi T; Shirouzu, Mikako M; Kimura, Kouki K; Tsumoto, Kouhei K; Asano, Ryutaro R; Tanaka, Yoshikazu Y; Kumagai, Izumi I

Publication Date: 2021-03-11

Variant appearance in text: EGFR: I491M

PubMed Link: 33707468

Variant Present in the following documents:

• Main text

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Tyrosine Kinase Receptors in Oncology.

International Journal Of Molecular Sciences

Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J

Publication Date: 2020-11-12

Variant appearance in text: EGFR: I491M

PubMed Link: 33198314

Variant Present in the following documents:

• Main text
• ijms-21-08529.pdf

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Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy.

Cancer Biology & Therapy

Price, Timothy T; Ang, Agnes A; Boedigheimer, Michael M; Kim, Tae Won TW; Li, Jin J; Cascinu, Stefano S; Ruff, Paul P; Satya Suresh, Attili A; Thomas, Anne A; Tjulandin, Sergei S; Peeters, Marc M

Publication Date: 2020-10-02

Variant appearance in text: EGFR: I491M

PubMed Link: 33026965

Variant Present in the following documents:

• Main text
• KCBT_21_1798695.pdf

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Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy.

Theranostics

von Baumgarten, Louisa L; Kumbrink, Jörg J; Jung, Andreas A; Reischer, Anna A; Flach, Madeleine M; Liebmann, Sibylle S; Metzeler, Klaus H KH; Holch, Julian W JW; Niyazi, Maximilian M; Thon, Niklas N; Straube, Andreas A; von Bergwelt-Baildon, Michael M; Heinemann, Volker V; Kirchner, Thomas T; Westphalen, Christoph Benedikt CB

Publication Date: 2020

Variant appearance in text: EGFR: 1473A>G

PubMed Link: 31903155

Variant Present in the following documents:

• Main text

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Advantage of Next-Generation Sequencing in Dynamic Monitoring of Circulating Tumor DNA over Droplet Digital PCR in Cetuximab Treated Colorectal Cancer Patients.

Translational Oncology

Zhang, Hangyu H; Liu, Rujiao R; Yan, Cong C; Liu, Lulu L; Tong, Zhou Z; Jiang, Weiqin W; Yao, Ming M; Fang, Weijia W; Chen, Zhiyu Z

Publication Date: 2019-03

Variant appearance in text: EGFR: I491M

PubMed Link: 30562681

Variant Present in the following documents:

• Main text
• main.pdf

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Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.

Cell Chemical Biology

Kaserer, Teresa T; Blagg, Julian J

Publication Date: 2018-11-15

Variant appearance in text: EGFR: I491M

PubMed Link: 30146241

Variant Present in the following documents:

• Main text
• mmc9.pdf
• main.pdf

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: EGFR: I491M

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 3

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Clinical Utility of Analyzing Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer.

The Oncologist

Nakamura, Yoshiaki Y; Yoshino, Takayuki T

Publication Date: 2018-11

Variant appearance in text: EGFR: I491M

PubMed Link: 29700206

Variant Present in the following documents:

• Main text

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: EGFR: I491M

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S1.xlsx, sheet 1

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Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nature Communications

Van Emburgh, Beth O BO; Arena, Sabrina S; Siravegna, Giulia G; Lazzari, Luca L; Crisafulli, Giovanni G; Corti, Giorgio G; Mussolin, Benedetta B; Baldi, Federica F; Buscarino, Michela M; Bartolini, Alice A; Valtorta, Emanuele E; Vidal, Joana J; Bellosillo, Beatriz B; Germano, Giovanni G; Pietrantonio, Filippo F; Ponzetti, Agostino A; Albanell, Joan J; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Di Nicolantonio, Federica F; Montagut, Clara C; Bardelli, Alberto A

Publication Date: 2016-12-08

Variant appearance in text: EGFR: I491M

PubMed Link: 27929064

Variant Present in the following documents:

• ncomms13665.pdf
• ncomms13665-s1.pdf

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The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.

Plos One

Sickmier, E Allen EA; Kurzeja, Robert J M RJ; Michelsen, Klaus K; Vazir, Mukta M; Yang, Evelyn E; Tasker, Andrew S AS

Publication Date: 2016

Variant appearance in text: EGFR: I491M

PubMed Link: 27658254

Variant Present in the following documents:

• Main text
• pone.0163366.pdf

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Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer.

World Journal Of Gastroenterology

Sforza, Vincenzo V; Martinelli, Erika E; Ciardiello, Fortunato F; Gambardella, Valentina V; Napolitano, Stefania S; Martini, Giulia G; Della Corte, Carminia C; Cardone, Claudia C; Ferrara, Marianna L ML; Reginelli, Alfonso A; Liguori, Giuseppina G; Belli, Giulio G; Troiani, Teresa T

Publication Date: 2016-07-28

Variant appearance in text: EGFR: I491M

PubMed Link: 27605871

Variant Present in the following documents:

• Main text

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Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

Oncotarget

Braig, Friederike F; Voigtlaender, Minna M; Schieferdecker, Aneta A; Busch, Chia-Jung CJ; Laban, Simon S; Grob, Tobias T; Kriegs, Malte M; Knecht, Rainald R; Bokemeyer, Carsten C; Binder, Mascha M

Publication Date: 2016-07-12

Variant appearance in text: EGFR: I491M

PubMed Link: 27119512

Variant Present in the following documents:

• Main text
• oncotarget-07-42988.pdf

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Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand?

Nature Reviews. Gastroenterology & Hepatology

Schirripa, Marta M; Lenz, Heinz-Josef HJ

Publication Date: 2016-05

Variant appearance in text: EGFR: Ile491Met

PubMed Link: 27006256

Variant Present in the following documents:

• Main text

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Profile of panitumumab as first-line treatment in patients with wild-type KRAS metastatic colorectal cancer.

Oncotargets And Therapy

Patel, Shiven B SB; Gill, David D; Garrido-Laguna, Ignacio I

Publication Date: 2016

Variant appearance in text: EGFR: I491M

PubMed Link: 26770060

Variant Present in the following documents:

• Main text
• ott-9-075.pdf

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Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.

British Journal Of Cancer

Khelwatty, Said A SA; Essapen, Sharadah S; Seddon, Alan M AM; Fan, Zhen Z; Modjtahedi, Helmout H

Publication Date: 2015-09-29

Variant appearance in text: EGFR: I491M

PubMed Link: 26372697

Variant Present in the following documents:

• Main text

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