EGFR c.2110_2112delinsAAC ;(p.L704N)

Variant ID: 7-55241662-TTG-AAC

NM_005228.3(EGFR):c.2110_2112delinsAAC;(p.L704N)

This variant was identified in 10 publications

View GRCh38 version.




Publications:


Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: EGFR: L704N
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Sato, Hiroki H; Offin, Michael M; Kubota, Daisuke D; Yu, Helena A HA; Wilhelm, Clare C; Toyooka, Shinichi S; Somwar, Romel R; Kris, Mark G MG; Ladanyi, Marc M
Publication Date: 2021-01

Variant appearance in text: EGFR: L704N
PubMed Link: 33038514
Variant Present in the following documents:
  • Main text
View BVdb publication page



EGFR forms ligand-independent oligomers that are distinct from the active state.

The Journal Of Biological Chemistry
Byrne, Patrick O PO; Hristova, Kalina K; Leahy, Daniel J DJ
Publication Date: 2020-09-18

Variant appearance in text: EGFR: L704N
PubMed Link: 32727847
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective.

Bmb Reports
Cho, Jeonghee J
Publication Date: 2020-03

Variant appearance in text: EGFR: L704N
PubMed Link: 32172728
Variant Present in the following documents:
  • Main text
  • BMB-53-133.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: EGFR: L704N
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ruan, Zheng Z; Kannan, Natarajan N
Publication Date: 2018-08-28

Variant appearance in text: EGFR: L704N
PubMed Link: 30104348
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.

Biochemistry
Ruan, Zheng Z; Kannan, Natarajan N
Publication Date: 2015-07-14

Variant appearance in text: EGFR: L704N
PubMed Link: 26101090
Variant Present in the following documents:
  • Main text
View BVdb publication page



Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants.

Oncotarget
Park, Angela K J AK; Francis, Joshua M JM; Park, Woong-Yang WY; Park, Joon-Oh JO; Cho, Jeonghee J
Publication Date: 2015-04-20

Variant appearance in text: EGFR: L704N
PubMed Link: 25826094
Variant Present in the following documents:
  • Main text
  • oncotarget-06-8839.pdf
View BVdb publication page



Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab.

Molecular Cancer
Cho, Jeonghee J; Bass, Adam J AJ; Lawrence, Michael S MS; Cibulskis, Kristian K; Cho, Ahye A; Lee, Shi-Nai SN; Yamauchi, Mai M; Wagle, Nikhil N; Pochanard, Panisa P; Kim, Nayoung N; Park, Angela Kj AK; Won, Jonghwa J; Hur, Hyung-Suk HS; Greulich, Heidi H; Ogino, Shuji S; Sougnez, Carrie C; Voet, Douglas D; Tabernero, Josep J; Jimenez, Jose J; Baselga, Jose J; Gabriel, Stacey B SB; Lander, Eric S ES; Getz, Gad G; Eck, Michael J MJ; Park, Woong-Yang WY; Meyerson, Matthew M
Publication Date: 2014-06-04

Variant appearance in text: EGFR: L704N
PubMed Link: 24894453
Variant Present in the following documents:
  • Main text
  • 1476-4598-13-141.pdf
View BVdb publication page



Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.

Cancer Research
Cho, Jeonghee J; Chen, Liang L; Sangji, Naveen N; Okabe, Takafumi T; Yonesaka, Kimio K; Francis, Joshua M JM; Flavin, Richard J RJ; Johnson, William W; Kwon, Jihyun J; Yu, Soyoung S; Greulich, Heidi H; Johnson, Bruce E BE; Eck, Michael J MJ; Jänne, Pasi A PA; Wong, Kwok-Kin KK; Meyerson, Matthew M
Publication Date: 2013-11-15

Variant appearance in text: EGFR: L704N
PubMed Link: 24063894
Variant Present in the following documents:
  • Main text
View BVdb publication page