Publications:

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Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting.

Nature Communications

Du, Zhenfang Z; Brown, Benjamin P BP; Kim, Soyeon S; Ferguson, Donna D; Pavlick, Dean C DC; Jayakumaran, Gowtham G; Benayed, Ryma R; Gallant, Jean-Nicolas JN; Zhang, Yun-Kai YK; Yan, Yingjun Y; Red-Brewer, Monica M; Ali, Siraj M SM; Schrock, Alexa B AB; Zehir, Ahmet A; Ladanyi, Marc M; Smith, Adam W AW; Meiler, Jens J; Lovly, Christine M CM

Publication Date: 2021-03-02

Variant appearance in text: EGFR: I706Q

PubMed Link: 33654076

Variant Present in the following documents:

• Main text
• 41467_2021_Article_21613.pdf
• 41467_2021_21613_MOESM8_ESM.xlsx, sheet 19
• 41467_2021_21613_MOESM8_ESM.xlsx, sheet 6
• 41467_2021_21613_MOESM1_ESM.pdf
• 41467_2021_21613_MOESM2_ESM.pdf

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EGFR forms ligand-independent oligomers that are distinct from the active state.

The Journal Of Biological Chemistry

Byrne, Patrick O PO; Hristova, Kalina K; Leahy, Daniel J DJ

Publication Date: 2020-09-18

Variant appearance in text: EGFR: I706Q

PubMed Link: 32727847

Variant Present in the following documents:

• Main text

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Pockets as structural descriptors of EGFR kinase conformations.

Plos One

Hasenahuer, Marcia Anahi MA; Barletta, German Patricio GP; Fernandez-Alberti, Sebastián S; Parisi, Gustavo G; Fornasari, María Silvina MS

Publication Date: 2017

Variant appearance in text: EGFR: I706Q

PubMed Link: 29228029

Variant Present in the following documents:

• pone.0189147.s003.xls, sheet 1

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The Epidermal Growth Factor Receptor Forms Location-Dependent Complexes in Resting Cells.

Biophysical Journal

Yavas, Sibel S; Macháň, Radek R; Wohland, Thorsten T

Publication Date: 2016-11-15

Variant appearance in text: EGFR: I706Q

PubMed Link: 27851946

Variant Present in the following documents:

• Main text

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Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.

Biophysical Journal

Coban, Oana O; Zanetti-Dominguez, Laura C LC; Matthews, Daniel R DR; Rolfe, Daniel J DJ; Weitsman, Gregory G; Barber, Paul R PR; Barbeau, Jody J; Devauges, Viviane V; Kampmeier, Florian F; Winn, Martyn M; Vojnovic, Borivoj B; Parker, Peter J PJ; Lidke, Keith A KA; Lidke, Diane S DS; Ameer-Beg, Simon M SM; Martin-Fernandez, Marisa L ML; Ng, Tony T

Publication Date: 2015-03-10

Variant appearance in text: EGFR: I706Q

PubMed Link: 25762314

Variant Present in the following documents:

• Main text
• mmc2.pdf
• main.pdf

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Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation.

Cell Communication And Signaling : Ccs

Kancha, Rama Krishna RK; von Bubnoff, Nikolas N; Duyster, Justus J

Publication Date: 2013-06-10

Variant appearance in text: EGFR: I706Q

PubMed Link: 23758840

Variant Present in the following documents:

• Main text
• 1478-811X-11-39-S3.pdf
• 1478-811X-11-39-S2.pdf
• 1478-811X-11-39.pdf

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Mechanistic insights into the activation of oncogenic forms of EGF receptor.

Nature Structural & Molecular Biology

Wang, Zhihong Z; Longo, Patti A PA; Tarrant, Mary Katherine MK; Kim, Kwangsoo K; Head, Sarah S; Leahy, Daniel J DJ; Cole, Philip A PA

Publication Date: 2011-11-20

Variant appearance in text: EGFR: I706Q

PubMed Link: 22101934

Variant Present in the following documents:

• Main text
• nihms328232.pdf
• NIHMS328232-supplement-2.pdf

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