EGFR c.2125_2127delinsCAT ;(p.E709H)

Variant ID: 7-55241677-GAA-CAT

NM_005228.3(EGFR):c.2125_2127delinsCAT;(p.E709H)

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Inconsistent clinical outcomes following afatinib treatment in NSCLC patients harboring uncommon epidermal growth factor receptor mutation.

Frontiers In Oncology
Dong, Wei W; Wang, Congjie C; Wang, Chunsheng C; Zhao, Kewei K; Ma, Zhao Z; Hu, Shanliang S
Publication Date: 2022

Variant appearance in text: EGFR: E709H
PubMed Link: 36425553
Variant Present in the following documents:
  • DataSheet_1.pdf
View BVdb publication page



Multiple mutations in the EGFR gene in lung cancer: a systematic review.

Translational Lung Cancer Research
Castañeda-González, Juan Pablo JP; Chaves, Juan José JJ; Parra-Medina, Rafael R
Publication Date: 2022-10

Variant appearance in text: EGFR: E709H
PubMed Link: 36386461
Variant Present in the following documents:
  • Main text
  • tlcr-11-10-2148.pdf
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: E709H
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: EGFR: E709H
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



A Lung Adenocarcinoma Patient With a Rare EGFR E709_T710delinsD Mutation Showed a Good Response to Afatinib Treatment: A Case Report and Literature Review.

Frontiers In Oncology
Wei, Yu Y; Cui, Yueli Y; Guo, Yao Y; Li, Lei L; Zeng, Liang L
Publication Date: 2021

Variant appearance in text: EGFR: E709H
PubMed Link: 34178699
Variant Present in the following documents:
  • Main text
  • fonc-11-700345.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: EGFR: E709H
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: EGFR: E709H
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Better Progression-Free Survival in Elderly Patients with Stage IV Lung Adenocarcinoma Harboring Uncommon Epidermal Growth Factor Receptor Mutations Treated with the First-line Tyrosine Kinase Inhibitors.

Cancers
Tsai, Ming-Ju MJ; Hung, Jen-Yu JY; Lee, Mei-Hsuan MH; Kuo, Chia-Yu CY; Tsai, Yu-Chen YC; Tsai, Ying-Ming YM; Liu, Ta-Chih TC; Yang, Chih-Jen CJ; Huang, Ming-Shyan MS; Chong, Inn-Wen IW
Publication Date: 2018-11-13

Variant appearance in text: EGFR: E709H
PubMed Link: 30428509
Variant Present in the following documents:
  • cancers-10-00434.pdf
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: EGFR: E709H
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer.

Oncotargets And Therapy
Wu, Jenn-Yu JY; Shih, Jin-Yuan JY
Publication Date: 2016

Variant appearance in text: EGFR: E709H
PubMed Link: 27785061
Variant Present in the following documents:
  • Main text
View BVdb publication page



Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy.

Cancer Science
Kobayashi, Yoshihisa Y; Mitsudomi, Tetsuya T
Publication Date: 2016-09

Variant appearance in text: EGFR: E709H
PubMed Link: 27323238
Variant Present in the following documents:
  • Main text
View BVdb publication page



Compound EGFR mutation is frequently detected with co-mutations of actionable genes and associated with poor clinical outcome in lung adenocarcinoma.

Cancer Biology & Therapy
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016

Variant appearance in text: EGFR: E709H
PubMed Link: 26785607
Variant Present in the following documents:
  • Main text
  • kcbt-17-03-1139235.pdf
View BVdb publication page



Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.

Scientific Reports
Fu, Yong Y; Cruz-Monserrate, Zobeida Z; Helen Lin, H H; Chung, Yiyin Y; Ji, Baoan B; Lin, Szu-Min SM; Vonderfecht, Steven S; Logsdon, Craig D CD; Li, Chien-Feng CF; Ann, David K DK
Publication Date: 2015-08-20

Variant appearance in text: EGFR: E709H
PubMed Link: 26289340
Variant Present in the following documents:
  • srep13347-s1.pdf
View BVdb publication page



Oncogene mutational profile in nasopharyngeal carcinoma.

Oncotargets And Therapy
Zhang, Zi-Chen ZC; Fu, Sha S; Wang, Fang F; Wang, Hai-Yun HY; Zeng, Yi-Xin YX; Shao, Jian-Yong JY
Publication Date: 2014

Variant appearance in text: EGFR: E709H
PubMed Link: 24672248
Variant Present in the following documents:
  • Main text
  • ott-7-457.pdf
View BVdb publication page



Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology
Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF
Publication Date: 2012-02

Variant appearance in text: EGFR: E709H
PubMed Link: 21748247
Variant Present in the following documents:
  • 10434_2011_1892_MOESM2_ESM.pdf
View BVdb publication page



Absence of common activating mutations of the epidermal growth factor receptor gene in thyroid cancers from American and Japanese patients.

International Journal Of Cancer
Ricarte-Filho, Julio C JC; Matsuse, Michiko M; Lau, Christopher C; Ryder, Mabel M; Nishihara, Eijun E; Ghossein, Ronald A RA; Ladanyi, Marc M; Yamashita, Shunichi S; Mitsutake, Norisato N; Fagin, James A JA
Publication Date: 2012-05-01

Variant appearance in text: EGFR: E709H
PubMed Link: 21717456
Variant Present in the following documents:
  • Main text
View BVdb publication page



Co-conserved features associated with cis regulation of ErbB tyrosine kinases.

Plos One
Mirza, Amar A; Mustafa, Morad M; Talevich, Eric E; Kannan, Natarajan N
Publication Date: 2010-12-13

Variant appearance in text: EGFR: E709H
PubMed Link: 21179209
Variant Present in the following documents:
  • Main text
  • pone.0014310.pdf
View BVdb publication page



Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One
Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS
Publication Date: 2008

Variant appearance in text: EGFR: E709H
PubMed Link: 19005564
Variant Present in the following documents:
  • pone.0003714.s003.xls, sheet 1
View BVdb publication page