Variant ID: 7-55241707-GGC-TGA

NM_005228.3(EGFR):c.2155_2157delinsTGA;(p.Gly719*)

This variant was identified in 580 publications




Publications:


Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: EGFR: G719X
PMID: 32729257
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Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report.

Journal Of Cardiothoracic Surgery
Y Yang, X Xie, G Jiang, H Liu
Publication Date: 2020-07-29

Variant appearance in text: EGFR: G719X
PMID: 32727606
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Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer.

Bmc Cancer
W Ouyang, J Yu, Y Zhou, J Hu, Z Huang, J Zhang, C Xie
Publication Date: 2020-07-28

Variant appearance in text: EGFR: G719X
PMID: 32723319
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Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology
HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32714871
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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
W Jin
Publication Date: 2020-07-16

Variant appearance in text: EGFR: G719X
PMID: 32708604
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Lymphocyte percentage and platelet count correlate with the treatment outcome to tyrosine kinase inhibitors in epidermal growth factor receptor-mutated lung adenocarcinoma.

Medicine
CC Li, CB Lin, SC Chu, WH Huang, JJ Lee, GG Yang, TF Wang, YF Wu
Publication Date: 2020-07-17

Variant appearance in text: EGFR: G719X
PMID: 32702917
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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy
HT Chan, YM Chin, SK Low
Publication Date: 2019-06

Variant appearance in text: EGFR: G719X
PMID: 32700193
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Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

Oncology And Therapy
M Sesé, R Somoza, I Maestu, MM Ureste, A Sanchez, JF Cordoba, I Sansano, G Venturas, S Ramón Y Cajal, J Hernández-Losa
Publication Date: 2019-12

Variant appearance in text: EGFR: G719x
PMID: 32699985
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Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand.

Bmc Cancer
PS Aye, S Tin Tin, MJ McKeage, P Khwaounjoo, A Cavadino, JM Elwood
Publication Date: 2020-07-14

Variant appearance in text: EGFR: G719X
PMID: 32664868
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Candidate biomarker assessment for pharmacological response.

Translational Oncology
WC Reinhold, F Elloumi, S Varma, J Robert, GB Mills, Y Pommier
Publication Date: 2020-07-08

Variant appearance in text: EGFR: G719X
PMID: 32652468
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Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors.

Journal Of Thoracic Disease
JA Chen, JW Riess
Publication Date: 2020-05

Variant appearance in text: EGFR: G719X
PMID: 32642199
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Potential treatment strategy for the rare osimertinib resistant mutation EGFR L718Q.

Journal Of Thoracic Disease
Y Song, Z Jia, Y Wang, Y Wang, P Liu, S Zhang, Z Bing, L Cao, Z Cao, E Rossi, R Zamarchi, MG Denis, C Camps, AB Fernandez-Diaz, N Liang, S Li
Publication Date: 2020-05

Variant appearance in text: EGFR: G719X
PMID: 32642185
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Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations.

Journal Of Thoracic Disease
HS Kang, AY Shin, CD Yeo, CK Park, JS Kim, JW Kim, SJ Kim, SH Lee, SK Kim
Publication Date: 2020-05

Variant appearance in text: EGFR: G719X
PMID: 32642093
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High-dose Radiotherapy for Oligo-progressive NSCLC Receiving EGFR Tyrosine Kinase Inhibitors: Real World Data.

In Vivo (Athens, Greece)
M Santarpia, G Altavilla, N Borsellino, A Girlando, G Mancuso, S Pergolizzi, D Piazza, A Pontoriero, MR Valerio, V Gebbia
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32606174
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Genetic Markers in Lung Cancer Diagnosis: A Review.

International Journal Of Molecular Sciences
K Wadowska, I Bil-Lula, Ł Trembecki, M Śliwińska-Mossoń
Publication Date: 2020-06-27

Variant appearance in text: EGFR: G719X
PMID: 32604993
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Liquid biopsy mutation panel for non-small cell lung cancer: analytical validation and clinical concordance.

Npj Precision Oncology
LS Schwartzberg, H Horinouchi, D Chan, S Chernilo, ML Tsai, D Isla, C Escriu, JP Bennett, K Clark-Langone, C Svedman, P Tomasini,
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32596507
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Assessment of Nine Driver Gene Mutations in Surgically Resected Samples from Patients with Non-Small-Cell Lung Cancer.

Cancer Management And Research
S Wang, X Qu, L Cao, X Hu, K Hou, Y Liu, X Che
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32581578
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Targeted Sequencing of Circulating Cell Free DNA Can Be Used to Monitor Therapeutic Efficacy of Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer Patients.

Cancer Genomics & Proteomics
CC Chiou, CL Wang, JD Luo, CY Liu, HW Ko, CT Yang
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32576586
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Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings.

Journal Of Oncology Pharmacy Practice : Official Publication Of The International Society Of Oncology Pharmacy Practitioners
RD Harvey, VR Adams, T Beardslee, P Medina
Publication Date: 2020-06-20

Variant appearance in text: EGFR: G719X
PMID: 32567494
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Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment.

Cancers
J Li, HF Kwok
Publication Date: 2020-06-15

Variant appearance in text: EGFR: G719X
PMID: 32549388
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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies.

Journal Of Clinical Medicine
S Rajurkar, I Mambetsariev, R Pharaon, B Leach, T Tan, P Kulkarni, R Salgia
Publication Date: 2020-06-15

Variant appearance in text: EGFR: G719X
PMID: 32549358
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Successful afatinib rechallenge in a patient with non-small cell lung cancer harboring EGFR G719C and S768I mutations.

Thoracic Cancer
T Masuda, N Sunaga, N Kasahara, K Takehara, M Yatomi, K Hara, Y Koga, T Maeno, T Hisada
Publication Date: 2020-06-11

Variant appearance in text: EGFR: G719X
PMID: 32529804
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Final Results from a Phase II Trial of Osimertinib for Elderly Patients with Epidermal Growth Factor Receptor t790m-Positive Non-Small Cell Lung Cancer That Progressed during Previous Treatment.

Journal Of Clinical Medicine
A Nakao, O Hiranuma, J Uchino, C Sakaguchi, T Araya, N Hiraoka, T Ishizuka, T Takeda, M Kawasaki, Y Goto, H Imai, N Hattori, K Nakatomi, H Uramoto, K Uryu, M Fukuda, Y Uchida, T Yokoyama, M Akai, T Mio, S Nagashima, Y Chihara, N Tamiya, Y Kaneko, T Mouri, T Yamada, K Yoshimura, M Fujita, K Takayama
Publication Date: 2020-06-05

Variant appearance in text: EGFR: G719X
PMID: 32517152
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Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.

Ebiomedicine
M de Wit, Y Gao, D Mercieca, I de Heer, B Valkenburg, ME van Royen, J Aerts, P Sillevis Smitt, P French
Publication Date: 2020-06-04

Variant appearance in text: EGFR: G719X
PMID: 32512509
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EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports
G Calibasi-Kocal, A Amirfallah, T Sever, O Umit Unal, D Gurel, I Oztop, H Ellidokuz, Y Basbinar
Publication Date: 2020-08

Variant appearance in text: EGFR: Gly719X
PMID: 32509305
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Glasgow prognostic score predicts efficacy and prognosis in patients with advanced non-small cell lung cancer receiving EGFR-TKI treatment.

Thoracic Cancer
N Kasahara, H Imai, I Naruse, Y Tsukagoshi, M Kotake, N Sunaga, K Kaira, T Maeno, T Asao, T Hisada
Publication Date: 2020-06-03

Variant appearance in text: EGFR: G719X
PMID: 32495520
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Successful treatment of a patient with NSCLC carrying uncommon compound EGFR G719X and S768I mutations using osimertinib: A case report.

The Journal Of International Medical Research
Y Cai, Y Wang, J Sun, X Wang, Y Xu, C Sun, Y Guo, M Sun, K Ma
Publication Date: 2020-06

Variant appearance in text: EGFR: G719X
PMID: 32493093
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Canadian consensus: a new systemic treatment algorithm for advanced EGFR-mutated non-small-cell lung cancer.

Current Oncology (Toronto, Ont.)
B Melosky, S Banerji, N Blais, Q Chu, R Juergens, NB Leighl, G Liu, P Cheema
Publication Date: 2020-04

Variant appearance in text: EGFR: G719X
PMID: 32489263
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The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).

Cancers
PC Hsu, CT Yang, DM Jablons, L You
Publication Date: 2020-05-26

Variant appearance in text: EGFR: G719X
PMID: 32466572
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Emerging therapeutic agents for advanced non-small cell lung cancer.

Journal Of Hematology & Oncology
R Chen, R Manochakian, L James, AG Azzouqa, H Shi, Y Zhang, Y Zhao, K Zhou, Y Lou
Publication Date: 2020-05-24

Variant appearance in text: EGFR: Gly719X
PMID: 32448366
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EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib.

Translational Lung Cancer Research
A Buder, MJ Hochmair, U Setinek, R Pirker, M Filipits
Publication Date: 2020-04

Variant appearance in text: EGFR: G719X
PMID: 32420063
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Variability of EGFR exon 20 insertions in 24,468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors.

Molecular Oncology
Y Qin, H Jian, X Tong, X Wu, F Wang, YW Shao, X Zhao
Publication Date: 2020-05-15

Variant appearance in text: EGFR: G719X
PMID: 32412152
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Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

Oncology Letters
T Yamaura, S Muto, H Mine, H Takagi, M Watanabe, Y Ozaki, T Inoue, M Fukuhara, N Okabe, Y Matsumura, T Hasegawa, J Osugi, M Hoshino, M Higuchi, Y Shio, H Suzuki
Publication Date: 2020-06

Variant appearance in text: EGFR: G719X
PMID: 32391110
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The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review.

Cancers
F van Delft, H Koffijberg, V Retèl, MVD Heuvel, M IJzerman
Publication Date: 2020-04-30

Variant appearance in text: EGFR: G719X
PMID: 32365836
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Long-term Survival With Afatinib in a Patient With Lung Adenocarcinoma Harboring Double Uncommon EGFR L861Q and G719X Mutations.

In Vivo (Athens, Greece)
G Ohara, S Okauchi, Y Sasatani, T Shiozawa, H Yamada, K Miyazaki, H Satoh
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32354946
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Comparison of the characteristics of uncommon epidermal growth factor receptor (EGFR) mutations and EGFR-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer from different ethnic groups.

Experimental And Therapeutic Medicine
Q Zhang, Y Cui, J Zhang, J Kenjiabieke, P Aerxiding
Publication Date: 2020-06

Variant appearance in text: EGFR: G719X
PMID: 32346412
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[Analysis of Clinical Characteristics and Driver Genes in 405 Patients with Lung Cancer Complicated with Tuberculosis].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Y Hu, X Yang, L Nie, D Zhao, J An, B Li
Publication Date: 2020-04-27

Variant appearance in text: EGFR: G719X
PMID: 32336065
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High MAF of EGFR mutations and high ratio of T790M sensitizing mutations in ctDNA predict better third-generation TKI outcomes.

Thoracic Cancer
Y Li, F Zhang, P Yuan, L Guo, Y Jianming, J He
Publication Date: 2020-04-14

Variant appearance in text: EGFR: G719X
PMID: 32285618
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Identification of somatic copy number variations in plasma cell free DNA correlating with intrinsic resistances to EGFR targeted therapy in T790M negative non-small cell lung cancer.

Journal Of Thoracic Disease
L Zhu, J Liang, B Xia, Y Xu, Z Qian, S Ma, S Zhang
Publication Date: 2020-03

Variant appearance in text: EGFR: G719X
PMID: 32274156
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Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

Journal Of Thoracic Disease
H Li, J Wang, G Zhang, Y Li, L Lin, H Yang, J Zhou, L Zhang, D Lv
Publication Date: 2020-03

Variant appearance in text: EGFR: G719X
PMID: 32274120
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Complete Remission of Multiple Brain Metastases in a Patient with EGFR-Mutated Non-Small-Cell Lung Cancer Treated with First-Line Osimertinib without Radiotherapy.

Case Reports In Oncological Medicine
K Ameku, M Higa
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32257480
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Concordance of Treatment Recommendations for Metastatic Non-Small-Cell Lung Cancer Between Watson for Oncology System and Medical Team.

Cancer Management And Research
HS You, CX Gao, HB Wang, SS Luo, SY Chen, YL Dong, J Lyu, T Tian
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32214852
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Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer.

Translational Lung Cancer Research
C Zhu, W Zhuang, L Chen, W Yang, WB Ou
Publication Date: 2020-02

Variant appearance in text: EGFR: G719X
PMID: 32206559
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Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non-Small Cell Lung Cancer: A Health Technology Assessment.

Ontario Health Technology Assessment Series
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32206157
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Clinicopathological parameters for circulating tumor DNA shedding in surgically resected non-small cell lung cancer with EGFR or KRAS mutation.

Plos One
MS Cho, CH Park, S Lee, HS Park
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32196518
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Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations.

Frontiers In Oncology
C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li, R Liu, L Xiang, C Huang, R Jiang
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32195178
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The Correlation between EGFR Mutation Status and DNA Content of Lung Adenocarcinoma Cells in Pleural Effusion.

Journal Of Cancer
Y Du, X Guo, R Wang, Y Ma, Y Zhang, Y Liu, L Dong, J Wu, X Ji, H Wang
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32127953
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A novel loop‑mediated isothermal amplification method for efficient and robust detection of EGFR mutations.

International Journal Of Oncology
S Horiuchi, Y Saito, A Matsui, N Takahashi, T Ikeya, E Hoshi, Y Shimizu, M Yasuda
Publication Date: 2020-01-14

Variant appearance in text: EGFR: G719X
PMID: 32124949
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The associations among quantitative spectral CT parameters, Ki-67 expression levels and EGFR mutation status in NSCLC.

Scientific Reports
L Lin, J Cheng, D Tang, Y Zhang, F Zhang, J Xu, H Jiang, H Wu
Publication Date: 2020-02-26

Variant appearance in text: EGFR: G719X
PMID: 32103127
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[Clinical Value of Droplet Digital PCR and Super-ARMS Detection of Epidermal Growth Factor Receptor Gene Mutation in Plasma Circulating Tumor DNA of Patients with Advanced Lung Adenocarcinoma].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Cao, J Wang, N Qin, K Li, J Lv, J Wang, X Yang, X Li, H Zhang, Q Zhang, H Long, C Shu, L Ma, S Zhang
Publication Date: 2020-02-20

Variant appearance in text: EGFR: G719X
PMID: 32093452
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The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma.

Biomedicines
PC Hsu, CW Wang, SC Kuo, SM Lin, YL Lo, AC Huang, LC Chiu, CT Yang
Publication Date: 2020-02-19

Variant appearance in text: EGFR: G719X
PMID: 32092879
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: EGFR: G719X
PMID: 32054005
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Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

Plos One
HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi, S Park, YJ Ryu, JH Lee, JH Chang
Publication Date: 2020

Variant appearance in text: EGFR: G719X
PMID: 32053675
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Comparison of next-generation sequencing and immunohistochemistry analysis for targeted therapy-related genomic status in lung cancer patients.

Journal Of Thoracic Disease
L Nong, Z Zhang, Y Xiong, Y Zheng, X Li, D Li, Q He, T Li
Publication Date: 2019-12

Variant appearance in text: EGFR: G719X
PMID: 32030215
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Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study.

Bmc Cancer
M Kogo, D Fujimoto, K Hosoya, K Nagata, A Nakagawa, R Tachikawa, D Yamashita, Y Kitamura, Y Imai, K Tomii
Publication Date: 2020-02-06

Variant appearance in text: EGFR: G719X
PMID: 32028905
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Extracellular vesicle-based EGFR genotyping in bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients.

Translational Lung Cancer Research
JY Hur, JS Lee, IA Kim, HJ Kim, WS Kim, KY Lee
Publication Date: 2019-12

Variant appearance in text: EGFR: G719X
PMID: 32010582
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Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers.

Translational Lung Cancer Research
J Ni, T Guo, Y Li, X Yang, Y Li, L Zou, L Chu, X Chu, S Li, L Ye, Y Zhang, Z Zhu
Publication Date: 2019-12

Variant appearance in text: EGFR: G719X
PMID: 32010575
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Genetic alteration profile of EGFR-mutant resected IIB-IIIA stage NSCLC and correlation to clinical outcomes.

Translational Lung Cancer Research
Q Deng, Y Qiu, J Jia, H Tang, L Liu, L Huang, D He, X Dong, H Yang
Publication Date: 2019-12

Variant appearance in text: EGFR: G719X
PMID: 32010562
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Poor Prognosis With Coexistence Of EGFR T790M Mutation And Common EGFR-Activating Mutation In Non- Small Cell Lung Cancer.

Cancer Management And Research
X Gao, Y Zhao, Y Bao, W Yin, L Liu, R Liu, Z Yu, X Zhou, J Shuai
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 32009817
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Detection of plasma EGFR mutations for personalized treatment of lung cancer patients without pathologic diagnosis.

Cancer Medicine
Q Deng, Q Fang, H Sun, AP Singh, M Alexander, S Li, H Cheng, S Zhou
Publication Date: 2020-01-28

Variant appearance in text: EGFR: G719X
PMID: 31991049
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New data highlighting the efficacy and safety outcomes of third-generation EGFR-TKI in NSCLC patients with rare EGFR mutations.

Thoracic Cancer
W Zhang, F Li, W Gao
Publication Date: 2020-01-28

Variant appearance in text: EGFR: Gly719X
PMID: 31989783
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Accuracy and clinical influence of plasma EGFR mutation detection in management of advanced lung adenocarcinoma.

International Journal Of Clinical And Experimental Pathology
M Ma, C Shi, J Qian, B Han
Publication Date: 2017

Variant appearance in text: EGFR: G719x
PMID: 31966832
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Clinical and pathological findings of surgically resected patients for lung adenocarcinomas harboring uncommon EGFR mutations.

International Journal Of Clinical And Experimental Pathology
S Yang, Z Jiang, H Lu
Publication Date: 2017

Variant appearance in text: EGFR: G719X
PMID: 31966607
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Comparison of clinicopathologic characteristics between patients with EGFR exon 19 deletion and EGFR L858R mutation in lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Chen, J Zhang, K Huang, Q Shen, X Teng
Publication Date: 2018

Variant appearance in text: EGFR: G719X
PMID: 31949864
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Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Zhang, S Zhou
Publication Date: 2018

Variant appearance in text: EGFR: G719X
PMID: 31949733
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Abivertinib in patients with T790M-positive advanced NSCLC and its subsequent treatment with osimertinib.

Thoracic Cancer
H Wang, R Pan, X Zhang, X Si, M Wang, L Zhang
Publication Date: 2020-01-14

Variant appearance in text: EGFR: G719X
PMID: 31943845
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Impact of age on EGFR mutations in never-smoking female lung adenocarcinoma patients with malignant pleural effusion.

International Journal Of Clinical And Experimental Pathology
Q Wu, M Chu, J Hu, Z Zhang, W Yi, X Ma
Publication Date: 2018

Variant appearance in text: EGFR: G719X
PMID: 31938400
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High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.

International Journal Of Clinical And Experimental Pathology
F Su, Y Fu, Q Wu, K Zheng, Y Tang, X Su, Y Wang, L Jiang
Publication Date: 2018

Variant appearance in text: EGFR: G719X
PMID: 31938383
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Identification of EGFR mutations in cytological specimens of non-small cell lung carcinoma from a single institute.

International Journal Of Clinical And Experimental Pathology
W Wang, Y Tang, J Li, Y Zhang, Y Zou, X Su
Publication Date: 2018

Variant appearance in text: EGFR: G719X
PMID: 31938186
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Distribution of PD-L1 expression and its relationship with clinicopathological variables: an audit from 1071 cases of surgically resected non-small cell lung cancer.

International Journal Of Clinical And Experimental Pathology
Q Chen, YY Fu, QN Yue, Q Wu, Y Tang, WY Wang, YS Wang, LL Jiang
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31933885
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Cutaneous metastasis from lung adenocarcinoma presenting before discovery of the primary malignancy: a case report.

International Journal Of Clinical And Experimental Pathology
Y Liao, L Zhou, M Li, S Yu, Y Zhou, L Xie
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31933871
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Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.

Scientific Reports
SY Kim, JY Lee, DH Kim, H- Joo, MR Yun, D Jung, J Yun, SG Heo, B- Ahn, CW Park, KH Pyo, YJ Chun, MH Hong, HR Kim, BC Cho
Publication Date: 2019-12-27

Variant appearance in text: EGFR: G719X
PMID: 31882684
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Role of BIM Deletion Polymorphism and BIM Expression as Predictive Biomarkers to Maximize the Benefit of EGFR-TKI Treatment in EGFR-Positive NSCLC.

Asian Pacific Journal Of Cancer Prevention : Apjcp
P Incharoen, C Charonpongsuntorn, S Saowapa, E Sirachainan, T Dejthevaporn, K Kampreasart, N Trachu, D Muntham, T Ruengwetwattana
Publication Date: 2019-12-01

Variant appearance in text: EGFR: G719X
PMID: 31870097
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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One
E Papadopoulou, N Tsoulos, K Tsantikidi, V Metaxa-Mariatou, PE Stamou, A Kladi-Skandali, E Kapeni, G Tsaousis, G Pentheroudakis, D Petrakis, DI Lampropoulou, G Aravantinos, I Varthalitis, G Kesisis, I Boukovinas, P Papakotoulas, N Katirtzoglou, E Athanasiadis, F Stavridi, C Christodoulou, A Koumarianou, Y Eralp, G Nasioulas
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31860648
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Clinicopathologic Characteristics, Treatment Outcomes, and Acquired Resistance Patterns of Atypical EGFR Mutations and HER2 Alterations in Stage IV Non-Small-Cell Lung Cancer.

Clinical Lung Cancer
T Patil, R Mushtaq, S Marsh, C Azelby, M Pujara, KD Davies, DL Aisner, WT Purcell, EL Schenk, JM Pacheco, PA Bunn, DR Camidge, RC Doebele
Publication Date: 2019-11-21

Variant appearance in text: EGFR: G719X
PMID: 31859066
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Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients.

Translational Lung Cancer Research
R Chiba, N Morikawa, K Sera, K Ishida, H Nagashima, W Shigeeda, H Deguchi, M Tomoyasu, T Hosokawa, H Saito, T Sugai, K Yamauchi, M Maemondo
Publication Date: 2019-11

Variant appearance in text: EGFR: G719X
PMID: 31857947
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The potential mechanism of primary resistance to icotinib in EGFR uncommon mutant advanced non-small cell lung cancer: a multi-center study.

Cancer Science
L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song
Publication Date: 2019-12-11

Variant appearance in text: EGFR: G719X
PMID: 31828849
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Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
JH Cho, SH Lim, HJ An, KH Kim, KU Park, EJ Kang, YH Choi, MS Ahn, MH Lee, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
Publication Date: 2019-12-11

Variant appearance in text: EGFR: Gly719X
PMID: 31825714
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The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Molecules (Basel, Switzerland)
N Van Der Steen, K Zwaenepoel, G Mazzaschi, R A Luirink, D P Geerke, K Op de Beeck, C Hermans, M Tiseo, P Van Schil, F Lardon, P Germonpré, C Rolfo, E Giovannetti, G J Peters, P Pauwels
Publication Date: 2019-12-04

Variant appearance in text: EGFR: G719X
PMID: 31817278
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Predictive biomarkers in nonsmall cell carcinoma and their clinico-pathological association.

South Asian Journal Of Cancer
A Mehta, NN Sriramanakoppa, P Agarwal, G Viswakarma, S Vasudevan, M Panigrahi, D Kumar, M Saifi, I Chowdhary, DC Doval, M Suryavanshi
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31807491
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Detection of clinically relevant epidermal growth factor receptor pathway mutations in circulating cell-free tumor DNA using next generation sequencing in squamous cell carcinoma lung.

South Asian Journal Of Cancer
KB Govind, D Koppaka, L Dasappa, LA Jacob, SM C Babu, NK Lokesh, RA Haleshappa, LK Rajeev, SC Saldanha, A Abhishek, V Asati, R Chethan, VL Ramprasad
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31807490
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Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation.

Oncotargets And Therapy
S Zhou, H Wang, W Jiang, Q Yu
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31802898
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Driver genes as predictive indicators of brain metastasis in patients with advanced NSCLC: EGFR, ALK, and RET gene mutations.

Cancer Medicine
H Wang, Z Wang, G Zhang, M Zhang, X Zhang, H Li, X Zheng, Z Ma
Publication Date: 2019-11-25

Variant appearance in text: EGFR: G719X
PMID: 31769228
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Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing.

Plos One
YJ Chun, JW Choi, MH Hong, D Jung, H Son, EK Cho, YJ Min, SW Kim, K Park, SS Lee, S Kim, HR Kim, BC Cho,
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31765373
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Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients.

Respiratory Research
T Aoki, T Akiba, J Nishiyama, S Tajiri, N Hayama, G Takahashi, J Tanaka, M Sato, H Takiguchi, H Tomomatsu, K Tomomatsu, T Takihara, K Niimi, T Oguma, M Kohno, R Masuda, T Urano, H Itoh, H Kajiwara, N Nakamura, E Kunieda, M Matsumae, M Iwazaki, K Asano
Publication Date: 2019-11-21

Variant appearance in text: EGFR: G719X
PMID: 31752884
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Current Approaches in NSCLC Targeting K-RAS and EGFR.

International Journal Of Molecular Sciences
V Aran, J Omerovic
Publication Date: 2019-11-14

Variant appearance in text: EGFR: G719X
PMID: 31739412
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Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine.

Frontiers In Medicine
J Pinsolle, A McLeer-Florin, M Giaj Levra, F de Fraipont, C Emprou, E Gobbini, AC Toffart
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31737634
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Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

Bmc Cancer
YI Cheng, YC Gan, D Liu, MPA Davies, WM Li, JK Field
Publication Date: 2019-11-08

Variant appearance in text: EGFR: G719X
PMID: 31703574
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Clinical And Imageological Features Of Lung Squamous Cell Carcinoma With EGFR Mutations.

Cancer Management And Research
X Gao, J Zhu, L Chen, Y Jiang, X Zhou, J Shuai, Y Zhao
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31695493
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Real-world efficacy and potential mechanism of resistance of icotinib in Asian advanced non-small cell lung cancer with EGFR uncommon mutations: A multi-center study.

Cancer Medicine
L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song
Publication Date: 2019-11-06

Variant appearance in text: EGFR: G719X
PMID: 31692291
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Great efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report.

Oncotargets And Therapy
N An, H Wang, H Zhu, W Yan, W Jing, L Kong, Y Zhang, J Yu
Publication Date: 2019

Variant appearance in text: EGFR: Gly719X
PMID: 31686847
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Determining factors of endobronchial ultrasound-guided transbronchial needle aspiration specimens for lung cancer subtyping and molecular testing.

Endoscopic Ultrasound
Y Zhang, F Xie, X Mao, X Zheng, Y Li, L Zhu, J Sun
Publication Date: 2019-10-31

Variant appearance in text: EGFR: G719X
PMID: 31670289
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Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study.

Bmc Cancer
YH Chen, YF Chen, CY Chen, JY Shih, CJ Yu
Publication Date: 2019-10-26

Variant appearance in text: EGFR: G719X
PMID: 31655564
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Osimertinib as treatment for EGFR exon 20 insertion-positive lung adenocarcinoma.

Excli Journal
C Murano, A Igarashi, K Yamauchi, S Inoue, M Watanabe
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31645848
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Tumor clonal status predicts clinical outcomes of lung adenocarcinoma with EGFR-TKI sensitizing mutation.

Journal Of Cancer
EY Kim, SH Lee, A Kim, T Kim, YS Chang
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31632498
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Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma.

Frontiers In Oncology
X Qu, Q Li, J Yang, H Zhao, F Wang, F Zhang, S Zhang, H Zhang, R Wang, Q Wang, Q Wang, G Li, X Peng, X Zhou, Y Hao, J Zhu, W Xiao
Publication Date: 2019

Variant appearance in text: EGFR: G719X
PMID: 31608233
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Post-progression survival is highly linked to overall survival in patients with non-small-cell lung cancer harboring sensitive EGFR mutations treated with first-line epidermal growth factor receptor-tyrosine kinase inhibitors.

Thoracic Cancer
H Imai, K Kaira, K Mori, M Kotake, M Mitani, N Kawashima, T Hisada, K Minato
Publication Date: 2019-12

Variant appearance in text: EGFR: G719X
PMID: 31595714
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000275493.2 c.2155_2157delinsTGA p.Gly719* stop_gained 18/28 -
ENST00000442591.1 c.*28+1086_*28+1088delinsTGA - intron_variant - 17/17
ENST00000454757.2 c.1996_1998delinsTGA p.Gly666* stop_gained 18/28 -
ENST00000455089.1 c.2020_2022delinsTGA p.Gly674* stop_gained 17/26 -
NM_001346897.2 c.2020_2022delinsTGA p.Gly674* stop_gained 17/26 -
NM_001346898.2 c.2155_2157delinsTGA p.Gly719* stop_gained 18/27 -
NM_001346899.1 c.2020_2022delinsTGA p.Gly674* stop_gained 17/27 -
NM_001346900.2 c.1996_1998delinsTGA p.Gly666* stop_gained 18/28 -
NM_001346941.2 c.1354_1356delinsTGA p.Gly452* stop_gained 12/22 -
NM_005228.5 c.2155_2157delinsTGA p.Gly719* stop_gained 18/28 -