EGFR c.2240T>A ;(p.L747*)

Variant ID: 7-55242470-T-A

NM_005228.3(EGFR):c.2240T>A;(p.L747*)

This variant was identified in 9 publications

View GRCh38 version.




Publications:


Durable response to afatinib rechallenge in a long-term survivor of non-small cell lung cancer harboring EGFR L858R and L747V mutations.

Thoracic Cancer
Kanbe, Mio M; Sunaga, Noriaki N; Hara, Kenichiro K; Sawada, Hiiru H; Wakamatsu, Ikuo I; Hara, Kentaro K; Muto, Sohei S; Sawada, Yuri Y; Masubuchi, Hiroaki H; Sato, Mari M; Miura, Yosuke Y; Tsurumaki, Hiroaki H; Yatomi, Masakiyo M; Sakurai, Reiko R; Koga, Yasuhiko Y; Ohtaki, Yoichi Y; Nagashima, Toshiteru T; Okano, Naoko N; Kubo, Nobuteru N; Maeno, Toshitaka T; Hisada, Takeshi T
Publication Date: 2022-11

Variant appearance in text: EGFR: L747X
PubMed Link: 36193787
Variant Present in the following documents:
  • Main text
  • TCA-13-3225.pdf
View BVdb publication page



Unarranged territory in uncommon EGFR mutations.

Translational Lung Cancer Research
Fujii, Hiroyuki H; Okuma, Yusuke Y
Publication Date: 2022-07

Variant appearance in text: EGFR: L747X
PubMed Link: 35958324
Variant Present in the following documents:
  • Main text
  • tlcr-11-07-1233.pdf
View BVdb publication page



Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report.

Frontiers In Oncology
Yang, James Chih-Hsin JC; Schuler, Martin M; Popat, Sanjay S; Miura, Satoru S; Park, Keunchil K; Passaro, Antonio A; De Marinis, Filippo F; Solca, Flavio F; Märten, Angela A; Kim, Edward S ES
Publication Date: 2022

Variant appearance in text: EGFR: L747X
PubMed Link: 35574304
Variant Present in the following documents:
  • Main text
  • fonc-12-834704.pdf
View BVdb publication page



Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin.

Scientific Reports
Chinnappan, Jayaprakash J; Ramu, Akilandeswari A; V, Vidhya Rajalakshmi VR; S, Akil Kavya AK
Publication Date: 2021-11-11

Variant appearance in text: EGFR: L747*
PubMed Link: 34764329
Variant Present in the following documents:
  • Main text
  • 41598_2021_Article_1508.pdf
View BVdb publication page



Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Publication Date: 2021-09

Variant appearance in text: EGFR: L747X
PubMed Link: 34526717
Variant Present in the following documents:
  • Main text
  • 41586_2021_Article_3898.pdf
View BVdb publication page



Current Approaches in NSCLC Targeting K-RAS and EGFR.

International Journal Of Molecular Sciences
Aran, Veronica V; Omerovic, Jasminka J
Publication Date: 2019-11-14

Variant appearance in text: EGFR: L747X
PubMed Link: 31739412
Variant Present in the following documents:
  • ijms-20-05701.pdf
View BVdb publication page



BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.

Oncotarget
Deihimi, Safoora S; Lev, Avital A; Slifker, Michael M; Shagisultanova, Elena E; Xu, Qifang Q; Jung, Kyungsuk K; Vijayvergia, Namrata N; Ross, Eric A EA; Xiu, Joanne J; Swensen, Jeffrey J; Gatalica, Zoran Z; Andrake, Mark M; Dunbrack, Roland L RL; El-Deiry, Wafik S WS
Publication Date: 2017-06-20

Variant appearance in text: EGFR: L747*
PubMed Link: 28591715
Variant Present in the following documents:
  • Main text
  • oncotarget-08-39945.pdf
View BVdb publication page



Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.

Genome Medicine
Chalmers, Zachary R ZR; Connelly, Caitlin F CF; Fabrizio, David D; Gay, Laurie L; Ali, Siraj M SM; Ennis, Riley R; Schrock, Alexa A; Campbell, Brittany B; Shlien, Adam A; Chmielecki, Juliann J; Huang, Franklin F; He, Yuting Y; Sun, James J; Tabori, Uri U; Kennedy, Mark M; Lieber, Daniel S DS; Roels, Steven S; White, Jared J; Otto, Geoffrey A GA; Ross, Jeffrey S JS; Garraway, Levi L; Miller, Vincent A VA; Stephens, Phillip J PJ; Frampton, Garrett M GM
Publication Date: 2017-04-19

Variant appearance in text: EGFR: L747*
PubMed Link: 28420421
Variant Present in the following documents:
  • 13073_2017_424_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page