EGFR c.2245G>A ;(p.E749K)

Variant ID: 7-55242475-G-A

NM_005228.3(EGFR):c.2245G>A;(p.E749K)

This variant was identified in 8 publications

View GRCh38 version.




Publications:


Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
White, Valerie A VA; Hyrcza, Martin D MD; Lennerz, Jochen K JK; Thierauf, Julia J; Lokuhetty, Dilani D; Cree, Ian A IA; Indave, Blanca Iciar BI
Publication Date: 2022-10

Variant appearance in text: EGFR: E749K
PubMed Link: 35871081
Variant Present in the following documents:
  • 41379_2022_1100_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Predicting osimertinib-treatment outcomes through EGFR mutant-fraction monitoring in the circulating tumor DNA of EGFR T790M-positive patients with non-small cell lung cancer (WJOG8815L).

Molecular Oncology
Sakai, Kazuko K; Takahama, Takayuki T; Shimokawa, Mototsugu M; Azuma, Koichi K; Takeda, Masayuki M; Kato, Terufumi T; Daga, Haruko H; Okamoto, Isamu I; Akamatsu, Hiroaki H; Teraoka, Shunsuke S; Ono, Akira A; Ohira, Tatsuo T; Yokoyama, Toshihide T; Yamamoto, Nobuyuki N; Nakagawa, Kazuhiko K; Nishio, Kazuto K
Publication Date: 2021-01

Variant appearance in text: EGFR: E749K
PubMed Link: 33131198
Variant Present in the following documents:
  • MOL2-15-126-s007.xlsx, sheet 1
View BVdb publication page



Multigene Mutation Profiling and Clinical Characteristics of Small-Cell Lung Cancer in Never-Smokers vs. Heavy Smokers (Geno1.3-CLICaP).

Frontiers In Oncology
Cardona, Andrés F AF; Rojas, Leonardo L; Zatarain-Barrón, Zyanya Lucia ZL; Ruiz-Patiño, Alejandro A; Ricaurte, Luisa L; Corrales, Luis L; Martín, Claudio C; Freitas, Helano H; Cordeiro de Lima, Vladmir Cláudio VC; Rodriguez, July J; Avila, Jenny J; Bravo, Melissa M; Archila, Pilar P; Carranza, Hernán H; Vargas, Carlos C; Otero, Jorge J; Barrón, Feliciano F; Karachaliou, Niki N; Rosell, Rafael R; Arrieta, Oscar O
Publication Date: 2019

Variant appearance in text: EGFR: E749K
PubMed Link: 31058075
Variant Present in the following documents:
  • Main text
  • fonc-09-00254.pdf
View BVdb publication page



Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.

The Journal Of Molecular Diagnostics : Jmd
Clark, Travis A TA; Chung, Jon H JH; Kennedy, Mark M; Hughes, Jason D JD; Chennagiri, Niru N; Lieber, Daniel S DS; Fendler, Bernard B; Young, Lauren L; Zhao, Mandy M; Coyne, Michael M; Breese, Virginia V; Young, Geneva G; Donahue, Amy A; Pavlick, Dean D; Tsiros, Alyssa A; Brennan, Timothy T; Zhong, Shan S; Mughal, Tariq T; Bailey, Mark M; He, Jie J; Roels, Steven S; Frampton, Garrett M GM; Spoerke, Jill M JM; Gendreau, Steven S; Lackner, Mark M; Schleifman, Erica E; Peters, Eric E; Ross, Jeffrey S JS; Ali, Siraj M SM; Miller, Vincent A VA; Gregg, Jeffrey P JP; Stephens, Philip J PJ; Welsh, Allison A; Otto, Geoff A GA; Lipson, Doron D
Publication Date: 2018-09

Variant appearance in text: EGFR: E749K
PubMed Link: 29936259
Variant Present in the following documents:
  • mmc12.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: E749K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
View BVdb publication page



Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial.

Oncotarget
Wang, Jack P JP; Wu, Chen-Yi CY; Yeh, Yi-Cheng YC; Shyr, Yi-Ming YM; Wu, Ying-Ying YY; Kuo, Chen-Yu CY; Hung, Yi-Ping YP; Chen, Ming-Huang MH; Lee, Wei-Ping WP; Luo, Jiing-Chyuan JC; Chao, Yee Y; Li, Chung-Pin CP
Publication Date: 2015-07-20

Variant appearance in text: EGFR: E749K
PubMed Link: 26046796
Variant Present in the following documents:
  • Main text
  • oncotarget-06-18162.pdf
View BVdb publication page



A growing family: adding mutated Erbb4 as a novel cancer target.

Cell Cycle (Georgetown, Tex.)
Rudloff, Udo U; Samuels, Yardena Y
Publication Date: 2010-04-15

Variant appearance in text: EGFR: E749K
PubMed Link: 20404484
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.

Bmc Medical Genetics
Yunxia, Zuo Z; Jun, Cao C; Guanshan, Zhu Z; Yachao, Lu L; Xueke, Zhou Z; Jin, Li L
Publication Date: 2010-02-26

Variant appearance in text: EGFR: Glu749Lys
PubMed Link: 20184776
Variant Present in the following documents:
  • Main text
  • 1471-2350-11-34.pdf
View BVdb publication page