EGFR c.2254T>C ;(p.S752P)

Variant ID: 7-55242484-T-C

NM_005228.3(EGFR):c.2254T>C;(p.S752P)

This variant was identified in 8 publications

View GRCh38 version.




Publications:


Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.

Nature Communications
van Alderwerelt van Rosenburgh, Iris K IK; Lu, David M DM; Grant, Michael J MJ; Stayrook, Steven E SE; Phadke, Manali M; Walther, Zenta Z; Goldberg, Sarah B SB; Politi, Katerina K; Lemmon, Mark A MA; Ashtekar, Kumar D KD; Tsutsui, Yuko Y
Publication Date: 2022-11-10

Variant appearance in text: EGFR: S752P
PubMed Link: 36357385
Variant Present in the following documents:
  • Main text
  • 41467_2022_Article_34398.pdf
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: S752P
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: EGFR: 2254T>C; S752P
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: S752P
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 1
View BVdb publication page



Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.

Genome Medicine
Li, Shuyu D SD; Ma, Meng M; Li, Hui H; Waluszko, Aneta A; Sidorenko, Tatyana T; Schadt, Eric E EE; Zhang, David Y DY; Chen, Rong R; Ye, Fei F
Publication Date: 2017-10-30

Variant appearance in text: EGFR: 2254T>C; S752P
PubMed Link: 29082853
Variant Present in the following documents:
  • 13073_2017_478_MOESM1_ESM.xlsx, sheet 2
View BVdb publication page



Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.

Scientific Reports
Fu, Yong Y; Cruz-Monserrate, Zobeida Z; Helen Lin, H H; Chung, Yiyin Y; Ji, Baoan B; Lin, Szu-Min SM; Vonderfecht, Steven S; Logsdon, Craig D CD; Li, Chien-Feng CF; Ann, David K DK
Publication Date: 2015-08-20

Variant appearance in text: EGFR: S752P
PubMed Link: 26289340
Variant Present in the following documents:
  • srep13347-s1.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: EGFR: S752P
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Williams, Michelle D MD; Roberts, Dianna B DB; Kies, Merrill S MS; Mao, Li L; Weber, Randal S RS; El-Naggar, Adel K AK
Publication Date: 2010-04-15

Variant appearance in text: EGFR: S752P
PubMed Link: 20371674
Variant Present in the following documents:
  • Main text
View BVdb publication page