Publications:

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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications

González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR

Publication Date: 2023-06-12

Variant appearance in text: EGFR: P753S

PubMed Link: 37308482

Variant Present in the following documents:

• 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5

View BVdb publication page

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Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.

Journal Of Medicinal Chemistry

Aarhus, Thomas Ihle TI; Bjørnstad, Frithjof F; Wolowczyk, Camilla C; Larsen, Kristin Uhlving KU; Rognstad, Line L; Leithaug, Trygve T; Unger, Anke A; Habenberger, Peter P; Wolf, Alexander A; Bjørkøy, Geir G; Pridans, Clare C; Eickhoff, Jan J; Klebl, Bert B; Hoff, Bård H BH; Sundby, Eirik E

Publication Date: 2023-05-16

Variant appearance in text: EGFR: P753S

PubMed Link: 37191268

Variant Present in the following documents:

• jm3c00428_si_001.pdf

View BVdb publication page

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Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy.

Molecular Diagnosis & Therapy

Fitzgerald, Sandra S; Blenkiron, Cherie C; Stephens, Rosalie R; Mathy, Jon A JA; Somers-Edgar, Tiffany T; Rolfe, Gill G; Martin, Richard R; Jackson, Christopher C; Eccles, Michael M; Robb, Tamsin T; Rodger, Euan E; Lawrence, Ben B; Guilford, Parry P; Lasham, Annette A; Print, Cristin G CG

Publication Date: 2023-04-26

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 37099071

Variant Present in the following documents:

• 40291_2023_651_MOESM1_ESM.xlsx, sheet 2

View BVdb publication page

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Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Acs Chemical Neuroscience

Ong, Han Wee HW; Liang, Yi Y; Richardson, William W; Lowry, Emily R ER; Wells, Carrow I CI; Chen, Xiangrong X; Silvestre, Margaux M; Dempster, Kelvin K; Silvaroli, Josie A JA; Smith, Jeffery L JL; Wichterle, Hynek H; Pabla, Navjot S NS; Ultanir, Sila K SK; Bullock, Alex N AN; Drewry, David H DH; Axtman, Alison D AD

Publication Date: 2023-04-21

Variant appearance in text: EGFR: P753S

PubMed Link: 37084253

Variant Present in the following documents:

• cn3c00135_si_001.pdf

View BVdb publication page

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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry

Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2023-04-07

Variant appearance in text: EGFR: P753S

PubMed Link: 37026591

Variant Present in the following documents:

• jm3c00155_si_002.xlsx, sheet 2

View BVdb publication page

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Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.

Acs Chemical Biology

Tredup, Claudia C; Ndreshkjana, Benardina B; Schneider, Natalie S NS; Tjaden, Amelie A; Kemas, Aurino M AM; Youhanna, Sonia S; Lauschke, Volker M VM; Berger, Benedict-Tilman BT; Krämer, Andreas A; Berger, Lena M LM; Röhm, Sandra S; Knapp, Stefan S; Farin, Henner F HF; Müller, Susanne S

Publication Date: 2023-03-21

Variant appearance in text: EGFR: P753S

PubMed Link: 36944371

Variant Present in the following documents:

• cb2c00877_si_004.xlsx, sheet 1

View BVdb publication page

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Exome sequencing in fetuses with short long bones detected by ultrasonography: A retrospective cohort study.

Frontiers In Genetics

Huang, Yanlin Y; Liu, Chang C; Ding, Hongke H; Wang, Yunan Y; Yu, Lihua L; Guo, Fangfang F; Li, Fake F; Shi, Xiaomei X; Zhang, Yan Y; Yin, Aihua A

Publication Date: 2023

Variant appearance in text: EGFR: 2257C>T; Pro753Ser

PubMed Link: 36923788

Variant Present in the following documents:

• Table3.xlsx, sheet 1

View BVdb publication page

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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.

Plos One

Kozaki, Ryohei R; Yasuhiro, Tomoko T; Kato, Hikaru H; Murai, Jun J; Hotta, Shingo S; Ariza, Yuko Y; Sakai, Shunsuke S; Fujikawa, Ryu R; Yoshida, Takao T

Publication Date: 2023

Variant appearance in text: EGFR: P753S

PubMed Link: 36897912

Variant Present in the following documents:

• pone.0282166.s009.xlsx, sheet 1

View BVdb publication page

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[Progress in Detection of EGFR Exon 20 Insertion Mutation and Targeted Therapies 
in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Yulu Y; Chu, Tianqing T

Publication Date: 2023-02-20

Variant appearance in text: EGFR: P753S

PubMed Link: 36872052

Variant Present in the following documents:

• zgfazz-26-135.pdf

View BVdb publication page

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: EGFR: 2257C>T; Pro753Ser

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: EGFR: P753S

PubMed Link: 36561320

Variant Present in the following documents:

• Table3.xlsx, sheet 1
• Table2.xlsx, sheet 4

View BVdb publication page

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics

Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,

Publication Date: 2022-12-01

Variant appearance in text: EGFR: P753S; rs121913231

PubMed Link: 36413997

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: EGFR: P753S

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia.

Leukemia

Sher, Steven S; Whipp, Ethan E; Walker, Janek J; Zhang, Pu P; Beaver, Larry L; Williams, Katie K; Orwick, Shelley S; Ravikrishnan, Janani J; Walker, Brandi B; Perry, Elizabeth E; Gregory, Charles C; Purcell, Matthew M; Pan, Alexander A; Yan, Pearlly P; Alinari, Lapo L; Johnson, Amy J AJ; Frigault, Melanie M MM; Greer, Joy M JM; Hamdy, Ahmed A; Izumi, Raquel R; Mo, Xiaokui X; Sampath, Deepa D; Woyach, Jennifer J; Blachly, James J; Byrd, John C JC; Lapalombella, Rosa R

Publication Date: 2022-11-14

Variant appearance in text: EGFR: P753S

PubMed Link: 36376377

Variant Present in the following documents:

• 41375_2022_1758_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology

Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ

Publication Date: 2022-10-11

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 36219477

Variant Present in the following documents:

• PATH-259-56-s004.xlsx, sheet 2

View BVdb publication page

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: EGFR: P753S

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

View BVdb publication page

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Designing Novel BCR-ABL Inhibitors for Chronic Myeloid Leukemia with Improved Cardiac Safety.

Journal Of Medicinal Chemistry

Pandrala, Mallesh M; Bruyneel, Arne Antoon N AAN; Hnatiuk, Anna P AP; Mercola, Mark M; Malhotra, Sanjay V SV

Publication Date: 2022-08-25

Variant appearance in text: EGFR: P753S

PubMed Link: 35944901

Variant Present in the following documents:

• jm1c01853_si_003.xlsx, sheet 1

View BVdb publication page

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Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

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Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.

Acs Medicinal Chemistry Letters

Hall, Adrian A; Abendroth, Jan J; Bolejack, Madison J MJ; Ceska, Tom T; Dell'Aiera, Sylvie S; Ellis, Victoria V; Fox, David D; François, Cyril C; Muruthi, Muigai M MM; Prével, Camille C; Poullennec, Karine K; Romanov, Sergei S; Valade, Anne A; Vanbellinghen, Alain A; Yano, Jason J; Geraerts, Martine M

Publication Date: 2022-07-14

Variant appearance in text: EGFR: P753S

PubMed Link: 35859861

Variant Present in the following documents:

• ml2c00134_si_001.pdf

View BVdb publication page

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Reengineering Ponatinib to Minimize Cardiovascular Toxicity.

Cancer Research

Hnatiuk, Anna P AP; Bruyneel, Arne A N AAN; Tailor, Dhanir D; Pandrala, Mallesh M; Dheeraj, Arpit A; Li, Wenqi W; Serrano, Ricardo R; Feyen, Dries A M DAM; Vu, Michelle M MM; Amatya, Prashila P; Gupta, Saloni S; Nakauchi, Yusuke Y; Morgado, Isabel I; Wiebking, Volker V; Liao, Ronglih R; Porteus, Matthew H MH; Majeti, Ravindra R; Malhotra, Sanjay V SV; Mercola, Mark M

Publication Date: 2022-08-03

Variant appearance in text: EGFR: P753S

PubMed Link: 35763671

Variant Present in the following documents:

• can-21-3652_supplementary_table_s1_suppst1.xls, sheet 2

View BVdb publication page

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal Of Medicinal Chemistry

Huckvale, Rosemary R; Harnden, Alice C AC; Cheung, Kwai-Ming J KJ; Pierrat, Olivier A OA; Talbot, Rachel R; Box, Gary M GM; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Hallsworth, Albert E AE; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; Hayes, Angela A; Gunnell, Emma A EA; Brennan, Alfie A; Davis, Owen A OA; Johnson, Louise D LD; de Klerk, Selby S; McAndrew, Craig C; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2022-06-23

Variant appearance in text: EGFR: P753S

PubMed Link: 35653645

Variant Present in the following documents:

• jm1c02175_si_002.xlsx, sheet 2

View BVdb publication page

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Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project.

Nature Communications

Cong, Pei-Kuan PK; Bai, Wei-Yang WY; Li, Jin-Chen JC; Yang, Meng-Yuan MY; Khederzadeh, Saber S; Gai, Si-Rui SR; Li, Nan N; Liu, Yu-Heng YH; Yu, Shi-Hui SH; Zhao, Wei-Wei WW; Liu, Jun-Quan JQ; Sun, Yi Y; Zhu, Xiao-Wei XW; Zhao, Pian-Pian PP; Xia, Jiang-Wei JW; Guan, Peng-Lin PL; Qian, Yu Y; Tao, Jian-Guo JG; Xu, Lin L; Tian, Geng G; Wang, Ping-Yu PY; Xie, Shu-Yang SY; Qiu, Mo-Chang MC; Liu, Ke-Qi KQ; Tang, Bei-Sha BS; Zheng, Hou-Feng HF

Publication Date: 2022-05-26

Variant appearance in text: EGFR: 2257C>T; P753S; rs121913231

PubMed Link: 35618720

Variant Present in the following documents:

• 41467_2022_30526_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon EGFR Mutations: A Retrospective International Cohort Study (UpSwinG).

The Oncologist

Popat, Sanjay S; Hsia, Te-Chun TC; Hung, Jen-Yu JY; Jung, Hyun Ae HA; Shih, Jin-Yuan JY; Park, Cheol Kyu CK; Lee, Seung Hyeun SH; Okamoto, Tatsuro T; Ahn, Hee Kyung HK; Lee, Yong Chul YC; Sato, Yuki Y; Lee, Sung Sook SS; Mascaux, Celine C; Daoud, Hasan H; Märten, Angela A; Miura, Satoru S

Publication Date: 2022-04-05

Variant appearance in text: EGFR: P753S

PubMed Link: 35274704

Variant Present in the following documents:

• Main text
• oyac022.pdf

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: EGFR: P753S

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Pro753Ser

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Ultrasensitive analysis of genetic instability related to chemical exposure.

Journal Of Applied Genetics

Domoradzki, Tomasz T; Grochowski, Piotr P; Jaśkiewicz, Anna A; Pająk, Beata B

Publication Date: 2022-05

Variant appearance in text: EGFR: P753S

PubMed Link: 34967917

Variant Present in the following documents:

• Main text
• 13353_2021_Article_677.pdf

View BVdb publication page

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Identification of the Unique Clinical and Genetic Features of Chinese Lung Cancer Patients With EGFR Germline Mutations in a Large-Scale Retrospective Study.

Frontiers In Oncology

Lin, Xinqing X; Peng, Muyun M; Chen, Quanfang Q; Yuan, Mingming M; Chen, Rongrong R; Deng, Haiyi H; Deng, Jiaxi J; Liu, Ouqi O; Weng, Yuqing Y; Chen, Mingjiu M; Zhou, Chengzhi C

Publication Date: 2021

Variant appearance in text: EGFR: P753S

PubMed Link: 34869019

Variant Present in the following documents:

• Main text
• fonc-11-774156.pdf

View BVdb publication page

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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Cell Death & Disease

Meng, Ya Y; Song, Chengcheng C; Ren, Zhili Z; Li, Xiaohong X; Yang, Xiangyu X; Ai, Nana N; Yang, Yang Y; Wang, Dongjin D; Zhan, Meixiao M; Wang, Jiaxian J; Lei, Chon Lok CL; Liu, Weiwei W; Ge, Wei W; Lu, Ligong L; Chen, Guokai G

Publication Date: 2021-11-29

Variant appearance in text: EGFR: P753S

PubMed Link: 34845199

Variant Present in the following documents:

• 41419_2021_4395_MOESM9_ESM.xlsx, sheet 1

View BVdb publication page

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Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin.

Scientific Reports

Chinnappan, Jayaprakash J; Ramu, Akilandeswari A; V, Vidhya Rajalakshmi VR; S, Akil Kavya AK

Publication Date: 2021-11-11

Variant appearance in text: EGFR: P753S

PubMed Link: 34764329

Variant Present in the following documents:

• Main text
• 41598_2021_Article_1508.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: P753S

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: Pro753Ser

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

View BVdb publication page

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: Pro753Ser

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

View BVdb publication page

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High Incidence of C797S Mutation in Patients With Long Treatment History of EGFR Tyrosine Kinase Inhibitors Including Osimertinib.

Jto Clinical And Research Reports

Osoegawa, Atsushi A; Yamaguchi, Masafumi M; Nakamura, Tomomi T; Morinaga, Ryotaro R; Tanaka, Kentaro K; Kashiwabara, Kosuke K; Miura, Takashi T; Suetsugu, Takayuki T; Harada, Taishi T; Asoh, Tatsuma T; Taguchi, Kenichi K; Nabeshima, Kazuki K; Kishimoto, Junji J; Sakai, Kazuko K; Nishio, Kazuto K; Sugio, Kenji K

Publication Date: 2021-07

Variant appearance in text: rs121913231

PubMed Link: 34590037

Variant Present in the following documents:

• mmc1.xlsx, sheet 1
• mmc2.xlsx, sheet 1

View BVdb publication page

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CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation.

Cancers

Luan, Haitao H; Bailey, Tameka A TA; Clubb, Robert J RJ; Mohapatra, Bhopal C BC; Bhat, Aaqib M AM; Chakraborty, Sukanya S; Islam, Namista N; Mushtaq, Insha I; Storck, Matthew D MD; Raja, Srikumar M SM; Band, Vimla V; Band, Hamid H

Publication Date: 2021-08-04

Variant appearance in text: EGFR: P753S

PubMed Link: 34439093

Variant Present in the following documents:

• Main text
• cancers-13-03936.pdf

View BVdb publication page

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal Of Medicinal Chemistry

Henderson, Scott H SH; Sorrell, Fiona F; Bennett, James J; Fedorov, Oleg O; Hanley, Marcus T MT; Godoi, Paulo H PH; Ruela de Sousa, Roberta R; Robinson, Sean S; Ashall-Kelly, Alexander A; Hopkins Navratilova, Iva I; Walter, Daryl S DS; Elkins, Jonathan M JM; Ward, Simon E SE

Publication Date: 2021-08-12

Variant appearance in text: EGFR: P753S

PubMed Link: 34342227

Variant Present in the following documents:

• jm1c01115_si_002.xlsx, sheet 5
• jm1c01115_si_002.xlsx, sheet 7
• jm1c01115_si_002.xlsx, sheet 3
• jm1c01115_si_002.xlsx, sheet 13
• jm1c01115_si_002.xlsx, sheet 6
• jm1c01115_si_002.xlsx, sheet 8
• jm1c01115_si_002.xlsx, sheet 14
• jm1c01115_si_002.xlsx, sheet 10
• jm1c01115_si_002.xlsx, sheet 4
• jm1c01115_si_002.xlsx, sheet 9
• jm1c01115_si_002.xlsx, sheet 11
• jm1c01115_si_002.xlsx, sheet 2
• jm1c01115_si_002.xlsx, sheet 12

View BVdb publication page

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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.

Journal Of Medicinal Chemistry

Eduful, Benjamin J BJ; O'Byrne, Sean N SN; Temme, Louisa L; Asquith, Christopher R M CRM; Liang, Yi Y; Picado, Alfredo A; Pilotte, Joseph R JR; Hossain, Mohammad Anwar MA; Wells, Carrow I CI; Zuercher, William J WJ; Catta-Preta, Carolina M C CMC; Zonzini Ramos, Priscila P; Santiago, André de S AS; Couñago, Rafael M RM; Langendorf, Christopher G CG; Nay, Kévin K; Oakhill, Jonathan S JS; Pulliam, Thomas L TL; Lin, Chenchu C; Awad, Dominik D; Willson, Timothy M TM; Frigo, Daniel E DE; Scott, John W JW; Drewry, David H DH

Publication Date: 2021-08-12

Variant appearance in text: EGFR: P753S

PubMed Link: 34264658

Variant Present in the following documents:

• jm0c02274_si_003.xlsx, sheet 1

View BVdb publication page

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Evolution of kinase polypharmacology across HSP90 drug discovery.

Cell Chemical Biology

Antolin, Albert A AA; Clarke, Paul A PA; Collins, Ian I; Workman, Paul P; Al-Lazikani, Bissan B

Publication Date: 2021-10-21

Variant appearance in text: EGFR: P753S

PubMed Link: 34077750

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

View BVdb publication page

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Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study.

Clinics (Sao Paulo, Brazil)

Lan, Yan Y; Zhou, Shuo S; Feng, Weihong W; Qiao, Ying Y; Du, Xueming X; Li, Fenge F

Publication Date: 2021

Variant appearance in text: EGFR: 2257C>T

PubMed Link: 33787673

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Visualization of Kinase Inhibition-Related Adverse Events Using the Japanese Adverse Drug Event Report Database.

Drugs - Real World Outcomes

Mizuno, Takahito T; Sakai, Takamasa T; Tanabe, Kouichi K; Umemura, Takumi T; Goto, Nobuyuki N; Ohtsu, Fumiko F

Publication Date: 2021-06

Variant appearance in text: EGFR: P753S

PubMed Link: 33686612

Variant Present in the following documents:

• 40801_2021_235_MOESM1_ESM.pdf

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Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics

Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM

Publication Date: 2020-12

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 33230298

Variant Present in the following documents:

• NIHMS1637640-supplement-SuppData1.xlsx, sheet 1

View BVdb publication page

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs121913231

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: EGFR: P753S

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma.

Signal Transduction And Targeted Therapy

Liu, Juan J; Liang, Qianmao Q; Wang, Aoli A; Zou, Fengming F; Qi, Ziping Z; Yu, Kailin K; Liu, Qingwang Q; Chen, Cheng C; Liu, Jing J; Liu, Qingsong Q

Publication Date: 2020-09-14

Variant appearance in text: EGFR: P753S

PubMed Link: 32929063

Variant Present in the following documents:

• 41392_2020_309_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy.

Iscience

Singh, Vibha V; Bhoir, Siddhant S; Chikhale, Rupesh V RV; Hussain, Javeena J; Dwyer, Donard D; Bryce, Richard A RA; Kirubakaran, Sivapriya S; De Benedetti, Arrigo A

Publication Date: 2020-08-20

Variant appearance in text: EGFR: P753S

PubMed Link: 32905878

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.

Molecular Genetics & Genomic Medicine

Zhang, Biao B; Chen, Yongsheng Y; Dai, Pingping P; Yu, Haoda H; Ma, Jianhui J; Chen, Chen C; Zhang, Yan Y; Guan, Yanfang Y; Chen, Rongrong R; Liu, Tao T; Wang, Jiayin J; Yang, Ling L; Yi, Xin X; Xia, Xuefeng X; Ma, Haitao H

Publication Date: 2020-10

Variant appearance in text: EGFR: P753S

PubMed Link: 32757330

Variant Present in the following documents:

• Main text
• MGG3-8-e1395.pdf

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: EGFR: P753S

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

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Epigenomic and genomic analysis of transcriptome modulation in skin cutaneous melanoma.

Aging

Chen, Wuzhen W; Cheng, Pu P; Jiang, Jingxin J; Ren, Yunqing Y; Wu, Dang D; Xue, Dan D

Publication Date: 2020-07-07

Variant appearance in text: EGFR: 2257C>T

PubMed Link: 32639949

Variant Present in the following documents:

• aging-12-103115-s013..xlsx, sheet 1

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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters

Ruan, Xingya X; Sun, Yonghua Y; Wang, Wei W; Ye, Jianwei J; Zhang, Daoyun D; Gong, Ziying Z; Yang, Mingxia M

Publication Date: 2020-05

Variant appearance in text: EGFR: P753S

PubMed Link: 32269623

Variant Present in the following documents:

• ol-19-05-3495.pdf

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Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

Bmc Cancer

Steeghs, Elisabeth M P EMP; Kroeze, Leonie I LI; Tops, Bastiaan B J BBJ; van Kempen, Leon C LC; Ter Elst, Arja A; Kastner-van Raaij, Annemiek W M AWM; Hendriks-Cornelissen, Sandra J B SJB; Hermsen, Mandy J W MJW; Jansen, Erik A M EAM; Nederlof, Petra M PM; Schuuring, Ed E; Ligtenberg, Marjolijn J L MJL; Eijkelenboom, Astrid A

Publication Date: 2020-04-07

Variant appearance in text: EGFR: 2257C>T; Pro753Ser

PubMed Link: 32264863

Variant Present in the following documents:

• 12885_2020_6785_MOESM2_ESM.xlsx, sheet 7

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: P753S

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11

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Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)

Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z

Publication Date: 2020-01

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 32067422

Variant Present in the following documents:

• CAC2-40-43-s001.xlsx, sheet 1

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M

Publication Date: 2020-01-07

Variant appearance in text: EGFR: 2257C>T; P753S

PubMed Link: 31925297

Variant Present in the following documents:

• 42003_2019_736_MOESM3_ESM.xlsx, sheet 1

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Molecules (Basel, Switzerland)

Asquith, Christopher R M CRM; Bennett, James M JM; Su, Lianyong L; Laitinen, Tuomo T; Elkins, Jonathan M JM; Pickett, Julie E JE; Wells, Carrow I CI; Li, Zengbiao Z; Willson, Timothy M TM; Zuercher, William J WJ

Publication Date: 2019-11-06

Variant appearance in text: EGFR: P753S

PubMed Link: 31698822

Variant Present in the following documents:

• molecules-24-04016-s001.pdf

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Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients.

Drug Design, Development And Therapy

Liu, Jixian J; Mu, Zhimin Z; Liu, Li L; Li, Kang K; Jiang, Richeng R; Chen, Peng P; Zhou, Qiang Q; Jin, Meiling M; Ma, Yuxiang Y; Xie, Yuancai Y; Xiang, Jianxing J; Li, Bing B; Ma, Yafeng Y; Mao, Xinru X; Zhang, Lu L; Zhang, Tengfei T; Wu, Da D

Publication Date: 2019

Variant appearance in text: EGFR: P753S

PubMed Link: 31213769

Variant Present in the following documents:

• dddt-13-1809.pdf

View BVdb publication page

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