Publications:

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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications

González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR

Publication Date: 2023-06-12

Variant appearance in text: EGFR: I759del

PubMed Link: 37308482

Variant Present in the following documents:

• 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5

View BVdb publication page

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Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Acs Chemical Neuroscience

Ong, Han Wee HW; Liang, Yi Y; Richardson, William W; Lowry, Emily R ER; Wells, Carrow I CI; Chen, Xiangrong X; Silvestre, Margaux M; Dempster, Kelvin K; Silvaroli, Josie A JA; Smith, Jeffery L JL; Wichterle, Hynek H; Pabla, Navjot S NS; Ultanir, Sila K SK; Bullock, Alex N AN; Drewry, David H DH; Axtman, Alison D AD

Publication Date: 2023-04-21

Variant appearance in text: EGFR: I759del

PubMed Link: 37084253

Variant Present in the following documents:

• cn3c00135_si_001.pdf

View BVdb publication page

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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry

Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2023-04-07

Variant appearance in text: EGFR: I759del

PubMed Link: 37026591

Variant Present in the following documents:

• jm3c00155_si_002.xlsx, sheet 2

View BVdb publication page

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Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.

Acs Chemical Biology

Tredup, Claudia C; Ndreshkjana, Benardina B; Schneider, Natalie S NS; Tjaden, Amelie A; Kemas, Aurino M AM; Youhanna, Sonia S; Lauschke, Volker M VM; Berger, Benedict-Tilman BT; Krämer, Andreas A; Berger, Lena M LM; Röhm, Sandra S; Knapp, Stefan S; Farin, Henner F HF; Müller, Susanne S

Publication Date: 2023-03-21

Variant appearance in text: EGFR: I759del

PubMed Link: 36944371

Variant Present in the following documents:

• cb2c00877_si_004.xlsx, sheet 1
• cb2c00877_si_002.xlsx, sheet 1

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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.

Plos One

Kozaki, Ryohei R; Yasuhiro, Tomoko T; Kato, Hikaru H; Murai, Jun J; Hotta, Shingo S; Ariza, Yuko Y; Sakai, Shunsuke S; Fujikawa, Ryu R; Yoshida, Takao T

Publication Date: 2023

Variant appearance in text: EGFR: I759del

PubMed Link: 36897912

Variant Present in the following documents:

• pone.0282166.s009.xlsx, sheet 1

View BVdb publication page

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VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia.

Leukemia

Sher, Steven S; Whipp, Ethan E; Walker, Janek J; Zhang, Pu P; Beaver, Larry L; Williams, Katie K; Orwick, Shelley S; Ravikrishnan, Janani J; Walker, Brandi B; Perry, Elizabeth E; Gregory, Charles C; Purcell, Matthew M; Pan, Alexander A; Yan, Pearlly P; Alinari, Lapo L; Johnson, Amy J AJ; Frigault, Melanie M MM; Greer, Joy M JM; Hamdy, Ahmed A; Izumi, Raquel R; Mo, Xiaokui X; Sampath, Deepa D; Woyach, Jennifer J; Blachly, James J; Byrd, John C JC; Lapalombella, Rosa R

Publication Date: 2022-11-14

Variant appearance in text: EGFR: I759del

PubMed Link: 36376377

Variant Present in the following documents:

• 41375_2022_1758_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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A High Percentage of NSCLC With Germline CHEK2 Mutation Harbors Actionable Driver Alterations: Survey of a Cancer Genomic Database and Review of Literature.

Jto Clinical And Research Reports

Zhang, Shannon S SS; Lee, Jessica K JK; Tukachinsky, Hanna H; Schrock, Alexa B AB; Nagasaka, Misako M; Ou, Sai-Hong Ignatius SI

Publication Date: 2022-09

Variant appearance in text: EGFR: I759del

PubMed Link: 36061833

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Comprehensive characterization of genomic and radiologic features reveals distinct driver patterns of RTK/RAS pathway in ground-glass opacity pulmonary nodules.

International Journal Of Cancer

Yu, Fenglei F; Peng, Muyun M; Bai, Jing J; Zhu, Xiuli X; Zhang, Bingyu B; Tang, Jingqun J; Liu, Wenliang W; Chen, Chen C; Wang, Xiang X; Chen, Mingjiu M; Tan, Sichuang S; Sun, Yi Y; Liang, Qingchun Q; Li, Jina J; Hu, Yan Y; Liao, Aihui A; Hu, Huali H; He, Yu Y; Xiao, Xiao X; Wang, Bin B; Xing, Guanlan G; Xu, Yaping Y; Chen, Rongrong R; Xia, Xuefeng X; Chen, Xiaofeng X

Publication Date: 2022-12-01

Variant appearance in text: EGFR: I759del

PubMed Link: 36029220

Variant Present in the following documents:

• IJC-151-2020-s001.pdf

View BVdb publication page

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Designing Novel BCR-ABL Inhibitors for Chronic Myeloid Leukemia with Improved Cardiac Safety.

Journal Of Medicinal Chemistry

Pandrala, Mallesh M; Bruyneel, Arne Antoon N AAN; Hnatiuk, Anna P AP; Mercola, Mark M; Malhotra, Sanjay V SV

Publication Date: 2022-08-25

Variant appearance in text: EGFR: I759del

PubMed Link: 35944901

Variant Present in the following documents:

• jm1c01853_si_003.xlsx, sheet 1

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Decoding kinase-adverse event associations for small molecule kinase inhibitors.

Nature Communications

Gong, Xiajing X; Hu, Meng M; Liu, Jinzhong J; Kim, Geoffrey G; Xu, James J; McKee, Amy A; Palmby, Todd T; de Claro, R Angelo RA; Zhao, Liang L

Publication Date: 2022-07-27

Variant appearance in text: EGFR: I759del

PubMed Link: 35896580

Variant Present in the following documents:

• 41467_2022_Article_32033.pdf

View BVdb publication page

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Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.

Acs Medicinal Chemistry Letters

Hall, Adrian A; Abendroth, Jan J; Bolejack, Madison J MJ; Ceska, Tom T; Dell'Aiera, Sylvie S; Ellis, Victoria V; Fox, David D; François, Cyril C; Muruthi, Muigai M MM; Prével, Camille C; Poullennec, Karine K; Romanov, Sergei S; Valade, Anne A; Vanbellinghen, Alain A; Yano, Jason J; Geraerts, Martine M

Publication Date: 2022-07-14

Variant appearance in text: EGFR: I759del

PubMed Link: 35859861

Variant Present in the following documents:

• ml2c00134_si_001.pdf

View BVdb publication page

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Reengineering Ponatinib to Minimize Cardiovascular Toxicity.

Cancer Research

Hnatiuk, Anna P AP; Bruyneel, Arne A N AAN; Tailor, Dhanir D; Pandrala, Mallesh M; Dheeraj, Arpit A; Li, Wenqi W; Serrano, Ricardo R; Feyen, Dries A M DAM; Vu, Michelle M MM; Amatya, Prashila P; Gupta, Saloni S; Nakauchi, Yusuke Y; Morgado, Isabel I; Wiebking, Volker V; Liao, Ronglih R; Porteus, Matthew H MH; Majeti, Ravindra R; Malhotra, Sanjay V SV; Mercola, Mark M

Publication Date: 2022-08-03

Variant appearance in text: EGFR: I759del

PubMed Link: 35763671

Variant Present in the following documents:

• can-21-3652_supplementary_table_s1_suppst1.xls, sheet 2

View BVdb publication page

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal Of Medicinal Chemistry

Huckvale, Rosemary R; Harnden, Alice C AC; Cheung, Kwai-Ming J KJ; Pierrat, Olivier A OA; Talbot, Rachel R; Box, Gary M GM; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Hallsworth, Albert E AE; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; Hayes, Angela A; Gunnell, Emma A EA; Brennan, Alfie A; Davis, Owen A OA; Johnson, Louise D LD; de Klerk, Selby S; McAndrew, Craig C; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2022-06-23

Variant appearance in text: EGFR: I759del

PubMed Link: 35653645

Variant Present in the following documents:

• jm1c02175_si_002.xlsx, sheet 2

View BVdb publication page

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Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene

Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S

Publication Date: 2022-04

Variant appearance in text: EGFR: I759del

PubMed Link: 35304574

Variant Present in the following documents:

• 41388_2022_Article_2263.pdf

View BVdb publication page

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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Cell Death & Disease

Meng, Ya Y; Song, Chengcheng C; Ren, Zhili Z; Li, Xiaohong X; Yang, Xiangyu X; Ai, Nana N; Yang, Yang Y; Wang, Dongjin D; Zhan, Meixiao M; Wang, Jiaxian J; Lei, Chon Lok CL; Liu, Weiwei W; Ge, Wei W; Lu, Ligong L; Chen, Guokai G

Publication Date: 2021-11-29

Variant appearance in text: EGFR: I759del

PubMed Link: 34845199

Variant Present in the following documents:

• 41419_2021_4395_MOESM9_ESM.xlsx, sheet 1

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Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin.

Scientific Reports

Chinnappan, Jayaprakash J; Ramu, Akilandeswari A; V, Vidhya Rajalakshmi VR; S, Akil Kavya AK

Publication Date: 2021-11-11

Variant appearance in text: EGFR: I759del

PubMed Link: 34764329

Variant Present in the following documents:

• Main text
• 41598_2021_Article_1508.pdf

View BVdb publication page

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Comprehensive analysis of NGS and ARMS-PCR for detecting EGFR mutations based on 4467 cases of NSCLC patients.

Journal Of Cancer Research And Clinical Oncology

He, Changlong C; Wei, Chengcheng C; Wen, Jun J; Chen, Shi S; Chen, Ling L; Wu, Yue Y; Shen, Yifan Y; Bai, Huili H; Zhang, Yangli Y; Chen, Xueping X; Li, Xiaosong X

Publication Date: 2021-10-24

Variant appearance in text: EGFR: I759del

PubMed Link: 34693477

Variant Present in the following documents:

• Main text
• 432_2021_Article_3818.pdf

View BVdb publication page

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Comprehensive analysis of NGS and ARMS-PCR for detecting EGFR mutations based on 4467 cases of NSCLC patients.

Journal Of Cancer Research And Clinical Oncology

He, Changlong C; Wei, Chengcheng C; Wen, Jun J; Chen, Shi S; Chen, Ling L; Wu, Yue Y; Shen, Yifan Y; Bai, Huili H; Zhang, Yangli Y; Chen, Xueping X; Li, Xiaosong X

Publication Date: 2022-02

Variant appearance in text: EGFR: I759del

PubMed Link: 34693477

Variant Present in the following documents:

• Main text
• 432_2021_Article_3818.pdf

View BVdb publication page

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Afatinib as a Potential Therapeutic Option for Patients With NSCLC With EGFR G724S.

Jto Clinical And Research Reports

Wei, Yang Y; Jiang, Benyuan B; Liu, Shulin S; Zhang, Zhonghan Z; Fang, Wenfeng W; Yang, Yunpeng Y; Li, Xin X; Zhao, Jingyi J; Zhao, Hongyun H

Publication Date: 2021-07

Variant appearance in text: EGFR: I759del

PubMed Link: 34590038

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature

Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV

Publication Date: 2021-09

Variant appearance in text: EGFR: I759del

PubMed Link: 34526717

Variant Present in the following documents:

• 41586_2021_3898_MOESM1_ESM.pdf

View BVdb publication page

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal Of Medicinal Chemistry

Henderson, Scott H SH; Sorrell, Fiona F; Bennett, James J; Fedorov, Oleg O; Hanley, Marcus T MT; Godoi, Paulo H PH; Ruela de Sousa, Roberta R; Robinson, Sean S; Ashall-Kelly, Alexander A; Hopkins Navratilova, Iva I; Walter, Daryl S DS; Elkins, Jonathan M JM; Ward, Simon E SE

Publication Date: 2021-08-12

Variant appearance in text: EGFR: I759del

PubMed Link: 34342227

Variant Present in the following documents:

• jm1c01115_si_002.xlsx, sheet 12
• jm1c01115_si_002.xlsx, sheet 4
• jm1c01115_si_002.xlsx, sheet 6
• jm1c01115_si_002.xlsx, sheet 3
• jm1c01115_si_002.xlsx, sheet 9
• jm1c01115_si_002.xlsx, sheet 11
• jm1c01115_si_002.xlsx, sheet 13
• jm1c01115_si_002.xlsx, sheet 5
• jm1c01115_si_002.xlsx, sheet 1
• jm1c01115_si_002.xlsx, sheet 8
• jm1c01115_si_002.xlsx, sheet 2
• jm1c01115_si_002.xlsx, sheet 14
• jm1c01115_si_002.xlsx, sheet 10
• jm1c01115_si_002.xlsx, sheet 7

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: I759del

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

View BVdb publication page

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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.

Journal Of Medicinal Chemistry

Eduful, Benjamin J BJ; O'Byrne, Sean N SN; Temme, Louisa L; Asquith, Christopher R M CRM; Liang, Yi Y; Picado, Alfredo A; Pilotte, Joseph R JR; Hossain, Mohammad Anwar MA; Wells, Carrow I CI; Zuercher, William J WJ; Catta-Preta, Carolina M C CMC; Zonzini Ramos, Priscila P; Santiago, André de S AS; Couñago, Rafael M RM; Langendorf, Christopher G CG; Nay, Kévin K; Oakhill, Jonathan S JS; Pulliam, Thomas L TL; Lin, Chenchu C; Awad, Dominik D; Willson, Timothy M TM; Frigo, Daniel E DE; Scott, John W JW; Drewry, David H DH

Publication Date: 2021-08-12

Variant appearance in text: EGFR: I759del

PubMed Link: 34264658

Variant Present in the following documents:

• jm0c02274_si_003.xlsx, sheet 1

View BVdb publication page

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Validation of ctDNA Quality Control Materials Through a Precompetitive Collaboration of the Foundation for the National Institutes of Health.

Jco Precision Oncology

Williams, P Mickey PM; Forbes, Thomas T; P Lund, Steven S; Cole, Kenneth D KD; He, Hua-Jun HJ; Karlovich, Chris C; Paweletz, Cloud P CP; Stetson, Daniel D; Yee, Laura M LM; Connors, Dana E DE; Keating, Susan M SM; Destenaves, Benoit B; Cleveland, Megan H MH; Lau, Christie J CJ; Barrett, J Carl JC; Kelloff, Gary J GJ; McCormack, Robert T RT

Publication Date: 2021

Variant appearance in text: EGFR: I759del

PubMed Link: 34250423

Variant Present in the following documents:

• Main text

View BVdb publication page

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Diving into the Pleural Fluid: Liquid Biopsy for Metastatic Malignant Pleural Effusions.

Cancers

Sorolla, Maria Alba MA; Sorolla, Anabel A; Parisi, Eva E; Salud, Antonieta A; Porcel, José M JM

Publication Date: 2021-06-04

Variant appearance in text: EGFR: I759del

PubMed Link: 34199799

Variant Present in the following documents:

• Main text
• cancers-13-02798.pdf

View BVdb publication page

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Molecular characterization of advanced non-small cell lung cancer patients by cfDNA analysis: experience from routine laboratory practice.

Journal Of Thoracic Disease

González de Aledo-Castillo, José Manuel JM; Arcocha, Ainara A; Victoria, Iván I; Martinez-Puchol, Ana Isabel AI; Sánchez, Cristina C; Jares, Pedro P; Rodríguez, Gabriel Felipe GF; Viñolas, Núria N; Reyes, Roxana R; Reguart, Noemí N; Puig-Butillé, Joan Antón JA

Publication Date: 2021-03

Variant appearance in text: EGFR: Ile759del

PubMed Link: 33841957

Variant Present in the following documents:

• Main text

View BVdb publication page

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Visualization of Kinase Inhibition-Related Adverse Events Using the Japanese Adverse Drug Event Report Database.

Drugs - Real World Outcomes

Mizuno, Takahito T; Sakai, Takamasa T; Tanabe, Kouichi K; Umemura, Takumi T; Goto, Nobuyuki N; Ohtsu, Fumiko F

Publication Date: 2021-06

Variant appearance in text: EGFR: I759del

PubMed Link: 33686612

Variant Present in the following documents:

• 40801_2021_235_MOESM1_ESM.pdf

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: EGFR: I759del

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma.

Signal Transduction And Targeted Therapy

Liu, Juan J; Liang, Qianmao Q; Wang, Aoli A; Zou, Fengming F; Qi, Ziping Z; Yu, Kailin K; Liu, Qingwang Q; Chen, Cheng C; Liu, Jing J; Liu, Qingsong Q

Publication Date: 2020-09-14

Variant appearance in text: EGFR: I759del

PubMed Link: 32929063

Variant Present in the following documents:

• 41392_2020_309_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy.

Iscience

Singh, Vibha V; Bhoir, Siddhant S; Chikhale, Rupesh V RV; Hussain, Javeena J; Dwyer, Donard D; Bryce, Richard A RA; Kirubakaran, Sivapriya S; De Benedetti, Arrigo A

Publication Date: 2020-08-20

Variant appearance in text: EGFR: I759del

PubMed Link: 32905878

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

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[Different Gene Mutation Spectrum of the Paired CSF and Plasma Samples in Lung Adenocarcinoma with Leptomeningeal Metastases: the Liquid Biopsy Based on Circulating Tumor DNA].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Li, Huiying H; Xie, Yu Y; Lin, Yongjuan Y; Yu, Tingting T; Yin, Zhenyu Z

Publication Date: 2020-08-20

Variant appearance in text: EGFR: I759del

PubMed Link: 32838487

Variant Present in the following documents:

• Main text
• zgfazz-23-8-646.pdf

View BVdb publication page

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EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports

Calibasi-Kocal, Gizem G; Amirfallah, Arsalan A; Sever, Tolga T; Umit Unal, Olcun O; Gurel, Duygu D; Oztop, Ilhan I; Ellidokuz, Hulya H; Basbinar, Yasemin Y

Publication Date: 2020-08

Variant appearance in text: EGFR: Ile759del

PubMed Link: 32509305

Variant Present in the following documents:

• Main text

View BVdb publication page

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New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).

Molecules (Basel, Switzerland)

Asquith, Christopher R M CRM; Laitinen, Tuomo T; Wells, Carrow I CI; Tizzard, Graham J GJ; Zuercher, William J WJ

Publication Date: 2020-04-07

Variant appearance in text: EGFR: I759del

PubMed Link: 32272798

Variant Present in the following documents:

• molecules-25-01697-s001.pdf

View BVdb publication page

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The kinase polypharmacology landscape of clinical PARP inhibitors.

Scientific Reports

Antolin, Albert A AA; Ameratunga, Malaka M; Banerji, Udai U; Clarke, Paul A PA; Workman, Paul P; Al-Lazikani, Bissan B

Publication Date: 2020-02-17

Variant appearance in text: EGFR: I759del

PubMed Link: 32066817

Variant Present in the following documents:

• 41598_2020_59074_MOESM1_ESM.xlsx, sheet 5

View BVdb publication page

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Molecules (Basel, Switzerland)

Asquith, Christopher R M CRM; Bennett, James M JM; Su, Lianyong L; Laitinen, Tuomo T; Elkins, Jonathan M JM; Pickett, Julie E JE; Wells, Carrow I CI; Li, Zengbiao Z; Willson, Timothy M TM; Zuercher, William J WJ

Publication Date: 2019-11-06

Variant appearance in text: EGFR: I759del

PubMed Link: 31698822

Variant Present in the following documents:

• molecules-24-04016-s001.pdf

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Variation in nomenclature of somatic variants for selection of oncological therapies: Can we reach a consensus soon?

Human Mutation

Keppens, Cleo C; Tack, Véronique V; Dufraing, Kelly K; Rouleau, Etienne E; Ligtenberg, Marjolijn J L MJL; Schuuring, Ed E; Dequeker, Elisabeth M C EMC

Publication Date: 2020-01

Variant appearance in text: EGFR: Ile759del

PubMed Link: 31553104

Variant Present in the following documents:

• Main text

View BVdb publication page

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Analysis of Predictive Biomarkers in Patients With Lung Adenocarcinoma From Southern Brazil Reveals a Distinct Profile From Other Regions of the Country.

Journal Of Global Oncology

Andreis, Tiago F TF; Correa, Bruno S BS; Vianna, Fernanda S FS; De-Paris, Fernanda F; Siebert, Marina M; Leistner-Segal, Sandra S; Hahn, Eriza C EC; Ulbrich, Jane M JM; Rivero, Luis F R LFR; De Oliveira, Francine H FH; Lorandi, Vinícius V; Ashton-Prolla, Patricia P; Macedo, Gabriel S GS

Publication Date: 2019-09

Variant appearance in text: EGFR: Ile759del

PubMed Link: 31532708

Variant Present in the following documents:

• JGO.19.00174.pdf

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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Acs Medicinal Chemistry Letters

Harris, Philip A PA; Marinis, Jill M JM; Lich, John D JD; Berger, Scott B SB; Chirala, Anirudh A; Cox, Julie A JA; Eidam, Patrick M PM; Finger, Joshua N JN; Gough, Peter J PJ; Jeong, Jae U JU; Kang, James J; Kasparcova, Viera V; Leister, Lara K LK; Mahajan, Mukesh K MK; Miller, George G; Nagilla, Rakesh R; Ouellette, Michael T MT; Reilly, Michael A MA; Rendina, Alan R AR; Rivera, Elizabeth J EJ; Sun, Helen H HH; Thorpe, James H JH; Totoritis, Rachel D RD; Wang, Wei W; Wu, Dongling D; Zhang, Daohua D; Bertin, John J; Marquis, Robert W RW

Publication Date: 2019-06-13

Variant appearance in text: EGFR: I759del

PubMed Link: 31223438

Variant Present in the following documents:

• ml9b00108_si_001.pdf

View BVdb publication page

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.

Cell Death And Differentiation

Patel, Snahel S; Webster, Joshua D JD; Varfolomeev, Eugene E; Kwon, Youngsu C YC; Cheng, Jason H JH; Zhang, Juan J; Dugger, Debra L DL; Wickliffe, Kate E KE; Maltzman, Allie A; Sujatha-Bhaskar, Swathi S; Bir Kohli, Pawan P; Ramaswamy, Sreema S; Deshmukh, Gauri G; Liederer, Bianca M BM; Fong, Rina R; Hamilton, Greg G; Lupardus, Patrick P; Caplazi, Patrick P; Lee, Wyne P WP; van Lookeren Campagne, Menno M; Johnson, Adam A; McKenzie, Brent S BS; Junttila, Melissa R MR; Newton, Kim K; Vucic, Domagoj D

Publication Date: 2020-01

Variant appearance in text: EGFR: I759del

PubMed Link: 31101885

Variant Present in the following documents:

• 41418_2019_347_MOESM2_ESM.xlsx, sheet 1

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On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Brown, Benjamin P BP; Zhang, Yun-Kai YK; Westover, David D; Yan, Yingjun Y; Qiao, Huan H; Huang, Vincent V; Du, Zhenfang Z; Smith, Jarrod A JA; Ross, Jeffrey S JS; Miller, Vincent A VA; Ali, Siraj S; Bazhenova, Lyudmila L; Schrock, Alexa B AB; Meiler, Jens J; Lovly, Christine M CM

Publication Date: 2019-06-01

Variant appearance in text: EGFR: I759del

PubMed Link: 30796031

Variant Present in the following documents:

• Main text

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Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.

Mbio

Caro-Vegas, Carolina C; Bailey, Aubrey A; Bigi, Rachele R; Damania, Blossom B; Dittmer, Dirk P DP

Publication Date: 2019-02-19

Variant appearance in text: EGFR: I759del

PubMed Link: 30782662

Variant Present in the following documents:

• mBio.02871-18-st001.xlsx, sheet 1

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B

Publication Date: 2019-02-12

Variant appearance in text: EGFR: I759del

PubMed Link: 30683722

Variant Present in the following documents:

• pnas.1812963116.sapp.pdf

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Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

The Embo Journal

Mariappan, Aruljothi A; Soni, Komal K; Schorpp, Kenji K; Zhao, Fan F; Minakar, Amin A; Zheng, Xiangdong X; Mandad, Sunit S; Macheleidt, Iris I; Ramani, Anand A; Kubelka, Tomáš T; Dawidowski, Maciej M; Golfmann, Kristina K; Wason, Arpit A; Yang, Chunhua C; Simons, Judith J; Schmalz, Hans-Günther HG; Hyman, Anthony A AA; Aneja, Ritu R; Ullrich, Roland R; Urlaub, Henning H; Odenthal, Margarete M; Büttner, Reinhardt R; Li, Haitao H; Sattler, Michael M; Hadian, Kamyar K; Gopalakrishnan, Jay J

Publication Date: 2019-01-15

Variant appearance in text: EGFR: I759del

PubMed Link: 30530478

Variant Present in the following documents:

• EMBJ-38-e99876-s004.xlsx, sheet 1

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DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.

Acs Chemical Biology

Richter, Hans H; Satz, Alexander L AL; Bedoucha, Marc M; Buettelmann, Bernd B; Petersen, Ann C AC; Harmeier, Anja A; Hermosilla, Ricardo R; Hochstrasser, Remo R; Burger, Dominique D; Gsell, Bernard B; Gasser, Rodolfo R; Huber, Sylwia S; Hug, Melanie N MN; Kocer, Buelent B; Kuhn, Bernd B; Ritter, Martin M; Rudolph, Markus G MG; Weibel, Franziska F; Molina-David, Judith J; Kim, Jin-Ju JJ; Santos, Javier Varona JV; Stihle, Martine M; Georges, Guy J GJ; Bonfil, R Daniel RD; Fridman, Rafael R; Uhles, Sabine S; Moll, Solange S; Faul, Christian C; Fornoni, Alessia A; Prunotto, Marco M

Publication Date: 2019-01-18

Variant appearance in text: EGFR: I759del

PubMed Link: 30452219

Variant Present in the following documents:

• cb8b00866_si_001.pdf

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The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.

Oncotarget

Kim, Sunkyu S; Tiedt, Ralph R; Loo, Alice A; Horn, Thomas T; Delach, Scott S; Kovats, Steven S; Haas, Kristy K; Engstler, Barbara Schacher BS; Cao, Alexander A; Pinzon-Ortiz, Maria M; Mulford, Iain I; Acker, Michael G MG; Chopra, Rajiv R; Brain, Christopher C; di Tomaso, Emmanuelle E; Sellers, William R WR; Caponigro, Giordano G

Publication Date: 2018-10-16

Variant appearance in text: EGFR: I759del

PubMed Link: 30443290

Variant Present in the following documents:

• oncotarget-09-35226-s002.xlsx, sheet 1

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Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors.

Nature Communications

Fassunke, Jana J; Müller, Fabienne F; Keul, Marina M; Michels, Sebastian S; Dammert, Marcel A MA; Schmitt, Anna A; Plenker, Dennis D; Lategahn, Jonas J; Heydt, Carina C; Brägelmann, Johannes J; Tumbrink, Hannah L HL; Alber, Yannic Y; Klein, Sebastian S; Heimsoeth, Alena A; Dahmen, Ilona I; Fischer, Rieke N RN; Scheffler, Matthias M; Ihle, Michaela A MA; Priesner, Vanessa V; Scheel, Andreas H AH; Wagener, Svenja S; Kron, Anna A; Frank, Konrad K; Garbert, Katia K; Persigehl, Thorsten T; Püsken, Michael M; Haneder, Stefan S; Schaaf, Bernhard B; Rodermann, Ernst E; Engel-Riedel, Walburga W; Felip, Enriqueta E; Smit, Egbert F EF; Merkelbach-Bruse, Sabine S; Reinhardt, H Christian HC; Kast, Stefan M SM; Wolf, Jürgen J; Rauh, Daniel D; Büttner, Reinhard R; Sos, Martin L ML

Publication Date: 2018-11-07

Variant appearance in text: EGFR: I759del

PubMed Link: 30405134

Variant Present in the following documents:

• Main text

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Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions.

Cancer Science

Kato, Yuka Y; Ninomiya, Kiichiro K; Ohashi, Kadoaki K; Tomida, Shuta S; Makimoto, Go G; Watanabe, Hiromi H; Kudo, Kenichiro K; Matsumoto, Shingo S; Umemura, Shigeki S; Goto, Koichi K; Ichihara, Eiki E; Ninomiya, Takashi T; Kubo, Toshio T; Sato, Akiko A; Hotta, Katsuyuki K; Tabata, Masahiro M; Toyooka, Shinichi S; Maeda, Yoshinobu Y; Kiura, Katsuyuki K

Publication Date: 2018-10

Variant appearance in text: EGFR: I759del

PubMed Link: 30053332

Variant Present in the following documents:

• Main text
• CAS-109-3149.pdf

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Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients.

Oncotargets And Therapy

Chen, Qiong Q; Li, Rong R; Zhang, Zhi-Gao ZG; Deng, Qiao-Ting QT; Li, Kun K; Wang, Hao H; Yang, Xue-Xi XX; Wu, Ying-Song YS

Publication Date: 2018

Variant appearance in text: EGFR: I759del

PubMed Link: 29719410

Variant Present in the following documents:

• Main text
• ott-11-2279.pdf

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CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells.

Oncotarget

Nakamura, Akito A; Nakata, Daisuke D; Kakoi, Yuichi Y; Kunitomo, Mihoko M; Murai, Saomi S; Ebara, Shunsuke S; Hata, Akito A; Hara, Takahito T

Publication Date: 2018-03-02

Variant appearance in text: EGFR: I759del

PubMed Link: 29568371

Variant Present in the following documents:

• oncotarget-09-13474-s003.xlsx, sheet 1
• oncotarget-09-13474-s002.xlsx, sheet 1

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Epidermal growth factor receptor somatic mutation analysis in 354 Chinese patients with non-small cell lung cancer.

Oncology Letters

Quan, Xueping X; Gao, Hongjun H; Wang, Zhikuan Z; Li, Jie J; Zhao, Wentao W; Liang, Wei W; Yu, Qiang Q; Guo, Dongliang D; Hao, Zhanping Z; Liu, Jingxin J

Publication Date: 2018-02

Variant appearance in text: EGFR: I759del

PubMed Link: 29434916

Variant Present in the following documents:

• Main text

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Molecular characteristics and clinical outcomes of EGFR exon 19 indel subtypes to EGFR TKIs in NSCLC patients.

Oncotarget

Su, Jian J; Zhong, Wenzhao W; Zhang, Xuchao X; Huang, Ying Y; Yan, Honghong H; Yang, Jinji J; Dong, Zhongyi Z; Xie, Zhi Z; Zhou, Qing Q; Huang, Xiaosui X; Lu, Danxia D; Yan, Wenqing W; Wu, Yi-Long YL

Publication Date: 2017-12-19

Variant appearance in text: EGFR: I759del

PubMed Link: 29340050

Variant Present in the following documents:

• oncotarget-08-111246.pdf

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Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs).

Oncotarget

Yu, Kailin K; Liu, Xuesong X; Jiang, Zongru Z; Hu, Chen C; Zou, Fengming F; Chen, Cheng C; Ge, Juan J; Wu, Jiaxin J; Liu, Xiaochuan X; Wang, Aoli A; Wang, Wenliang W; Wang, Wenchao W; Qi, Ziping Z; Wang, Beilei B; Wang, Li L; Yan, Hezhong H; Wang, Jiaoxue J; Ren, Tao T; Tang, Jun J; Liu, Qingsong Q; Liu, Jing J

Publication Date: 2017-12-19

Variant appearance in text: EGFR: I759del

PubMed Link: 29340041

Variant Present in the following documents:

• oncotarget-08-111110-s002.xlsx, sheet 1

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Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity.

Oncotarget

Dohmen, Amy J C AJC; Qiao, Xiaohang X; Duursma, Anja A; Wijdeven, Ruud H RH; Lieftink, Cor C; Hageman, Floor F; Morris, Ben B; Halonen, Pasi P; Vens, Conchita C; van den Brekel, Michiel W M MWM; Ovaa, Huib H; Neefjes, Jacques J; Zuur, Charlotte L CL

Publication Date: 2017-09-26

Variant appearance in text: EGFR: I759del

PubMed Link: 29088757

Variant Present in the following documents:

• oncotarget-08-73925-s002.xlsx, sheet 1

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Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Scientific Reports

Huang, Bill X BX; Newcomer, Kenny K; Kevala, Karl K; Barnaeva, Elena E; Zheng, Wei W; Hu, Xin X; Patnaik, Samarjit S; Southall, Noel N; Marugan, Juan J; Ferrer, Marc M; Kim, Hee-Yong HY

Publication Date: 2017-09-15

Variant appearance in text: EGFR: I759del

PubMed Link: 28916818

Variant Present in the following documents:

• 41598_2017_11870_MOESM1_ESM.pdf

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A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.

Cell Reports

Mujahid, Nisma N; Liang, Yanke Y; Murakami, Ryo R; Choi, Hwan Geun HG; Dobry, Allison S AS; Wang, Jinhua J; Suita, Yusuke Y; Weng, Qing Yu QY; Allouche, Jennifer J; Kemeny, Lajos V LV; Hermann, Andrea L AL; Roider, Elisabeth M EM; Gray, Nathanael S NS; Fisher, David E DE

Publication Date: 2017-06-13

Variant appearance in text: EGFR: I759del

PubMed Link: 28614705

Variant Present in the following documents:

• NIHMS882886-supplement-2.xlsx, sheet 1

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Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia.

Acs Omega

Jarusiewicz, Jamie A JA; Jeon, Jae Yoon JY; Connelly, Michele C MC; Chen, Yizhe Y; Yang, Lei L; Baker, Sharyn D SD; Guy, R Kiplin RK

Publication Date: 2017-05-31

Variant appearance in text: EGFR: I759del

PubMed Link: 28580438

Variant Present in the following documents:

• ao7b00144_si_001.pdf

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