EGFR c.2281G>A ;(p.D761N)

Variant ID: 7-55242511-G-A

NM_005228.3(EGFR):c.2281G>A;(p.D761N)

This variant was identified in 63 publications

View GRCh38 version.




Publications:


Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications
Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G
Publication Date: 2023-03-11

Variant appearance in text: EGFR: 2281G>A; Asp761Asn
PubMed Link: 36906579
Variant Present in the following documents:
  • 41467_2023_36922_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: EGFR: 2281G>A; Asp761Asn
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: EGFR: D761N
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: EGFR: D761N
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 4
View BVdb publication page



An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 3
  • Table_2.xlsx, sheet 2
View BVdb publication page



Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.

Nature Communications
Shah, Jennifer B JB; Pueschl, Dana D; Wubbenhorst, Bradley B; Fan, Mengyao M; Pluta, John J; D'Andrea, Kurt K; Hubert, Anna P AP; Shilan, Jake S JS; Zhou, Wenting W; Kraya, Adam A AA; Llop Guevara, Alba A; Ruan, Catherine C; Serra, Violeta V; Balmaña, Judith J; Feldman, Michael M; Morin, Pat J PJ; Nayak, Anupma A; Maxwell, Kara N KN; Domchek, Susan M SM; Nathanson, Katherine L KL
Publication Date: 2022-11-07

Variant appearance in text: EGFR: D761N
PubMed Link: 36344544
Variant Present in the following documents:
  • 41467_2022_34523_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine
Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y
Publication Date: 2022-07

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 35393784
Variant Present in the following documents:
  • CAM4-11-2767-s001.xlsx, sheet 1
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.

Nature Biotechnology
Sánchez-Rivera, Francisco J FJ; Diaz, Bianca J BJ; Kastenhuber, Edward R ER; Schmidt, Henri H; Katti, Alyna A; Kennedy, Margaret M; Tem, Vincent V; Ho, Yu-Jui YJ; Leibold, Josef J; Paffenholz, Stella V SV; Barriga, Francisco M FM; Chu, Kevan K; Goswami, Sukanya S; Wuest, Alexandra N AN; Simon, Janelle M JM; Tsanov, Kaloyan M KM; Chakravarty, Debyani D; Zhang, Hongxin H; Leslie, Christina S CS; Lowe, Scott W SW; Dow, Lukas E LE
Publication Date: 2022-06

Variant appearance in text: EGFR: D761N
PubMed Link: 35165384
Variant Present in the following documents:
  • NIHMS1760571-supplement-Supplementary_Table_S2.xlsx, sheet 4
View BVdb publication page



Ultrasensitive analysis of genetic instability related to chemical exposure.

Journal Of Applied Genetics
Domoradzki, Tomasz T; Grochowski, Piotr P; Jaśkiewicz, Anna A; Pająk, Beata B
Publication Date: 2022-05

Variant appearance in text: EGFR: D761N
PubMed Link: 34967917
Variant Present in the following documents:
  • Main text
  • 13353_2021_Article_677.pdf
View BVdb publication page



Evaluation of the Mutation Profile via Next-Generation Sequencing in a Turkish Population With Non-small Cell Lung Cancer.

Balkan Medical Journal
Kahraman Çetin, Nesibe N; Erdoğdu, İbrahim Halil İH; Bozkurt, Emin E; Meteoğlu, İbrahim İ
Publication Date: 2021-11

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 34860166
Variant Present in the following documents:
  • bmj-38-6-382.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: EGFR: D761N
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Asp761Asn
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Asp761Asn
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Publication Date: 2021-09

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 34526717
Variant Present in the following documents:
  • 41586_2021_3898_MOESM1_ESM.pdf
View BVdb publication page



Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations.

The American Journal Of Surgical Pathology
Monteagudo, Carlos C; Fúnez, Rafael R; Sánchez-Sendra, Beatriz B; González-Muñoz, José F JF; Nieto, Gema G; Alfaro-Cervelló, Clara C; Murgui, Amelia A; Barr, Ronald J RJ
Publication Date: 2021-10-01

Variant appearance in text: EGFR: Asp761Asn
PubMed Link: 34232601
Variant Present in the following documents:
  • Main text
  • pas-45-1382.pdf
View BVdb publication page



Expression of Immuno-Oncologic Biomarkers Is Enriched in Colorectal Cancers and Other Solid Tumors Harboring the A59T Variant of KRAS.

Cells
Lou, Emil E; Xiu, Joanne J; Baca, Yasmine Y; Nelson, Andrew C AC; Weinberg, Benjamin A BA; Beg, Muhammad Shaalan MS; Salem, Mohamed E ME; Lenz, Heinz-Josef HJ; Philip, Philip P; El-Deiry, Wafik S WS; Korn, W Michael WM
Publication Date: 2021-05-21

Variant appearance in text: EGFR: D761N
PubMed Link: 34063999
Variant Present in the following documents:
  • Main text
  • cells-10-01275.pdf
View BVdb publication page



Dynamic cfDNA Analysis by NGS in EGFR T790M-Positive Advanced NSCLC Patients Failed to the First-Generation EGFR-TKIs.

Frontiers In Oncology
Ma, Li L; Li, Haoyang H; Wang, Dongpo D; Hu, Ying Y; Yu, Mengjun M; Zhang, Quan Q; Qin, Na N; Zhang, Xinyong X; Li, Xi X; Zhang, Hui H; Wu, Yuhua Y; Lv, Jialin J; Yang, Xinjie X; Yu, Ruoying R; Zhang, Shucai S; Wang, Jinghui J
Publication Date: 2021

Variant appearance in text: EGFR: D761N
PubMed Link: 33842353
Variant Present in the following documents:
  • Main text
  • fonc-11-643199.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Clinical Value of EGFR Copy Number Gain Determined by Amplicon-Based Targeted Next Generation Sequencing in Patients with EGFR-Mutated NSCLC.

Targeted Oncology
Wei, Jiacong J; Meng, Pei P; Terpstra, Miente Martijn MM; van Rijk, Anke A; Tamminga, Menno M; Scherpen, Frank F; Ter Elst, Arja A; Alimohamed, Mohamed Z MZ; Johansson, Lennart F LF; Stigt, Jos J; Gijtenbeek, Rolof P G RPG; van Putten, John J; Hiltermann, T Jeroen N TJN; Groen, Harry J M HJM; Kok, Klaas K; van der Wekken, Anthonie J AJ; van den Berg, Anke A
Publication Date: 2021-03

Variant appearance in text: EGFR: D761N
PubMed Link: 33606136
Variant Present in the following documents:
  • 11523_2021_798_MOESM1_ESM.pdf
View BVdb publication page



Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer
Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F
Publication Date: 2020

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 33145402
Variant Present in the following documents:
  • 41523_2020_201_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913418
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: EGFR: D761N
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
Mack, Philip C PC; Banks, Kimberly C KC; Espenschied, Carin R CR; Burich, Rebekah A RA; Zill, Oliver A OA; Lee, Christine E CE; Riess, Jonathan W JW; Mortimer, Stefanie A SA; Talasaz, AmirAli A; Lanman, Richard B RB; Gandara, David R DR
Publication Date: 2020-07-15

Variant appearance in text: EGFR: D761N
PubMed Link: 32365229
Variant Present in the following documents:
  • Main text
  • CNCR-126-3219.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: EGFR: D761N
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 2
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z
Publication Date: 2020-01

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 32067422
Variant Present in the following documents:
  • CAC2-40-43-s001.xlsx, sheet 1
View BVdb publication page



Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
Publication Date: 2019-11

Variant appearance in text: EGFR: Asp761Asn
PubMed Link: 31645765
Variant Present in the following documents:
  • 41586_2019_1689_MOESM14_ESM.xlsx, sheet 1
  • 41586_2019_1689_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: EGFR: D761N
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Profiling the Mutational Landscape in Known Driver Genes and Novel Genes in African American Non-Small Cell Lung Cancer Patients.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Lusk, Christine M CM; Watza, Donovan D; Dyson, Greg G; Craig, Douglas D; Ratliff, Valerie V; Wenzlaff, Angela S AS; Lonardo, Fulvio F; Bollig-Fischer, Aliccia A; Bepler, Gerold G; Purrington, Kristen K; Gadgeel, Shirish S; Schwartz, Ann G AG
Publication Date: 2019-07-15

Variant appearance in text: EGFR: D761N
PubMed Link: 30979741
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted mutation detection in breast cancer using MammaSeq™.

Breast Cancer Research : Bcr
Smith, Nicholas G NG; Gyanchandani, Rekha R; Shah, Osama S OS; Gurda, Grzegorz T GT; Lucas, Peter C PC; Hartmaier, Ryan J RJ; Brufsky, Adam M AM; Puhalla, Shannon S; Bahreini, Amir A; Kota, Karthik K; Wald, Abigail I AI; Nikiforov, Yuri E YE; Nikiforova, Marina N MN; Oesterreich, Steffi S; Lee, Adrian V AV
Publication Date: 2019-02-08

Variant appearance in text: EGFR: D761N
PubMed Link: 30736836
Variant Present in the following documents:
  • 13058_2019_1102_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

Bmc Urology
Kim, Young Saing YS; Kim, Kyung K; Kwon, Ghee-Young GY; Lee, Su Jin SJ; Park, Se Hoon SH
Publication Date: 2018-07-31

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 30064409
Variant Present in the following documents:
  • 12894_2018_380_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Detailed overview on the mutations detected by and the sensitivity of the GeneReader NGS sequencing platform.

Data In Brief
Lüsebrink, Jessica J; Pieper, Monika M; Tillmann, Ramona-Liza RL; Brockmann, Michael M; Schildgen, Oliver O; Schildgen, Verena V
Publication Date: 2018-06

Variant appearance in text: EGFR: D761N
PubMed Link: 29904702
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience.

Oncotarget
D'Haene, Nicky N; Fontanges, Quitterie Q; De Nève, Nancy N; Blanchard, Oriane O; Melendez, Barbara B; Delos, Monique M; Dehou, Marie-Françoise MF; Maris, Calliope C; Nagy, Nathalie N; Rousseau, Emmanuel E; Vandenhove, Josse J; Gilles, André A; De Prez, Carine C; Verset, Laurine L; Van Craynest, Marie-Paule MP; Demetter, Pieter P; Van Laethem, Jean-Luc JL; Salmon, Isabelle I; Le Mercier, Marie M
Publication Date: 2018-04-17

Variant appearance in text: EGFR: D761N
PubMed Link: 29755687
Variant Present in the following documents:
  • Main text
  • oncotarget-09-20761.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: D761N
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.

Japanese Journal Of Clinical Oncology
Naito, Yoichi Y; Takahashi, Hideaki H; Shitara, Kohei K; Okamoto, Wataru W; Bando, Hideaki H; Kuwata, Takeshi T; Kuboki, Yasutoshi Y; Matsumoto, Shingo S; Miki, Izumi I; Yamanaka, Takeharu T; Watanabe, Atsushi A; Kojima, Motohiro M
Publication Date: 2018-06-01

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 29659903
Variant Present in the following documents:
  • hyy052supplementaltable1ionver1.xls, sheet 1
View BVdb publication page



Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow.

Nature Communications
Zhu, Yafeng Y; Orre, Lukas M LM; Johansson, Henrik J HJ; Huss, Mikael M; Boekel, Jorrit J; Vesterlund, Mattias M; Fernandez-Woodbridge, Alejandro A; Branca, Rui M M RMM; Lehtiö, Janne J
Publication Date: 2018-03-02

Variant appearance in text: rs121913418
PubMed Link: 29500430
Variant Present in the following documents:
  • 41467_2018_3311_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract.

Translational Oncology
Lee, Ji Yun JY; Kim, Kyung K; Sung, Hyun Hwan HH; Jeon, Hwang Gyun HG; Jeong, Byong Chang BC; Seo, Seong Il SI; Jeon, Seong Soo SS; Lee, Hyun Moo HM; Choi, Han-Yong HY; Kwon, Ghee-Young GY; Kim, Kyoung-Mee KM; Lee, Jeeyun J; Lim, Ho Yeong HY; Park, Se Hoon SH
Publication Date: 2018-02

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 29161613
Variant Present in the following documents:
  • mmc1.xlsx, sheet 1
View BVdb publication page



Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.

Genes, Chromosomes & Cancer
Wang, Xia X; Teer, Jamie K JK; Tousignant, Renee N RN; Levin, Albert M AM; Boulware, David D; Chitale, Dhananjay A DA; Shaw, Brandon M BM; Chen, Zhihua Z; Zhang, Yonghong Y; Blakeley, Jaishri O JO; Acosta, Maria T MT; Messiaen, Ludwine M LM; Korf, Bruce R BR; Tainsky, Michael A MA
Publication Date: 2018-01

Variant appearance in text: EGFR: D761N; rs121913418
PubMed Link: 28891274
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine
Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T
Publication Date: 2017-07-18

Variant appearance in text: rs121913418
PubMed Link: 28716134
Variant Present in the following documents:
  • 13073_2017_454_MOESM7_ESM.xlsx, sheet 1
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Utility of Genomic Analysis In Circulating Tumor DNA from Patients with Carcinoma of Unknown Primary.

Cancer Research
Kato, Shumei S; Krishnamurthy, Nithya N; Banks, Kimberly C KC; De, Pradip P; Williams, Kirstin K; Williams, Casey C; Leyland-Jones, Brian B; Lippman, Scott M SM; Lanman, Richard B RB; Kurzrock, Razelle R
Publication Date: 2017-08-15

Variant appearance in text: EGFR: D761N
PubMed Link: 28642281
Variant Present in the following documents:
  • Main text
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Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits.

Molecular Diagnosis & Therapy
Ma, Wanlong W; Brodie, Steven S; Agersborg, Sally S; Funari, Vincent A VA; Albitar, Maher M
Publication Date: 2017-10

Variant appearance in text: EGFR: 2281G>A; Asp761Asn
PubMed Link: 28639239
Variant Present in the following documents:
  • Main text
  • 40291_2017_Article_290.pdf
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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: N/A
PubMed Link: 28492226
Variant Present in the following documents:
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Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.

Oncotarget
Youssef, Omar O; Knuuttila, Aija A; Piirilä, Päivi P; Böhling, Tom T; Sarhadi, Virinder V; Knuutila, Sakari S
Publication Date: 2017-03-14

Variant appearance in text: EGFR: D761N
PubMed Link: 28199989
Variant Present in the following documents:
  • Main text
  • oncotarget-08-18166.pdf
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Protein-structure-guided discovery of functional mutations across 19 cancer types.

Nature Genetics
Niu, Beifang B; Scott, Adam D AD; Sengupta, Sohini S; Bailey, Matthew H MH; Batra, Prag P; Ning, Jie J; Wyczalkowski, Matthew A MA; Liang, Wen-Wei WW; Zhang, Qunyuan Q; McLellan, Michael D MD; Sun, Sam Q SQ; Tripathi, Piyush P; Lou, Carolyn C; Ye, Kai K; Mashl, R Jay RJ; Wallis, John J; Wendl, Michael C MC; Chen, Feng F; Ding, Li L
Publication Date: 2016-08

Variant appearance in text: EGFR: Asp761Asn
PubMed Link: 27294619
Variant Present in the following documents:
  • Main text
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REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.

Scientific Reports
Zhao, Min M; Rotgans, Bronwyn B; Wang, Tianfang T; Cummins, S F SF
Publication Date: 2016-03-15

Variant appearance in text: EGFR: D761N
PubMed Link: 26975833
Variant Present in the following documents:
  • srep23167-s9.xls, sheet 1
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Epidermal growth factor receptor exon 20 p.S768I mutation in non-small cell lung carcinoma: A case report combined with a review of the literature and investigation of clinical significance.

Oncology Letters
Improta, Giuseppina G; Pettinato, Angela A; Gieri, Stefania S; Scandurra, Giuseppa G; Skovrider-Ruminski, Wojciech W; Høgdall, Estrid E; Fraggetta, Filippo F
Publication Date: 2016-01

Variant appearance in text: EGFR: D761N
PubMed Link: 26870223
Variant Present in the following documents:
  • Main text
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Circulating tumor DNA identified by targeted sequencing in advanced-stage non-small cell lung cancer patients.

Cancer Letters
Xu, Song S; Lou, Feng F; Wu, Yi Y; Sun, Da-Qiang DQ; Zhang, Jing-Bo JB; Chen, Wei W; Ye, Hua H; Liu, Jing-Hao JH; Wei, Sen S; Zhao, Ming-Yu MY; Wu, Wen-Jun WJ; Su, Xue-Xia XX; Shi, Rong R; Jones, Lindsey L; Huang, Xue F XF; Chen, Si-Yi SY; Chen, Jun J
Publication Date: 2016-01-28

Variant appearance in text: EGFR: D761N
PubMed Link: 26582655
Variant Present in the following documents:
  • Main text
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Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer.

Oncotarget
Lee, Ji Yun JY; Park, Kyunghee K; Lim, Sung Hee SH; Kim, Hae Su HS; Yoo, Kwai Han KH; Jung, Ki Sun KS; Song, Haa-Na HN; Hong, Mineui M; Do, In-Gu IG; Ahn, TaeJin T; Lee, Se Kyung SK; Bae, Soo Youn SY; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Jung, Hae Hyun HH; Kim, Ji-Yeon JY; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-12-22

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 26527317
Variant Present in the following documents:
  • oncotarget-06-43731-s002.xlsx, sheet 1
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Patient-derived cell models as preclinical tools for genome-directed targeted therapy.

Oncotarget
Lee, Ji Yun JY; Kim, Sun Young SY; Park, Charny C; Kim, Nayoung K D NK; Jang, Jiryeon J; Park, Kyunghee K; Yi, Jun Ho JH; Hong, Mineui M; Ahn, Taejin T; Rath, Oliver O; Schueler, Julia J; Kim, Seung Tae ST; Do, In-Gu IG; Lee, Sujin S; Park, Se Hoon SH; Ji, Yong Ick YI; Kim, Dukwhan D; Park, Joon Oh JO; Park, Young Suk YS; Kang, Won Ki WK; Kim, Kyoung-Mee KM; Park, Woong-Yang WY; Lim, Ho Yeong HY; Lee, Jeeyun J
Publication Date: 2015-09-22

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 26296973
Variant Present in the following documents:
  • oncotarget-06-25619-s003.xls, sheet 1
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Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.

Scientific Reports
Fu, Yong Y; Cruz-Monserrate, Zobeida Z; Helen Lin, H H; Chung, Yiyin Y; Ji, Baoan B; Lin, Szu-Min SM; Vonderfecht, Steven S; Logsdon, Craig D CD; Li, Chien-Feng CF; Ann, David K DK
Publication Date: 2015-08-20

Variant appearance in text: EGFR: D761N
PubMed Link: 26289340
Variant Present in the following documents:
  • srep13347-s1.pdf
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Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay.

Oncotarget
Park, Kyunghee K; Choi, Moon Ki MK; Jung, Hae Hyun HH; Do, In-Gu IG; Lee, Kwang Hee KH; Ahn, TaeJin T; Kil, Won Ho WH; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-09-15

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 26009992
Variant Present in the following documents:
  • oncotarget-06-24499-s002.xlsx, sheet 1
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High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer.

Plos One
Kim, Seokhwi S; Lee, Jeeyun J; Hong, Min Eui ME; Do, In-Gu IG; Kang, So Young SY; Ha, Sang Yun SY; Kim, Seung Tae ST; Park, Se Hoon SH; Kang, Won Ki WK; Choi, Min-Gew MG; Lee, Jun Ho JH; Sohn, Tae Sung TS; Bae, Jae Moon JM; Kim, Sung S; Kim, Duk-Hwan DH; Kim, Kyoung-Mee KM
Publication Date: 2014

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 25372287
Variant Present in the following documents:
  • pone.0111693.s003.xls, sheet 1
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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: EGFR: D761N
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
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Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

The Journal Of Molecular Diagnostics : Jmd
MacConaill, Laura E LE; Garcia, Elizabeth E; Shivdasani, Priyanka P; Ducar, Matthew M; Adusumilli, Ravali R; Breneiser, Marc M; Byrne, Mark M; Chung, Lawrence L; Conneely, Jodie J; Crosby, Lauren L; Garraway, Levi A LA; Gong, Xin X; Hahn, William C WC; Hatton, Charlie C; Kantoff, Philip W PW; Kluk, Michael M; Kuo, Frank F; Jia, Yonghui Y; Joshi, Ruchi R; Longtine, Janina J; Manning, Allison A; Palescandolo, Emanuele E; Sharaf, Nematullah N; Sholl, Lynette L; van Hummelen, Paul P; Wade, Jacqueline J; Wollinson, Bruce M BM; Zepf, Dimity D; Rollins, Barrett J BJ; Lindeman, Neal I NI
Publication Date: 2014-11

Variant appearance in text: EGFR: D761N
PubMed Link: 25157968
Variant Present in the following documents:
  • Main text
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Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

The Journal Of Investigative Dermatology
Siroy, Alan E AE; Boland, Genevieve M GM; Milton, Denái R DR; Roszik, Jason J; Frankian, Silva S; Malke, Jared J; Haydu, Lauren L; Prieto, Victor G VG; Tetzlaff, Michael M; Ivan, Doina D; Wang, Wei-Lien WL; Torres-Cabala, Carlos C; Curry, Jonathan J; Roy-Chowdhuri, Sinchita S; Broaddus, Russell R; Rashid, Asif A; Stewart, John J; Gershenwald, Jeffrey E JE; Amaria, Rodabe N RN; Patel, Sapna P SP; Papadopoulos, Nicholas E NE; Bedikian, Agop A; Hwu, Wen-Jen WJ; Hwu, Patrick P; Diab, Adi A; Woodman, Scott E SE; Aldape, Kenneth D KD; Luthra, Rajyalakshmi R; Patel, Keyur P KP; Shaw, Kenna R KR; Mills, Gordon B GB; Mendelsohn, John J; Meric-Bernstam, Funda F; Kim, Kevin B KB; Routbort, Mark J MJ; Lazar, Alexander J AJ; Davies, Michael A MA
Publication Date: 2015-02

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 25148578
Variant Present in the following documents:
  • NIHMS622327-supplement-supplement_1.pdf
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Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population.

Oncotarget
Wheler, Jennifer J; Falchook, Gerald G; Tsimberidou, Apostolia M AM; Hong, David D; Naing, Aung A; Piha-Paul, Sarina S; Chen, Su S SS; Heymach, John J; Fu, Siqing S; Stephen, Bettzy B; Fok, Jansina Y JY; Janku, Filip F; Kurzrock, Razelle R
Publication Date: 2013-05

Variant appearance in text: EGFR: D761N
PubMed Link: 23800712
Variant Present in the following documents:
  • Main text
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Increased detection rates of EGFR and KRAS mutations in NSCLC specimens with low tumour cell content by 454 deep sequencing.

Virchows Archiv : An International Journal Of Pathology
Moskalev, Evgeny A EA; Stöhr, Robert R; Rieker, Ralf R; Hebele, Simone S; Fuchs, Florian F; Sirbu, Horia H; Mastitsky, Sergey E SE; Boltze, Carsten C; König, Helmut H; Agaimy, Abbas A; Hartmann, Arndt A; Haller, Florian F
Publication Date: 2013-04

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 23468066
Variant Present in the following documents:
  • Main text
  • 428_2013_Article_1376.pdf
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature
Barretina, Jordi J; Caponigro, Giordano G; Stransky, Nicolas N; Venkatesan, Kavitha K; Margolin, Adam A AA; Kim, Sungjoon S; Wilson, Christopher J CJ; Lehár, Joseph J; Kryukov, Gregory V GV; Sonkin, Dmitriy D; Reddy, Anupama A; Liu, Manway M; Murray, Lauren L; Berger, Michael F MF; Monahan, John E JE; Morais, Paula P; Meltzer, Jodi J; Korejwa, Adam A; Jané-Valbuena, Judit J; Mapa, Felipa A FA; Thibault, Joseph J; Bric-Furlong, Eva E; Raman, Pichai P; Shipway, Aaron A; Engels, Ingo H IH; Cheng, Jill J; Yu, Guoying K GK; Yu, Jianjun J; Aspesi, Peter P; de Silva, Melanie M; Jagtap, Kalpana K; Jones, Michael D MD; Wang, Li L; Hatton, Charles C; Palescandolo, Emanuele E; Gupta, Supriya S; Mahan, Scott S; Sougnez, Carrie C; Onofrio, Robert C RC; Liefeld, Ted T; MacConaill, Laura L; Winckler, Wendy W; Reich, Michael M; Li, Nanxin N; Mesirov, Jill P JP; Gabriel, Stacey B SB; Getz, Gad G; Ardlie, Kristin K; Chan, Vivien V; Myer, Vic E VE; Weber, Barbara L BL; Porter, Jeff J; Warmuth, Markus M; Finan, Peter P; Harris, Jennifer L JL; Meyerson, Matthew M; Golub, Todd R TR; Morrissey, Michael P MP; Sellers, William R WR; Schlegel, Robert R; Garraway, Levi A LA
Publication Date: 2012-03-28

Variant appearance in text: EGFR: 2281G>A; D761N
PubMed Link: 22460905
Variant Present in the following documents:
  • NIHMS361223-supplement-4.xlsx, sheet 3
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The energy landscape analysis of cancer mutations in protein kinases.

Plos One
Dixit, Anshuman A; Verkhivker, Gennady M GM
Publication Date: 2011

Variant appearance in text: EGFR: D761N
PubMed Link: 21998754
Variant Present in the following documents:
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Good Clinical Response to Erlotinib in a Non-Small Cell Lung Cancer Patient Harboring Multiple Brain Metastases and a Double Active Somatic Epidermal Growth Factor Gene Mutation.

Case Reports In Oncology
Masago, Katsuhiro K; Togashi, Yosuke Y; Fukudo, Masahide M; Terada, Tomohiro T; Irisa, Kaoru K; Sakamori, Yuichi Y; Fujita, Shiro S; Kim, Young Hak YH; Mio, Tadashi T; Inui, Ken-Ichi KI; Mishima, Michiaki M
Publication Date: 2010-04-22

Variant appearance in text: EGFR: D761N
PubMed Link: 20740181
Variant Present in the following documents:
  • Main text
  • cro0003-0098.pdf
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Profiling critical cancer gene mutations in clinical tumor samples.

Plos One
MacConaill, Laura E LE; Campbell, Catarina D CD; Kehoe, Sarah M SM; Bass, Adam J AJ; Hatton, Charles C; Niu, Lili L; Davis, Matt M; Yao, Keluo K; Hanna, Megan M; Mondal, Chandrani C; Luongo, Lauren L; Emery, Caroline M CM; Baker, Alissa C AC; Philips, Juliet J; Goff, Deborah J DJ; Fiorentino, Michelangelo M; Rubin, Mark A MA; Polyak, Kornelia K; Chan, Jennifer J; Wang, Yuexiang Y; Fletcher, Jonathan A JA; Santagata, Sandro S; Corso, Gianni G; Roviello, Franco F; Shivdasani, Ramesh R; Kieran, Mark W MW; Ligon, Keith L KL; Stiles, Charles D CD; Hahn, William C WC; Meyerson, Matthew L ML; Garraway, Levi A LA
Publication Date: 2009-11-18

Variant appearance in text: EGFR: D761N
PubMed Link: 19924296
Variant Present in the following documents:
  • pone.0007887.s002.xls, sheet 1
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Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors.

British Journal Of Cancer
Weber, F F; Fukino, K K; Sawada, T T; Williams, N N; Sweet, K K; Brena, R M RM; Plass, C C; Caldes, T T; Mutter, G L GL; Villalona-Calero, M A MA; Eng, C C
Publication Date: 2005-05-23

Variant appearance in text: EGFR: D761N
PubMed Link: 15841079
Variant Present in the following documents:
  • Main text
  • 92-6602557a.pdf
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