Publications:

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Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?

Biochemical Society Transactions

Shevchenko, Ekaterina E; Pantsar, Tatu T

Publication Date: 2022-02-28

Variant appearance in text: EGFR: M766T

PubMed Link: 35226061

Variant Present in the following documents:

• Main text
• BST-50-633.pdf

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Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ruan, Zheng Z; Kannan, Natarajan N

Publication Date: 2018-08-28

Variant appearance in text: EGFR: M766T

PubMed Link: 30104348

Variant Present in the following documents:

• Main text

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: EGFR: M766T

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 2

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Mechanisms of resistance to irreversible epidermal growth factor receptor tyrosine kinase inhibitors and therapeutic strategies in non-small cell lung cancer.

Oncotarget

Xu, Jing J; Wang, Jinghui J; Zhang, Shucai S

Publication Date: 2017-10-27

Variant appearance in text: EGFR: M766T

PubMed Link: 29163853

Variant Present in the following documents:

• Main text
• oncotarget-08-90557.pdf

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Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.

Scientific Reports

Kannan, Srinivasaraghavan S; Pradhan, Mohan R MR; Tiwari, Garima G; Tan, Wei-Chong WC; Chowbay, Balram B; Tan, Eng Huat EH; Tan, Daniel Shao-Weng DS; Verma, Chandra C

Publication Date: 2017-05-08

Variant appearance in text: EGFR: M766T

PubMed Link: 28484248

Variant Present in the following documents:

• Main text
• 41598_2017_Article_1491.pdf

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Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Biochemistry

Ruan, Zheng Z; Katiyar, Samiksha S; Kannan, Natarajan N

Publication Date: 2017-01-10

Variant appearance in text: EGFR: M766T

PubMed Link: 27936599

Variant Present in the following documents:

• Main text

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Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell

Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R

Publication Date: 2015-09-24

Variant appearance in text: EGFR: M766T

PubMed Link: 26388441

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships.

Bmc Genomics

Goyal, Sukriti S; Jamal, Salma S; Shanker, Asheesh A; Grover, Abhinav A

Publication Date: 2015

Variant appearance in text: EGFR: M766T

PubMed Link: 26041145

Variant Present in the following documents:

• Main text
• 1471-2164-16-S5-S8.pdf

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: EGFR: M766T

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 2

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