Variant ID: 7-55249005-G-T

NM_005228.3(EGFR):c.2303G>T;(p.Ser768Ile)

This variant was identified in 526 publications




Publications:


Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: EGFR: S768I
PMID: 32729257
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Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology
HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32714871
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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
W Jin
Publication Date: 2020-07-16

Variant appearance in text: EGFR: S768I
PMID: 32708604
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Lymphocyte percentage and platelet count correlate with the treatment outcome to tyrosine kinase inhibitors in epidermal growth factor receptor-mutated lung adenocarcinoma.

Medicine
CC Li, CB Lin, SC Chu, WH Huang, JJ Lee, GG Yang, TF Wang, YF Wu
Publication Date: 2020-07-17

Variant appearance in text: EGFR: S768I
PMID: 32702917
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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy
HT Chan, YM Chin, SK Low
Publication Date: 2019-06

Variant appearance in text: EGFR: S768I
PMID: 32700193
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Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

Oncology And Therapy
M Sesé, R Somoza, I Maestu, MM Ureste, A Sanchez, JF Cordoba, I Sansano, G Venturas, S Ramón Y Cajal, J Hernández-Losa
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 32699985
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A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients.

World Journal Of Surgical Oncology
X Zhang, Y Jiang, H Yu, H Xia, X Wang
Publication Date: 2020-07-16

Variant appearance in text: EGFR: S768I
PMID: 32677962
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ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib.

Translational Lung Cancer Research
A Romero, R Serna-Blasco, C Alfaro, E Sánchez-Herrero, M Barquín, MC Turpin, S Chico, S Sanz-Moreno, A Rodrigez-Festa, R Laza-Briviesca, A Cruz-Bermudez, V Calvo, A Royuela, M Provencio
Publication Date: 2020-06

Variant appearance in text: EGFR: S768I
PMID: 32676317
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Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand.

Bmc Cancer
PS Aye, S Tin Tin, MJ McKeage, P Khwaounjoo, A Cavadino, JM Elwood
Publication Date: 2020-07-14

Variant appearance in text: EGFR: S768I
PMID: 32664868
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Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors.

Journal Of Thoracic Disease
JA Chen, JW Riess
Publication Date: 2020-05

Variant appearance in text: EGFR: S768I
PMID: 32642199
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Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.

Practical Laboratory Medicine
EB Bernhardt, MD Chamberlin, IP Gorlov, FB de Abreu, KJ Bloch, JD Peterson, GJ Tsongalis, K Shirai, KH Dragnev, TW Miller, LJ Tafe
Publication Date: 2020-08

Variant appearance in text: EGFR: S768I
PMID: 32613070
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Liquid biopsy mutation panel for non-small cell lung cancer: analytical validation and clinical concordance.

Npj Precision Oncology
LS Schwartzberg, H Horinouchi, D Chan, S Chernilo, ML Tsai, D Isla, C Escriu, JP Bennett, K Clark-Langone, C Svedman, P Tomasini,
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32596507
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Assessment of Nine Driver Gene Mutations in Surgically Resected Samples from Patients with Non-Small-Cell Lung Cancer.

Cancer Management And Research
S Wang, X Qu, L Cao, X Hu, K Hou, Y Liu, X Che
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32581578
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Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings.

Journal Of Oncology Pharmacy Practice : Official Publication Of The International Society Of Oncology Pharmacy Practitioners
RD Harvey, VR Adams, T Beardslee, P Medina
Publication Date: 2020-06-20

Variant appearance in text: EGFR: S768I
PMID: 32567494
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Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment.

Cancers
J Li, HF Kwok
Publication Date: 2020-06-15

Variant appearance in text: EGFR: S768I
PMID: 32549388
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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies.

Journal Of Clinical Medicine
S Rajurkar, I Mambetsariev, R Pharaon, B Leach, T Tan, P Kulkarni, R Salgia
Publication Date: 2020-06-15

Variant appearance in text: EGFR: S768I
PMID: 32549358
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Successful afatinib rechallenge in a patient with non-small cell lung cancer harboring EGFR G719C and S768I mutations.

Thoracic Cancer
T Masuda, N Sunaga, N Kasahara, K Takehara, M Yatomi, K Hara, Y Koga, T Maeno, T Hisada
Publication Date: 2020-06-11

Variant appearance in text: EGFR: S768I
PMID: 32529804
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Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.

Ebiomedicine
M de Wit, Y Gao, D Mercieca, I de Heer, B Valkenburg, ME van Royen, J Aerts, P Sillevis Smitt, P French
Publication Date: 2020-06-04

Variant appearance in text: EGFR: S768I
PMID: 32512509
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EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports
G Calibasi-Kocal, A Amirfallah, T Sever, O Umit Unal, D Gurel, I Oztop, H Ellidokuz, Y Basbinar
Publication Date: 2020-08

Variant appearance in text: EGFR: Ser768Ile
PMID: 32509305
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Successful treatment of a patient with NSCLC carrying uncommon compound EGFR G719X and S768I mutations using osimertinib: A case report.

The Journal Of International Medical Research
Y Cai, Y Wang, J Sun, X Wang, Y Xu, C Sun, Y Guo, M Sun, K Ma
Publication Date: 2020-06

Variant appearance in text: EGFR: S768I
PMID: 32493093
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Canadian consensus: a new systemic treatment algorithm for advanced EGFR-mutated non-small-cell lung cancer.

Current Oncology (Toronto, Ont.)
B Melosky, S Banerji, N Blais, Q Chu, R Juergens, NB Leighl, G Liu, P Cheema
Publication Date: 2020-04

Variant appearance in text: EGFR: S768I
PMID: 32489263
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Current status and future perspectives of liquid biopsy in non-small cell lung cancer.

Journal Of Pathology And Translational Medicine
S Chang, JY Hur, YL Choi, CH Lee, WS Kim
Publication Date: 2020-05

Variant appearance in text: EGFR: S768I
PMID: 32460474
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Emerging therapeutic agents for advanced non-small cell lung cancer.

Journal Of Hematology & Oncology
R Chen, R Manochakian, L James, AG Azzouqa, H Shi, Y Zhang, Y Zhao, K Zhou, Y Lou
Publication Date: 2020-05-24

Variant appearance in text: EGFR: Ser768Ile
PMID: 32448366
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Analysis of lung biopsies using the 2015 WHO criteria and detection of sensitizing mutations--a single-institution experience of 5032 cases.

Diagnostic Pathology
Y Zeng, Y Zhu, Y Ding, L Xu, B Zhai, X Zhang, Q Ge, J Li, Q Song, X Li, Z Zhang
Publication Date: 2020-05-19

Variant appearance in text: EGFR: S768I
PMID: 32429938
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EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib.

Translational Lung Cancer Research
A Buder, MJ Hochmair, U Setinek, R Pirker, M Filipits
Publication Date: 2020-04

Variant appearance in text: EGFR: S768I
PMID: 32420063
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Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

Oncology Letters
T Yamaura, S Muto, H Mine, H Takagi, M Watanabe, Y Ozaki, T Inoue, M Fukuhara, N Okabe, Y Matsumura, T Hasegawa, J Osugi, M Hoshino, M Higuchi, Y Shio, H Suzuki
Publication Date: 2020-06

Variant appearance in text: EGFR: S768I
PMID: 32391110
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Targeted RNA sequencing with touch imprint cytology samples for non-small cell lung cancer patients.

Thoracic Cancer
K Seto, K Masago, S Fujita, M Haneda, Y Horio, T Hida, H Kuroda, W Hosoda, KI Okubo
Publication Date: 2020-05-05

Variant appearance in text: EGFR: Ser768Ile
PMID: 32372482
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The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review.

Cancers
F van Delft, H Koffijberg, V Retèl, MVD Heuvel, M IJzerman
Publication Date: 2020-04-30

Variant appearance in text: EGFR: S768I
PMID: 32365836
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara
Publication Date: 2020-05-04

Variant appearance in text: EGFR: S768I
PMID: 32365229
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Long-term Survival With Afatinib in a Patient With Lung Adenocarcinoma Harboring Double Uncommon EGFR L861Q and G719X Mutations.

In Vivo (Athens, Greece)
G Ohara, S Okauchi, Y Sasatani, T Shiozawa, H Yamada, K Miyazaki, H Satoh
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32354946
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Comparison of the characteristics of uncommon epidermal growth factor receptor (EGFR) mutations and EGFR-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer from different ethnic groups.

Experimental And Therapeutic Medicine
Q Zhang, Y Cui, J Zhang, J Kenjiabieke, P Aerxiding
Publication Date: 2020-06

Variant appearance in text: EGFR: S768I
PMID: 32346412
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[Analysis of Clinical Characteristics and Driver Genes in 405 Patients with Lung Cancer Complicated with Tuberculosis].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Y Hu, X Yang, L Nie, D Zhao, J An, B Li
Publication Date: 2020-04-27

Variant appearance in text: EGFR: S768I
PMID: 32336065
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Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France).

Cancers
S Lassalle, V Hofman, S Heeke, J Benzaquen, E Long, M Poudenx, E Lantéri, J Boutros, V Tanga, K Zahaf, S Lalvée, V Lespinet, O Bordone, JM Félix, C Bonnetaud, C Marquette, M Ilie, P Hofman
Publication Date: 2020-04-13

Variant appearance in text: EGFR: S768I
PMID: 32294880
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Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

Journal Of Thoracic Disease
H Li, J Wang, G Zhang, Y Li, L Lin, H Yang, J Zhou, L Zhang, D Lv
Publication Date: 2020-03

Variant appearance in text: EGFR: S768I
PMID: 32274120
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Complete Remission of Multiple Brain Metastases in a Patient with EGFR-Mutated Non-Small-Cell Lung Cancer Treated with First-Line Osimertinib without Radiotherapy.

Case Reports In Oncological Medicine
K Ameku, M Higa
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32257480
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Evaluation of Two EGFR Mutation Tests on Tumor and Plasma from Patients with Non-Small Cell Lung Cancer.

Cancers
JO Kim, JY Shin, SR Kim, KS Shin, J Kim, MY Kim, MR Lee, Y Kim, M Kim, SH Hong, JH Kang
Publication Date: 2020-03-26

Variant appearance in text: EGFR: S768I
PMID: 32224854
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Concordance of Treatment Recommendations for Metastatic Non-Small-Cell Lung Cancer Between Watson for Oncology System and Medical Team.

Cancer Management And Research
HS You, CX Gao, HB Wang, SS Luo, SY Chen, YL Dong, J Lyu, T Tian
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32214852
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Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer.

Translational Lung Cancer Research
C Zhu, W Zhuang, L Chen, W Yang, WB Ou
Publication Date: 2020-02

Variant appearance in text: EGFR: S768I
PMID: 32206559
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Clinicopathological parameters for circulating tumor DNA shedding in surgically resected non-small cell lung cancer with EGFR or KRAS mutation.

Plos One
MS Cho, CH Park, S Lee, HS Park
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32196518
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Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations.

Frontiers In Oncology
C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li, R Liu, L Xiang, C Huang, R Jiang
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32195178
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Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge.

Practical Laboratory Medicine
MR Al-Turkmani, MA Suriawinata, SJ Deharvengt, DC Green, CC Black, K Shirai, KH Dragnev, GJ Tsongalis
Publication Date: 2020-05

Variant appearance in text: EGFR: S768I
PMID: 32181314
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Evaluation of epidermal growth factor receptor mutations and thyroid transcription factor-1 status in Turkish non-small cell lung carcinoma patients: A study of 600 cases from a single center.

Turk Gogus Kalp Damar Cerrahisi Dergisi
M Musayeva, SD Sak, H Özakıncı, Ş Boyacıgil, Ö Coşkun
Publication Date: 2020-01

Variant appearance in text: EGFR: S768I
PMID: 32175155
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The Correlation between EGFR Mutation Status and DNA Content of Lung Adenocarcinoma Cells in Pleural Effusion.

Journal Of Cancer
Y Du, X Guo, R Wang, Y Ma, Y Zhang, Y Liu, L Dong, J Wu, X Ji, H Wang
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32127953
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A novel loop‑mediated isothermal amplification method for efficient and robust detection of EGFR mutations.

International Journal Of Oncology
S Horiuchi, Y Saito, A Matsui, N Takahashi, T Ikeya, E Hoshi, Y Shimizu, M Yasuda
Publication Date: 2020-01-14

Variant appearance in text: EGFR: S768I
PMID: 32124949
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The associations among quantitative spectral CT parameters, Ki-67 expression levels and EGFR mutation status in NSCLC.

Scientific Reports
L Lin, J Cheng, D Tang, Y Zhang, F Zhang, J Xu, H Jiang, H Wu
Publication Date: 2020-02-26

Variant appearance in text: EGFR: S768I
PMID: 32103127
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[Research Progress in Consistency of Driver Gene Status between Primary and Corresponding Metastatic Lesions in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
B Zhou, J Xiong
Publication Date: 2020-02-27

Variant appearance in text: EGFR: S768i
PMID: 32102137
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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports
Y Hirotsu, S Otake, H Ohyama, K Amemiya, R Higuchi, T Oyama, H Mochizuki, T Goto, M Omata
Publication Date: 2020-02-25

Variant appearance in text: EGFR: S768I
PMID: 32099048
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The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma.

Biomedicines
PC Hsu, CW Wang, SC Kuo, SM Lin, YL Lo, AC Huang, LC Chiu, CT Yang
Publication Date: 2020-02-19

Variant appearance in text: EGFR: S768I
PMID: 32092879
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The importance of programmed death ligand 1 gene expression, epidermal growth factor receptor gene mutations and serum epidermal growth factor receptor levels in Turkish non-small cell lung cancer patients.

Turk Gogus Kalp Damar Cerrahisi Dergisi
A Turna, C Horozoğlu, Ö Koç Erbaşoğlu, Ş Ercan, Ö Küçükhüseyin, S Turan, MT Hakan, HV Kara, E Hekimoğlu, Ü Zeybek, E Coşkunpınar, C Cacına, A Ergen, İ Yaylım
Publication Date: 2018-07

Variant appearance in text: EGFR: 2303G>T
PMID: 32082777
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Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
H Liu, B Zhang, Z Sun
Publication Date: 2020-02-18

Variant appearance in text: EGFR: S768I
PMID: 32067422
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: EGFR: S768I
PMID: 32054005
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Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

Plos One
HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi, S Park, YJ Ryu, JH Lee, JH Chang
Publication Date: 2020

Variant appearance in text: EGFR: S768I
PMID: 32053675
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Comparison of next-generation sequencing and immunohistochemistry analysis for targeted therapy-related genomic status in lung cancer patients.

Journal Of Thoracic Disease
L Nong, Z Zhang, Y Xiong, Y Zheng, X Li, D Li, Q He, T Li
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 32030215
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Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study.

Bmc Cancer
M Kogo, D Fujimoto, K Hosoya, K Nagata, A Nakagawa, R Tachikawa, D Yamashita, Y Kitamura, Y Imai, K Tomii
Publication Date: 2020-02-06

Variant appearance in text: EGFR: S768I
PMID: 32028905
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Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers.

Translational Lung Cancer Research
J Ni, T Guo, Y Li, X Yang, Y Li, L Zou, L Chu, X Chu, S Li, L Ye, Y Zhang, Z Zhu
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 32010575
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Circulating tumor cells in lung cancer are prognostic and predictive for worse tumor response in both targeted- and chemotherapy.

Translational Lung Cancer Research
M Tamminga, S de Wit, E Schuuring, W Timens, LWMM Terstappen, TJN Hiltermann, HJM Groen
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 32010564
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Genetic alteration profile of EGFR-mutant resected IIB-IIIA stage NSCLC and correlation to clinical outcomes.

Translational Lung Cancer Research
Q Deng, Y Qiu, J Jia, H Tang, L Liu, L Huang, D He, X Dong, H Yang
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 32010562
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Detection of plasma EGFR mutations for personalized treatment of lung cancer patients without pathologic diagnosis.

Cancer Medicine
Q Deng, Q Fang, H Sun, AP Singh, M Alexander, S Li, H Cheng, S Zhou
Publication Date: 2020-01-28

Variant appearance in text: EGFR: S768I
PMID: 31991049
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New data highlighting the efficacy and safety outcomes of third-generation EGFR-TKI in NSCLC patients with rare EGFR mutations.

Thoracic Cancer
W Zhang, F Li, W Gao
Publication Date: 2020-01-28

Variant appearance in text: EGFR: Ser768Ile
PMID: 31989783
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Accuracy and clinical influence of plasma EGFR mutation detection in management of advanced lung adenocarcinoma.

International Journal Of Clinical And Experimental Pathology
M Ma, C Shi, J Qian, B Han
Publication Date: 2017

Variant appearance in text: EGFR: S768I
PMID: 31966832
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Clinical and pathological findings of surgically resected patients for lung adenocarcinomas harboring uncommon EGFR mutations.

International Journal Of Clinical And Experimental Pathology
S Yang, Z Jiang, H Lu
Publication Date: 2017

Variant appearance in text: EGFR: S768I
PMID: 31966607
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Rapid detection of EGFR mutations in decalcified lung cancer bone metastasis.

Journal Of Bone Oncology
A Boureille, C Ferraro-Peyret, G Pontarollo, C Confavreux, JB Pialat, S Isaac, F Forest, V Yvorel, E Watkin, N Girard, M Brevet
Publication Date: 2020-04

Variant appearance in text: EGFR: S768I
PMID: 31956476
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Comparison of clinicopathologic characteristics between patients with EGFR exon 19 deletion and EGFR L858R mutation in lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Chen, J Zhang, K Huang, Q Shen, X Teng
Publication Date: 2018

Variant appearance in text: EGFR: S768I
PMID: 31949864
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Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Zhang, S Zhou
Publication Date: 2018

Variant appearance in text: EGFR: S768I
PMID: 31949733
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Results of Liquid Biopsy Studies by Next Generation Sequencing in Patients with Advanced Stage Non-small Cell Lung Cancer: Single Center Experience from Turkey.

Balkan Journal Of Medical Genetics : Bjmg
M Buyuksimsek, M Togun, KI Oguz, A Bisgin, I Boga, M Tohumcuoglu, A Ogul, YA Evren, B Sahin, SH Erdem, C Mirili
Publication Date: 2019-12

Variant appearance in text: EGFR: S768I
PMID: 31942412
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Impact of age on EGFR mutations in never-smoking female lung adenocarcinoma patients with malignant pleural effusion.

International Journal Of Clinical And Experimental Pathology
Q Wu, M Chu, J Hu, Z Zhang, W Yi, X Ma
Publication Date: 2018

Variant appearance in text: EGFR: S768I
PMID: 31938400
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High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.

International Journal Of Clinical And Experimental Pathology
F Su, Y Fu, Q Wu, K Zheng, Y Tang, X Su, Y Wang, L Jiang
Publication Date: 2018

Variant appearance in text: EGFR: S768I
PMID: 31938383
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Identification of EGFR mutations in cytological specimens of non-small cell lung carcinoma from a single institute.

International Journal Of Clinical And Experimental Pathology
W Wang, Y Tang, J Li, Y Zhang, Y Zou, X Su
Publication Date: 2018

Variant appearance in text: EGFR: S768I
PMID: 31938186
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Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy.

Theranostics
L von Baumgarten, J Kumbrink, A Jung, A Reischer, M Flach, S Liebmann, KH Metzeler, JW Holch, M Niyazi, N Thon, A Straube, M von Bergwelt-Baildon, V Heinemann, T Kirchner, CB Westphalen
Publication Date: 2020

Variant appearance in text: EGFR: 2303G>T; S768I
PMID: 31903155
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Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel.

Cancers
G Froyen, M Le Mercier, E Lierman, K Vandepoele, F Nollet, E Boone, J Van der Meulen, K Jacobs, S Lambin, S Vander Borght, E Van Valckenborgh, A Antoniou, A Hébrant
Publication Date: 2019-12-16

Variant appearance in text: EGFR: 2303G>T; Ser768Ile
PMID: 31888289
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Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.

Scientific Reports
SY Kim, JY Lee, DH Kim, H- Joo, MR Yun, D Jung, J Yun, SG Heo, B- Ahn, CW Park, KH Pyo, YJ Chun, MH Hong, HR Kim, BC Cho
Publication Date: 2019-12-27

Variant appearance in text: EGFR: S768I
PMID: 31882684
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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One
E Papadopoulou, N Tsoulos, K Tsantikidi, V Metaxa-Mariatou, PE Stamou, A Kladi-Skandali, E Kapeni, G Tsaousis, G Pentheroudakis, D Petrakis, DI Lampropoulou, G Aravantinos, I Varthalitis, G Kesisis, I Boukovinas, P Papakotoulas, N Katirtzoglou, E Athanasiadis, F Stavridi, C Christodoulou, A Koumarianou, Y Eralp, G Nasioulas
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31860648
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The potential mechanism of primary resistance to icotinib in EGFR uncommon mutant advanced non-small cell lung cancer: a multi-center study.

Cancer Science
L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song
Publication Date: 2019-12-11

Variant appearance in text: EGFR: S768I
PMID: 31828849
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Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
JH Cho, SH Lim, HJ An, KH Kim, KU Park, EJ Kang, YH Choi, MS Ahn, MH Lee, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
Publication Date: 2019-12-11

Variant appearance in text: EGFR: S768I
PMID: 31825714
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The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Molecules (Basel, Switzerland)
N Van Der Steen, K Zwaenepoel, G Mazzaschi, R A Luirink, D P Geerke, K Op de Beeck, C Hermans, M Tiseo, P Van Schil, F Lardon, P Germonpré, C Rolfo, E Giovannetti, G J Peters, P Pauwels
Publication Date: 2019-12-04

Variant appearance in text: EGFR: S768I
PMID: 31817278
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Detection of clinically relevant epidermal growth factor receptor pathway mutations in circulating cell-free tumor DNA using next generation sequencing in squamous cell carcinoma lung.

South Asian Journal Of Cancer
KB Govind, D Koppaka, L Dasappa, LA Jacob, SM C Babu, NK Lokesh, RA Haleshappa, LK Rajeev, SC Saldanha, A Abhishek, V Asati, R Chethan, VL Ramprasad
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31807490
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Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation.

Oncotargets And Therapy
S Zhou, H Wang, W Jiang, Q Yu
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31802898
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Population pharmacokinetics of afatinib and exposure-safety relationships in Japanese patients with EGFR mutation-positive non-small cell lung cancer.

Scientific Reports
K Nakao, S Kobuchi, S Marutani, A Iwazaki, A Tamiya, S Isa, K Okishio, M Kanazu, M Tamiya, T Hirashima, K Imai, T Sakaeda, S Atagi
Publication Date: 2019-12-03

Variant appearance in text: EGFR: S768I
PMID: 31796841
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Successful treatment of an elderly patient with an uncommon L861Q epidermal growth factor receptor mutation with low-dose afatinib: A case report.

Thoracic Cancer
Y Iida, F Kumasawa, T Shimizu, Y Shintani, N Takahashi, Y Gon
Publication Date: 2019-11-28

Variant appearance in text: EGFR: S768I
PMID: 31779047
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Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing.

Plos One
YJ Chun, JW Choi, MH Hong, D Jung, H Son, EK Cho, YJ Min, SW Kim, K Park, SS Lee, S Kim, HR Kim, BC Cho,
Publication Date: 2019

Variant appearance in text: EGFR: 2303G>T; Ser768Ile
PMID: 31765373
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Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer.

Frontiers In Genetics
H Meng, X Guo, D Sun, Y Liang, J Lang, Y Han, Q Lu, Y Zhang, Y An, G Tian, D Yuan, S Xu, J Geng
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31749831
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Current Approaches in NSCLC Targeting K-RAS and EGFR.

International Journal Of Molecular Sciences
V Aran, J Omerovic
Publication Date: 2019-11-14

Variant appearance in text: EGFR: Ser768Ile
PMID: 31739412
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Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine.

Frontiers In Medicine
J Pinsolle, A McLeer-Florin, M Giaj Levra, F de Fraipont, C Emprou, E Gobbini, AC Toffart
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31737634
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EGFR T790M detection rate in lung adenocarcinomas at baseline using droplet digital PCR and validation by ultra-deep next generation sequencing.

Translational Lung Cancer Research
L Lettig, N Sahnane, F Pepe, R Cerutti, C Albeni, F Franzi, G Veronesi, F Ogliari, A Pastore, A Tuzi, G Pinotti, A Bovio, C Verusio, M Giordano, G Troncone, F Sessa, U Malapelle, D Furlan
Publication Date: 2019-10

Variant appearance in text: EGFR: S768I
PMID: 31737495
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Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

Bmc Cancer
YI Cheng, YC Gan, D Liu, MPA Davies, WM Li, JK Field
Publication Date: 2019-11-08

Variant appearance in text: EGFR: S768I
PMID: 31703574
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Real-world efficacy and potential mechanism of resistance of icotinib in Asian advanced non-small cell lung cancer with EGFR uncommon mutations: A multi-center study.

Cancer Medicine
L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song
Publication Date: 2019-11-06

Variant appearance in text: EGFR: S768I
PMID: 31692291
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Great efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report.

Oncotargets And Therapy
N An, H Wang, H Zhu, W Yan, W Jing, L Kong, Y Zhang, J Yu
Publication Date: 2019

Variant appearance in text: EGFR: Ser768Ile
PMID: 31686847
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Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study.

Bmc Cancer
YH Chen, YF Chen, CY Chen, JY Shih, CJ Yu
Publication Date: 2019-10-26

Variant appearance in text: EGFR: S768I
PMID: 31655564
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Osimertinib as treatment for EGFR exon 20 insertion-positive lung adenocarcinoma.

Excli Journal
C Murano, A Igarashi, K Yamauchi, S Inoue, M Watanabe
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31645848
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Impact of clinical features on the efficacy of osimertinib treatment in epidermal growth factor receptor mutant non-small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors due to T790M mutation.

Journal Of Thoracic Disease
CK Liam, ME Poh, YS Liam
Publication Date: 2019-09

Variant appearance in text: EGFR: S768I
PMID: 31632766
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Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma.

Frontiers In Oncology
X Qu, Q Li, J Yang, H Zhao, F Wang, F Zhang, S Zhang, H Zhang, R Wang, Q Wang, Q Wang, G Li, X Peng, X Zhou, Y Hao, J Zhu, W Xiao
Publication Date: 2019

Variant appearance in text: EGFR: S768I
PMID: 31608233
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Tracking longitudinal genetic changes of circulating tumor DNA (ctDNA) in advanced Lung adenocarcinoma treated with chemotherapy.

Journal Of Translational Medicine
X Han, Y Han, Q Tan, Y Huang, J Yang, S Yang, X He, S Zhou, Y Song, J Pi, L Zuo, J Yao, D Wu, Z Zhang, Y Shi
Publication Date: 2019-10-10

Variant appearance in text: EGFR: S768I
PMID: 31597567
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Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer.

The Journal Of Pathology. Clinical Research
M Southwood, T Krenz, N Cant, M Maurya, J Gazdova, P Maxwell, C McGready, E Moseley, S Hughes, P Stewart, M Salto-Tellez, D Groelz, D Rassl,
Publication Date: 2019-09-30

Variant appearance in text: EGFR: 2303G>T; S768I
PMID: 31571426
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000275493.2 c.2303G>T p.Ser768Ile missense_variant 20/28 -
ENST00000442411.1 n.1244C>A - non_coding_transcript_exon_variant 2/2 -
ENST00000442591.1 c.*28+8384G>T - intron_variant - 17/17
ENST00000454757.2 c.2144G>T p.Ser715Ile missense_variant 20/28 -
ENST00000455089.1 c.2168G>T p.Ser723Ile missense_variant 19/26 -
NM_001346897.2 c.2168G>T p.Ser723Ile missense_variant 19/26 -
NM_001346898.2 c.2303G>T p.Ser768Ile missense_variant 20/27 -
NM_001346899.1 c.2168G>T p.Ser723Ile missense_variant 19/27 -
NM_001346900.2 c.2144G>T p.Ser715Ile missense_variant 20/28 -
NM_001346941.2 c.1502G>T p.Ser501Ile missense_variant 14/22 -
NM_005228.5 c.2303G>T p.Ser768Ile missense_variant 20/28 -
NR_047551.1 n.1259C>A - non_coding_transcript_exon_variant 2/2 -
- - TF_binding_site_variant - -
- - TF_binding_site_variant - -
- - TF_binding_site_variant - -
- - TF_binding_site_variant - -