Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Structure-based classification predicts drug response in EGFR-mutant NSCLC.
Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Durable response to immunotherapy plus chemotherapy in a patient with untreated, brain-metastatic, EGFR exon 20 insertion mutation lung adenocarcinoma: A case report.
Medicine
Nong, Jingying J; Gu, Yanfei Y; Yao, Shuyang S; Zhang, Yi Y
Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress.
Cancers
Napolitano, Virginia V; Russo, Daniela D; Morra, Francesco F; Merolla, Francesco F; Varricchio, Silvia S; Ilardi, Gennaro G; Di Crescenzo, Rosa Maria RM; Martino, Francesco F; Mascolo, Massimo M; Celetti, Angela A; Tamagnone, Luca L; Staibano, Stefania S
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.
Ebiomedicine
Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors.
Oncotarget
Silva-Oliveira, Renato José RJ; Melendez, Matias M; Martinho, Olga O; Zanon, Maicon F MF; de Souza Viana, Luciano L; Carvalho, André Lopes AL; Reis, Rui Manuel RM
Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.
Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma.
Yonsei Medical Journal
Kim, Hye Ryun HR; Ahn, Jung Ryun JR; Lee, Jin Gu JG; Bang, Doo Hee DH; Ha, Sang-Jun SJ; Hong, Yun Kyoung YK; Kim, Sun Mi SM; Nam, Ki Chang KC; Rha, Sun Young SY; Soo, Ross A RA; Riely, Gregory J GJ; Kim, Joo Hang JH; Cho, Byoung Chul BC
EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.
Molecular Cancer Therapeutics
Arcila, Maria E ME; Nafa, Khedoudja K; Chaft, Jamie E JE; Rekhtman, Natasha N; Lau, Christopher C; Reva, Boris A BA; Zakowski, Maureen F MF; Kris, Mark G MG; Ladanyi, Marc M
DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Yeh, Paul P; Chen, Heidi H; Andrews, Jenny J; Naser, Riyad R; Pao, William W; Horn, Leora L
Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy.
Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Wheler, J J JJ; Falchook, G S GS; Tsimberidou, A M AM; Hong, D S DS; Naing, A A; Piha-Paul, S A SA; Chen, S S SS; Fu, S S; Stephen, B B; Fok, J Y JY; Janku, F F; Kurzrock, R R