Variant ID: 7-55249071-C-T

NM_005228.3(EGFR):c.2369C>T;(p.Thr790Met)

This variant was identified in 4657 publications




Publications:


Predictors of Acquired T790M Mutation in Patients Failing First- or Second-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors.

Cancer Management And Research
CS Chai, CK Liam, ME Poh, DB Ong, YK Pang, PL Cheah, GF Ho, A Alip
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32753961
View BVdb publication page



Primary Resistance to Combination Therapy with First- and Third-Generation EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinoma Harboring EGFR 19Del/T790M/in Trans-C797S Mutations with Co-Occurring CTNNB1 Alteration.

Oncotargets And Therapy
J Chen, J Wang, X Wu
Publication Date: 2020

Variant appearance in text: EGFR: 2369C>T; T790M
PMID: 32753903
View BVdb publication page



Association of TP53 Mutations with Response to Anlotinib Treatment in Advanced Non-Small Cell Lung Cancer.

Oncotargets And Therapy
S Fang, W Cheng, M Zhang, R Yang
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32753898
View BVdb publication page



Non-Small-Cell Lung Cancer-Sensitive Detection of the p.Thr790Met EGFR Alteration by Preamplification before PNA-Mediated PCR Clamping and Pyrosequencing.

Diagnostics (Basel, Switzerland)
A Billaud, V Verriele, J Dauvé, LM Chevalier, A Morel
Publication Date: 2020-07-29

Variant appearance in text: EGFR: Thr790Met
PMID: 32751202
View BVdb publication page



Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells.

Marine Drugs
CH Liao, YT Tzeng, GM Lai, CL Chang, MH Hu, WL Tsai, YR Liu, S Hsia, SE Chuang, TJ Chiou, LM Wang, J Whang-Peng, CJ Yao
Publication Date: 2020-07-29

Variant appearance in text: EGFR: T790M
PMID: 32751169
View BVdb publication page



Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management.

Diagnostics (Basel, Switzerland)
J Wehrle, U Philipp, M Jolic, M Follo, S Hussung, S Waldeck, M Deuter, M Rassner, J Braune, J Rawluk, C Greil, CF Waller, H Becker, J Duque-Afonso, AL Illert, RM Fritsch, F Meiss, J Duyster, N von Bubnoff, F Scherer
Publication Date: 2020-08-02

Variant appearance in text: EGFR: T790M
PMID: 32748806
View BVdb publication page



Application of exosomes as liquid biopsy in clinical diagnosis.

Signal Transduction And Targeted Therapy
B Zhou, K Xu, X Zheng, T Chen, J Wang, Y Song, Y Shao, S Zheng
Publication Date: 2020-08-03

Variant appearance in text: EGFR: T790M
PMID: 32747657
View BVdb publication page



Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer.

Bmc Research Notes
VT Tran, TT Phan, ST Nguyen, BT Tran, TT Ho, SP Pho, TB Nguyen, TTB Pham, AT Le, VT Le, HT Nguyen
Publication Date: 2020-08-03

Variant appearance in text: EGFR: T790M
PMID: 32746896
View BVdb publication page



Effective inhibition of cancer cells by recombinant adenovirus expressing EGFR-targeting artificial microRNA and reversed-caspase-3.

Plos One
M Yan, J Chen, H Jiang, Y Xie, C Li, L Chen, B Yang, J Cao
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32745124
View BVdb publication page



Role of YES1 amplification in EGFR mutation-positive non-small cell lung cancer: Primary resistance to afatinib in a patient.

Thoracic Cancer
J Tao, D Sun, H Hou
Publication Date: 2020-08-03

Variant appearance in text: EGFR: T790M
PMID: 32744377
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng
Publication Date: 2020-08-01

Variant appearance in text: EGFR: T790M
PMID: 32738923
View BVdb publication page



Whole brain radiotherapy (WBRT) for leptomeningeal metastasis from NSCLC in the era of targeted therapy: a retrospective study.

Radiation Oncology (London, England)
J Zhen, L Wen, M Lai, Z Zhou, C Shan, S Li, T Lin, J Wu, W Wang, S Xu, D Liu, M Lu, D Zhu, L Chen, L Cai, C Zhou
Publication Date: 2020-07-31

Variant appearance in text: EGFR: T790M
PMID: 32736566
View BVdb publication page



Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: EGFR: T790M
PMID: 32729257
View BVdb publication page



Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report.

Journal Of Cardiothoracic Surgery
Y Yang, X Xie, G Jiang, H Liu
Publication Date: 2020-07-29

Variant appearance in text: EGFR: T790M
PMID: 32727606
View BVdb publication page



Next Generation Sequencing for Gene Fusion Analysis in Lung Cancer: A Literature Review.

Diagnostics (Basel, Switzerland)
R Bruno, G Fontanini
Publication Date: 2020-07-27

Variant appearance in text: EGFR: T790M
PMID: 32726941
View BVdb publication page



Anlotinib as a molecular targeted therapy for tumors.

Oncology Letters
Y Gao, P Liu, R Shi
Publication Date: 2020-08

Variant appearance in text: EGFR: T790M
PMID: 32724339
View BVdb publication page



EZH2: a novel target for cancer treatment.

Journal Of Hematology & Oncology
R Duan, W Du, W Guo
Publication Date: 2020-07-28

Variant appearance in text: EGFR: T790M
PMID: 32723346
View BVdb publication page



Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer.

Bmc Cancer
W Ouyang, J Yu, Y Zhou, J Hu, Z Huang, J Zhang, C Xie
Publication Date: 2020-07-28

Variant appearance in text: EGFR: T790M
PMID: 32723319
View BVdb publication page



Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials.

Technology In Cancer Research & Treatment
YT Qi, Y Hou, LC Qi
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32723164
View BVdb publication page



Ultra-Short Circulating Tumor DNA (usctDNA) in Plasma and Saliva of Non-Small Cell Lung Cancer (NSCLC) Patients.

Cancers
F Li, F Wei, WL Huang, CC Lin, L Li, MM Shen, Q Yan, W Liao, D Chia, M Tu, JH Tang, Z Feng, Y Kim, WC Su, DTW Wong
Publication Date: 2020-07-24

Variant appearance in text: EGFR: T790M
PMID: 32722209
View BVdb publication page



Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis.

Cancers
T Azad, R Rezaei, A Surendran, R Singaravelu, S Boulton, J Dave, JC Bell, CS Ilkow
Publication Date: 2020-07-24

Variant appearance in text: EGFR: T790M
PMID: 32722184
View BVdb publication page



Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology
HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32714871
View BVdb publication page



Efficacy and Safety of Epidermal Growth Factor Receptor (EGFR) Inhibitors Plus Antiangiogenic Agents as First-Line Treatments for Patients With Advanced EGFR-Mutated Non-small Cell Lung Cancer: A Meta-Analysis.

Frontiers In Oncology
F Chen, N Chen, Y Yu, J Cui
Publication Date: 2020

Variant appearance in text: EGFR: T790M
PMID: 32714857
View BVdb publication page



Small-cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report.

Molecular And Clinical Oncology
R Otoshi, A Sekine, K Okudela, M Asaoka, Y Sato, S Ikeda, T Baba, S Komatsu, E Hagiwara, T Ogura
Publication Date: 2020-08

Variant appearance in text: EGFR: T790M
PMID: 32714535
View BVdb publication page



Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing.

Bmc Cancer
Y Zhao, JY He, JZ Cui, ZQ Meng, YL Zou, XS Guo, X Chen, X Wang, LT Yan, WX Han, C Li, L Guo, H Bu
Publication Date: 2020-07-25

Variant appearance in text: EGFR: T790M
PMID: 32711494
View BVdb publication page



Metabolic Reprogramming of Chemoresistant Cancer Cells and the Potential Significance of Metabolic Regulation in the Reversal of Cancer Chemoresistance.

Metabolites
X Chen, S Chen, D Yu
Publication Date: 2020-07-16

Variant appearance in text: EGFR: T790M
PMID: 32708822
View BVdb publication page



ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
W Jin
Publication Date: 2020-07-16

Variant appearance in text: EGFR: T790M
PMID: 32708604
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000275493.2 c.2369C>T p.Thr790Met missense_variant 20/28 -
ENST00000442411.1 n.1178G>A - non_coding_transcript_exon_variant 2/2 -
ENST00000442591.1 c.*28+8450C>T - intron_variant - 17/17
ENST00000454757.2 c.2210C>T p.Thr737Met missense_variant 20/28 -
ENST00000455089.1 c.2234C>T p.Thr745Met missense_variant 19/26 -
NM_001346897.2 c.2234C>T p.Thr745Met missense_variant 19/26 -
NM_001346898.2 c.2369C>T p.Thr790Met missense_variant 20/27 -
NM_001346899.1 c.2234C>T p.Thr745Met missense_variant 19/27 -
NM_001346900.2 c.2210C>T p.Thr737Met missense_variant 20/28 -
NM_001346941.2 c.1568C>T p.Thr523Met missense_variant 14/22 -
NM_005228.5 c.2369C>T p.Thr790Met missense_variant 20/28 -
NR_047551.1 n.1193G>A - non_coding_transcript_exon_variant 2/2 -