Publications:

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Current therapy and development of therapeutic agents for lung cancer.

Cell Insight

Wang, Zilai Z; Kim, Jiyeon J; Zhang, Pin P; Galvan Achi, Jazmin M JM; Jiang, Yuwei Y; Rong, Lijun L

Publication Date: 2022-04

Variant appearance in text: EGFR: L798I

PubMed Link: 37193130

Variant Present in the following documents:

• Main text
• main.pdf

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Nanotechnology - a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer.

Beilstein Journal Of Nanotechnology

Gorachinov, Filip F; Mraiche, Fatima F; Moustafa, Diala Alhaj DA; Hishari, Ola O; Ismail, Yomna Y; Joseph, Jensa J; Crcarevska, Maja Simonoska MS; Dodov, Marija Glavas MG; Geskovski, Nikola N; Goracinova, Katerina K

Publication Date: 2023

Variant appearance in text: EGFR: L798I

PubMed Link: 36865093

Variant Present in the following documents:

• Beilstein_J_Nanotechnol-14-240.pdf

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Engaging innate immunity for targeting the epidermal growth factor receptor: Therapeutic options leveraging innate immunity versus adaptive immunity versus inhibition of signaling.

Frontiers In Oncology

Hintzen, Gabriele G; Dulat, Holger J HJ; Rajkovic, Erich E

Publication Date: 2022

Variant appearance in text: EGFR: L798I

PubMed Link: 36185288

Variant Present in the following documents:

• Main text
• fonc-12-892212.pdf

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Making the Rounds: Exploring the Role of Circulating Tumor DNA (ctDNA) in Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Shields, Misty Dawn MD; Chen, Kevin K; Dutcher, Giselle G; Patel, Ishika I; Pellini, Bruna B

Publication Date: 2022-08-12

Variant appearance in text: EGFR: L798I

PubMed Link: 36012272

Variant Present in the following documents:

• Main text
• ijms-23-09006.pdf

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"Sandwich" Strategy to Intensify EGFR Blockade by Concurrent Tyrosine Kinase Inhibitor and Monoclonal Antibody Treatment in Highly Selected Patients.

Frontiers In Oncology

Zhang, Guoqing G; Yan, Beibei B; Guo, Yanan Y; Yang, Hang H; Li, Jindong J

Publication Date: 2022

Variant appearance in text: EGFR: L798I

PubMed Link: 35903676

Variant Present in the following documents:

• Main text
• fonc-12-952939.pdf

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: EGFR: L798I

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Leu798Ile

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

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Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancers.

Molecular Cancer

Kolesar, Jill J; Peh, Spencer S; Thomas, Levin L; Baburaj, Gayathri G; Mukherjee, Nayonika N; Kantamneni, Raveena R; Lewis, Shirley S; Pai, Ananth A; Udupa, Karthik S KS; Kumar An, Naveena N; Rangnekar, Vivek M VM; Rao, Mahadev M

Publication Date: 2022-02-24

Variant appearance in text: EGFR: L798I

PubMed Link: 35209919

Variant Present in the following documents:

• Main text
• 12943_2022_Article_1534.pdf

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Targeted Therapies in Cancer: To Be or Not to Be, Selective.

Biomedicines

Montoya, Skye S; Soong, Deborah D; Nguyen, Nina N; Affer, Maurizio M; Munamarty, Sailasya P SP; Taylor, Justin J

Publication Date: 2021-11-01

Variant appearance in text: EGFR: L798I

PubMed Link: 34829820

Variant Present in the following documents:

• Main text
• biomedicines-09-01591.pdf

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Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring.

Cancers

Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M

Publication Date: 2021-09-30

Variant appearance in text: EGFR: L798I

PubMed Link: 34638411

Variant Present in the following documents:

• Main text

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FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth.

Nature Communications

Niu, Mengmeng M; Xu, Jing J; Liu, Yang Y; Li, Yuhuang Y; He, Tao T; Ding, Liangping L; He, Yajun Y; Yi, Yong Y; Li, Fengtian F; Guo, Rongtian R; Gao, Ya Y; Li, Rui R; Li, Luping L; Fu, Mengyuan M; Hu, Qingyong Q; Luo, Yangkun Y; Zhang, Chunyan C; Qin, Kewei K; Yi, Jianqiao J; Yu, Shuhan S; Yang, Jian J; Chen, Hu H; Wang, Liang L; Li, Zhonghan Z; Dong, Biao B; Qi, Shiqian S; Ouyang, Liang L; Zhang, Yujun Y; Cao, Yang Y; Xiao, Zhi-Xiong Jim ZJ

Publication Date: 2021-10-11

Variant appearance in text: EGFR: L798I

PubMed Link: 34635651

Variant Present in the following documents:

• Main text

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Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective.

Pharmaceutics

Zhu, Jing J; Yang, Qian Q; Xu, Weiguo W

Publication Date: 2021-09-18

Variant appearance in text: EGFR: L798I

PubMed Link: 34575576

Variant Present in the following documents:

• Main text

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Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review).

International Journal Of Oncology

He, Jingyi J; Huang, Zhengrong Z; Han, Linzhi L; Gong, Yan Y; Xie, Conghua C

Publication Date: 2021-11

Variant appearance in text: EGFR: L798I

PubMed Link: 34558640

Variant Present in the following documents:

• Main text
• ijo-59-05-05270.pdf

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (Cambridge (Mass.))

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: L798I

PubMed Link: 34557754

Variant Present in the following documents:

• Main text

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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (New York, N.Y.)

Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J

Publication Date: 2021-05-28

Variant appearance in text: EGFR: L798I

PubMed Link: 34557754

Variant Present in the following documents:

• Main text

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Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer.

Molecular Cancer

Wu, Shaocong S; Luo, Min M; To, Kenneth K W KKW; Zhang, Jianye J; Su, Chaoyue C; Zhang, Hong H; An, Sainan S; Wang, Fang F; Chen, Da D; Fu, Liwu L

Publication Date: 2021-01-18

Variant appearance in text: EGFR: L798I

PubMed Link: 33461557

Variant Present in the following documents:

• Main text
• 12943_2021_Article_1307.pdf

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Development of EGFR TKIs and Options to Manage Resistance of Third-Generation EGFR TKI Osimertinib: Conventional Ways and Immune Checkpoint Inhibitors.

Frontiers In Oncology

Wu, Leilei L; Ke, Linping L; Zhang, Zhenshan Z; Yu, Jinming J; Meng, Xue X

Publication Date: 2020

Variant appearance in text: EGFR: L798I

PubMed Link: 33392095

Variant Present in the following documents:

• Main text
• fonc-10-602762.pdf

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The Role of the Liquid Biopsy in Decision-Making for Patients with Non-Small Cell Lung Cancer.

Journal Of Clinical Medicine

Akhoundova, D D; Mosquera Martinez, J J; Musmann, L E LE; Britschgi, C C; Rütsche, C C; Rechsteiner, M M; Nadal, E E; Garcia Campelo, M R MR; Curioni-Fontecedro, A A

Publication Date: 2020-11-16

Variant appearance in text: EGFR: L798I

PubMed Link: 33207619

Variant Present in the following documents:

• Main text
• jcm-09-03674.pdf

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Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small-Cell Lung Cancer (NSCLC).

Pharmaceuticals (Basel, Switzerland)

O'Leary, Connor C; Gasper, Harry H; Sahin, Katherine B KB; Tang, Ming M; Kulasinghe, Arutha A; Adams, Mark N MN; Richard, Derek J DJ; O'Byrne, Ken J KJ

Publication Date: 2020-09-25

Variant appearance in text: EGFR: L798I

PubMed Link: 32992872

Variant Present in the following documents:

• Main text
• pharmaceuticals-13-00273.pdf

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Applications of cell-free circulating tumor DNA detection in EGFR mutant lung cancer.

Journal Of Thoracic Disease

Bulbul, Ajaz A; Leal, Alessandro A; Husain, Hatim H

Publication Date: 2020-05

Variant appearance in text: EGFR: L798I

PubMed Link: 32642200

Variant Present in the following documents:

• Main text

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[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Zhao, Zitong Z; Ni, Yu Y; Li, Li L; Xin, Tao T

Publication Date: 2020-04-20

Variant appearance in text: EGFR: L798I

PubMed Link: 32316715

Variant Present in the following documents:

• Main text

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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters

Ruan, Xingya X; Sun, Yonghua Y; Wang, Wei W; Ye, Jianwei J; Zhang, Daoyun D; Gong, Ziying Z; Yang, Mingxia M

Publication Date: 2020-05

Variant appearance in text: EGFR: L798I

PubMed Link: 32269623

Variant Present in the following documents:

• Main text

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Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction.

Molecular Oncology

Han, Rui R; Hao, Shuai S; Lu, Conghua C; Zhang, Chong C; Lin, Caiyu C; Li, Li L; Wang, Yubo Y; Hu, Chen C; He, Yong Y

Publication Date: 2020-06

Variant appearance in text: EGFR: L798I

PubMed Link: 32239624

Variant Present in the following documents:

• Main text
• MOL2-14-1152.pdf

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Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation.

Thoracic Cancer

Hayakawa, Daisuke D; Takahashi, Fumiyuki F; Mitsuishi, Yoichiro Y; Tajima, Ken K; Hidayat, Moulid M; Winardi, Wira W; Ihara, Hiroaki H; Kanamori, Koichiro K; Matsumoto, Naohisa N; Asao, Tetsuhiko T; Ko, Ryo R; Shukuya, Takehito T; Takamochi, Kazuya K; Hayashi, Takuo T; Suehara, Yoshiyuki Y; Takeda Nakamura, Ikuko I; Ueno, Toshihide T; Kohsaka, Shinji S; Mano, Hiroyuki H; Takahashi, Kazuhisa K

Publication Date: 2020-01

Variant appearance in text: EGFR: L798I

PubMed Link: 31758670

Variant Present in the following documents:

• Main text
• TCA-11-140.pdf

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Towards Circulating-Tumor DNA-Based Precision Medicine.

Journal Of Clinical Medicine

Hironaka-Mitsuhashi, Ai A; Sanchez Calle, Anna A; Ochiya, Takahiro T; Takayama, Shin S; Suto, Akihiko A

Publication Date: 2019-09-02

Variant appearance in text: EGFR: L798I

PubMed Link: 31480647

Variant Present in the following documents:

• Main text
• jcm-08-01365.pdf

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Immune checkpoint inhibitor treatment in patients with oncogene- addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion.

Esmo Open

Berghoff, Anna S AS; Bellosillo, Beatriz B; Caux, Christophe C; de Langen, Adrianus A; Mazieres, Julien J; Normanno, Nicola N; Preusser, Matthias M; Provencio, Mariano M; Rojo, Federico F; Wolf, Jurgen J; Zielinski, Christoph C CC

Publication Date: 2019

Variant appearance in text: EGFR: L798I

PubMed Link: 31297240

Variant Present in the following documents:

• Main text

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Newer-Generation EGFR Inhibitors in Lung Cancer: How Are They Best Used?

Cancers

Le, Tri T; Gerber, David E DE

Publication Date: 2019-03-15

Variant appearance in text: EGFR: L798I

PubMed Link: 30875928

Variant Present in the following documents:

• Main text
• cancers-11-00366.pdf

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Newly emergent acquired EGFR exon 18 G724S mutation after resistance of a T790M specific EGFR inhibitor osimertinib in non-small-cell lung cancer: a case report.

Oncotargets And Therapy

Zhang, Yan Y; He, Bixiu B; Zhou, Dongbo D; Li, Min M; Hu, Chengping C

Publication Date: 2019

Variant appearance in text: EGFR: L798I

PubMed Link: 30588029

Variant Present in the following documents:

• Main text

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The amount of activating EGFR mutations in circulating cell-free DNA is a marker to monitor osimertinib response.

British Journal Of Cancer

Del Re, Marzia M; Bordi, Paola P; Rofi, Eleonora E; Restante, Giuliana G; Valleggi, Simona S; Minari, Roberta R; Crucitta, Stefania S; Arrigoni, Elena E; Chella, Antonio A; Morganti, Riccardo R; Tiseo, Marcello M; Petrini, Iacopo I; Danesi, Romano R

Publication Date: 2018-11

Variant appearance in text: EGFR: L798I

PubMed Link: 30397287

Variant Present in the following documents:

• Main text
• 41416_2018_Article_238.pdf

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Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M.

Frontiers In Pharmacology

Wang, Yuwei Y; Lai, Huanling H; Fan, Xingxing X; Luo, Lianxiang L; Duan, Fugang F; Jiang, Zebo Z; Wang, Qianqian Q; Leung, Elaine Lai Han ELH; Liu, Liang L; Yao, Xiaojun X

Publication Date: 2018

Variant appearance in text: EGFR: L798I

PubMed Link: 30038571

Variant Present in the following documents:

• Main text
• fphar-09-00728.pdf

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Circulating tumour DNA in EGFR-mutant non-small-cell lung cancer.

Current Oncology (Toronto, Ont.)

Cabanero, M M; Tsao, M S MS

Publication Date: 2018-06

Variant appearance in text: EGFR: L798I

PubMed Link: 29910646

Variant Present in the following documents:

• Main text

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Resistance to epidermal growth factor receptor tyrosine kinase inhibitors, T790M, and clinical trials.

Current Oncology (Toronto, Ont.)

O'Kane, G M GM; Barnes, T A TA; Leighl, N B NB

Publication Date: 2018-06

Variant appearance in text: EGFR: L798I

PubMed Link: 29910645

Variant Present in the following documents:

• Main text

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Current and Future Molecular Testing in NSCLC, What Can We Expect from New Sequencing Technologies?

Journal Of Clinical Medicine

Garinet, Simon S; Laurent-Puig, Pierre P; Blons, Hélène H; Oudart, Jean-Baptiste JB

Publication Date: 2018-06-09

Variant appearance in text: EGFR: Leu798Ile

PubMed Link: 29890761

Variant Present in the following documents:

• Main text
• jcm-07-00144.pdf

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[Mechanisms of Resistance to the Third-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Ni, Lianfang L; Nie, Ligong L

Publication Date: 2018-02-20

Variant appearance in text: EGFR: L798I

PubMed Link: 29526178

Variant Present in the following documents:

• Main text

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Third generation EGFR TKIs: current data and future directions.

Molecular Cancer

Tan, Chee-Seng CS; Kumarakulasinghe, Nesaretnam Barr NB; Huang, Yi-Qing YQ; Ang, Yvonne Li En YLE; Choo, Joan Rou-En JR; Goh, Boon-Cher BC; Soo, Ross A RA

Publication Date: 2018-02-19

Variant appearance in text: EGFR: L798I

PubMed Link: 29455654

Variant Present in the following documents:

• Main text

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MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib.

Scientific Reports

Ninomiya, Kiichiro K; Ohashi, Kadoaki K; Makimoto, Go G; Tomida, Shuta S; Higo, Hisao H; Kayatani, Hiroe H; Ninomiya, Takashi T; Kubo, Toshio T; Ichihara, Eiki E; Hotta, Katsuyuki K; Tabata, Masahiro M; Maeda, Yoshinobu Y; Kiura, Katsuyuki K

Publication Date: 2018-01-31

Variant appearance in text: EGFR: L798I

PubMed Link: 29386539

Variant Present in the following documents:

• Main text

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Incorporating blood-based liquid biopsy information into cancer staging: time for a TNMB system?

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Yang, M M; Forbes, M E ME; Bitting, R L RL; O'Neill, S S SS; Chou, P-C PC; Topaloglu, U U; Miller, L D LD; Hawkins, G A GA; Grant, S C SC; DeYoung, B R BR; Petty, W J WJ; Chen, K K; Pasche, B C BC; Zhang, W W

Publication Date: 2018-02-01

Variant appearance in text: EGFR: L798I

PubMed Link: 29216340

Variant Present in the following documents:

• Main text

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Mechanisms of resistance to irreversible epidermal growth factor receptor tyrosine kinase inhibitors and therapeutic strategies in non-small cell lung cancer.

Oncotarget

Xu, Jing J; Wang, Jinghui J; Zhang, Shucai S

Publication Date: 2017-10-27

Variant appearance in text: EGFR: L798I

PubMed Link: 29163853

Variant Present in the following documents:

• oncotarget-08-90557.pdf

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The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer.

Journal Of Hematology & Oncology

Zhang, Yi-Chen YC; Zhou, Qing Q; Wu, Yi-Long YL

Publication Date: 2017-10-23

Variant appearance in text: EGFR: L798I

PubMed Link: 29061113

Variant Present in the following documents:

• Main text

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Non-invasive diagnostic platforms in management of non-small cell lung cancer: opportunities and challenges.

Annals Of Translational Medicine

Velcheti, Vamsidhar V; Pennell, Nathan A NA

Publication Date: 2017-09

Variant appearance in text: EGFR: L798I

PubMed Link: 29057238

Variant Present in the following documents:

• Main text

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Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Martinez-Marti, A A; Felip, E E; Matito, J J; Mereu, E E; Navarro, A A; Cedrés, S S; Pardo, N N; Martinez de Castro, A A; Remon, J J; Miquel, J M JM; Guillaumet-Adkins, A A; Nadal, E E; Rodriguez-Esteban, G G; Arqués, O O; Fasani, R R; Nuciforo, P P; Heyn, H H; Villanueva, A A; Palmer, H G HG; Vivancos, A A

Publication Date: 2017-10-01

Variant appearance in text: EGFR: L798I

PubMed Link: 28961841

Variant Present in the following documents:

• Main text
• mdx396.pdf

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Osimertinib in the treatment of non-small-cell lung cancer: design, development and place in therapy.

Lung Cancer (Auckland, N.Z.)

Santarpia, Mariacarmela M; Liguori, Alessia A; Karachaliou, Niki N; Gonzalez-Cao, Maria M; Daffinà, Maria Grazia MG; D'Aveni, Alessandro A; Marabello, Grazia G; Altavilla, Giuseppe G; Rosell, Rafael R

Publication Date: 2017

Variant appearance in text: EGFR: L798I

PubMed Link: 28860885

Variant Present in the following documents:

• Main text

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Treating EGFR mutation resistance in non-small cell lung cancer - role of osimertinib.

The Application Of Clinical Genetics

Mazza, Valentina V; Cappuzzo, Federico F

Publication Date: 2017

Variant appearance in text: EGFR: L798I

PubMed Link: 28794650

Variant Present in the following documents:

• Main text

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Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Barnes, Tristan A TA; O'Kane, Grainne M GM; Vincent, Mark David MD; Leighl, Natasha B NB

Publication Date: 2017

Variant appearance in text: EGFR: L798I

PubMed Link: 28620581

Variant Present in the following documents:

• Main text

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