EGFR c.2477A>G ;(p.N826S)

Variant ID: 7-55259419-A-G

NM_005228.3(EGFR):c.2477A>G;(p.N826S)

This variant was identified in 23 publications

View GRCh38 version.




Publications:


Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study.

Targeted Oncology
Chamorro, Diego F DF; Cardona, Andrés F AF; Rodríguez, July J; Ruiz-Patiño, Alejandro A; Arrieta, Oscar O; Moreno-Pérez, Darwin A DA; Rojas, Leonardo L; Zatarain-Barrón, Zyanya Lucia ZL; Ardila, Dora V DV; Viola, Lucia L; Recondo, Gonzalo G; Blaquier, Juan B JB; Martín, Claudio C; Raez, Luis L; Samtani, Suraj S; Ordóñez-Reyes, Camila C; Garcia-Robledo, Juan Esteban JE; Corrales, Luis L; Sotelo, Carolina C; Ricaurte, Luisa L; Cuello, Mauricio M; Mejía, Sergio S; Jaller, Elvira E; Vargas, Carlos C; Carranza, Hernán H; Otero, Jorge J; Archila, Pilar P; Bermudez, Maritza M; Gamez, Tatiana T; Russo, Alessandro A; Malapelle, Umberto U; de Miguel Perez, Diego D; de Lima, Vladmir C Cordeiro VCC; Freitas, Helano H; Saldahna, Erick E; Rolfo, Christian C; Rosell, Rafael R; ,
Publication Date: 2023-04-05

Variant appearance in text: EGFR: N826S
PubMed Link: 37017806
Variant Present in the following documents:
  • Main text
  • 11523_2023_Article_955.pdf
View BVdb publication page



Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT).

Therapeutic Advances In Medical Oncology
Addeo, Alfredo A; Hochmair, Maximilian M; Janzic, Urska U; Dudnik, Elizabeth E; Charpidou, Andriani A; Płużański, Adam A; Ciuleanu, Tudor T; Donev, Ivan Shterev IS; Elbaz, Judith J; Aarøe, Jørgen J; Ott, René R; Peled, Nir N
Publication Date: 2021

Variant appearance in text: EGFR: N826S
PubMed Link: 35173817
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359211059874.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: EGFR: N826S
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer
Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY
Publication Date: 2020-10

Variant appearance in text: EGFR: N826S
PubMed Link: 33077514
Variant Present in the following documents:
  • jitc-2020-001199supp002.pdf
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: EGFR: N826S
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports
Calibasi-Kocal, Gizem G; Amirfallah, Arsalan A; Sever, Tolga T; Umit Unal, Olcun O; Gurel, Duygu D; Oztop, Ilhan I; Ellidokuz, Hulya H; Basbinar, Yasemin Y
Publication Date: 2020-08

Variant appearance in text: EGFR: Asn826Ser
PubMed Link: 32509305
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: EGFR: N826S
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
View BVdb publication page



[A Review of EGFR-TKIs Therapy of Non-small Cell Lung Cancer
with Uncommon EGFR Mutations].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Du, Wenxing W; Wo, Yang Y; Lu, Tong T; Wang, Yuanyong Y; Jiao, Wenjie W
Publication Date: 2019-09-20

Variant appearance in text: EGFR: N826S
PubMed Link: 31526464
Variant Present in the following documents:
  • Main text
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: EGFR: N826S
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: N826S
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Clinical Analysis of Uncommon Epidermal Growth Factor Receptor Mutations in 16 Cases of Nonsmall Cell Lung Cancer.

Chinese Medical Journal
Hu, Ai-Min AM; Li, Yun-Song YS; Zhao, Dan D; Hu, Fan-Bin FB; Wang, Qun-Hui QH; Li, Bao-Lan BL
Publication Date: 2018-04-20

Variant appearance in text: EGFR: N826S
PubMed Link: 29664067
Variant Present in the following documents:
  • CMJ-131-1005.pdf
View BVdb publication page



Epidermal growth factor receptor somatic mutation analysis in 354 Chinese patients with non-small cell lung cancer.

Oncology Letters
Quan, Xueping X; Gao, Hongjun H; Wang, Zhikuan Z; Li, Jie J; Zhao, Wentao W; Liang, Wei W; Yu, Qiang Q; Guo, Dongliang D; Hao, Zhanping Z; Liu, Jingxin J
Publication Date: 2018-02

Variant appearance in text: EGFR: N826S
PubMed Link: 29434916
Variant Present in the following documents:
  • Main text
  • ol-15-02-2131.pdf
View BVdb publication page



Efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in targeted therapy of lung squamous cell carcinoma patients with EGFR mutation: a pooled analysis.

Oncotarget
Zhuang, Jingqi J; Yu, Yongfeng Y; Li, Ziming Z; Lu, Shun S
Publication Date: 2017-08-08

Variant appearance in text: EGFR: N826S
PubMed Link: 28881841
Variant Present in the following documents:
  • Main text
  • oncotarget-08-53675.pdf
View BVdb publication page



Mutational profiling of non-small-cell lung cancer patients resistant to first-generation EGFR tyrosine kinase inhibitors using next generation sequencing.

Oncotarget
Jin, Ying Y; Shao, Yang Y; Shi, Xun X; Lou, Guangyuan G; Zhang, Yiping Y; Wu, Xue X; Tong, Xiaoling X; Yu, Xinmin X
Publication Date: 2016-09-20

Variant appearance in text: EGFR: N826S
PubMed Link: 27528220
Variant Present in the following documents:
  • Main text
  • oncotarget-07-61755.pdf
View BVdb publication page



Epidermal growth factor receptor exon 20 p.S768I mutation in non-small cell lung carcinoma: A case report combined with a review of the literature and investigation of clinical significance.

Oncology Letters
Improta, Giuseppina G; Pettinato, Angela A; Gieri, Stefania S; Scandurra, Giuseppa G; Skovrider-Ruminski, Wojciech W; Høgdall, Estrid E; Fraggetta, Filippo F
Publication Date: 2016-01

Variant appearance in text: EGFR: N826S
PubMed Link: 26870223
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: EGFR: N826S
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Epidermal growth factor receptor in non-small cell lung cancer.

Translational Lung Cancer Research
Prabhakar, Charles N CN
Publication Date: 2015-04

Variant appearance in text: EGFR: N826S
PubMed Link: 25870793
Variant Present in the following documents:
  • Main text
View BVdb publication page



Efficacy of gefitinib or erlotinib in patients with squamous cell lung cancer.

Archives Of Medical Science : Ams
Song, Zhengbo Z; Zhang, Yiping Y
Publication Date: 2015-03-16

Variant appearance in text: EGFR: N826S
PubMed Link: 25861304
Variant Present in the following documents:
  • Main text
  • AMS-11-21885.pdf
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: EGFR: N826S
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: EGFR: N826S
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 3
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 4
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 2
View BVdb publication page



The energy landscape analysis of cancer mutations in protein kinases.

Plos One
Dixit, Anshuman A; Verkhivker, Gennady M GM
Publication Date: 2011

Variant appearance in text: EGFR: N826S
PubMed Link: 21998754
Variant Present in the following documents:
View BVdb publication page



Mechanisms of drug resistance in kinases.

Expert Opinion On Investigational Drugs
Barouch-Bentov, Rina R; Sauer, Karsten K
Publication Date: 2011-02

Variant appearance in text: EGFR: N826S
PubMed Link: 21235428
Variant Present in the following documents:
  • Main text
View BVdb publication page



Good Clinical Response to Erlotinib in a Non-Small Cell Lung Cancer Patient Harboring Multiple Brain Metastases and a Double Active Somatic Epidermal Growth Factor Gene Mutation.

Case Reports In Oncology
Masago, Katsuhiro K; Togashi, Yosuke Y; Fukudo, Masahide M; Terada, Tomohiro T; Irisa, Kaoru K; Sakamori, Yuichi Y; Fujita, Shiro S; Kim, Young Hak YH; Mio, Tadashi T; Inui, Ken-Ichi KI; Mishima, Michiaki M
Publication Date: 2010-04-22

Variant appearance in text: EGFR: N826S
PubMed Link: 20740181
Variant Present in the following documents:
  • Main text
  • cro0003-0098.pdf
View BVdb publication page