EGFR c.2499G>C ;(p.L833F)

Variant ID: 7-55259441-G-C

NM_005228.3(EGFR):c.2499G>C;(p.L833F)

This variant was identified in 30 publications

View GRCh38 version.




Publications:


Genomic alterations dissection revealed MUC4 mutation as a potential driver in lung adenocarcinoma local recurrence.

Translational Lung Cancer Research
Yuan, Chongze C; Yao, Xingxin X; Dai, Pengfei P; Zhao, Yue Y; Sun, Yihua Y
Publication Date: 2023-05-31

Variant appearance in text: EGFR: L833F
PubMed Link: 37323170
Variant Present in the following documents:
  • Main text
  • tlcr-12-05-985.pdf
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Osimertinib in NSCLC With Atypical EGFR-Activating Mutations: A Retrospective Multicenter Study.

Jto Clinical And Research Reports
Ji, Jingran J; Aredo, Jacqueline V JV; Piper-Vallillo, Andrew A; Huppert, Laura L; Rotow, Julia K JK; Husain, Hatim H; Stewart, Susan S; Cobb, Rosemary R; Wakelee, Heather A HA; Blakely, Collin M CM; Wong, Melisa L ML; Gubens, Matthew A MA; Madani, Mohammad H MH; Digumarthy, Subba R SR; McCoach, Caroline C; Piotrowska, Zofia Z; Neal, Joel W JW; Riess, Jonathan W JW
Publication Date: 2023-03

Variant appearance in text: EGFR: L833F
PubMed Link: 36879929
Variant Present in the following documents:
  • Main text
  • main.pdf
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An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: EGFR: 2499G>C; L833F
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 2
View BVdb publication page



Inconsistent clinical outcomes following afatinib treatment in NSCLC patients harboring uncommon epidermal growth factor receptor mutation.

Frontiers In Oncology
Dong, Wei W; Wang, Congjie C; Wang, Chunsheng C; Zhao, Kewei K; Ma, Zhao Z; Hu, Shanliang S
Publication Date: 2022

Variant appearance in text: EGFR: L833F
PubMed Link: 36425553
Variant Present in the following documents:
  • DataSheet_1.pdf
View BVdb publication page



Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology
Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J
Publication Date: 2022

Variant appearance in text: EGFR: 2499G>C; L833F
PubMed Link: 35814426
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 2
View BVdb publication page



Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China.

Genes And Environment : The Official Journal Of The Japanese Environmental Mutagen Society
Wang, Jun-Ling JL; Fu, Yu-Dong YD; Gao, Yan-Hong YH; Li, Xiu-Ping XP; Xiong, Qian Q; Li, Rui R; Hou, Bo B; Huang, Ruo-Shan RS; Wang, Jun-Feng JF; Zhang, Jian-Kun JK; Lv, Jia-Ling JL; Zhang, Chao C; Li, Hong-Wei HW
Publication Date: 2022-05-23

Variant appearance in text: EGFR: L833F
PubMed Link: 35606799
Variant Present in the following documents:
  • Main text
  • 41021_2022_248_MOESM1_ESM.xlsx, sheet 1
  • 41021_2022_Article_248.pdf
View BVdb publication page



Non-small-cell lung cancer with epidermal growth factor receptor L861Q-L833F compound mutation benefits from both afatinib and osimertinib: A case report.

World Journal Of Clinical Cases
Zhang, Yao Y; Shen, Ji-Qiao JQ; Shao, Lin L; Chen, Yan Y; Lei, Lei L; Wang, Jia-Lei JL
Publication Date: 2021-09-26

Variant appearance in text: EGFR: L833F
PubMed Link: 34621884
Variant Present in the following documents:
  • Main text
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Leu833Phe
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Leu833Phe
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations.

Thoracic Cancer
Li, Teng T; Wang, Shouzheng S; Ying, Jianming J; Wang, Yan Y; Hu, Xingsheng X; Hao, Xuezhi X; Xu, Ziyi Z; Xing, Puyuan P; Li, Junling J
Publication Date: 2021-11

Variant appearance in text: EGFR: L833F
PubMed Link: 34549528
Variant Present in the following documents:
  • Main text
  • TCA-12-2924.pdf
View BVdb publication page



Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations.

Thoracic Cancer
Li, Teng T; Wang, Shouzheng S; Ying, Jianming J; Wang, Yan Y; Hu, Xingsheng X; Hao, Xuezhi X; Xu, Ziyi Z; Xing, Puyuan P; Li, Junling J
Publication Date: 2021-11

Variant appearance in text: EGFR: L833F
PubMed Link: 34549528
Variant Present in the following documents:
  • Main text
  • TCA-12-2924.pdf
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: EGFR: L833F
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 17
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: EGFR: L833F
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: EGFR: 2499G>C; L833F
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM9_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Chronic Plasma Exposure to Kinase Inhibitors in Patients with Oncogene-Addicted Non-Small Cell Lung Cancer.

Cancers
Geraud, Arthur A; Mezquita, Laura L; Auclin, Edouard E; Combarel, David D; Delahousse, Julia J; Gougis, Paul P; Massard, Christophe C; Jovelet, Cécile C; Caramella, Caroline C; Adam, Julien J; Naltet, Charles C; Lavaud, Pernelle P; Gazzah, Anas A; Lacroix, Ludovic L; Rouleau, Etienne E; Vasseur, Damien D; Mir, Olivier O; Planchard, David D; Paci, Angelo A; Besse, Benjamin B
Publication Date: 2020-12-14

Variant appearance in text: EGFR: L833F
PubMed Link: 33327482
Variant Present in the following documents:
  • Main text
  • cancers-12-03758-s001.pdf
  • cancers-12-03758.pdf
View BVdb publication page



Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications
Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG
Publication Date: 2020-07-30

Variant appearance in text: EGFR: L833F
PubMed Link: 32732999
Variant Present in the following documents:
  • 41467_2020_17659_MOESM3_ESM.xls, sheet 1
View BVdb publication page



Changes in the gene mutation profiles of circulating tumor DNA detected using CAPP-Seq in neoadjuvant chemotherapy-treated advanced ovarian cancer.

Oncology Letters
Noguchi, Tomoko T; Sakai, Kazuko K; Iwahashi, Naoyuki N; Matsuda, Kaho K; Matsukawa, Hitomi H; Yahata, Tamaki T; Toujima, Saori S; Nishio, Kazuto K; Ino, Kazuhiko K
Publication Date: 2020-04

Variant appearance in text: EGFR: L833F
PubMed Link: 32218822
Variant Present in the following documents:
  • Main text
  • ol-19-04-2713.pdf
View BVdb publication page



Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z
Publication Date: 2020-01

Variant appearance in text: EGFR: L833F
PubMed Link: 32067422
Variant Present in the following documents:
  • Main text
  • CAC2-40-43.pdf
View BVdb publication page



Survival Disparities in Black Patients With EGFR-mutated Non-small-cell Lung Cancer.

Clinical Lung Cancer
Cheng, Haiying H; Hosgood, H Dean HD; Deng, Lei L; Ye, Kenny K; Su, Christopher C; Sharma, Janaki J; Yang, Yuanquan Y; Halmos, Balazs B; Perez-Soler, Roman R
Publication Date: 2020-03

Variant appearance in text: EGFR: L833F
PubMed Link: 31420240
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ikemura, Shinnosuke S; Yasuda, Hiroyuki H; Matsumoto, Shingo S; Kamada, Mayumi M; Hamamoto, Junko J; Masuzawa, Keita K; Kobayashi, Keigo K; Manabe, Tadashi T; Arai, Daisuke D; Nakachi, Ichiro I; Kawada, Ichiro I; Ishioka, Kota K; Nakamura, Morio M; Namkoong, Ho H; Naoki, Katsuhiko K; Ono, Fumie F; Araki, Mitsugu M; Kanada, Ryo R; Ma, Biao B; Hayashi, Yuichiro Y; Mimaki, Sachiyo S; Yoh, Kiyotaka K; Kobayashi, Susumu S SS; Kohno, Takashi T; Okuno, Yasushi Y; Goto, Koichi K; Tsuchihara, Katsuya K; Soejima, Kenzo K
Publication Date: 2019-05-14

Variant appearance in text: EGFR: L833F
PubMed Link: 31043566
Variant Present in the following documents:
  • pnas.1819430116.sapp.pdf
View BVdb publication page



The in cis compound EGFR mutations in Chinese advanced non-small cell lung cancer patients.

Cancer Biology & Therapy
Li, Min M; Zhou, Cheng-Zhi CZ; Yang, Jin-Ji JJ; Lu, Shun S; Zheng, Di D; Hu, Jie J; Zeng, Hui H; Lu, You Y; Lu, Kai-Hua KH; Li, Shu-Ang SA; Mao, Xin-Ru XR; Han-Zhang, Han H; Lizaso, Analyn A; Ye, Jun-Yi JY; Hu, Cheng-Ping CP
Publication Date: 2019

Variant appearance in text: EGFR: L833F
PubMed Link: 30990107
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical Characteristics and Molecular Patterns of RET-Rearranged Lung Cancer in Chinese Patients.

Oncology Research
Zhang, Kai K; Chen, Huajun H; Wang, Ye Y; Yang, Lin L; Zhou, Chengzhi C; Yin, Weiqiang W; Wang, Guangsuo G; Mao, Xinru X; Xiang, Jianxing J; Li, Bing B; Zhang, Tengfei T; Fei, Shihong S
Publication Date: 2019-05-07

Variant appearance in text: EGFR: L833F
PubMed Link: 30131091
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: EGFR: L833F
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 13
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 8
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: L833F
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Cancer Cell
Hellmann, Matthew D MD; Nathanson, Tavi T; Rizvi, Hira H; Creelan, Benjamin C BC; Sanchez-Vega, Francisco F; Ahuja, Arun A; Ni, Ai A; Novik, Jacki B JB; Mangarin, Levi M B LMB; Abu-Akeel, Mohsen M; Liu, Cailian C; Sauter, Jennifer L JL; Rekhtman, Natasha N; Chang, Eliza E; Callahan, Margaret K MK; Chaft, Jamie E JE; Voss, Martin H MH; Tenet, Megan M; Li, Xue-Mei XM; Covello, Kelly K; Renninger, Andrea A; Vitazka, Patrik P; Geese, William J WJ; Borghaei, Hossein H; Rudin, Charles M CM; Antonia, Scott J SJ; Swanton, Charles C; Hammerbacher, Jeff J; Merghoub, Taha T; McGranahan, Nicholas N; Snyder, Alexandra A; Wolchok, Jedd D JD
Publication Date: 2018-05-14

Variant appearance in text: EGFR: L833F
PubMed Link: 29657128
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.

Oncotarget
Fertig, Elana J EJ; Ozawa, Hiroyuki H; Thakar, Manjusha M; Howard, Jason D JD; Kagohara, Luciane T LT; Krigsfeld, Gabriel G; Ranaweera, Ruchira S RS; Hughes, Robert M RM; Perez, Jimena J; Jones, Siân S; Favorov, Alexander V AV; Carey, Jacob J; Stein-O'Brien, Genevieve G; Gaykalova, Daria A DA; Ochs, Michael F MF; Chung, Christine H CH
Publication Date: 2016-11-08

Variant appearance in text: EGFR: L833F
PubMed Link: 27650546
Variant Present in the following documents:
  • oncotarget-07-73845-s007.xlsx, sheet 1
View BVdb publication page



Protein-structure-guided discovery of functional mutations across 19 cancer types.

Nature Genetics
Niu, Beifang B; Scott, Adam D AD; Sengupta, Sohini S; Bailey, Matthew H MH; Batra, Prag P; Ning, Jie J; Wyczalkowski, Matthew A MA; Liang, Wen-Wei WW; Zhang, Qunyuan Q; McLellan, Michael D MD; Sun, Sam Q SQ; Tripathi, Piyush P; Lou, Carolyn C; Ye, Kai K; Mashl, R Jay RJ; Wallis, John J; Wendl, Michael C MC; Chen, Feng F; Ding, Li L
Publication Date: 2016-08

Variant appearance in text: EGFR: Leu833Phe
PubMed Link: 27294619
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparison of uncommon EGFR exon 21 L858R compound mutations with single mutation.

Oncotargets And Therapy
Peng, Liang L; Song, Zhigang Z; Jiao, Shunchang S
Publication Date: 2015

Variant appearance in text: EGFR: L833F
PubMed Link: 25960661
Variant Present in the following documents:
  • Main text
  • ott-8-905.pdf
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: EGFR: L833F
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Publication Date: 2014-12

Variant appearance in text: EGFR: L833F
PubMed Link: 25326804
Variant Present in the following documents:
  • NIHMS630249-supplement-5.xlsx, sheet 1
View BVdb publication page



Efficacy analysis of tyrosine kinase inhibitors on rare non-small cell lung cancer patients harboring complex EGFR mutations.

Scientific Reports
Peng, Liang L; Song, Zhi-Gang ZG; Jiao, Shun-Chang SC
Publication Date: 2014-08-18

Variant appearance in text: EGFR: L833F
PubMed Link: 25130612
Variant Present in the following documents:
  • Main text
  • srep06104.pdf
View BVdb publication page



Common and rare EGFR and KRAS mutations in a Dutch non-small-cell lung cancer population and their clinical outcome.

Plos One
Kerner, Gerald S M A GS; Schuuring, Ed E; Sietsma, Johanna J; Hiltermann, Thijo J N TJ; Pieterman, Remge M RM; de Leede, Gerard P J GP; van Putten, John W G JW; Liesker, Jeroen J; Renkema, Tineke E J TE; van Hengel, Peter P; Platteel, Inge I; Timens, Wim W; Groen, Harry J M HJ; ,
Publication Date: 2013

Variant appearance in text: EGFR: L833F
PubMed Link: 23922984
Variant Present in the following documents:
  • Main text
  • pone.0070346.pdf
View BVdb publication page