Publications:

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Identifying potential ligand molecules EGFR mediated TNBC targeting the kinase domain-identification of customized drugs through in silico methods.

Research In Pharmaceutical Sciences

Vyshnavi, Hima H; Namboori, Krishnan K

Publication Date: 2023-04

Variant appearance in text: rs2229066

PubMed Link: 36873279

Variant Present in the following documents:

• Main text
• RPS-18-121.pdf

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Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases.

Journal Of Molecular Cell Biology

Varinelli, Luca L; Guaglio, Marcello M; Brich, Silvia S; Zanutto, Susanna S; Belfiore, Antonino A; Zanardi, Federica F; Iannelli, Fabio F; Oldani, Amanda A; Costa, Elisa E; Chighizola, Matteo M; Lorenc, Ewelina E; Minardi, Simone P SP; Fortuzzi, Stefano S; Filugelli, Martina M; Garzone, Giovanna G; Pisati, Federica F; Vecchi, Manuela M; Pruneri, Giancarlo G; Kusamura, Shigeki S; Baratti, Dario D; Cattaneo, Laura L; Parazzoli, Dario D; Podestà, Alessandro A; Milione, Massimo M; Deraco, Marcello M; Pierotti, Marco A MA; Gariboldi, Manuela M

Publication Date: 2022-12-02

Variant appearance in text: EGFR: R836R

PubMed Link: 36460033

Variant Present in the following documents:

• mjac064_supplemental_file.pdf

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Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies.

Journal Of Cancer Research And Clinical Oncology

Kleo, Karsten K; Jovanovic, Vladimir M VM; Arndold, Alexander A; Lehmann, Annika A; Lammert, Hedwig H; Berg, Erika E; Harloff, Hannah H; Treese, Christoph C; Hummel, Michael M; Daum, Severin S

Publication Date: 2022-03-05

Variant appearance in text: EGFR: 2508C>T; rs2229066

PubMed Link: 35246724

Variant Present in the following documents:

• 432_2022_3944_MOESM1_ESM.xlsx, sheet 1

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Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma.

Frontiers In Oncology

Jiang, Haiping H; Wang, Yinan Y; Xu, Hanlin H; Lei, Wei W; Yu, Xiaoyun X; Tian, Haiying H; Meng, Cong C; Wang, Xueying X; Zhao, Zicheng Z; Jin, Xiangfeng X

Publication Date: 2021

Variant appearance in text: EGFR: R836R; rs2229066

PubMed Link: 35186718

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology

Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD

Publication Date: 2021-11-18

Variant appearance in text: N/A

PubMed Link: 34797250

Variant Present in the following documents:

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PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer.

Journal For Immunotherapy Of Cancer

Stein, Alexander A; Simnica, Donjete D; Schultheiß, Christoph C; Scholz, Rebekka R; Tintelnot, Joseph J; Gökkurt, Eray E; von Wenserski, Lisa L; Willscher, Edith E; Paschold, Lisa L; Sauer, Markus M; Lorenzen, Sylvie S; Riera-Knorrenschild, Jorge J; Depenbusch, Reinhard R; Ettrich, Thomas J TJ; Dörfel, Steffen S; Al-Batran, Salah-Eddin SE; Karthaus, Meinolf M; Pelzer, Uwe U; Waberer, Lisa L; Hinke, Axel A; Bauer, Marcus M; Massa, Chiara C; Seliger, Barbara B; Wickenhauser, Claudia C; Bokemeyer, Carsten C; Hegewisch-Becker, Susanna S; Binder, Mascha M

Publication Date: 2021-07

Variant appearance in text: N/A

PubMed Link: 34315821

Variant Present in the following documents:

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: R836R

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

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Next generation sequencing of glioblastoma circulating tumor cells: non-invasive solution for disease monitoring.

American Journal Of Translational Research

Kolostova, Katarina K; Pospisilova, Eliska E; Pavlickova, Vladimira V; Bartos, Robert R; Sames, Martin M; Pawlak, Ireneusz I; Bobek, Vladimir V

Publication Date: 2021

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 34150029

Variant Present in the following documents:

• Main text

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The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes.

British Journal Of Cancer

Salas-Benito, Diego D; Conde, Enrique E; Tamayo-Uria, Ibon I; Mancheño, Uxua U; Elizalde, Edurne E; Garcia-Ros, David D; Aramendia, Jose M JM; Muruzabal, Juan C JC; Alcaide, Julia J; Guillen-Grima, Francisco F; Minguez, Jose A JA; Amores-Tirado, Jose J; Gonzalez-Martin, Antonio A; Sarobe, Pablo P; Lasarte, Juan J JJ; Ponz-Sarvise, Mariano M; De Andrea, Carlos E CE; Hervas-Stubbs, Sandra S

Publication Date: 2021-03

Variant appearance in text: N/A

PubMed Link: 33402737

Variant Present in the following documents:

View BVdb publication page

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Cas9 activates the p53 pathway and selects for p53-inactivating mutations.

Nature Genetics

Enache, Oana M OM; Rendo, Veronica V; Abdusamad, Mai M; Lam, Daniel D; Davison, Desiree D; Pal, Sangita S; Currimjee, Naomi N; Hess, Julian J; Pantel, Sasha S; Nag, Anwesha A; Thorner, Aaron R AR; Doench, John G JG; Vazquez, Francisca F; Beroukhim, Rameen R; Golub, Todd R TR; Ben-David, Uri U

Publication Date: 2020-07

Variant appearance in text: N/A

PubMed Link: 32424350

Variant Present in the following documents:

View BVdb publication page

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Genomics of lethal prostate cancer at diagnosis and castration resistance.

The Journal Of Clinical Investigation

Mateo, Joaquin J; Seed, George G; Bertan, Claudia C; Rescigno, Pasquale P; Dolling, David D; Figueiredo, Ines I; Miranda, Susana S; Nava Rodrigues, Daniel D; Gurel, Bora B; Clarke, Matthew M; Atkin, Mark M; Chandler, Rob R; Messina, Carlo C; Sumanasuriya, Semini S; Bianchini, Diletta D; Barrero, Maialen M; Petermolo, Antonella A; Zafeiriou, Zafeiris Z; Fontes, Mariane M; Perez-Lopez, Raquel R; Tunariu, Nina N; Fulton, Ben B; Jones, Robert R; McGovern, Ursula U; Ralph, Christy C; Varughese, Mohini M; Parikh, Omi O; Jain, Suneil S; Elliott, Tony T; Sandhu, Shahneen S; Porta, Nuria N; Hall, Emma E; Yuan, Wei W; Carreira, Suzanne S; de Bono, Johann S JS

Publication Date: 2020-04-01

Variant appearance in text: EGFR: 2508C>T; rs2229066

PubMed Link: 31874108

Variant Present in the following documents:

• jci-130-132031-s100.xlsx, sheet 1

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Better Progression-Free Survival in Elderly Patients with Stage IV Lung Adenocarcinoma Harboring Uncommon Epidermal Growth Factor Receptor Mutations Treated with the First-line Tyrosine Kinase Inhibitors.

Cancers

Tsai, Ming-Ju MJ; Hung, Jen-Yu JY; Lee, Mei-Hsuan MH; Kuo, Chia-Yu CY; Tsai, Yu-Chen YC; Tsai, Ying-Ming YM; Liu, Ta-Chih TC; Yang, Chih-Jen CJ; Huang, Ming-Shyan MS; Chong, Inn-Wen IW

Publication Date: 2018-11-13

Variant appearance in text: EGFR: R836R

PubMed Link: 30428509

Variant Present in the following documents:

• Main text
• cancers-10-00434.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: EGFR: R836R

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 3

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Frequency and clinical relevance of EGFR mutations and EML4-ALK translocations in octogenarians with non-small cell lung cancer.

Oncotargets And Therapy

Tufman, Amanda A; Kahnert, Kathrin K; Duell, Thomas T; Kauffmann-Guerrero, Diego D; Milger, Katrin K; Schneider, Christian C; Stump, Julia J; Syunyaeva, Zulfiya Z; Huber, Rudolf Maria RM; Reu, Simone S

Publication Date: 2017

Variant appearance in text: EGFR: R836R

PubMed Link: 29123416

Variant Present in the following documents:

• Main text
• ott-10-5179.pdf

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Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population.

Journal Of Cancer Epidemiology

Berois, Nora N; Touya, Diego D; Ubillos, Luis L; Bertoni, Bernardo B; Osinaga, Eduardo E; Varangot, Mario M

Publication Date: 2017

Variant appearance in text: N/A

PubMed Link: 28744312

Variant Present in the following documents:

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: EGFR: R836R; rs2229066

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma.

Oncotarget

Mao, Xinfang X; Chen, Zhenghu Z; Zhao, Yanling Y; Yu, Yang Y; Guan, Shan S; Woodfield, Sarah E SE; Vasudevan, Sanjeev A SA; Tao, Ling L; Pang, Jonathan C JC; Lu, Jiaxiong J; Zhang, Huiyuan H; Zhang, Fuchun F; Yang, Jianhua J

Publication Date: 2017-01-03

Variant appearance in text: EGFR: 2508C>T

PubMed Link: 27902463

Variant Present in the following documents:

• Main text
• oncotarget-08-1555.pdf

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Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.

Oncogene

Nickerson, M L ML; Witte, N N; Im, K M KM; Turan, S S; Owens, C C; Misner, K K; Tsang, S X SX; Cai, Z Z; Wu, S S; Dean, M M; Costello, J C JC; Theodorescu, D D

Publication Date: 2017-01-05

Variant appearance in text: EGFR: R836R

PubMed Link: 27270441

Variant Present in the following documents:

• onc2016172x3.xls, sheet 3

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The status of epidermal growth factor receptor in borderline ovarian tumours.

Oncotarget

Showeil, Rania R; Romano, Claudia C; Valganon, Mikel M; Lambros, Maryou M; Trivedi, Pritesh P; Van Noorden, Susan S; Sriraksa, Ruethairat R; El-Kaffash, Dalal D; El-Etreby, Nour N; Natrajan, Rachael R; Foroni, Letizia L; Osborne, Richard R; El-Bahrawy, Mona M

Publication Date: 2016-03-01

Variant appearance in text: EGFR: 2508C>T; rs2229066

PubMed Link: 26870997

Variant Present in the following documents:

• Main text
• oncotarget-07-10568.pdf

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Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.

Acta Neuropathologica Communications

Shankar, Ganesh M GM; Taylor-Weiner, Amaro A; Lelic, Nina N; Jones, Robert T RT; Kim, James C JC; Francis, Joshua M JM; Abedalthagafi, Malak M; Borges, Lawrence F LF; Coumans, Jean-Valery JV; Curry, William T WT; Nahed, Brian V BV; Shin, John H JH; Paek, Sun Ha SH; Park, Sung-Hye SH; Stewart, Chip C; Lawrence, Michael S MS; Cibulskis, Kristian K; Thorner, Aaron R AR; Van Hummelen, Paul P; Stemmer-Rachamimov, Anat O AO; Batchelor, Tracy T TT; Carter, Scott L SL; Hoang, Mai P MP; Santagata, Sandro S; Louis, David N DN; Barker, Fred G FG; Meyerson, Matthew M; Getz, Gad G; Brastianos, Priscilla K PK; Cahill, Daniel P DP

Publication Date: 2014-12-24

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 25589003

Variant Present in the following documents:

• 40478_2014_167_MOESM1_ESM.xlsx, sheet 6

View BVdb publication page

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Whole-genome sequencing of the world's oldest people.

Plos One

Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK

Publication Date: 2014

Variant appearance in text: EGFR: R836R

PubMed Link: 25390934

Variant Present in the following documents:

• pone.0112430.s004.xlsx, sheet 1

View BVdb publication page

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Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.

Oncotarget

Abedalthagafi, Malak S MS; Merrill, Parker H PH; Bi, Wenya Linda WL; Jones, Robert T RT; Listewnik, Marc L ML; Ramkissoon, Shakti H SH; Thorner, Aaron R AR; Dunn, Ian F IF; Beroukhim, Rameen R; Alexander, Brian M BM; Brastianos, Priscilla K PK; Francis, Joshua M JM; Folkerth, Rebecca D RD; Ligon, Keith L KL; Van Hummelen, Paul P; Ligon, Azra H AH; Santagata, Sandro S

Publication Date: 2014-11-15

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 25347344

Variant Present in the following documents:

• oncotarget-05-10596-s002.xlsx, sheet 4

View BVdb publication page

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Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response.

Bmc Research Notes

Boeckx, Carolien C; Weyn, Christine C; Vanden Bempt, Isabelle I; Deschoolmeester, Vanessa V; Wouters, An A; Specenier, Pol P; Van Laer, Carl C; Van den Weyngaert, Danielle D; Kockx, Mark M; Vermorken, Jan B JB; Peeters, Marc M; Pauwels, Patrick P; Lardon, Filip F; Baay, Marc M

Publication Date: 2014-06-04

Variant appearance in text: EGFR: R836R

PubMed Link: 24899223

Variant Present in the following documents:

• Main text
• 1756-0500-7-337.pdf

View BVdb publication page

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Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors.

Pancreas

Gilbert, Judith A JA; Adhikari, Laura J LJ; Lloyd, Ricardo V RV; Halfdanarson, Thorvardur R TR; Muders, Michael H MH; Ames, Matthew M MM

Publication Date: 2013-04

Variant appearance in text: rs2229066

PubMed Link: 23211371

Variant Present in the following documents:

• Main text

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Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas.

Bmc Cancer

Gonzaga, Isabela Martins IM; Soares-Lima, Sheila Coelho SC; de Santos, Paulo Thiago Souza PT; Blanco, Tania Cristina Moita TC; de Reis, Bruno Souza Bianchi BS; Quintella, Danielle Carvalho DC; de Oliveira, Ivanir Martins IM; de Faria, Paulo Antonio Silvestre PA; Kruel, Cleber Dario Pinto CD; Andreollo, Nelson Adami NA; de Simão, Tatiana Almeida TA; Pinto, Luis Felipe Ribeiro LF

Publication Date: 2012-12-04

Variant appearance in text: EGFR: R836R

PubMed Link: 23207070

Variant Present in the following documents:

• Main text
• 1471-2407-12-569.pdf

View BVdb publication page

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EGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors?

British Journal Of Cancer

Paliga, A A; Onerheim, R R; Gologan, A A; Chong, G G; Spatz, A A; Niazi, T T; Garant, A A; Macheto, D D; Alcindor, T T; Vuong, T T

Publication Date: 2012-11-20

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 23093229

Variant Present in the following documents:

• Main text

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Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles.

Breast Cancer Research : Bcr

Jacot, William W; Lopez-Crapez, Evelyne E; Thezenas, Simon S; Senal, Romain R; Fina, Frédéric F; Bibeau, Frédéric F; Romieu, Gilles G; Lamy, Pierre-Jean PJ

Publication Date: 2011

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 22192147

Variant Present in the following documents:

• Main text

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The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain.

Bmc Medical Genetics

Metzger, Brigitte B; Chambeau, Laetitia L; Begon, Dominique Y DY; Faber, Carlo C; Kayser, Jacques J; Berchem, Guy G; Pauly, Marc M; Boniver, Jacques J; Delvenne, Philippe P; Dicato, Mario M; Wenner, Thomas T

Publication Date: 2011-10-25

Variant appearance in text: EGFR: R836R

PubMed Link: 22026926

Variant Present in the following documents:

• Main text

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Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.

Journal Of Oncology

Caldera, Valentina V; Mellai, Marta M; Annovazzi, Laura L; Piazzi, Angela A; Lanotte, Michele M; Cassoni, Paola P; Schiffer, Davide D

Publication Date: 2011

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 21869887

Variant Present in the following documents:

• Main text
• JO2011-314962.pdf

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Screening for EGFR Mutations in Patients with Head and Neck Cancer Treated with Gefitinib on a Compassionate-Use Program: A Hellenic Cooperative Oncology Group Study.

Journal Of Oncology

Murray, Samuel S; Bobos, Mattheos M; Angouridakis, Nikolaos N; Nikolaou, Angelos A; Linardou, Helena H; Razis, Evangelia E; Fountzilas, George G

Publication Date: 2010

Variant appearance in text: EGFR: R836R

PubMed Link: 21274259

Variant Present in the following documents:

• Main text
• JO2010-709678.pdf

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High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies.

Bmc Cancer

Do, Hongdo H; Krypuy, Michael M; Mitchell, Paul L PL; Fox, Stephen B SB; Dobrovic, Alexander A

Publication Date: 2008-05-21

Variant appearance in text: EGFR: 2508C>T; R836R

PubMed Link: 18495026

Variant Present in the following documents:

• Main text

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Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study.

Bmc Cancer

Choi, Jin Eun JE; Park, Sun Ha SH; Kim, Kyung Mee KM; Lee, Won Kee WK; Kam, Sin S; Cha, Sung Ick SI; Kim, Chang Ho CH; Kang, Young Mo YM; Kim, Young-Chul YC; Han, Sung Beom SB; Jung, Tae Hoon TH; Park, Jae Yong JY

Publication Date: 2007-10-24

Variant appearance in text: EGFR: R836R

PubMed Link: 17956637

Variant Present in the following documents:

• 1471-2407-7-199.pdf

View BVdb publication page

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