EGFR c.2569G>A ;(p.G857R)

Variant ID: 7-55259511-G-A

NM_005228.3(EGFR):c.2569G>A;(p.G857R)

This variant was identified in 14 publications

View GRCh38 version.




Publications:


Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: EGFR: 2569G>A; G857R
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: G857R
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma.

Frontiers In Oncology
Chen, Ying Y; Cui, Xiaoying X; Wang, Di D; Xia, Guojie G; Xing, Minyan M; Cheng, Lei L; Sheng, Liming L; Du, Xianghui X
Publication Date: 2021

Variant appearance in text: EGFR: G857R
PubMed Link: 35096557
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton.

Oncology Letters
Taher, Mohiuddin M MM; Hassan, Amal Ali AA; Saeed, Muhammad M; Jastania, Raid A RA; Nageeti, Tahani H TH; Alkhalidi, Hisham H; Dairi, Ghida G; Abduljaleel, Zainularifeen Z; Athar, Mohammad M; Bouazzaoui, Abdellatif A; El-Bjeirami, Wafa M WM; Al-Allaf, Faisal A FA
Publication Date: 2019-11

Variant appearance in text: EGFR: 2569G>A; G857R
PubMed Link: 31612017
Variant Present in the following documents:
  • Main text
  • Supplementary_Data.pdf
  • ol-18-05-5063.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: G857R
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Compound EGFR mutation is frequently detected with co-mutations of actionable genes and associated with poor clinical outcome in lung adenocarcinoma.

Cancer Biology & Therapy
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016

Variant appearance in text: EGFR: G857R
PubMed Link: 26785607
Variant Present in the following documents:
  • Main text
  • kcbt-17-03-1139235.pdf
View BVdb publication page



Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.

Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016-01-18

Variant appearance in text: EGFR: 2569G>A
PubMed Link: 26782967
Variant Present in the following documents:
  • 12885_2016_2049_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B.

Journal Of Molecular Cell Biology
Engelmann, David D; Mayoli-Nüssle, Deborah D; Mayrhofer, Christian C; Fürst, Katharina K; Alla, Vijay V; Stoll, Anja A; Spitschak, Alf A; Abshagen, Kerstin K; Vollmar, Brigitte B; Ran, Sophia S; Pützer, Brigitte M BM
Publication Date: 2013-12

Variant appearance in text: EGFR: G857R
PubMed Link: 24014887
Variant Present in the following documents:
  • Main text
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: EGFR: G857R
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 2
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: EGFR: G857R
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.

Plos Pathogens
Karki, Roshan R; Lang, Sabine M SM; Means, Robert E RE
Publication Date: 2011-04

Variant appearance in text: EGFR: G857R
PubMed Link: 21490960
Variant Present in the following documents:
  • Main text
View BVdb publication page



Panitumumab: the evidence for its use in the treatment of metastatic colorectal cancer.

Core Evidence
Berardi, Rossana R; Onofri, Azzurra A; Pistelli, Mirco M; Maccaroni, Elena E; Scartozzi, Mario M; Pierantoni, Chiara C; Cascinu, Stefano S
Publication Date: 2010-10-21

Variant appearance in text: EGFR: Gly857Arg
PubMed Link: 21042543
Variant Present in the following documents:
  • Main text
  • ce-5-061.pdf
View BVdb publication page



Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.

Journal Of The National Cancer Institute
Siena, Salvatore S; Sartore-Bianchi, Andrea A; Di Nicolantonio, Federica F; Balfour, Julia J; Bardelli, Alberto A
Publication Date: 2009-10-07

Variant appearance in text: EGFR: Gly857Arg
PubMed Link: 19738166
Variant Present in the following documents:
  • Main text
  • djp280.pdf
View BVdb publication page



Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Kwak, Eunice L EL; Jankowski, Janusz J; Thayer, Sarah P SP; Lauwers, Gregory Y GY; Brannigan, Brian W BW; Harris, Patricia L PL; Okimoto, Ross A RA; Haserlat, Sara M SM; Driscoll, David R DR; Ferry, David D; Muir, Beth B; Settleman, Jeff J; Fuchs, Charles S CS; Kulke, Matthew H MH; Ryan, David P DP; Clark, Jeff W JW; Sgroi, Dennis C DC; Haber, Daniel A DA; Bell, Daphne W DW
Publication Date: 2006-07-15

Variant appearance in text: EGFR: G857R
PubMed Link: 16857803
Variant Present in the following documents:
  • Main text
View BVdb publication page