Variant ID: 7-55259515-T-G

NM_005228.3(EGFR):c.2573T>G;(p.Leu858Arg)

This variant was identified in 4563 publications




Publications:


Predictors of Acquired T790M Mutation in Patients Failing First- or Second-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors.

Cancer Management And Research
CS Chai, CK Liam, ME Poh, DB Ong, YK Pang, PL Cheah, GF Ho, A Alip
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32753961
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Association of TP53 Mutations with Response to Anlotinib Treatment in Advanced Non-Small Cell Lung Cancer.

Oncotargets And Therapy
S Fang, W Cheng, M Zhang, R Yang
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32753898
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Sequential Whole Exome Sequencing Reveals Somatic Mutations Associated with Platinum Response in NSCLC.

Oncotargets And Therapy
AX Guo, F Xiao, WH Shao, Y Zhan, L Zhang, J Xiong, Y Gao, JY Yin
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32753889
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Non-Small-Cell Lung Cancer-Sensitive Detection of the p.Thr790Met EGFR Alteration by Preamplification before PNA-Mediated PCR Clamping and Pyrosequencing.

Diagnostics (Basel, Switzerland)
A Billaud, V Verriele, J Dauvé, LM Chevalier, A Morel
Publication Date: 2020-07-29

Variant appearance in text: EGFR: Leu858Arg
PMID: 32751202
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Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells.

Marine Drugs
CH Liao, YT Tzeng, GM Lai, CL Chang, MH Hu, WL Tsai, YR Liu, S Hsia, SE Chuang, TJ Chiou, LM Wang, J Whang-Peng, CJ Yao
Publication Date: 2020-07-29

Variant appearance in text: EGFR: L858R
PMID: 32751169
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Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management.

Diagnostics (Basel, Switzerland)
J Wehrle, U Philipp, M Jolic, M Follo, S Hussung, S Waldeck, M Deuter, M Rassner, J Braune, J Rawluk, C Greil, CF Waller, H Becker, J Duque-Afonso, AL Illert, RM Fritsch, F Meiss, J Duyster, N von Bubnoff, F Scherer
Publication Date: 2020-08-02

Variant appearance in text: EGFR: L858R
PMID: 32748806
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Smoking habit and chemo-radiotherapy and/or surgery affect the sensitivity of EGFR plasma test in non-small cell lung cancer.

Bmc Research Notes
VT Tran, TT Phan, ST Nguyen, BT Tran, TT Ho, SP Pho, TB Nguyen, TTB Pham, AT Le, VT Le, HT Nguyen
Publication Date: 2020-08-03

Variant appearance in text: EGFR: L858R
PMID: 32746896
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Role of YES1 amplification in EGFR mutation-positive non-small cell lung cancer: Primary resistance to afatinib in a patient.

Thoracic Cancer
J Tao, D Sun, H Hou
Publication Date: 2020-08-03

Variant appearance in text: EGFR: L858R
PMID: 32744377
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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng
Publication Date: 2020-08-01

Variant appearance in text: EGFR: L858R
PMID: 32738923
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Whole brain radiotherapy (WBRT) for leptomeningeal metastasis from NSCLC in the era of targeted therapy: a retrospective study.

Radiation Oncology (London, England)
J Zhen, L Wen, M Lai, Z Zhou, C Shan, S Li, T Lin, J Wu, W Wang, S Xu, D Liu, M Lu, D Zhu, L Chen, L Cai, C Zhou
Publication Date: 2020-07-31

Variant appearance in text: EGFR: L858R
PMID: 32736566
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Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: EGFR: L858R
PMID: 32729257
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Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report.

Journal Of Cardiothoracic Surgery
Y Yang, X Xie, G Jiang, H Liu
Publication Date: 2020-07-29

Variant appearance in text: EGFR: L858R
PMID: 32727606
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Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer.

Bmc Cancer
W Ouyang, J Yu, Y Zhou, J Hu, Z Huang, J Zhang, C Xie
Publication Date: 2020-07-28

Variant appearance in text: EGFR: L858R
PMID: 32723319
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Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials.

Technology In Cancer Research & Treatment
YT Qi, Y Hou, LC Qi
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32723164
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Ultra-Short Circulating Tumor DNA (usctDNA) in Plasma and Saliva of Non-Small Cell Lung Cancer (NSCLC) Patients.

Cancers
F Li, F Wei, WL Huang, CC Lin, L Li, MM Shen, Q Yan, W Liao, D Chia, M Tu, JH Tang, Z Feng, Y Kim, WC Su, DTW Wong
Publication Date: 2020-07-24

Variant appearance in text: EGFR: L858R
PMID: 32722209
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Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology
HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32714871
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Efficacy and Safety of Epidermal Growth Factor Receptor (EGFR) Inhibitors Plus Antiangiogenic Agents as First-Line Treatments for Patients With Advanced EGFR-Mutated Non-small Cell Lung Cancer: A Meta-Analysis.

Frontiers In Oncology
F Chen, N Chen, Y Yu, J Cui
Publication Date: 2020

Variant appearance in text: EGFR: Leu858Arg
PMID: 32714857
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Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing.

Bmc Cancer
Y Zhao, JY He, JZ Cui, ZQ Meng, YL Zou, XS Guo, X Chen, X Wang, LT Yan, WX Han, C Li, L Guo, H Bu
Publication Date: 2020-07-25

Variant appearance in text: EGFR: L858R
PMID: 32711494
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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
W Jin
Publication Date: 2020-07-16

Variant appearance in text: EGFR: L858R
PMID: 32708604
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Rescue of Non-Informative Circulating Tumor DNA to Monitor the Mutational Landscape in NSCLC.

Cancers
S Mayer, G Schmidtke-Schrezenmeier, C Buske, FG Rücker, TFE Barth, P Möller, R Marienfeld
Publication Date: 2020-07-16

Variant appearance in text: EGFR: L858R
PMID: 32708545
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Lymphocyte percentage and platelet count correlate with the treatment outcome to tyrosine kinase inhibitors in epidermal growth factor receptor-mutated lung adenocarcinoma.

Medicine
CC Li, CB Lin, SC Chu, WH Huang, JJ Lee, GG Yang, TF Wang, YF Wu
Publication Date: 2020-07-17

Variant appearance in text: EGFR: L858R
PMID: 32702917
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[Application of Organoids in Lung Cancer Precision Medicine].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Jia, N Liang, S Li
Publication Date: 2020-07-20

Variant appearance in text: EGFR: L858R
PMID: 32702796
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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy
HT Chan, YM Chin, SK Low
Publication Date: 2019-06

Variant appearance in text: EGFR: L858R
PMID: 32700193
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Osimertinib for Previously Treated Patients With Advanced EGFR T790M Mutation-Positive NSCLC: Tolerability and Diagnostic Methods From an Expanded Access Program.

Oncology And Therapy
ES Santos, B Kaplan, E Kirshner, EF Croft, LV Sequist, M Chau, J Munley, GR Oxnard
Publication Date: 2018-06

Variant appearance in text: EGFR: L858R
PMID: 32700141
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Real-World EGFR T790M Testing in Advanced Non-Small-Cell Lung Cancer: A Prospective Observational Study in Japan.

Oncology And Therapy
T Seto, N Nogami, N Yamamoto, S Atagi, N Tashiro, Y Yoshimura, Y Yabuki, H Saka
Publication Date: 2018-12

Variant appearance in text: EGFR: L858R
PMID: 32700028
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Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

Oncology And Therapy
M Sesé, R Somoza, I Maestu, MM Ureste, A Sanchez, JF Cordoba, I Sansano, G Venturas, S Ramón Y Cajal, J Hernández-Losa
Publication Date: 2019-12

Variant appearance in text: EGFR: L858R
PMID: 32699985
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Discrimination of CpG Methylation Status and Nucleotide Differences in Tissue Specimen DNA by Oligoribonucleotide Interference-PCR.

International Journal Of Molecular Sciences
T Shimizu, T Fujita, S Fukushi, Y Horino, H Fujii
Publication Date: 2020-07-20

Variant appearance in text: EGFR: L858R
PMID: 32698480
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Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.

Cell Reports
W Yan, E Markegard, S Dharmaiah, A Urisman, M Drew, D Esposito, K Scheffzek, DV Nissley, F McCormick, DK Simanshu
Publication Date: 2020-07-21

Variant appearance in text: EGFR: L858R
PMID: 32697994
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TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target.

Nature Communications
JJ Yu, DD Zhou, XX Yang, B Cui, FW Tan, J Wang, K Li, S Shang, C Zhang, XX Lv, XW Zhang, SS Liu, JM Yu, F Wang, B Huang, F Hua, ZW Hu
Publication Date: 2020-07-21

Variant appearance in text: EGFR: L858R
PMID: 32694521
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Nivolumab treatment of elderly Japanese patients with non-small cell lung cancer: subanalysis of a real-world retrospective observational study (CA209-9CR).

Esmo Open
K Okishio, R Morita, J Shimizu, H Saito, H Sakai, YH Kim, O Hataji, M Yomota, M Nishio, K Aoe, O Kanai, T Kumagai, K Kibata, H Tsukamoto, S Oizumi, D Fujimoto, H Tanaka, K Mizuno, T Masuda, T Kozuki, T Haku, H Suzuki, I Okamoto, H Hoshiyama, N Yada, Y Ohe
Publication Date: 2020-07

Variant appearance in text: EGFR: L858R
PMID: 32690620
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The prognostic value of a Methylome-based Malignancy Density Scoring System to predict recurrence risk in early-stage Lung Adenocarcinoma.

Theranostics
L Yang, J Zhang, G Yang, H Xu, J Lin, L Shao, J Li, C Guo, Y Du, L Guo, X Li, H Han-Zhang, C Wang, S Chuai, J Ye, Q Kang, H Liu, J Ying, Y Wang
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32685009
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Detection of epidermal growth factor receptor T790M mutation by allele-specific loop mediated isothermal amplification.

Journal Of Carcinogenesis
S Arjuna, G Chakraborty, R Venkataram, PN Dechamma, A Chakraborty
Publication Date: 2020

Variant appearance in text: EGFR: L858R
PMID: 32684851
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A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients.

World Journal Of Surgical Oncology
X Zhang, Y Jiang, H Yu, H Xia, X Wang
Publication Date: 2020-07-16

Variant appearance in text: EGFR: L858R
PMID: 32677962
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000275493.2 c.2573T>G p.Leu858Arg missense_variant 21/28 -
ENST00000442591.1 c.*28+18894T>G - intron_variant - 17/17
ENST00000454757.2 c.2414T>G p.Leu805Arg missense_variant 21/28 -
ENST00000455089.1 c.2438T>G p.Leu813Arg missense_variant 20/26 -
NM_001346897.2 c.2438T>G p.Leu813Arg missense_variant 20/26 -
NM_001346898.2 c.2573T>G p.Leu858Arg missense_variant 21/27 -
NM_001346899.1 c.2438T>G p.Leu813Arg missense_variant 20/27 -
NM_001346900.2 c.2414T>G p.Leu805Arg missense_variant 21/28 -
NM_001346941.2 c.1772T>G p.Leu591Arg missense_variant 15/22 -
NM_005228.5 c.2573T>G p.Leu858Arg missense_variant 21/28 -