EGFR c.2581_2582delinsTA ;(p.L861*)

Variant ID: 7-55259523-CT-TA

NM_005228.3(EGFR):c.2581_2582delinsTA;(p.L861*)

This variant was identified in 44 publications

View GRCh38 version.




Publications:


Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

International Journal Of Molecular Sciences
Pretelli, Giulia G; Spagnolo, Calogera Claudia CC; Ciappina, Giuliana G; Santarpia, Mariacarmela M; Pasello, Giulia G
Publication Date: 2023-05-17

Variant appearance in text: EGFR: L861X
PubMed Link: 37240224
Variant Present in the following documents:
  • Main text
  • ijms-24-08878.pdf
View BVdb publication page



Lung adenocarcinoma promotion by air pollutants.

Nature
Hill, William W; Lim, Emilia L EL; Weeden, Clare E CE; Lee, Claudia C; Augustine, Marcellus M; Chen, Kezhong K; Kuan, Feng-Che FC; Marongiu, Fabio F; Evans, Edward J EJ; Moore, David A DA; Rodrigues, Felipe S FS; Pich, Oriol O; Bakker, Bjorn B; Cha, Hongui H; Myers, Renelle R; van Maldegem, Febe F; Boumelha, Jesse J; Veeriah, Selvaraju S; Rowan, Andrew A; Naceur-Lombardelli, Cristina C; Karasaki, Takahiro T; Sivakumar, Monica M; De, Swapnanil S; Caswell, Deborah R DR; Nagano, Ai A; Black, James R M JRM; Martínez-Ruiz, Carlos C; Ryu, Min Hyung MH; Huff, Ryan D RD; Li, Shijia S; Favé, Marie-Julie MJ; Magness, Alastair A; Suárez-Bonnet, Alejandro A; Priestnall, Simon L SL; Lüchtenborg, Margreet M; Lavelle, Katrina K; Pethick, Joanna J; Hardy, Steven S; McRonald, Fiona E FE; Lin, Meng-Hung MH; Troccoli, Clara I CI; Ghosh, Moumita M; Miller, York E YE; Merrick, Daniel T DT; Keith, Robert L RL; Al Bakir, Maise M; Bailey, Chris C; Hill, Mark S MS; Saal, Lao H LH; Chen, Yilun Y; George, Anthony M AM; Abbosh, Christopher C; Kanu, Nnennaya N; Lee, Se-Hoon SH; McGranahan, Nicholas N; Berg, Christine D CD; Sasieni, Peter P; Houlston, Richard R; Turnbull, Clare C; Lam, Stephen S; Awadalla, Philip P; Grönroos, Eva E; Downward, Julian J; Jacks, Tyler T; Carlsten, Christopher C; Malanchi, Ilaria I; Hackshaw, Allan A; Litchfield, Kevin K; , ; DeGregori, James J; Jamal-Hanjani, Mariam M; Swanton, Charles C
Publication Date: 2023-04

Variant appearance in text: EGFR: L861X
PubMed Link: 37020004
Variant Present in the following documents:
  • EMS173669.pdf
View BVdb publication page



Uncommon EGFR-Mutant NSCLC-One Drug Does Not Fit All.

Jto Clinical And Research Reports
Wang, Yang Y; Arulananda, Surein S
Publication Date: 2023-04

Variant appearance in text: EGFR: L861X
PubMed Link: 36994309
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Osimertinib in NSCLC With Atypical EGFR-Activating Mutations: A Retrospective Multicenter Study.

Jto Clinical And Research Reports
Ji, Jingran J; Aredo, Jacqueline V JV; Piper-Vallillo, Andrew A; Huppert, Laura L; Rotow, Julia K JK; Husain, Hatim H; Stewart, Susan S; Cobb, Rosemary R; Wakelee, Heather A HA; Blakely, Collin M CM; Wong, Melisa L ML; Gubens, Matthew A MA; Madani, Mohammad H MH; Digumarthy, Subba R SR; McCoach, Caroline C; Piotrowska, Zofia Z; Neal, Joel W JW; Riess, Jonathan W JW
Publication Date: 2023-03

Variant appearance in text: EGFR: L861X
PubMed Link: 36879929
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer.

Cancers
Chhouri, Houssein H; Alexandre, David D; Grumolato, Luca L
Publication Date: 2023-01-13

Variant appearance in text: EGFR: L861X
PubMed Link: 36672453
Variant Present in the following documents:
  • Main text
  • cancers-15-00504.pdf
View BVdb publication page



Mutational Analysis of EGFR Mutations in Non-Small Cell Lung Carcinoma-An Indian Perspective of 212 Patients.

International Journal Of Environmental Research And Public Health
Kaler, Amrit Kaur AK; Patel, Khushi K; Patil, Harshali H; Tiwarekar, Yash Y; Kulkarni, Bijal B; Hastak, Meenal M; Athikari, Nivetha N; Rane, Samrudhi S; Nikam, Ankita A; Umarji, Smita S; Shaikh, Imran I; Goyle, Sandeep S; Mistry, Rajesh R
Publication Date: 2022-12-31

Variant appearance in text: EGFR: L861X
PubMed Link: 36613084
Variant Present in the following documents:
  • Main text
  • ijerph-20-00758.pdf
View BVdb publication page



Bronchiolar adenoma/ciliated muconodular papillary tumor mixed with adenocarcinoma in situ in the same tumor.

Thoracic Cancer
Uchiyama, Suiha S; Mizutani, Kenichi K; Suzuki, Eriko E; Yoshii, Naoko N; Watanabe, Takuya T; Tsuchida, Hiroyuki H; Yobita, Shogo S; Iguchi, Kensuke K; Nakamura, Minori M; Endo, Takumi T; Takahashi, Seishiro S; Ogawa, Hiroshi H; Tanahashi, Masayuki M
Publication Date: 2022-12-28

Variant appearance in text: EGFR: L861X
PubMed Link: 36578104
Variant Present in the following documents:
  • Main text
  • TCA-14-427.pdf
View BVdb publication page



Predominance of the Rare EGFR Mutation p.L861Q in Tunisian Patients with Non-Small Cell Lung Carcinoma.

Genes
Abdelmaksoud-Dammak, Rania R; Ammous-Boukhris, Nihel N; Saadallah-Kallel, Amèna A; Charfi, Slim S; Khemiri, Souhir S; Khemakhem, Rim R; Kallel, Nesrin N; Ben Kridis-Rejeb, Wala W; Sallemi-Boudawara, Tahya T; Khanfir, Afef A; Yangui, Ilhem I; Daoud, Jamel J; Mokdad-Gargouri, Raja R
Publication Date: 2022-08-22

Variant appearance in text: EGFR: L861X
PubMed Link: 36011410
Variant Present in the following documents:
  • Main text
  • genes-13-01499.pdf
View BVdb publication page



Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18-18 and EGFR amplification: A case report.

Frontiers In Oncology
Wang, Pascal P; Fabre, Emmanuelle E; Martin, Antoine A; Chouahnia, Kader K; Benabadji, Ambre A; Matton, Lise L; Duchemann, Boris B
Publication Date: 2022

Variant appearance in text: EGFR: L861X
PubMed Link: 35957870
Variant Present in the following documents:
  • Main text
  • fonc-12-918855.pdf
View BVdb publication page



Dacomitinib for Advanced Non-small Cell Lung Cancer Patients Harboring Major Uncommon EGFR Alterations: A Dual-Center, Single-Arm, Ambispective Cohort Study in China.

Frontiers In Pharmacology
Li, Hong-Shuai HS; Yang, Guang-Jian GJ; Cai, Yi Y; Li, Jun-Ling JL; Xu, Hai-Yan HY; Zhang, Tao T; Zhou, Li-Qiang LQ; Wang, Yu-Ying YY; Wang, Jin-Liang JL; Hu, Xing-Sheng XS; Yan, Xiang X; Wang, Yan Y
Publication Date: 2022

Variant appearance in text: EGFR: L861X
PubMed Link: 35770100
Variant Present in the following documents:
  • Main text
  • fphar-13-919652.pdf
View BVdb publication page



Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China.

Genes And Environment : The Official Journal Of The Japanese Environmental Mutagen Society
Wang, Jun-Ling JL; Fu, Yu-Dong YD; Gao, Yan-Hong YH; Li, Xiu-Ping XP; Xiong, Qian Q; Li, Rui R; Hou, Bo B; Huang, Ruo-Shan RS; Wang, Jun-Feng JF; Zhang, Jian-Kun JK; Lv, Jia-Ling JL; Zhang, Chao C; Li, Hong-Wei HW
Publication Date: 2022-05-23

Variant appearance in text: EGFR: L861X
PubMed Link: 35606799
Variant Present in the following documents:
  • Main text
  • 41021_2022_Article_248.pdf
View BVdb publication page



Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT).

Therapeutic Advances In Medical Oncology
Addeo, Alfredo A; Hochmair, Maximilian M; Janzic, Urska U; Dudnik, Elizabeth E; Charpidou, Andriani A; Płużański, Adam A; Ciuleanu, Tudor T; Donev, Ivan Shterev IS; Elbaz, Judith J; Aarøe, Jørgen J; Ott, René R; Peled, Nir N
Publication Date: 2021

Variant appearance in text: EGFR: L861X
PubMed Link: 35173817
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359211059874.pdf
View BVdb publication page



Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine
Duffy, Michael J MJ; Crown, John J
Publication Date: 2022-01-13

Variant appearance in text: EGFR: L861X
PubMed Link: 35055414
Variant Present in the following documents:
  • Main text
  • jpm-12-00099.pdf
View BVdb publication page



Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine
Duffy, Michael J MJ; Crown, John J
Publication Date: 2022-01-13

Variant appearance in text: EGFR: L861X
PubMed Link: 35055414
Variant Present in the following documents:
  • Main text
  • jpm-12-00099.pdf
View BVdb publication page



Phase 1b Open-Label Trial of Afatinib Plus Xentuzumab (BI 836845) in Patients With EGFR Mutation-Positive NSCLC After Progression on EGFR Tyrosine Kinase Inhibitors.

Jto Clinical And Research Reports
Park, Keunchil K; Tan, Daniel Shao Weng DSW; Su, Wu-Chou WC; Cho, Byoung Chul BC; Kim, Sang-We SW; Lee, Ki Hyeong KH; Wang, Chin-Chou CC; Seto, Takashi T; Huang, Dennis Chin-Lun DC; Jung, Helen Hayoun HH; Hsu, Ming-Chi MC; Bogenrieder, Thomas T; Lin, Chia-Chi CC
Publication Date: 2021-09

Variant appearance in text: EGFR: L861X
PubMed Link: 34590052
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR-Mutated Non-Small Cell Lung Cancer.

Cancer Discovery
Jänne, Pasi A PA; Baik, Christina C; Su, Wu-Chou WC; Johnson, Melissa L ML; Hayashi, Hidetoshi H; Nishio, Makoto M; Kim, Dong-Wan DW; Koczywas, Marianna M; Gold, Kathryn A KA; Steuer, Conor E CE; Murakami, Haruyasu H; Yang, James Chih-Hsin JC; Kim, Sang-We SW; Vigliotti, Michele M; Shi, Rong R; Qi, Zhenhao Z; Qiu, Yang Y; Zhao, Lihui L; Sternberg, David D; Yu, Channing C; Yu, Helena A HA
Publication Date: 2022-01

Variant appearance in text: EGFR: L861X
PubMed Link: 34548309
Variant Present in the following documents:
  • Main text
  • 74.pdf
View BVdb publication page



A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers
Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC
Publication Date: 2021-07-20

Variant appearance in text: EGFR: L861X
PubMed Link: 34298851
Variant Present in the following documents:
  • Main text
  • cancers-13-03641.pdf
View BVdb publication page



Sensitivity, specificity, and accuracy of a liquid biopsy approach utilizing molecular amplification pools.

Scientific Reports
Garcia, Jessica J; Kamps-Hughes, Nick N; Geiguer, Florence F; Couraud, Sébastien S; Sarver, Brice B; Payen, Léa L; Ionescu-Zanetti, Cristian C
Publication Date: 2021-05-24

Variant appearance in text: EGFR: L861X
PubMed Link: 34031447
Variant Present in the following documents:
  • Main text
View BVdb publication page



Unique Profile of Driver Gene Mutations in Patients With Non-Small-Cell Lung Cancer in Qujing City, Yunnan Province, Southwest China.

Frontiers In Oncology
Zhou, Yongchun Y; Ge, Feng F; Du, Yaxi Y; Li, Quan Q; Cai, Jingjing J; Liu, Xin X; Guo, Yinjin Y; Shen, Zhenghai Z; Duan, Lincan L; Huang, Zhan Z; Yao, Fei F; Zhu, Changbin C; Shi, Hutao H; Huang, Yunchao Y
Publication Date: 2021

Variant appearance in text: EGFR: L861X
PubMed Link: 33928034
Variant Present in the following documents:
  • Main text
View BVdb publication page



Development of EGFR TKIs and Options to Manage Resistance of Third-Generation EGFR TKI Osimertinib: Conventional Ways and Immune Checkpoint Inhibitors.

Frontiers In Oncology
Wu, Leilei L; Ke, Linping L; Zhang, Zhenshan Z; Yu, Jinming J; Meng, Xue X
Publication Date: 2020

Variant appearance in text: EGFR: L861X
PubMed Link: 33392095
Variant Present in the following documents:
  • Main text
View BVdb publication page



Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer.

The Cochrane Database Of Systematic Reviews
Ferrara, Roberto R; Imbimbo, Martina M; Malouf, Reem R; Paget-Bailly, Sophie S; Calais, François F; Marchal, Corynne C; Westeel, Virginie V
Publication Date: 2020-12-14

Variant appearance in text: EGFR: L861X
PubMed Link: 33316104
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic characteristics of driver genes in Chinese patients with non-small cell lung cancer.

Thoracic Cancer
Si, Xiaoyan X; Pan, Ruili R; Ma, Shaohua S; Li, Lin L; Liang, Li L; Zhang, Ping P; Chu, Yuping Y; Wang, Hanping H; Wang, Mengzhao M; Zhang, Xiaotong X; Zhang, Li L
Publication Date: 2021-02

Variant appearance in text: EGFR: L861X
PubMed Link: 33300283
Variant Present in the following documents:
  • Main text
  • TCA-12-357.pdf
View BVdb publication page



2020 Innovation-Based Optimism for Lung Cancer Outcomes.

The Oncologist
Schenk, Erin L EL; Patil, Tejas T; Pacheco, Jose J; Bunn, Paul A PA
Publication Date: 2021-03

Variant appearance in text: EGFR: L861X
PubMed Link: 33179378
Variant Present in the following documents:
  • Main text
View BVdb publication page



An Observational Study of Acquired EGFR T790M-Dependent Resistance to EGFR-TKI Treatment in Lung Adenocarcinoma Patients in Taiwan.

Frontiers In Oncology
Wu, Shang-Gin SG; Chiang, Chi-Lu CL; Liu, Chien-Ying CY; Wang, Chin-Chou CC; Su, Po-Lan PL; Hsia, Te-Chun TC; Shih, Jin-Yuan JY; Chang, Gee-Chen GC
Publication Date: 2020

Variant appearance in text: EGFR: L861X
PubMed Link: 33014788
Variant Present in the following documents:
  • Main text
  • fonc-10-01481.pdf
View BVdb publication page



Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations.

Journal Of Thoracic Disease
Kang, Hye Seon HS; Shin, Ah Young AY; Yeo, Chang Dong CD; Park, Chan Kwon CK; Kim, Ju Sang JS; Kim, Jin Woo JW; Kim, Seung Joon SJ; Lee, Sang Haak SH; Kim, Sung Kyoung SK
Publication Date: 2020-05

Variant appearance in text: EGFR: L861X
PubMed Link: 32642093
Variant Present in the following documents:
  • Main text
  • jtd-12-05-1895.pdf
View BVdb publication page



High MAF of EGFR mutations and high ratio of T790M sensitizing mutations in ctDNA predict better third-generation TKI outcomes.

Thoracic Cancer
Li, Yan Y; Zhang, Fanshuang F; Yuan, Pei P; Guo, Lei L; Jianming, Ying Y; He, Jie J
Publication Date: 2020-06

Variant appearance in text: EGFR: L861X
PubMed Link: 32285618
Variant Present in the following documents:
  • Main text
  • TCA-11-1503.pdf
View BVdb publication page



Current Approaches in NSCLC Targeting K-RAS and EGFR.

International Journal Of Molecular Sciences
Aran, Veronica V; Omerovic, Jasminka J
Publication Date: 2019-11-14

Variant appearance in text: EGFR: L861X
PubMed Link: 31739412
Variant Present in the following documents:
  • ijms-20-05701.pdf
View BVdb publication page



Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC).

Lung Cancer (Amsterdam, Netherlands)
Gelatti, Ana C Z ACZ; Drilon, Alexander A; Santini, Fernando C FC
Publication Date: 2019-11

Variant appearance in text: EGFR: L861X
PubMed Link: 31568888
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations.

Molecular Cancer
Lin, Anqi A; Wei, Ting T; Meng, Hui H; Luo, Peng P; Zhang, Jian J
Publication Date: 2019-09-16

Variant appearance in text: EGFR: L861X
PubMed Link: 31526368
Variant Present in the following documents:
  • Main text
  • 12943_2019_Article_1062.pdf
View BVdb publication page



The in cis compound EGFR mutations in Chinese advanced non-small cell lung cancer patients.

Cancer Biology & Therapy
Li, Min M; Zhou, Cheng-Zhi CZ; Yang, Jin-Ji JJ; Lu, Shun S; Zheng, Di D; Hu, Jie J; Zeng, Hui H; Lu, You Y; Lu, Kai-Hua KH; Li, Shu-Ang SA; Mao, Xin-Ru XR; Han-Zhang, Han H; Lizaso, Analyn A; Ye, Jun-Yi JY; Hu, Cheng-Ping CP
Publication Date: 2019

Variant appearance in text: EGFR: L861X
PubMed Link: 30990107
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer.

The Oncologist
Wen, Shiwang S; Dai, Lei L; Wang, Lei L; Wang, Wenjian W; Wu, Duoguang D; Wang, Kefeng K; He, Zhanghai Z; Wang, Aodi A; Chen, Hui H; Zhang, Peng P; Dong, Xiaowei X; Dong, Yu-An YA; Wang, Kai K; Yao, Ming M; Wang, Minghui M
Publication Date: 2019-11

Variant appearance in text: EGFR: L861X
PubMed Link: 30902917
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling.

Oncotarget
Zamani, Ali A; Fan, Huahao H; Luo, Guangxiang G
Publication Date: 2017-11-10

Variant appearance in text: EGFR: L861X
PubMed Link: 29221196
Variant Present in the following documents:
  • oncotarget-08-96171-s017.pdf
View BVdb publication page



The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma.

Plos One
de Biase, Dario D; Genestreti, Giovenzio G; Visani, Michela M; Acquaviva, Giorgia G; Di Battista, Monica M; Cavallo, Giovanna G; Paccapelo, Alexandro A; Cancellieri, Alessandra A; Trisolini, Rocco R; Degli Esposti, Roberta R; Bartolini, Stefania S; Pession, Annalisa A; Tallini, Giovanni G; Brandes, Alba A AA
Publication Date: 2017

Variant appearance in text: EGFR: L861X
PubMed Link: 28520821
Variant Present in the following documents:
  • Main text
  • pone.0177822.pdf
View BVdb publication page



Therapeutic value of EGFR inhibition in CRC and NSCLC: 15 years of clinical evidence.

Esmo Open
Troiani, Teresa T; Napolitano, Stefania S; Della Corte, Carminia Maria CM; Martini, Giulia G; Martinelli, Erika E; Morgillo, Floriana F; Ciardiello, Fortunato F
Publication Date: 2016

Variant appearance in text: EGFR: L861X
PubMed Link: 27843640
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer.

Oncotargets And Therapy
Wu, Jenn-Yu JY; Shih, Jin-Yuan JY
Publication Date: 2016

Variant appearance in text: EGFR: L861X
PubMed Link: 27785061
Variant Present in the following documents:
  • Main text
  • ott-9-6137.pdf
View BVdb publication page



The epidermal growth factor receptor (EGRF) in lung cancer.

Translational Respiratory Medicine
Carcereny, Enric E; Morán, Teresa T; Capdevila, Laia L; Cros, Sara S; Vilà, Laia L; de Los Llanos Gil, Maria M; Remón, Jordi J; Rosell, Rafael R
Publication Date: 2015

Variant appearance in text: EGFR: L861X
PubMed Link: 25810955
Variant Present in the following documents:
  • Main text
  • 40247_2015_Article_13.pdf
View BVdb publication page



Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations-a review.

Translational Lung Cancer Research
Stewart, Erin L EL; Tan, Samuel Zhixing SZ; Liu, Geoffrey G; Tsao, Ming-Sound MS
Publication Date: 2015-02

Variant appearance in text: EGFR: L861X
PubMed Link: 25806347
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives.

Oncotargets And Therapy
Cheng, Xinghua X; Chen, Haiquan H
Publication Date: 2014

Variant appearance in text: EGFR: L861X
PubMed Link: 25285017
Variant Present in the following documents:
  • Main text
  • ott-7-1689.pdf
View BVdb publication page