Publications:

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Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management.

Diagnostics (Basel, Switzerland)

J Wehrle, U Philipp, M Jolic, M Follo, S Hussung, S Waldeck, M Deuter, M Rassner, J Braune, J Rawluk, C Greil, CF Waller, H Becker, J Duque-Afonso, AL Illert, RM Fritsch, F Meiss, J Duyster, N von Bubnoff, F Scherer

Publication Date: 2020-08-02

Variant appearance in text: EGFR: L861Q

PMID: 32748806

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Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer

D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing

Publication Date: 2020-07-30

Variant appearance in text: EGFR: L861Q

PMID: 32729257

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Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology

HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32714871

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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine

W Jin

Publication Date: 2020-07-16

Variant appearance in text: EGFR: L861Q

PMID: 32708604

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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy

HT Chan, YM Chin, SK Low

Publication Date: 2019-06

Variant appearance in text: EGFR: L861Q

PMID: 32700193

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Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

Oncology And Therapy

M Sesé, R Somoza, I Maestu, MM Ureste, A Sanchez, JF Cordoba, I Sansano, G Venturas, S Ramón Y Cajal, J Hernández-Losa

Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q

PMID: 32699985

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Discrimination of CpG Methylation Status and Nucleotide Differences in Tissue Specimen DNA by Oligoribonucleotide Interference-PCR.

International Journal Of Molecular Sciences

T Shimizu, T Fujita, S Fukushi, Y Horino, H Fujii

Publication Date: 2020-07-20

Variant appearance in text: EGFR: L861Q

PMID: 32698480

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A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients.

World Journal Of Surgical Oncology

X Zhang, Y Jiang, H Yu, H Xia, X Wang

Publication Date: 2020-07-16

Variant appearance in text: EGFR: L861Q

PMID: 32677962

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Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand.

Bmc Cancer

PS Aye, S Tin Tin, MJ McKeage, P Khwaounjoo, A Cavadino, JM Elwood

Publication Date: 2020-07-14

Variant appearance in text: EGFR: L861Q

PMID: 32664868

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Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors.

Journal Of Thoracic Disease

JA Chen, JW Riess

Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q

PMID: 32642199

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Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations.

Journal Of Thoracic Disease

HS Kang, AY Shin, CD Yeo, CK Park, JS Kim, JW Kim, SJ Kim, SH Lee, SK Kim

Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q

PMID: 32642093

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Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines.

International Journal Of Molecular Sciences

V Sarne, S Huter, S Braunmueller, L Rakob, N Jacobi, M Kitzwögerer, C Wiesner, P Obrist, R Seeboeck

Publication Date: 2020-06-28

Variant appearance in text: EGFR: L861Q

PMID: 32605217

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Genetic Markers in Lung Cancer Diagnosis: A Review.

International Journal Of Molecular Sciences

K Wadowska, I Bil-Lula, Ł Trembecki, M Śliwińska-Mossoń

Publication Date: 2020-06-27

Variant appearance in text: EGFR: L861Q

PMID: 32604993

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Liquid biopsy mutation panel for non-small cell lung cancer: analytical validation and clinical concordance.

Npj Precision Oncology

LS Schwartzberg, H Horinouchi, D Chan, S Chernilo, ML Tsai, D Isla, C Escriu, JP Bennett, K Clark-Langone, C Svedman, P Tomasini,

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32596507

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Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene.

Scientific Reports

Z Qiu, B Ye, K Wang, P Zhou, S Zhao, W Li, P Tian

Publication Date: 2020-06-25

Variant appearance in text: EGFR: L861Q

PMID: 32587276

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A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib combined with moxifloxacin.

Bmc Pulmonary Medicine

S Bian, X Tang, W Lei

Publication Date: 2020-06-24

Variant appearance in text: EGFR: L861Q

PMID: 32580784

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Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings.

Journal Of Oncology Pharmacy Practice : Official Publication Of The International Society Of Oncology Pharmacy Practitioners

RD Harvey, VR Adams, T Beardslee, P Medina

Publication Date: 2020-06-20

Variant appearance in text: EGFR: L861Q

PMID: 32567494

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Application of immune checkpoint inhibitors in EGFR-mutant non-small-cell lung cancer: from bed to bench.

Therapeutic Advances In Medical Oncology

R Jin, J Zhao, L Xia, Q Li, W Li, L Peng, Y Xia

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32565926

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Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment.

Cancers

J Li, HF Kwok

Publication Date: 2020-06-15

Variant appearance in text: EGFR: L861Q

PMID: 32549388

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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies.

Journal Of Clinical Medicine

S Rajurkar, I Mambetsariev, R Pharaon, B Leach, T Tan, P Kulkarni, R Salgia

Publication Date: 2020-06-15

Variant appearance in text: EGFR: L861Q

PMID: 32549358

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The role of EGFR mutations in predicting recurrence in early and locally advanced lung adenocarcinoma following definitive therapy.

Oncotarget

C Galvez, S Jacob, BS Finkelman, J Zhao, K Tegtmeyer, YK Chae, N Mohindra, R Salgia, B Jovanovic, A Behdad, V Villaflor

Publication Date: 2020-05-26

Variant appearance in text: EGFR: L861Q

PMID: 32523650

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Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.

Ebiomedicine

M de Wit, Y Gao, D Mercieca, I de Heer, B Valkenburg, ME van Royen, J Aerts, P Sillevis Smitt, P French

Publication Date: 2020-06-04

Variant appearance in text: EGFR: L861Q

PMID: 32512509

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EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports

G Calibasi-Kocal, A Amirfallah, T Sever, O Umit Unal, D Gurel, I Oztop, H Ellidokuz, Y Basbinar

Publication Date: 2020-08

Variant appearance in text: EGFR: Leu861Gln

PMID: 32509305

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Association of CD8 T cell apoptosis and EGFR mutation in non-small lung cancer patients.

Thoracic Cancer

C Zhao, C Su, X Li, C Zhou

Publication Date: 2020-06-04

Variant appearance in text: EGFR: L861Q

PMID: 32500560

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Glasgow prognostic score predicts efficacy and prognosis in patients with advanced non-small cell lung cancer receiving EGFR-TKI treatment.

Thoracic Cancer

N Kasahara, H Imai, I Naruse, Y Tsukagoshi, M Kotake, N Sunaga, K Kaira, T Maeno, T Asao, T Hisada

Publication Date: 2020-06-03

Variant appearance in text: EGFR: L861Q

PMID: 32495520

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Successful treatment of a patient with NSCLC carrying uncommon compound EGFR G719X and S768I mutations using osimertinib: A case report.

The Journal Of International Medical Research

Y Cai, Y Wang, J Sun, X Wang, Y Xu, C Sun, Y Guo, M Sun, K Ma

Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q

PMID: 32493093

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Canadian consensus: a new systemic treatment algorithm for advanced EGFR-mutated non-small-cell lung cancer.

Current Oncology (Toronto, Ont.)

B Melosky, S Banerji, N Blais, Q Chu, R Juergens, NB Leighl, G Liu, P Cheema

Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q

PMID: 32489263

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The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).

Cancers

PC Hsu, CT Yang, DM Jablons, L You

Publication Date: 2020-05-26

Variant appearance in text: EGFR: L861Q

PMID: 32466572

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Current status and future perspectives of liquid biopsy in non-small cell lung cancer.

Journal Of Pathology And Translational Medicine

S Chang, JY Hur, YL Choi, CH Lee, WS Kim

Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q

PMID: 32460474

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Emerging therapeutic agents for advanced non-small cell lung cancer.

Journal Of Hematology & Oncology

R Chen, R Manochakian, L James, AG Azzouqa, H Shi, Y Zhang, Y Zhao, K Zhou, Y Lou

Publication Date: 2020-05-24

Variant appearance in text: EGFR: Leu861Gln

PMID: 32448366

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Analysis of lung biopsies using the 2015 WHO criteria and detection of sensitizing mutations--a single-institution experience of 5032 cases.

Diagnostic Pathology

Y Zeng, Y Zhu, Y Ding, L Xu, B Zhai, X Zhang, Q Ge, J Li, Q Song, X Li, Z Zhang

Publication Date: 2020-05-19

Variant appearance in text: EGFR: L861Q

PMID: 32429938

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Hormone receptor expression correlates with EGFR gene mutation in lung cancer in patients with simultaneous primary breast cancer.

Translational Lung Cancer Research

Z Hu, X Zou, S Qin, Y Li, H Wang, H Yu, S Sun, X Wu, J Wang, J Chang

Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q

PMID: 32420072

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EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib.

Translational Lung Cancer Research

A Buder, MJ Hochmair, U Setinek, R Pirker, M Filipits

Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q

PMID: 32420063

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Variability of EGFR exon 20 insertions in 24,468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors.

Molecular Oncology

Y Qin, H Jian, X Tong, X Wu, F Wang, YW Shao, X Zhao

Publication Date: 2020-05-15

Variant appearance in text: EGFR: L861Q

PMID: 32412152

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Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

Oncology Letters

T Yamaura, S Muto, H Mine, H Takagi, M Watanabe, Y Ozaki, T Inoue, M Fukuhara, N Okabe, Y Matsumura, T Hasegawa, J Osugi, M Hoshino, M Higuchi, Y Shio, H Suzuki

Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q

PMID: 32391110

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A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC.

Theranostics

M Lim, J Park, AC Lowe, HO Jeong, S Lee, HC Park, K Lee, GH Kim, MH Kim, YK Cho

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32373206

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Targeted RNA sequencing with touch imprint cytology samples for non-small cell lung cancer patients.

Thoracic Cancer

K Seto, K Masago, S Fujita, M Haneda, Y Horio, T Hida, H Kuroda, W Hosoda, KI Okubo

Publication Date: 2020-05-05

Variant appearance in text: EGFR: L861Q

PMID: 32372482

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The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review.

Cancers

F van Delft, H Koffijberg, V Retèl, MVD Heuvel, M IJzerman

Publication Date: 2020-04-30

Variant appearance in text: EGFR: L861Q

PMID: 32365836

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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer

PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara

Publication Date: 2020-05-04

Variant appearance in text: EGFR: L861Q

PMID: 32365229

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Long-term Survival With Afatinib in a Patient With Lung Adenocarcinoma Harboring Double Uncommon EGFR L861Q and G719X Mutations.

In Vivo (Athens, Greece)

G Ohara, S Okauchi, Y Sasatani, T Shiozawa, H Yamada, K Miyazaki, H Satoh

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32354946

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Comparison of the characteristics of uncommon epidermal growth factor receptor (EGFR) mutations and EGFR-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer from different ethnic groups.

Experimental And Therapeutic Medicine

Q Zhang, Y Cui, J Zhang, J Kenjiabieke, P Aerxiding

Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q

PMID: 32346412

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[Analysis of Clinical Characteristics and Driver Genes in 405 Patients with Lung Cancer Complicated with Tuberculosis].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Y Hu, X Yang, L Nie, D Zhao, J An, B Li

Publication Date: 2020-04-27

Variant appearance in text: EGFR: L861Q

PMID: 32336065

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Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France).

Cancers

S Lassalle, V Hofman, S Heeke, J Benzaquen, E Long, M Poudenx, E Lantéri, J Boutros, V Tanga, K Zahaf, S Lalvée, V Lespinet, O Bordone, JM Félix, C Bonnetaud, C Marquette, M Ilie, P Hofman

Publication Date: 2020-04-13

Variant appearance in text: EGFR: L861Q

PMID: 32294880

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Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

Journal Of Thoracic Disease

H Li, J Wang, G Zhang, Y Li, L Lin, H Yang, J Zhou, L Zhang, D Lv

Publication Date: 2020-03

Variant appearance in text: EGFR: L861Q

PMID: 32274120

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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters

X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang

Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q

PMID: 32269623

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Complete Remission of Multiple Brain Metastases in a Patient with EGFR-Mutated Non-Small-Cell Lung Cancer Treated with First-Line Osimertinib without Radiotherapy.

Case Reports In Oncological Medicine

K Ameku, M Higa

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32257480

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Evaluation of Two EGFR Mutation Tests on Tumor and Plasma from Patients with Non-Small Cell Lung Cancer.

Cancers

JO Kim, JY Shin, SR Kim, KS Shin, J Kim, MY Kim, MR Lee, Y Kim, M Kim, SH Hong, JH Kang

Publication Date: 2020-03-26

Variant appearance in text: EGFR: L861Q

PMID: 32224854

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Biopsy on progression in patients with EGFR mutation-positive advanced non-small-cell lung cancer-a Canadian experience.

Current Oncology (Toronto, Ont.)

Q Chu, A Agha, N Devost, RN Walton, S Ghosh, C Ho

Publication Date: 2020-02

Variant appearance in text: EGFR: L861Q

PMID: 32218657

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Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer.

Translational Lung Cancer Research

C Zhu, W Zhuang, L Chen, W Yang, WB Ou

Publication Date: 2020-02

Variant appearance in text: EGFR: L861Q

PMID: 32206559

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Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non-Small Cell Lung Cancer: A Health Technology Assessment.

Ontario Health Technology Assessment Series

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32206157

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Clinicopathological parameters for circulating tumor DNA shedding in surgically resected non-small cell lung cancer with EGFR or KRAS mutation.

Plos One

MS Cho, CH Park, S Lee, HS Park

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32196518

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Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations.

Frontiers In Oncology

C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li, R Liu, L Xiang, C Huang, R Jiang

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32195178

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HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant.

Cell & Bioscience

N Sueangoen, A Tantiwetrueangdet, R Panvichian

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32190291

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Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge.

Practical Laboratory Medicine

MR Al-Turkmani, MA Suriawinata, SJ Deharvengt, DC Green, CC Black, K Shirai, KH Dragnev, GJ Tsongalis

Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q

PMID: 32181314

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The Correlation between EGFR Mutation Status and DNA Content of Lung Adenocarcinoma Cells in Pleural Effusion.

Journal Of Cancer

Y Du, X Guo, R Wang, Y Ma, Y Zhang, Y Liu, L Dong, J Wu, X Ji, H Wang

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32127953

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The associations among quantitative spectral CT parameters, Ki-67 expression levels and EGFR mutation status in NSCLC.

Scientific Reports

L Lin, J Cheng, D Tang, Y Zhang, F Zhang, J Xu, H Jiang, H Wu

Publication Date: 2020-02-26

Variant appearance in text: EGFR: L861Q

PMID: 32103127

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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports

Y Hirotsu, S Otake, H Ohyama, K Amemiya, R Higuchi, T Oyama, H Mochizuki, T Goto, M Omata

Publication Date: 2020-02-25

Variant appearance in text: EGFR: L861Q

PMID: 32099048

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[Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

W Zhou, W Zhang, B Han

Publication Date: 2020-02-20

Variant appearance in text: EGFR: L861Q

PMID: 32093456

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[Clinical Value of Droplet Digital PCR and Super-ARMS Detection of Epidermal Growth Factor Receptor Gene Mutation in Plasma Circulating Tumor DNA of Patients with Advanced Lung Adenocarcinoma].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Z Cao, J Wang, N Qin, K Li, J Lv, J Wang, X Yang, X Li, H Zhang, Q Zhang, H Long, C Shu, L Ma, S Zhang

Publication Date: 2020-02-20

Variant appearance in text: EGFR: L861Q

PMID: 32093452

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The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma.

Biomedicines

PC Hsu, CW Wang, SC Kuo, SM Lin, YL Lo, AC Huang, LC Chiu, CT Yang

Publication Date: 2020-02-19

Variant appearance in text: EGFR: L861Q

PMID: 32092879

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Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)

H Liu, B Zhang, Z Sun

Publication Date: 2020-02-18

Variant appearance in text: EGFR: L861Q

PMID: 32067422

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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput

A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi

Publication Date: 2020-02-11

Variant appearance in text: EGFR: L861Q

PMID: 32054005

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Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

Plos One

HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi, S Park, YJ Ryu, JH Lee, JH Chang

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 32053675

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Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study.

Bmc Cancer

M Kogo, D Fujimoto, K Hosoya, K Nagata, A Nakagawa, R Tachikawa, D Yamashita, Y Kitamura, Y Imai, K Tomii

Publication Date: 2020-02-06

Variant appearance in text: EGFR: L861Q

PMID: 32028905

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The growth of non-solid neoplastic lung nodules is associated with low PD L1 expression, irrespective of sampling technique.

Journal Of Translational Medicine

C Bortolotto, C Maglia, A Ciuffreda, M Coretti, R Catania, F Antonacci, S Carnevale, I Sarotto, R Dore, AR Filippi, G Chiara, D Regge, L Preda, P Morbini, GM Stella

Publication Date: 2020-02-03

Variant appearance in text: EGFR: L861Q

PMID: 32013991

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Extracellular vesicle-based EGFR genotyping in bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients.

Translational Lung Cancer Research

JY Hur, JS Lee, IA Kim, HJ Kim, WS Kim, KY Lee

Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q

PMID: 32010582

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Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers.

Translational Lung Cancer Research

J Ni, T Guo, Y Li, X Yang, Y Li, L Zou, L Chu, X Chu, S Li, L Ye, Y Zhang, Z Zhu

Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q

PMID: 32010575

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Genetic alteration profile of EGFR-mutant resected IIB-IIIA stage NSCLC and correlation to clinical outcomes.

Translational Lung Cancer Research

Q Deng, Y Qiu, J Jia, H Tang, L Liu, L Huang, D He, X Dong, H Yang

Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q

PMID: 32010562

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Poor Prognosis With Coexistence Of EGFR T790M Mutation And Common EGFR-Activating Mutation In Non- Small Cell Lung Cancer.

Cancer Management And Research

X Gao, Y Zhao, Y Bao, W Yin, L Liu, R Liu, Z Yu, X Zhou, J Shuai

Publication Date: 2019

Variant appearance in text: EGFR: L861Q

PMID: 32009817

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Detection of plasma EGFR mutations for personalized treatment of lung cancer patients without pathologic diagnosis.

Cancer Medicine

Q Deng, Q Fang, H Sun, AP Singh, M Alexander, S Li, H Cheng, S Zhou

Publication Date: 2020-01-28

Variant appearance in text: EGFR: L861Q

PMID: 31991049

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New data highlighting the efficacy and safety outcomes of third-generation EGFR-TKI in NSCLC patients with rare EGFR mutations.

Thoracic Cancer

W Zhang, F Li, W Gao

Publication Date: 2020-01-28

Variant appearance in text: EGFR: Leu861Gln

PMID: 31989783

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Accuracy and clinical influence of plasma EGFR mutation detection in management of advanced lung adenocarcinoma.

International Journal Of Clinical And Experimental Pathology

M Ma, C Shi, J Qian, B Han

Publication Date: 2017

Variant appearance in text: EGFR: L861Q

PMID: 31966832

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Clinical and pathological findings of surgically resected patients for lung adenocarcinomas harboring uncommon EGFR mutations.

International Journal Of Clinical And Experimental Pathology

S Yang, Z Jiang, H Lu

Publication Date: 2017

Variant appearance in text: EGFR: L861Q

PMID: 31966607

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Comparison of clinicopathologic characteristics between patients with EGFR exon 19 deletion and EGFR L858R mutation in lung cancer.

International Journal Of Clinical And Experimental Pathology

Z Chen, J Zhang, K Huang, Q Shen, X Teng

Publication Date: 2018

Variant appearance in text: EGFR: L861Q

PMID: 31949864

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Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer.

International Journal Of Clinical And Experimental Pathology

Z Zhang, S Zhou

Publication Date: 2018

Variant appearance in text: EGFR: L861Q

PMID: 31949733

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Abivertinib in patients with T790M-positive advanced NSCLC and its subsequent treatment with osimertinib.

Thoracic Cancer

H Wang, R Pan, X Zhang, X Si, M Wang, L Zhang

Publication Date: 2020-01-14

Variant appearance in text: EGFR: L861Q

PMID: 31943845

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Impact of age on EGFR mutations in never-smoking female lung adenocarcinoma patients with malignant pleural effusion.

International Journal Of Clinical And Experimental Pathology

Q Wu, M Chu, J Hu, Z Zhang, W Yi, X Ma

Publication Date: 2018

Variant appearance in text: EGFR: L861Q

PMID: 31938400

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High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.

International Journal Of Clinical And Experimental Pathology

F Su, Y Fu, Q Wu, K Zheng, Y Tang, X Su, Y Wang, L Jiang

Publication Date: 2018

Variant appearance in text: EGFR: L861Q

PMID: 31938383

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Identification of EGFR mutations in cytological specimens of non-small cell lung carcinoma from a single institute.

International Journal Of Clinical And Experimental Pathology

W Wang, Y Tang, J Li, Y Zhang, Y Zou, X Su

Publication Date: 2018

Variant appearance in text: EGFR: L861Q

PMID: 31938186

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

X Dong, D Huang, X Yi, S Zhang, Z Wang, B Yan, P Chung Sham, K Chen, M Jun Li

Publication Date: 2020-01-07

Variant appearance in text: EGFR: L861Q

PMID: 31925297

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T790M mutations identified by circulating tumor DNA test in lung adenocarcinoma patients who progressed on first-line epidermal growth factor receptor-tyrosine kinase inhibitors.

Lung India : Official Organ Of Indian Chest Society

V Merinda, G Soegiarto, L Wulandari

Publication Date: 2020

Variant appearance in text: EGFR: L861Q

PMID: 31898615

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Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.

Scientific Reports

SY Kim, JY Lee, DH Kim, H- Joo, MR Yun, D Jung, J Yun, SG Heo, B- Ahn, CW Park, KH Pyo, YJ Chun, MH Hong, HR Kim, BC Cho

Publication Date: 2019-12-27

Variant appearance in text: EGFR: L861Q

PMID: 31882684

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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One

E Papadopoulou, N Tsoulos, K Tsantikidi, V Metaxa-Mariatou, PE Stamou, A Kladi-Skandali, E Kapeni, G Tsaousis, G Pentheroudakis, D Petrakis, DI Lampropoulou, G Aravantinos, I Varthalitis, G Kesisis, I Boukovinas, P Papakotoulas, N Katirtzoglou, E Athanasiadis, F Stavridi, C Christodoulou, A Koumarianou, Y Eralp, G Nasioulas

Publication Date: 2019

Variant appearance in text: EGFR: L861Q

PMID: 31860648

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Clinicopathologic Characteristics, Treatment Outcomes, and Acquired Resistance Patterns of Atypical EGFR Mutations and HER2 Alterations in Stage IV Non-Small-Cell Lung Cancer.

Clinical Lung Cancer

T Patil, R Mushtaq, S Marsh, C Azelby, M Pujara, KD Davies, DL Aisner, WT Purcell, EL Schenk, JM Pacheco, PA Bunn, DR Camidge, RC Doebele

Publication Date: 2019-11-21

Variant appearance in text: EGFR: L861Q

PMID: 31859066

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The potential mechanism of primary resistance to icotinib in EGFR uncommon mutant advanced non-small cell lung cancer: a multi-center study.

Cancer Science

L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song

Publication Date: 2019-12-11

Variant appearance in text: EGFR: L861Q

PMID: 31828849

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Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

JH Cho, SH Lim, HJ An, KH Kim, KU Park, EJ Kang, YH Choi, MS Ahn, MH Lee, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn

Publication Date: 2019-12-11

Variant appearance in text: EGFR: Leu861Gln

PMID: 31825714

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Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas.

Aging

C Yang, Y Tan, S Li, J Zhou, Q Wang, Y Wang, Y Xie, L Chen, J Li, C Fang, C Kang

Publication Date: 2019-12-10

Variant appearance in text: EGFR: L861Q

PMID: 31822636

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The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Molecules (Basel, Switzerland)

N Van Der Steen, K Zwaenepoel, G Mazzaschi, R A Luirink, D P Geerke, K Op de Beeck, C Hermans, M Tiseo, P Van Schil, F Lardon, P Germonpré, C Rolfo, E Giovannetti, G J Peters, P Pauwels

Publication Date: 2019-12-04

Variant appearance in text: EGFR: L861Q

PMID: 31817278

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Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer Patients.

Cancers

L Jahangiri, T Hurst

Publication Date: 2019-12-04

Variant appearance in text: EGFR: L861Q

PMID: 31817150

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Predictive biomarkers in nonsmall cell carcinoma and their clinico-pathological association.

South Asian Journal Of Cancer

A Mehta, NN Sriramanakoppa, P Agarwal, G Viswakarma, S Vasudevan, M Panigrahi, D Kumar, M Saifi, I Chowdhary, DC Doval, M Suryavanshi

Publication Date: 2019

Variant appearance in text: EGFR: L861Q

PMID: 31807491

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Detection of clinically relevant epidermal growth factor receptor pathway mutations in circulating cell-free tumor DNA using next generation sequencing in squamous cell carcinoma lung.

South Asian Journal Of Cancer

KB Govind, D Koppaka, L Dasappa, LA Jacob, SM C Babu, NK Lokesh, RA Haleshappa, LK Rajeev, SC Saldanha, A Abhishek, V Asati, R Chethan, VL Ramprasad

Publication Date: 2019

Variant appearance in text: EGFR: L861Q

PMID: 31807490

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Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation.

Oncotargets And Therapy

S Zhou, H Wang, W Jiang, Q Yu

Publication Date: 2019

Variant appearance in text: EGFR: L861Q

PMID: 31802898

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000275493.2	c.2582T>A	p.Leu861Gln	missense_variant	21/28	-
ENST00000442591.1	c.*28+18903T>A	-	intron_variant	-	17/17
ENST00000454757.2	c.2423T>A	p.Leu808Gln	missense_variant	21/28	-
ENST00000455089.1	c.2447T>A	p.Leu816Gln	missense_variant	20/26	-
NM_001346897.2	c.2447T>A	p.Leu816Gln	missense_variant	20/26	-
NM_001346898.2	c.2582T>A	p.Leu861Gln	missense_variant	21/27	-
NM_001346899.1	c.2447T>A	p.Leu816Gln	missense_variant	20/27	-
NM_001346900.2	c.2423T>A	p.Leu808Gln	missense_variant	21/28	-
NM_001346941.2	c.1781T>A	p.Leu594Gln	missense_variant	15/22	-
NM_005228.5	c.2582T>A	p.Leu861Gln	missense_variant	21/28	-