Variant ID: 7-55259524-T-A

NM_005228.3(EGFR):c.2582T>A;(p.Leu861Gln)

This variant was identified in 858 publications




Publications:


Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management.

Diagnostics (Basel, Switzerland)
J Wehrle, U Philipp, M Jolic, M Follo, S Hussung, S Waldeck, M Deuter, M Rassner, J Braune, J Rawluk, C Greil, CF Waller, H Becker, J Duque-Afonso, AL Illert, RM Fritsch, F Meiss, J Duyster, N von Bubnoff, F Scherer
Publication Date: 2020-08-02

Variant appearance in text: EGFR: L861Q
PMID: 32748806
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Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: EGFR: L861Q
PMID: 32729257
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Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic.

Frontiers In Oncology
HC Freitas, GT Torrezan, IW da Cunha, MP Macedo, V Karen de Sá, M Corassa, ENE Ferreira, AO Saito, GZ Dal Molin, VC Cordeiro de Lima, DM Carraro
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32714871
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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
W Jin
Publication Date: 2020-07-16

Variant appearance in text: EGFR: L861Q
PMID: 32708604
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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy
HT Chan, YM Chin, SK Low
Publication Date: 2019-06

Variant appearance in text: EGFR: L861Q
PMID: 32700193
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Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

Oncology And Therapy
M Sesé, R Somoza, I Maestu, MM Ureste, A Sanchez, JF Cordoba, I Sansano, G Venturas, S Ramón Y Cajal, J Hernández-Losa
Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q
PMID: 32699985
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Discrimination of CpG Methylation Status and Nucleotide Differences in Tissue Specimen DNA by Oligoribonucleotide Interference-PCR.

International Journal Of Molecular Sciences
T Shimizu, T Fujita, S Fukushi, Y Horino, H Fujii
Publication Date: 2020-07-20

Variant appearance in text: EGFR: L861Q
PMID: 32698480
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A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients.

World Journal Of Surgical Oncology
X Zhang, Y Jiang, H Yu, H Xia, X Wang
Publication Date: 2020-07-16

Variant appearance in text: EGFR: L861Q
PMID: 32677962
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Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand.

Bmc Cancer
PS Aye, S Tin Tin, MJ McKeage, P Khwaounjoo, A Cavadino, JM Elwood
Publication Date: 2020-07-14

Variant appearance in text: EGFR: L861Q
PMID: 32664868
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Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors.

Journal Of Thoracic Disease
JA Chen, JW Riess
Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q
PMID: 32642199
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Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations.

Journal Of Thoracic Disease
HS Kang, AY Shin, CD Yeo, CK Park, JS Kim, JW Kim, SJ Kim, SH Lee, SK Kim
Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q
PMID: 32642093
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Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines.

International Journal Of Molecular Sciences
V Sarne, S Huter, S Braunmueller, L Rakob, N Jacobi, M Kitzwögerer, C Wiesner, P Obrist, R Seeboeck
Publication Date: 2020-06-28

Variant appearance in text: EGFR: L861Q
PMID: 32605217
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Genetic Markers in Lung Cancer Diagnosis: A Review.

International Journal Of Molecular Sciences
K Wadowska, I Bil-Lula, Ł Trembecki, M Śliwińska-Mossoń
Publication Date: 2020-06-27

Variant appearance in text: EGFR: L861Q
PMID: 32604993
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Liquid biopsy mutation panel for non-small cell lung cancer: analytical validation and clinical concordance.

Npj Precision Oncology
LS Schwartzberg, H Horinouchi, D Chan, S Chernilo, ML Tsai, D Isla, C Escriu, JP Bennett, K Clark-Langone, C Svedman, P Tomasini,
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32596507
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Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene.

Scientific Reports
Z Qiu, B Ye, K Wang, P Zhou, S Zhao, W Li, P Tian
Publication Date: 2020-06-25

Variant appearance in text: EGFR: L861Q
PMID: 32587276
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A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib combined with moxifloxacin.

Bmc Pulmonary Medicine
S Bian, X Tang, W Lei
Publication Date: 2020-06-24

Variant appearance in text: EGFR: L861Q
PMID: 32580784
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Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings.

Journal Of Oncology Pharmacy Practice : Official Publication Of The International Society Of Oncology Pharmacy Practitioners
RD Harvey, VR Adams, T Beardslee, P Medina
Publication Date: 2020-06-20

Variant appearance in text: EGFR: L861Q
PMID: 32567494
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Application of immune checkpoint inhibitors in EGFR-mutant non-small-cell lung cancer: from bed to bench.

Therapeutic Advances In Medical Oncology
R Jin, J Zhao, L Xia, Q Li, W Li, L Peng, Y Xia
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32565926
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Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment.

Cancers
J Li, HF Kwok
Publication Date: 2020-06-15

Variant appearance in text: EGFR: L861Q
PMID: 32549388
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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies.

Journal Of Clinical Medicine
S Rajurkar, I Mambetsariev, R Pharaon, B Leach, T Tan, P Kulkarni, R Salgia
Publication Date: 2020-06-15

Variant appearance in text: EGFR: L861Q
PMID: 32549358
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The role of EGFR mutations in predicting recurrence in early and locally advanced lung adenocarcinoma following definitive therapy.

Oncotarget
C Galvez, S Jacob, BS Finkelman, J Zhao, K Tegtmeyer, YK Chae, N Mohindra, R Salgia, B Jovanovic, A Behdad, V Villaflor
Publication Date: 2020-05-26

Variant appearance in text: EGFR: L861Q
PMID: 32523650
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Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.

Ebiomedicine
M de Wit, Y Gao, D Mercieca, I de Heer, B Valkenburg, ME van Royen, J Aerts, P Sillevis Smitt, P French
Publication Date: 2020-06-04

Variant appearance in text: EGFR: L861Q
PMID: 32512509
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EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports
G Calibasi-Kocal, A Amirfallah, T Sever, O Umit Unal, D Gurel, I Oztop, H Ellidokuz, Y Basbinar
Publication Date: 2020-08

Variant appearance in text: EGFR: Leu861Gln
PMID: 32509305
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Association of CD8 T cell apoptosis and EGFR mutation in non-small lung cancer patients.

Thoracic Cancer
C Zhao, C Su, X Li, C Zhou
Publication Date: 2020-06-04

Variant appearance in text: EGFR: L861Q
PMID: 32500560
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Glasgow prognostic score predicts efficacy and prognosis in patients with advanced non-small cell lung cancer receiving EGFR-TKI treatment.

Thoracic Cancer
N Kasahara, H Imai, I Naruse, Y Tsukagoshi, M Kotake, N Sunaga, K Kaira, T Maeno, T Asao, T Hisada
Publication Date: 2020-06-03

Variant appearance in text: EGFR: L861Q
PMID: 32495520
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Successful treatment of a patient with NSCLC carrying uncommon compound EGFR G719X and S768I mutations using osimertinib: A case report.

The Journal Of International Medical Research
Y Cai, Y Wang, J Sun, X Wang, Y Xu, C Sun, Y Guo, M Sun, K Ma
Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q
PMID: 32493093
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Canadian consensus: a new systemic treatment algorithm for advanced EGFR-mutated non-small-cell lung cancer.

Current Oncology (Toronto, Ont.)
B Melosky, S Banerji, N Blais, Q Chu, R Juergens, NB Leighl, G Liu, P Cheema
Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q
PMID: 32489263
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The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).

Cancers
PC Hsu, CT Yang, DM Jablons, L You
Publication Date: 2020-05-26

Variant appearance in text: EGFR: L861Q
PMID: 32466572
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Current status and future perspectives of liquid biopsy in non-small cell lung cancer.

Journal Of Pathology And Translational Medicine
S Chang, JY Hur, YL Choi, CH Lee, WS Kim
Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q
PMID: 32460474
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Emerging therapeutic agents for advanced non-small cell lung cancer.

Journal Of Hematology & Oncology
R Chen, R Manochakian, L James, AG Azzouqa, H Shi, Y Zhang, Y Zhao, K Zhou, Y Lou
Publication Date: 2020-05-24

Variant appearance in text: EGFR: Leu861Gln
PMID: 32448366
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Analysis of lung biopsies using the 2015 WHO criteria and detection of sensitizing mutations--a single-institution experience of 5032 cases.

Diagnostic Pathology
Y Zeng, Y Zhu, Y Ding, L Xu, B Zhai, X Zhang, Q Ge, J Li, Q Song, X Li, Z Zhang
Publication Date: 2020-05-19

Variant appearance in text: EGFR: L861Q
PMID: 32429938
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Hormone receptor expression correlates with EGFR gene mutation in lung cancer in patients with simultaneous primary breast cancer.

Translational Lung Cancer Research
Z Hu, X Zou, S Qin, Y Li, H Wang, H Yu, S Sun, X Wu, J Wang, J Chang
Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q
PMID: 32420072
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EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib.

Translational Lung Cancer Research
A Buder, MJ Hochmair, U Setinek, R Pirker, M Filipits
Publication Date: 2020-04

Variant appearance in text: EGFR: L861Q
PMID: 32420063
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Variability of EGFR exon 20 insertions in 24,468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors.

Molecular Oncology
Y Qin, H Jian, X Tong, X Wu, F Wang, YW Shao, X Zhao
Publication Date: 2020-05-15

Variant appearance in text: EGFR: L861Q
PMID: 32412152
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Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

Oncology Letters
T Yamaura, S Muto, H Mine, H Takagi, M Watanabe, Y Ozaki, T Inoue, M Fukuhara, N Okabe, Y Matsumura, T Hasegawa, J Osugi, M Hoshino, M Higuchi, Y Shio, H Suzuki
Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q
PMID: 32391110
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A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC.

Theranostics
M Lim, J Park, AC Lowe, HO Jeong, S Lee, HC Park, K Lee, GH Kim, MH Kim, YK Cho
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32373206
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Targeted RNA sequencing with touch imprint cytology samples for non-small cell lung cancer patients.

Thoracic Cancer
K Seto, K Masago, S Fujita, M Haneda, Y Horio, T Hida, H Kuroda, W Hosoda, KI Okubo
Publication Date: 2020-05-05

Variant appearance in text: EGFR: L861Q
PMID: 32372482
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The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review.

Cancers
F van Delft, H Koffijberg, V Retèl, MVD Heuvel, M IJzerman
Publication Date: 2020-04-30

Variant appearance in text: EGFR: L861Q
PMID: 32365836
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara
Publication Date: 2020-05-04

Variant appearance in text: EGFR: L861Q
PMID: 32365229
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Long-term Survival With Afatinib in a Patient With Lung Adenocarcinoma Harboring Double Uncommon EGFR L861Q and G719X Mutations.

In Vivo (Athens, Greece)
G Ohara, S Okauchi, Y Sasatani, T Shiozawa, H Yamada, K Miyazaki, H Satoh
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32354946
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Comparison of the characteristics of uncommon epidermal growth factor receptor (EGFR) mutations and EGFR-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer from different ethnic groups.

Experimental And Therapeutic Medicine
Q Zhang, Y Cui, J Zhang, J Kenjiabieke, P Aerxiding
Publication Date: 2020-06

Variant appearance in text: EGFR: L861Q
PMID: 32346412
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[Analysis of Clinical Characteristics and Driver Genes in 405 Patients with Lung Cancer Complicated with Tuberculosis].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Y Hu, X Yang, L Nie, D Zhao, J An, B Li
Publication Date: 2020-04-27

Variant appearance in text: EGFR: L861Q
PMID: 32336065
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Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France).

Cancers
S Lassalle, V Hofman, S Heeke, J Benzaquen, E Long, M Poudenx, E Lantéri, J Boutros, V Tanga, K Zahaf, S Lalvée, V Lespinet, O Bordone, JM Félix, C Bonnetaud, C Marquette, M Ilie, P Hofman
Publication Date: 2020-04-13

Variant appearance in text: EGFR: L861Q
PMID: 32294880
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Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

Journal Of Thoracic Disease
H Li, J Wang, G Zhang, Y Li, L Lin, H Yang, J Zhou, L Zhang, D Lv
Publication Date: 2020-03

Variant appearance in text: EGFR: L861Q
PMID: 32274120
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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters
X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang
Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q
PMID: 32269623
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Complete Remission of Multiple Brain Metastases in a Patient with EGFR-Mutated Non-Small-Cell Lung Cancer Treated with First-Line Osimertinib without Radiotherapy.

Case Reports In Oncological Medicine
K Ameku, M Higa
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32257480
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Evaluation of Two EGFR Mutation Tests on Tumor and Plasma from Patients with Non-Small Cell Lung Cancer.

Cancers
JO Kim, JY Shin, SR Kim, KS Shin, J Kim, MY Kim, MR Lee, Y Kim, M Kim, SH Hong, JH Kang
Publication Date: 2020-03-26

Variant appearance in text: EGFR: L861Q
PMID: 32224854
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Biopsy on progression in patients with EGFR mutation-positive advanced non-small-cell lung cancer-a Canadian experience.

Current Oncology (Toronto, Ont.)
Q Chu, A Agha, N Devost, RN Walton, S Ghosh, C Ho
Publication Date: 2020-02

Variant appearance in text: EGFR: L861Q
PMID: 32218657
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Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer.

Translational Lung Cancer Research
C Zhu, W Zhuang, L Chen, W Yang, WB Ou
Publication Date: 2020-02

Variant appearance in text: EGFR: L861Q
PMID: 32206559
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Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non-Small Cell Lung Cancer: A Health Technology Assessment.

Ontario Health Technology Assessment Series
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32206157
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Clinicopathological parameters for circulating tumor DNA shedding in surgically resected non-small cell lung cancer with EGFR or KRAS mutation.

Plos One
MS Cho, CH Park, S Lee, HS Park
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32196518
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Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations.

Frontiers In Oncology
C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li, R Liu, L Xiang, C Huang, R Jiang
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32195178
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HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant.

Cell & Bioscience
N Sueangoen, A Tantiwetrueangdet, R Panvichian
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32190291
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Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge.

Practical Laboratory Medicine
MR Al-Turkmani, MA Suriawinata, SJ Deharvengt, DC Green, CC Black, K Shirai, KH Dragnev, GJ Tsongalis
Publication Date: 2020-05

Variant appearance in text: EGFR: L861Q
PMID: 32181314
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The Correlation between EGFR Mutation Status and DNA Content of Lung Adenocarcinoma Cells in Pleural Effusion.

Journal Of Cancer
Y Du, X Guo, R Wang, Y Ma, Y Zhang, Y Liu, L Dong, J Wu, X Ji, H Wang
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32127953
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The associations among quantitative spectral CT parameters, Ki-67 expression levels and EGFR mutation status in NSCLC.

Scientific Reports
L Lin, J Cheng, D Tang, Y Zhang, F Zhang, J Xu, H Jiang, H Wu
Publication Date: 2020-02-26

Variant appearance in text: EGFR: L861Q
PMID: 32103127
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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports
Y Hirotsu, S Otake, H Ohyama, K Amemiya, R Higuchi, T Oyama, H Mochizuki, T Goto, M Omata
Publication Date: 2020-02-25

Variant appearance in text: EGFR: L861Q
PMID: 32099048
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[Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
W Zhou, W Zhang, B Han
Publication Date: 2020-02-20

Variant appearance in text: EGFR: L861Q
PMID: 32093456
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[Clinical Value of Droplet Digital PCR and Super-ARMS Detection of Epidermal Growth Factor Receptor Gene Mutation in Plasma Circulating Tumor DNA of Patients with Advanced Lung Adenocarcinoma].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Cao, J Wang, N Qin, K Li, J Lv, J Wang, X Yang, X Li, H Zhang, Q Zhang, H Long, C Shu, L Ma, S Zhang
Publication Date: 2020-02-20

Variant appearance in text: EGFR: L861Q
PMID: 32093452
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The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma.

Biomedicines
PC Hsu, CW Wang, SC Kuo, SM Lin, YL Lo, AC Huang, LC Chiu, CT Yang
Publication Date: 2020-02-19

Variant appearance in text: EGFR: L861Q
PMID: 32092879
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Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
H Liu, B Zhang, Z Sun
Publication Date: 2020-02-18

Variant appearance in text: EGFR: L861Q
PMID: 32067422
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: EGFR: L861Q
PMID: 32054005
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Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

Plos One
HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi, S Park, YJ Ryu, JH Lee, JH Chang
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 32053675
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Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study.

Bmc Cancer
M Kogo, D Fujimoto, K Hosoya, K Nagata, A Nakagawa, R Tachikawa, D Yamashita, Y Kitamura, Y Imai, K Tomii
Publication Date: 2020-02-06

Variant appearance in text: EGFR: L861Q
PMID: 32028905
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The growth of non-solid neoplastic lung nodules is associated with low PD L1 expression, irrespective of sampling technique.

Journal Of Translational Medicine
C Bortolotto, C Maglia, A Ciuffreda, M Coretti, R Catania, F Antonacci, S Carnevale, I Sarotto, R Dore, AR Filippi, G Chiara, D Regge, L Preda, P Morbini, GM Stella
Publication Date: 2020-02-03

Variant appearance in text: EGFR: L861Q
PMID: 32013991
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Extracellular vesicle-based EGFR genotyping in bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients.

Translational Lung Cancer Research
JY Hur, JS Lee, IA Kim, HJ Kim, WS Kim, KY Lee
Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q
PMID: 32010582
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Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers.

Translational Lung Cancer Research
J Ni, T Guo, Y Li, X Yang, Y Li, L Zou, L Chu, X Chu, S Li, L Ye, Y Zhang, Z Zhu
Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q
PMID: 32010575
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Genetic alteration profile of EGFR-mutant resected IIB-IIIA stage NSCLC and correlation to clinical outcomes.

Translational Lung Cancer Research
Q Deng, Y Qiu, J Jia, H Tang, L Liu, L Huang, D He, X Dong, H Yang
Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q
PMID: 32010562
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Poor Prognosis With Coexistence Of EGFR T790M Mutation And Common EGFR-Activating Mutation In Non- Small Cell Lung Cancer.

Cancer Management And Research
X Gao, Y Zhao, Y Bao, W Yin, L Liu, R Liu, Z Yu, X Zhou, J Shuai
Publication Date: 2019

Variant appearance in text: EGFR: L861Q
PMID: 32009817
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Detection of plasma EGFR mutations for personalized treatment of lung cancer patients without pathologic diagnosis.

Cancer Medicine
Q Deng, Q Fang, H Sun, AP Singh, M Alexander, S Li, H Cheng, S Zhou
Publication Date: 2020-01-28

Variant appearance in text: EGFR: L861Q
PMID: 31991049
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New data highlighting the efficacy and safety outcomes of third-generation EGFR-TKI in NSCLC patients with rare EGFR mutations.

Thoracic Cancer
W Zhang, F Li, W Gao
Publication Date: 2020-01-28

Variant appearance in text: EGFR: Leu861Gln
PMID: 31989783
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Accuracy and clinical influence of plasma EGFR mutation detection in management of advanced lung adenocarcinoma.

International Journal Of Clinical And Experimental Pathology
M Ma, C Shi, J Qian, B Han
Publication Date: 2017

Variant appearance in text: EGFR: L861Q
PMID: 31966832
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Clinical and pathological findings of surgically resected patients for lung adenocarcinomas harboring uncommon EGFR mutations.

International Journal Of Clinical And Experimental Pathology
S Yang, Z Jiang, H Lu
Publication Date: 2017

Variant appearance in text: EGFR: L861Q
PMID: 31966607
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Comparison of clinicopathologic characteristics between patients with EGFR exon 19 deletion and EGFR L858R mutation in lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Chen, J Zhang, K Huang, Q Shen, X Teng
Publication Date: 2018

Variant appearance in text: EGFR: L861Q
PMID: 31949864
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Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer.

International Journal Of Clinical And Experimental Pathology
Z Zhang, S Zhou
Publication Date: 2018

Variant appearance in text: EGFR: L861Q
PMID: 31949733
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Abivertinib in patients with T790M-positive advanced NSCLC and its subsequent treatment with osimertinib.

Thoracic Cancer
H Wang, R Pan, X Zhang, X Si, M Wang, L Zhang
Publication Date: 2020-01-14

Variant appearance in text: EGFR: L861Q
PMID: 31943845
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Impact of age on EGFR mutations in never-smoking female lung adenocarcinoma patients with malignant pleural effusion.

International Journal Of Clinical And Experimental Pathology
Q Wu, M Chu, J Hu, Z Zhang, W Yi, X Ma
Publication Date: 2018

Variant appearance in text: EGFR: L861Q
PMID: 31938400
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High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.

International Journal Of Clinical And Experimental Pathology
F Su, Y Fu, Q Wu, K Zheng, Y Tang, X Su, Y Wang, L Jiang
Publication Date: 2018

Variant appearance in text: EGFR: L861Q
PMID: 31938383
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Identification of EGFR mutations in cytological specimens of non-small cell lung carcinoma from a single institute.

International Journal Of Clinical And Experimental Pathology
W Wang, Y Tang, J Li, Y Zhang, Y Zou, X Su
Publication Date: 2018

Variant appearance in text: EGFR: L861Q
PMID: 31938186
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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
X Dong, D Huang, X Yi, S Zhang, Z Wang, B Yan, P Chung Sham, K Chen, M Jun Li
Publication Date: 2020-01-07

Variant appearance in text: EGFR: L861Q
PMID: 31925297
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T790M mutations identified by circulating tumor DNA test in lung adenocarcinoma patients who progressed on first-line epidermal growth factor receptor-tyrosine kinase inhibitors.

Lung India : Official Organ Of Indian Chest Society
V Merinda, G Soegiarto, L Wulandari
Publication Date: 2020

Variant appearance in text: EGFR: L861Q
PMID: 31898615
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Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.

Scientific Reports
SY Kim, JY Lee, DH Kim, H- Joo, MR Yun, D Jung, J Yun, SG Heo, B- Ahn, CW Park, KH Pyo, YJ Chun, MH Hong, HR Kim, BC Cho
Publication Date: 2019-12-27

Variant appearance in text: EGFR: L861Q
PMID: 31882684
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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One
E Papadopoulou, N Tsoulos, K Tsantikidi, V Metaxa-Mariatou, PE Stamou, A Kladi-Skandali, E Kapeni, G Tsaousis, G Pentheroudakis, D Petrakis, DI Lampropoulou, G Aravantinos, I Varthalitis, G Kesisis, I Boukovinas, P Papakotoulas, N Katirtzoglou, E Athanasiadis, F Stavridi, C Christodoulou, A Koumarianou, Y Eralp, G Nasioulas
Publication Date: 2019

Variant appearance in text: EGFR: L861Q
PMID: 31860648
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Clinicopathologic Characteristics, Treatment Outcomes, and Acquired Resistance Patterns of Atypical EGFR Mutations and HER2 Alterations in Stage IV Non-Small-Cell Lung Cancer.

Clinical Lung Cancer
T Patil, R Mushtaq, S Marsh, C Azelby, M Pujara, KD Davies, DL Aisner, WT Purcell, EL Schenk, JM Pacheco, PA Bunn, DR Camidge, RC Doebele
Publication Date: 2019-11-21

Variant appearance in text: EGFR: L861Q
PMID: 31859066
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The potential mechanism of primary resistance to icotinib in EGFR uncommon mutant advanced non-small cell lung cancer: a multi-center study.

Cancer Science
L Lei, WX Wang, YC Zhu, JL Li, Y Fang, H Wang, W Zhuang, YB Zhang, LP Wang, MY Fang, CW Xu, XJ Wang, TF Lv, Y Song
Publication Date: 2019-12-11

Variant appearance in text: EGFR: L861Q
PMID: 31828849
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Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
JH Cho, SH Lim, HJ An, KH Kim, KU Park, EJ Kang, YH Choi, MS Ahn, MH Lee, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
Publication Date: 2019-12-11

Variant appearance in text: EGFR: Leu861Gln
PMID: 31825714
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Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas.

Aging
C Yang, Y Tan, S Li, J Zhou, Q Wang, Y Wang, Y Xie, L Chen, J Li, C Fang, C Kang
Publication Date: 2019-12-10

Variant appearance in text: EGFR: L861Q
PMID: 31822636
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The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Molecules (Basel, Switzerland)
N Van Der Steen, K Zwaenepoel, G Mazzaschi, R A Luirink, D P Geerke, K Op de Beeck, C Hermans, M Tiseo, P Van Schil, F Lardon, P Germonpré, C Rolfo, E Giovannetti, G J Peters, P Pauwels
Publication Date: 2019-12-04

Variant appearance in text: EGFR: L861Q
PMID: 31817278
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Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer Patients.

Cancers
L Jahangiri, T Hurst
Publication Date: 2019-12-04

Variant appearance in text: EGFR: L861Q
PMID: 31817150
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Predictive biomarkers in nonsmall cell carcinoma and their clinico-pathological association.

South Asian Journal Of Cancer
A Mehta, NN Sriramanakoppa, P Agarwal, G Viswakarma, S Vasudevan, M Panigrahi, D Kumar, M Saifi, I Chowdhary, DC Doval, M Suryavanshi
Publication Date: 2019

Variant appearance in text: EGFR: L861Q
PMID: 31807491
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Detection of clinically relevant epidermal growth factor receptor pathway mutations in circulating cell-free tumor DNA using next generation sequencing in squamous cell carcinoma lung.

South Asian Journal Of Cancer
KB Govind, D Koppaka, L Dasappa, LA Jacob, SM C Babu, NK Lokesh, RA Haleshappa, LK Rajeev, SC Saldanha, A Abhishek, V Asati, R Chethan, VL Ramprasad
Publication Date: 2019

Variant appearance in text: EGFR: L861Q
PMID: 31807490
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Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation.

Oncotargets And Therapy
S Zhou, H Wang, W Jiang, Q Yu
Publication Date: 2019

Variant appearance in text: EGFR: L861Q
PMID: 31802898
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000275493.2 c.2582T>A p.Leu861Gln missense_variant 21/28 -
ENST00000442591.1 c.*28+18903T>A - intron_variant - 17/17
ENST00000454757.2 c.2423T>A p.Leu808Gln missense_variant 21/28 -
ENST00000455089.1 c.2447T>A p.Leu816Gln missense_variant 20/26 -
NM_001346897.2 c.2447T>A p.Leu816Gln missense_variant 20/26 -
NM_001346898.2 c.2582T>A p.Leu861Gln missense_variant 21/27 -
NM_001346899.1 c.2447T>A p.Leu816Gln missense_variant 20/27 -
NM_001346900.2 c.2423T>A p.Leu808Gln missense_variant 21/28 -
NM_001346941.2 c.1781T>A p.Leu594Gln missense_variant 15/22 -
NM_005228.5 c.2582T>A p.Leu861Gln missense_variant 21/28 -