Publications:

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Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Frontiers In Oncology

He, Ping P; Liu, Jie J; Xu, Qingyuan Q; Ma, Huaijun H; Niu, Beifang B; Huang, Gang G; Wu, Wei W

Publication Date: 2023

Variant appearance in text: EGFR: 2618G>A; G873E

PubMed Link: 36910641

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 8

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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology

Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J

Publication Date: 2022

Variant appearance in text: EGFR: 2618G>A; G873E

PubMed Link: 35814426

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 2

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Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene

Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S

Publication Date: 2022-04

Variant appearance in text: EGFR: G873E

PubMed Link: 35304574

Variant Present in the following documents:

• 41388_2022_Article_2263.pdf

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Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma.

Cell Death & Disease

Deng, Zhiyong Z; Cui, Liang L; Li, Pansong P; Ren, Nianjun N; Zhong, Zhe Z; Tang, Zhi Z; Wang, Lei L; Gong, Jianwu J; Cheng, Haofeng H; Guan, Yanfang Y; Yi, Xin X; Xia, Xuefeng X; Zhou, Rongrong R; He, Zhengwen Z

Publication Date: 2021-10-12

Variant appearance in text: EGFR: G873E

PubMed Link: 34642306

Variant Present in the following documents:

• Main text
• 41419_2021_Article_4223.pdf

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: G873E

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: EGFR: 2618G>A; G873E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: EGFR: 2618G>A; G873E

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine

Jin, Wook W

Publication Date: 2020-07-16

Variant appearance in text: EGFR: G873E

PubMed Link: 32708604

Variant Present in the following documents:

• Main text
• jcm-09-02255.pdf

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Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics

Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z

Publication Date: 2021-05-20

Variant appearance in text: EGFR: G873E

PubMed Link: 32510566

Variant Present in the following documents:

• Main text

View BVdb publication page

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The in cis compound EGFR mutations in Chinese advanced non-small cell lung cancer patients.

Cancer Biology & Therapy

Li, Min M; Zhou, Cheng-Zhi CZ; Yang, Jin-Ji JJ; Lu, Shun S; Zheng, Di D; Hu, Jie J; Zeng, Hui H; Lu, You Y; Lu, Kai-Hua KH; Li, Shu-Ang SA; Mao, Xin-Ru XR; Han-Zhang, Han H; Lizaso, Analyn A; Ye, Jun-Yi JY; Hu, Cheng-Ping CP

Publication Date: 2019

Variant appearance in text: EGFR: G873E

PubMed Link: 30990107

Variant Present in the following documents:

• Main text

View BVdb publication page

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: EGFR: G873E

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2

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Epidermal growth factor receptor somatic mutation analysis in 354 Chinese patients with non-small cell lung cancer.

Oncology Letters

Quan, Xueping X; Gao, Hongjun H; Wang, Zhikuan Z; Li, Jie J; Zhao, Wentao W; Liang, Wei W; Yu, Qiang Q; Guo, Dongliang D; Hao, Zhanping Z; Liu, Jingxin J

Publication Date: 2018-02

Variant appearance in text: EGFR: G873E

PubMed Link: 29434916

Variant Present in the following documents:

• Main text

View BVdb publication page

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Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.

International Journal Of Oncology

Yamamoto, Gou G; Kikuchi, Mari M; Kobayashi, Shiho S; Arai, Yoshiko Y; Fujiyoshi, Kenji K; Wakatsuki, Tomokazu T; Kakuta, Miho M; Yamane, Yuki Y; Iijima, Yoshihito Y; Mizutani, Hideaki H; Nakajima, Yuki Y; Sudo, Junko J; Kinoshita, Hiroyasu H; Kurimoto, Futoshi F; Akiyama, Hirohiko H; Uramoto, Hidetaka H; Sakai, Hiroshi H; Akagi, Yoshito Y; Akagi, Kiwamu K

Publication Date: 2017-05

Variant appearance in text: EGFR: G873E

PubMed Link: 28350094

Variant Present in the following documents:

• Main text

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Non-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment.

British Journal Of Cancer

Kuiper, J L JL; Hashemi, S M S SM; Thunnissen, E E; Snijders, P J F PJ; Grünberg, K K; Bloemena, E E; Sie, D D; Postmus, P E PE; Heideman, D A M DA; Smit, E F EF

Publication Date: 2016-12-06

Variant appearance in text: EGFR: G873E

PubMed Link: 27875527

Variant Present in the following documents:

• Main text
• bjc2016372a.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: EGFR: G873E

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.

Journal Of Translational Medicine

Dallol, Ashraf A; Buhmeida, Abdelbaset A; Al-Ahwal, Mahmoud Shaheen MS; Al-Maghrabi, Jaudah J; Bajouh, Osama O; Al-Khayyat, Shadi S; Alam, Rania R; Abusanad, Atlal A; Turki, Rola R; Elaimi, Aisha A; Alhadrami, Hani A HA; Abuzenadah, Mohammed M; Banni, Huda H; Al-Qahtani, Mohammed H MH; Abuzenadah, Adel M AM

Publication Date: 2016-05-04

Variant appearance in text: EGFR: Gly873Glu

PubMed Link: 27146902

Variant Present in the following documents:

• Main text
• 12967_2016_Article_878.pdf

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Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer.

Cell Death & Disease

Sette, G G; Salvati, V V; Mottolese, M M; Visca, P P; Gallo, E E; Fecchi, K K; Pilozzi, E E; Duranti, E E; Policicchio, E E; Tartaglia, M M; Milella, M M; De Maria, R R; Eramo, A A

Publication Date: 2015-08-06

Variant appearance in text: EGFR: G873E

PubMed Link: 26247735

Variant Present in the following documents:

• Main text
• cddis2015217a.pdf

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: EGFR: G873E

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 5

View BVdb publication page

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Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population.

Oncotarget

Wheler, Jennifer J; Falchook, Gerald G; Tsimberidou, Apostolia M AM; Hong, David D; Naing, Aung A; Piha-Paul, Sarina S; Chen, Su S SS; Heymach, John J; Fu, Siqing S; Stephen, Bettzy B; Fok, Jansina Y JY; Janku, Filip F; Kurzrock, Razelle R

Publication Date: 2013-05

Variant appearance in text: EGFR: G873E

PubMed Link: 23800712

Variant Present in the following documents:

• Main text

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Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer.

Oncotarget

Falchook, Gerald S GS; Naing, Aung A; Hong, David S DS; Zinner, Ralph R; Fu, Siqing S; Piha-Paul, Sarina A SA; Tsimberidou, Apostolia M AM; Morgan-Linnell, Sonia K SK; Jiang, Yunfang Y; Bastida, Christel C; Wheler, Jennifer J JJ; Kurzrock, Razelle R

Publication Date: 2013-01

Variant appearance in text: EGFR: G873E

PubMed Link: 23435217

Variant Present in the following documents:

• Main text
• oncotarget-04-118.pdf

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The impact of initial gefitinib or erlotinib versus chemotherapy on central nervous system progression in advanced non-small cell lung cancer with EGFR mutations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Heon, Stephanie S; Yeap, Beow Y BY; Lindeman, Neal I NI; Joshi, Victoria A VA; Butaney, Mohit M; Britt, Gregory J GJ; Costa, Daniel B DB; Rabin, Michael S MS; Jackman, David M DM; Johnson, Bruce E BE

Publication Date: 2012-08-15

Variant appearance in text: EGFR: G873E

PubMed Link: 22733536

Variant Present in the following documents:

• Main text

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The energy landscape analysis of cancer mutations in protein kinases.

Plos One

Dixit, Anshuman A; Verkhivker, Gennady M GM

Publication Date: 2011

Variant appearance in text: EGFR: G873E

PubMed Link: 21998754

Variant Present in the following documents:

View BVdb publication page

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Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Heon, Stephanie S; Yeap, Beow Y BY; Britt, Gregory J GJ; Costa, Daniel B DB; Rabin, Michael S MS; Jackman, David M DM; Johnson, Bruce E BE

Publication Date: 2010-12-01

Variant appearance in text: EGFR: G873E

PubMed Link: 21030498

Variant Present in the following documents:

• Main text

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Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Jackman, David M DM; Miller, Vincent A VA; Cioffredi, Leigh-Anne LA; Yeap, Beow Y BY; Jänne, Pasi A PA; Riely, Gregory J GJ; Ruiz, Marielle Gallegos MG; Giaccone, Giuseppe G; Sequist, Lecia V LV; Johnson, Bruce E BE

Publication Date: 2009-08-15

Variant appearance in text: EGFR: G873E

PubMed Link: 19671843

Variant Present in the following documents:

• Main text

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