EGFR c.2650G>A ;(p.E884K)

Variant ID: 7-55260483-G-A

NM_005228.3(EGFR):c.2650G>A;(p.E884K)

This variant was identified in 35 publications

View GRCh38 version.




Publications:


Molecular targeted therapy for anticancer treatment.

Experimental & Molecular Medicine
Min, Hye-Young HY; Lee, Ho-Young HY
Publication Date: 2022-10

Variant appearance in text: EGFR: E884K
PubMed Link: 36224343
Variant Present in the following documents:
  • Main text
  • 12276_2022_Article_864.pdf
View BVdb publication page



Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology
Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ
Publication Date: 2022-10-11

Variant appearance in text: EGFR: 2650G>A; E884K
PubMed Link: 36219477
Variant Present in the following documents:
  • PATH-259-56-s004.xlsx, sheet 2
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: E884K
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors.

Molecules (Basel, Switzerland)
Amelia, Tasia T; Kartasasmita, Rahmana Emran RE; Ohwada, Tomohiko T; Tjahjono, Daryono Hadi DH
Publication Date: 2022-01-26

Variant appearance in text: EGFR: E884K
PubMed Link: 35164092
Variant Present in the following documents:
  • Main text
  • molecules-27-00819.pdf
View BVdb publication page



Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors.

Molecules (Basel, Switzerland)
Amelia, Tasia T; Kartasasmita, Rahmana Emran RE; Ohwada, Tomohiko T; Tjahjono, Daryono Hadi DH
Publication Date: 2022-01-26

Variant appearance in text: EGFR: E884K
PubMed Link: 35164092
Variant Present in the following documents:
  • Main text
  • molecules-27-00819.pdf
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: EGFR: E884K
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin.

Scientific Reports
Chinnappan, Jayaprakash J; Ramu, Akilandeswari A; V, Vidhya Rajalakshmi VR; S, Akil Kavya AK
Publication Date: 2021-11-11

Variant appearance in text: EGFR: E884K
PubMed Link: 34764329
Variant Present in the following documents:
  • Main text
  • 41598_2021_Article_1508.pdf
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Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring.

Cancers
Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M
Publication Date: 2021-09-30

Variant appearance in text: EGFR: E884K
PubMed Link: 34638411
Variant Present in the following documents:
  • Main text
  • cancers-13-04926.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: EGFR: E884K
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer
Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY
Publication Date: 2020-10

Variant appearance in text: EGFR: E884K
PubMed Link: 33077514
Variant Present in the following documents:
  • jitc-2020-001199supp002.pdf
View BVdb publication page



Incorporating representation learning and multihead attention to improve biomedical cross-sentence n-ary relation extraction.

Bmc Bioinformatics
Zhao, Di D; Wang, Jian J; Zhang, Yijia Y; Wang, Xin X; Lin, Hongfei H; Yang, Zhihao Z
Publication Date: 2020-07-16

Variant appearance in text: EGFR: E884K
PubMed Link: 32677883
Variant Present in the following documents:
  • Main text
  • 12859_2020_Article_3629.pdf
View BVdb publication page



Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Frontiers In Oncology
Wang, Shuhang S; Chen, Rongrong R; Tang, Yu Y; Yu, Yue Y; Fang, Yuan Y; Huang, Huiyao H; Wu, Dawei D; Fang, Hong H; Bai, Ying Y; Sun, Chao C; Yu, Anqi A; Fan, Qi Q; Gu, Dejian D; Yi, Xin X; Li, Ning N
Publication Date: 2020

Variant appearance in text: EGFR: 2650G>A; E884K
PubMed Link: 32373528
Variant Present in the following documents:
  • Table_6.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: EGFR: E884K
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: EGFR: E884K
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Heterogeneous Responses to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) in Patients with Uncommon EGFR Mutations: New Insights and Future Perspectives in this Complex Clinical Scenario.

International Journal Of Molecular Sciences
Russo, Alessandro A; Franchina, Tindara T; Ricciardi, Giuseppina G; Battaglia, Alessandra A; Picciotto, Maria M; Adamo, Vincenzo V
Publication Date: 2019-03-21

Variant appearance in text: EGFR: E884K
PubMed Link: 30901844
Variant Present in the following documents:
  • Main text
  • ijms-20-01431.pdf
View BVdb publication page



Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues.

American Society Of Clinical Oncology Educational Book. American Society Of Clinical Oncology. Annual Meeting
Wu, Xiaoliang X; Zhu, Lin L; Ma, Patrick C PC
Publication Date: 2018-05-23

Variant appearance in text: EGFR: E884K
PubMed Link: 30231325
Variant Present in the following documents:
  • Main text
View BVdb publication page



Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer.

Therapeutic Advances In Medical Oncology
Elster, Naomi N; Toomey, Sinead S; Fan, Yue Y; Cremona, Mattia M; Morgan, Clare C; Weiner Gorzel, Karolina K; Bhreathnach, Una U; Milewska, Malgorzata M; Murphy, Madeline M; Madden, Stephen S; Naidoo, Jarushka J; Fay, Joanna J; Kay, Elaine E; Carr, Aoife A; Kennedy, Sean S; Furney, Simon S; Mezynski, Janusz J; Breathhnach, Oscar O; Morris, Patrick P; Grogan, Liam L; Hill, Arnold A; Kennedy, Susan S; Crown, John J; Gallagher, William W; Hennessy, Bryan B; Eustace, Alex A
Publication Date: 2018

Variant appearance in text: EGFR: E884K
PubMed Link: 30023006
Variant Present in the following documents:
  • Supplementary_material.pdf
View BVdb publication page



Molecular characterization of circulating colorectal tumor cells defines genetic signatures for individualized cancer care.

Oncotarget
Kong, Say Li SL; Liu, Xingliang X; Suhaimi, Nur-Afidah Mohamed NM; Koh, Kenneth Jia Hao KJH; Hu, Min M; Lee, Daniel Yoke San DYS; Cima, Igor I; Phyo, Wai Min WM; Lee, Esther Xing Wei EXW; Tai, Joyce A JA; Foong, Yu Miin YM; Vo, Jess Honganh JH; Koh, Poh Koon PK; Zhang, Tong T; Ying, Jackie Y JY; Lim, Bing B; Tan, Min-Han MH; Hillmer, Axel M AM
Publication Date: 2017-09-15

Variant appearance in text: EGFR: E884K
PubMed Link: 28978093
Variant Present in the following documents:
  • oncotarget-08-68026-s002.xlsx, sheet 3
View BVdb publication page



BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.

Oncotarget
Deihimi, Safoora S; Lev, Avital A; Slifker, Michael M; Shagisultanova, Elena E; Xu, Qifang Q; Jung, Kyungsuk K; Vijayvergia, Namrata N; Ross, Eric A EA; Xiu, Joanne J; Swensen, Jeffrey J; Gatalica, Zoran Z; Andrake, Mark M; Dunbrack, Roland L RL; El-Deiry, Wafik S WS
Publication Date: 2017-06-20

Variant appearance in text: EGFR: E884K
PubMed Link: 28591715
Variant Present in the following documents:
  • Main text
  • oncotarget-08-39945.pdf
View BVdb publication page



Epidermal growth factor receptor tyrosine kinase inhibitors with conventional chemotherapy for the treatment of non-small cell lung cancer.

Oncotargets And Therapy
Gao, Yuan Y; Song, PingPing P; Li, Hui H; Guo, HongBo H; Jia, Hui H; Zhang, BaiJiang B
Publication Date: 2016

Variant appearance in text: EGFR: E884K
PubMed Link: 26719713
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure.

The Korean Journal Of Internal Medicine
Cho, Kyoung Min KM; Keam, Bhumsuk B; Kim, Tae Min TM; Lee, Se-Hoon SH; Kim, Dong-Wan DW; Heo, Dae Seog DS
Publication Date: 2015-11

Variant appearance in text: EGFR: E884K
PubMed Link: 26552465
Variant Present in the following documents:
  • Main text
  • kjim-30-6-891.pdf
View BVdb publication page



Protein domain-level landscape of cancer-type-specific somatic mutations.

Plos Computational Biology
Yang, Fan F; Petsalaki, Evangelia E; Rolland, Thomas T; Hill, David E DE; Vidal, Marc M; Roth, Frederick P FP
Publication Date: 2015-03

Variant appearance in text: EGFR: E884K
PubMed Link: 25794154
Variant Present in the following documents:
  • pcbi.1004147.s001.xlsx, sheet 1
View BVdb publication page



Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature.

World Journal Of Clinical Oncology
Singh, Navneet N; Jindal, Aditya A; Behera, Digambar D
Publication Date: 2014-12-10

Variant appearance in text: EGFR: E884K
PubMed Link: 25493223
Variant Present in the following documents:
  • Main text
View BVdb publication page



Global connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy.

Scientific Reports
Soundararajan, Venky V; Aravamudan, Murali M
Publication Date: 2014-12-03

Variant appearance in text: EGFR: E884K
PubMed Link: 25465236
Variant Present in the following documents:
  • Main text
  • srep07294.pdf
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: EGFR: E884K
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page



Temozolomide and/or Erlotinib in the Treatment of Lung Cancer Patients With Progressive Central Nervous System Metastases.

Journal Of Neurology Research
Lukas, Rimas V RV; Nicholas, Martin Kelly MK; Villaflor, Victoria V; Hoffman, Philip C PC; Salgia, Ravi R
Publication Date: 2012-02-01

Variant appearance in text: EGFR: E884K
PubMed Link: 23504695
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cancer genes in lung cancer: racial disparities: are there any?

Genes & Cancer
El-Telbany, Ahmed A; Ma, Patrick C PC
Publication Date: 2012-07

Variant appearance in text: EGFR: E884K
PubMed Link: 23264847
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases.

Human Mutation
Hashimoto, Kosuke K; Rogozin, Igor B IB; Panchenko, Anna R AR
Publication Date: 2012-11

Variant appearance in text: EGFR: Glu884Lys
PubMed Link: 22753356
Variant Present in the following documents:
  • Main text
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: EGFR: E884K
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Mechanisms of drug resistance in kinases.

Expert Opinion On Investigational Drugs
Barouch-Bentov, Rina R; Sauer, Karsten K
Publication Date: 2011-02

Variant appearance in text: EGFR: E884K
PubMed Link: 21235428
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of erlotinib in first-line and maintenance treatment of advanced non-small-cell lung cancer.

Cancer Management And Research
Reguart, Noemí N; Cardona, Andrés Felipe AF; Rosell, Rafael R
Publication Date: 2010-06-01

Variant appearance in text: EGFR: E884K
PubMed Link: 21188105
Variant Present in the following documents:
  • Main text
  • cmr-2-143.pdf
View BVdb publication page



Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array.

Biosensors & Bioelectronics
Ghosh, Gargi G; Yan, Xiaoliang X; Lee, Andrew G AG; Kron, Stephen J SJ; Palecek, Sean P SP
Publication Date: 2010-10-15

Variant appearance in text: EGFR: E884K
PubMed Link: 20729058
Variant Present in the following documents:
  • Main text
View BVdb publication page



Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.

Oncogene
Tang, Z Z; Jiang, S S; Du, R R; Petri, E T ET; El-Telbany, A A; Chan, P S O PS; Kijima, T T; Dietrich, S S; Matsui, K K; Kobayashi, M M; Sasada, S S; Okamoto, N N; Suzuki, H H; Kawahara, K K; Iwasaki, T T; Nakagawa, K K; Kawase, I I; Christensen, J G JG; Hirashima, T T; Halmos, B B; Salgia, R R; Boggon, T J TJ; Kern, J A JA; Ma, P C PC
Publication Date: 2009-01-29

Variant appearance in text: EGFR: E884K
PubMed Link: 19015641
Variant Present in the following documents:
  • Main text
  • nihms72114.pdf
View BVdb publication page



Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One
Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS
Publication Date: 2008

Variant appearance in text: EGFR: E884K
PubMed Link: 19005564
Variant Present in the following documents:
  • pone.0003714.s003.xls, sheet 1
View BVdb publication page



Phase II study of erlotinib as a salvage treatment for non-small-cell lung cancer patients after failure of gefitinib treatment.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Lee, D H DH; Kim, S-W SW; Suh, C C; Yoon, D H DH; Yi, E J EJ; Lee, J-S JS
Publication Date: 2008-12

Variant appearance in text: EGFR: E884K
PubMed Link: 18644828
Variant Present in the following documents:
  • Main text
View BVdb publication page