Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01
Variant appearance in text: ABCB4: 175C>T; L59L; rs2302387
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.
Scientific Reports
Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA
Publication Date: 2019-10-09
Variant appearance in text: ABCB4: L59L; rs2302387
Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.
Molecular Pharmacology
Sissung, Tristan M TM; Huang, Phoebe A PA; Hauke, Ralph J RJ; McCrea, Edel M EM; Peer, Cody J CJ; Barbier, Roberto H RH; Strope, Jonathan D JD; Ley, Ariel M AM; Zhang, Mary M; Hong, Julie A JA; Venzon, David D; Jackson, Jonathan P JP; Brouwer, Kenneth R KR; Grohar, Patrick P; Glod, Jon J; Widemann, Brigitte C BC; Heller, Theo T; Schrump, David S DS; Figg, William D WD
Publication Date: 2019-08
Variant appearance in text: ABCB4: L59L; rs2302387
A likely pathogenic variant putatively affecting splicing of PIGA identified in a multiple congenital anomalies hypotonia-seizures syndrome 2 (MCAHS2) family pedigree via whole-exome sequencing.
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.
Oncotarget
Kürschner, Gerrit G; Zhang, Qingzhou Q; Clima, Rosanna R; Xiao, Yi Y; Busch, Jonas Felix JF; Kilic, Ergin E; Jung, Klaus K; Berndt, Nikolaus N; Bulik, Sascha S; Holzhütter, Hermann-Georg HG; Gasparre, Giuseppe G; Attimonelli, Marcella M; Babu, Mohan M; Meierhofer, David D
Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.
Pharmacogenomics
Sissung, Tristan M TM; Deeken, John J; Leibrand, Crystal R CR; Price, Douglas K DK; Ehrlich, Sheryl S; Steinberg, Seth M SM; Liewehr, David J DJ; Dahut, William W; Figg, William D WD
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.
Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Whole-genome sequencing of the world's oldest people.
Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Publication Date: 2014
Variant appearance in text: ABCB4: L59L; rs2302387
Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping.
Blood
Johnson, David C DC; Corthals, Sophie S; Ramos, Christine C; Hoering, Antje A; Cocks, Kim K; Dickens, Nicholas J NJ; Haessler, Jeff J; Goldschmidt, Harmut H; Child, J Anthony JA; Bell, Sue E SE; Jackson, Graham G; Baris, Dalsu D; Rajkumar, S Vincent SV; Davies, Faith E FE; Durie, Brian G M BG; Crowley, John J; Sonneveld, Pieter P; Van Ness, Brian B; Morgan, Gareth J GJ