Publications:

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Functional evaluation of cyclosporine metabolism by CYP3A4 variants and potential drug interactions.

Frontiers In Pharmacology

Kong, Qihui Q; Gao, Nanyong N; Wang, Yahui Y; Hu, Guoxin G; Qian, Jianchang J; Chen, Bingbing B

Publication Date: 2022

Variant appearance in text: CYP3A4: L373F

PubMed Link: 36686709

Variant Present in the following documents:

• Main text
• fphar-13-1044817.pdf

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Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Frontiers In Pharmacology

Zhai, Qinglian Q; van der Lee, Maaike M; van Gelder, Teun T; Swen, Jesse J JJ

Publication Date: 2022

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 35784699

Variant Present in the following documents:

• Main text
• fphar-13-912618.pdf

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Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.

Pharmacogenomics And Personalized Medicine

Nthontho, Keneuoe Cecilia KC; Ndlovu, Andrew Khulekani AK; Sharma, Kirthana K; Kasvosve, Ishmael I; Hertz, Daniel Louis DL; Paganotti, Giacomo Maria GM

Publication Date: 2022

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 35761855

Variant Present in the following documents:

• Main text
• pgpm-15-613.pdf

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

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Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children's Hospital.

Journal Of Personalized Medicine

Gill, Pritmohinder S PS; Yu, Feliciano B FB; Porter-Gill, Patricia A PA; Boyanton, Bobby L BL; Allen, Judy C JC; Farrar, Jason E JE; Veerapandiyan, Aravindhan A; Prodhan, Parthak P; Bielamowicz, Kevin J KJ; Sellars, Elizabeth E; Burrow, Andrew A; Kennedy, Joshua L JL; Clothier, Jeffery L JL; Becton, David L DL; Rule, Don D; Schaefer, G Bradley GB

Publication Date: 2021-05-11

Variant appearance in text: rs12721629

PubMed Link: 34064668

Variant Present in the following documents:

• Main text
• jpm-11-00394.pdf

View BVdb publication page

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Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment.

Antimicrobial Agents And Chemotherapy

Pernaute-Lau, Leyre L; Adegnika, Ayola Akim AA; Zhou, Yitian Y; Zinsou, Jeannot F JF; Gil, Jose Pedro JP; Krishna, Sanjeev S; Kremsner, Peter G PG; Lauschke, Volker M VM; Velavan, Thirumalaisamy P TP

Publication Date: 2021-06-17

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 33875422

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variants related to successful migraine prophylaxis with verapamil.

Molecular Genetics & Genomic Medicine

Cutrer, Fred Michael FM; Moyer, Ann M AM; Atkinson, Elizabeth J EJ; Wang, Liguo L; Tian, Shulan S; Wu, Yanhong Y; Garza, Ivan I; Robertson, Carrie E CE; Huebert, Carey A CA; Moore, Brenda E BE; Klein, Christopher J CJ

Publication Date: 2021-06

Variant appearance in text: rs12721629

PubMed Link: 33829662

Variant Present in the following documents:

• Main text
• MGG3-9-e1680.pdf

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Genetic variants related to successful migraine prophylaxis with verapamil.

Molecular Genetics & Genomic Medicine

Cutrer, Fred Michael FM; Moyer, Ann M AM; Atkinson, Elizabeth J EJ; Wang, Liguo L; Tian, Shulan S; Wu, Yanhong Y; Garza, Ivan I; Robertson, Carrie E CE; Huebert, Carey A CA; Moore, Brenda E BE; Klein, Christopher J CJ

Publication Date: 2021-06

Variant appearance in text: rs12721629

PubMed Link: 33829662

Variant Present in the following documents:

• Main text
• MGG3-9-e1680.pdf

View BVdb publication page

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Variation in 100 relevant pharmacogenes among emiratis with insights from understudied populations.

Scientific Reports

Al-Mahayri, Zeina N ZN; Patrinos, George P GP; Wattanapokayakit, Sukanya S; Iemwimangsa, Nareenart N; Fukunaga, Koya K; Mushiroda, Taisei T; Chantratita, Wasun W; Ali, Bassam R BR

Publication Date: 2020-12-04

Variant appearance in text: rs12721629

PubMed Link: 33277594

Variant Present in the following documents:

• 41598_2020_78231_MOESM1_ESM.pdf

View BVdb publication page

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Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.

Clinical And Translational Science

Scott, Stuart A SA; Scott, Erick R ER; Seki, Yoshinori Y; Chen, Annette J AJ; Wallsten, Richard R; Owusu Obeng, Aniwaa A; Botton, Mariana R MR; Cody, Neal N; Shi, Huanzhi H; Zhao, Geping G; Brake, Paul P; Nicoletti, Paola P; Yang, Yao Y; Delio, Maria M; Shi, Lisong L; Kornreich, Ruth R; Schadt, Eric E EE; Edelmann, Lisa L

Publication Date: 2021-01

Variant appearance in text: rs12721629

PubMed Link: 32931151

Variant Present in the following documents:

• CTS-14-204-s001.xlsx, sheet 1

View BVdb publication page

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates.

Biomedicines

Saiz-Rodríguez, Miriam M; Almenara, Susana S; Navares-Gómez, Marcos M; Ochoa, Dolores D; Román, Manuel M; Zubiaur, Pablo P; Koller, Dora D; Santos, María M; Mejía, Gina G; Borobia, Alberto M AM; Rodríguez-Antona, Cristina C; Abad-Santos, Francisco F

Publication Date: 2020-04-22

Variant appearance in text: rs12721629

PubMed Link: 32331352

Variant Present in the following documents:

• Main text
• biomedicines-08-00094.pdf

View BVdb publication page

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Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro.

Frontiers In Pharmacology

Zhou, Xiao-Yang XY; Hu, Xiao-Xia XX; Wang, Chen-Chen CC; Lu, Xiang-Ran XR; Chen, Zhe Z; Liu, Qian Q; Hu, Guo-Xin GX; Cai, Jian-Ping JP

Publication Date: 2019

Variant appearance in text: CYP3A4: L373F

PubMed Link: 31214030

Variant Present in the following documents:

• Main text
• fphar-10-00591.pdf

View BVdb publication page

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Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related.

Frontiers In Genetics

Guttman, Yelena Y; Nudel, Adi A; Kerem, Zohar Z

Publication Date: 2019

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 30941162

Variant Present in the following documents:

• Main text
• fgene-10-00224.pdf
• Table_2.xlsx, sheet 8
• Table_2.xlsx, sheet 7
• Table_2.xlsx, sheet 2

View BVdb publication page

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Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

Obstetrics And Gynecology

Lazorwitz, Aaron A; Aquilante, Christina L CL; Oreschak, Kris K; Sheeder, Jeanelle J; Guiahi, Maryam M; Teal, Stephanie S

Publication Date: 2019-04

Variant appearance in text: rs12721629

PubMed Link: 30870275

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution.

Scientific Reports

Arendse, Lauren B LB; Blackburn, Jonathan M JM

Publication Date: 2018-08-08

Variant appearance in text: CYP3A4: L373F

PubMed Link: 30089838

Variant Present in the following documents:

• Main text
• 41598_2018_30195_MOESM1_ESM.pdf
• 41598_2018_Article_30195.pdf

View BVdb publication page

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Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs12721629

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics

Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM

Publication Date: 2017-10

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 28378927

Variant Present in the following documents:

• Main text
• CPT-102-688.pdf

View BVdb publication page

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Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Sevrioukova, Irina F IF; Poulos, Thomas L TL

Publication Date: 2017-01-17

Variant appearance in text: CYP3A4: L373F

PubMed Link: 28031486

Variant Present in the following documents:

• Main text

View BVdb publication page

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

View BVdb publication page

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Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients.

Scientific Reports

Chen, Miao M; Zhang, Rong R; Jiang, Feng F; Wang, Jie J; Peng, Danfeng D; Yan, Jing J; Wang, Shiyun S; Wang, Tao T; Bao, Yuqian Y; Hu, Cheng C; Jia, Weiping W

Publication Date: 2016-03-17

Variant appearance in text: rs12721629

PubMed Link: 26983698

Variant Present in the following documents:

• Main text
• srep23266.pdf

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs12721629

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs12721629

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs12721629

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

View BVdb publication page

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The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.

Journal Of Personalized Medicine

Wang, Danxin D; Sadee, Wolfgang W

Publication Date: 2012-10-29

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 24466438

Variant Present in the following documents:

• Main text
• jpm-02-00175.pdf

View BVdb publication page

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics

Klein, Kathrin K; Zanger, Ulrich M UM

Publication Date: 2013

Variant appearance in text: rs12721629

PubMed Link: 23444277

Variant Present in the following documents:

• Main text
• fgene-04-00012.pdf

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Characterization of the genetic variation present in CYP3A4 in three South African populations.

Frontiers In Genetics

Drögemöller, Britt B; Plummer, Marieth M; Korkie, Lundi L; Agenbag, Gloudi G; Dunaiski, Anke A; Niehaus, Dana D; Koen, Liezl L; Gebhardt, Stefan S; Schneider, Nicol N; Olckers, Antonel A; Wright, Galen G; Warnich, Louise L

Publication Date: 2013

Variant appearance in text: CYP3A4: L373F; rs12721629

PubMed Link: 23423246

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genotyping panel for assessing response to cancer chemotherapy.

Bmc Medical Genomics

Dai, Zunyan Z; Papp, Audrey C AC; Wang, Danxin D; Hampel, Heather H; Sadee, Wolfgang W

Publication Date: 2008-06-11

Variant appearance in text: rs12721629

PubMed Link: 18547414

Variant Present in the following documents:

• 1755-8794-1-24-S1.xls, sheet 1

View BVdb publication page

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Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

Journal Of Clinical Pharmacology

Lee, Su-Jun SJ; Jusko, William J WJ; Salaita, Christine G CG; Calis, Karim A KA; Jann, Michael W MW; Spratlin, Vicky E VE; Goldstein, Joyce A JA; Hon, Yuen Yi YY

Publication Date: 2006-05

Variant appearance in text: CYP3A4: Leu373Phe

PubMed Link: 16638735

Variant Present in the following documents:

• Main text

View BVdb publication page

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