Publications:

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The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.

The Pharmacogenomics Journal

Zhou, Yitian Y; Lauschke, Volker M VM

Publication Date: 2022-12

Variant appearance in text: CYP3A4: 484C>T; Arg162Trp; rs57409622

PubMed Link: 36068297

Variant Present in the following documents:

• 41397_2022_288_MOESM4_ESM.xlsx, sheet 1

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Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.

Frontiers In Pharmacology

Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ

Publication Date: 2022

Variant appearance in text: CYP3A4: 484C>T; Arg162Trp; rs57409622

PubMed Link: 35846994

Variant Present in the following documents:

• Table3.xlsx, sheet 1

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Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Frontiers In Pharmacology

Zhai, Qinglian Q; van der Lee, Maaike M; van Gelder, Teun T; Swen, Jesse J JJ

Publication Date: 2022

Variant appearance in text: CYP3A4: R162W; rs57409622

PubMed Link: 35784699

Variant Present in the following documents:

• Main text
• fphar-13-912618.pdf

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Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.

Pharmacogenomics And Personalized Medicine

Nthontho, Keneuoe Cecilia KC; Ndlovu, Andrew Khulekani AK; Sharma, Kirthana K; Kasvosve, Ishmael I; Hertz, Daniel Louis DL; Paganotti, Giacomo Maria GM

Publication Date: 2022

Variant appearance in text: CYP3A4: R162W; rs57409622

PubMed Link: 35761855

Variant Present in the following documents:

• Main text
• pgpm-15-613.pdf

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Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism.

Drug Design, Development And Therapy

Tang, Peng-Fei PF; Zheng, Xiang X; Hu, Xiao-Xia XX; Yang, Cheng-Cheng CC; Chen, Zhe Z; Qian, Jian-Chang JC; Cai, Jian-Ping JP; Hu, Guo-Xin GX

Publication Date: 2020

Variant appearance in text: CYP3A4: R162W

PubMed Link: 33262574

Variant Present in the following documents:

• Main text
• dddt-14-5129.pdf

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Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro.

Frontiers In Pharmacology

Zhou, Xiao-Yang XY; Hu, Xiao-Xia XX; Wang, Chen-Chen CC; Lu, Xiang-Ran XR; Chen, Zhe Z; Liu, Qian Q; Hu, Guo-Xin GX; Cai, Jian-Ping JP

Publication Date: 2019

Variant appearance in text: CYP3A4: R162W

PubMed Link: 31214030

Variant Present in the following documents:

• Main text
• fphar-10-00591.pdf

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Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related.

Frontiers In Genetics

Guttman, Yelena Y; Nudel, Adi A; Kerem, Zohar Z

Publication Date: 2019

Variant appearance in text: rs57409622

PubMed Link: 30941162

Variant Present in the following documents:

• Table_2.xlsx, sheet 7
• Table_2.xlsx, sheet 4
• Table_2.xlsx, sheet 8
• Table_2.xlsx, sheet 3
• Table_2.xlsx, sheet 2

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Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs57409622

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro.

Drug Design, Development And Therapy

Fang, Ping P; Tang, Peng-Fei PF; Xu, Ren-Ai RA; Zheng, Xiang X; Wen, Jian J; Bao, Su-Su SS; Cai, Jian-Ping JP; Hu, Guo-Xin GX

Publication Date: 2017

Variant appearance in text: CYP3A4: R162W

PubMed Link: 29263648

Variant Present in the following documents:

• Main text
• dddt-11-3503.pdf

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: rs57409622

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: CYP3A4: R162W

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s3.xls, sheet 1

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics

Klein, Kathrin K; Zanger, Ulrich M UM

Publication Date: 2013

Variant appearance in text: rs57409622

PubMed Link: 23444277

Variant Present in the following documents:

• Main text
• fgene-04-00012.pdf

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Characterization of the genetic variation present in CYP3A4 in three South African populations.

Frontiers In Genetics

Drögemöller, Britt B; Plummer, Marieth M; Korkie, Lundi L; Agenbag, Gloudi G; Dunaiski, Anke A; Niehaus, Dana D; Koen, Liezl L; Gebhardt, Stefan S; Schneider, Nicol N; Olckers, Antonel A; Wright, Galen G; Warnich, Louise L

Publication Date: 2013

Variant appearance in text: CYP3A4: R162W; rs57409622

PubMed Link: 23423246

Variant Present in the following documents:

• Main text

View BVdb publication page

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