Publications:

---

Effects of CYP3A4*22 and CYP3A5 on clinical outcome in patients treated with ticagrelor for ST-segment elevation myocardial infarction: POPular Genetics sub-study.

Frontiers In Pharmacology

Azzahhafi, Jaouad J; Bergmeijer, Thomas O TO; van den Broek, Wout W A WWA; Chan Pin Yin, Dean R P P DRPP; Rayhi, Senna S; Peper, Joyce J; Bor, Willem L WL; Claassens, Daniel M F DMF; van Schaik, Ron H N RHN; Ten Berg, Jurriën M JM

Publication Date: 2022

Variant appearance in text: rs56324128

PubMed Link: 36545312

Variant Present in the following documents:

• Main text
• fphar-13-1032995.pdf

View BVdb publication page

---

Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Frontiers In Pharmacology

Zhai, Qinglian Q; van der Lee, Maaike M; van Gelder, Teun T; Swen, Jesse J JJ

Publication Date: 2022

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 35784699

Variant Present in the following documents:

• Main text
• fphar-13-912618.pdf

View BVdb publication page

---

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.

Nature Neuroscience

Baxi, Emily G EG; Thompson, Terri T; Li, Jonathan J; Kaye, Julia A JA; Lim, Ryan G RG; Wu, Jie J; Ramamoorthy, Divya D; Lima, Leandro L; Vaibhav, Vineet V; Matlock, Andrea A; Frank, Aaron A; Coyne, Alyssa N AN; Landin, Barry B; Ornelas, Loren L; Mosmiller, Elizabeth E; Thrower, Sara S; Farr, S Michelle SM; Panther, Lindsey L; Gomez, Emilda E; Galvez, Erick E; Perez, Daniel D; Meepe, Imara I; Lei, Susan S; Mandefro, Berhan B; Trost, Hannah H; Pinedo, Louis L; Banuelos, Maria G MG; Liu, Chunyan C; Moran, Ruby R; Garcia, Veronica V; Workman, Michael M; Ho, Richie R; Wyman, Stacia S; Roggenbuck, Jennifer J; Harms, Matthew B MB; Stocksdale, Jennifer J; Miramontes, Ricardo R; Wang, Keona K; Venkatraman, Vidya V; Holewenski, Ronald R; Sundararaman, Niveda N; Pandey, Rakhi R; Manalo, Danica-Mae DM; Donde, Aneesh A; Huynh, Nhan N; Adam, Miriam M; Wassie, Brook T BT; Vertudes, Edward E; Amirani, Naufa N; Raja, Krishna K; Thomas, Reuben R; Hayes, Lindsey L; Lenail, Alex A; Cerezo, Aianna A; Luppino, Sarah S; Farrar, Alanna A; Pothier, Lindsay L; Prina, Carolyn C; Morgan, Todd T; Jamil, Arish A; Heintzman, Sarah S; Jockel-Balsarotti, Jennifer J; Karanja, Elizabeth E; Markway, Jesse J; McCallum, Molly M; Joslin, Ben B; Alibazoglu, Deniz D; Kolb, Stephen S; Ajroud-Driss, Senda S; Baloh, Robert R; Heitzman, Daragh D; Miller, Tim T; Glass, Jonathan D JD; Patel-Murray, Natasha Leanna NL; Yu, Hong H; Sinani, Ervin E; Vigneswaran, Prasha P; Sherman, Alexander V AV; Ahmad, Omar O; Roy, Promit P; Beavers, Jay C JC; Zeiler, Steven S; Krakauer, John W JW; Agurto, Carla C; Cecchi, Guillermo G; Bellard, Mary M; Raghav, Yogindra Y; Sachs, Karen K; Ehrenberger, Tobias T; Bruce, Elizabeth E; Cudkowicz, Merit E ME; Maragakis, Nicholas N; Norel, Raquel R; Van Eyk, Jennifer E JE; Finkbeiner, Steven S; Berry, James J; Sareen, Dhruv D; Thompson, Leslie M LM; Fraenkel, Ernest E; Svendsen, Clive N CN; Rothstein, Jeffrey D JD

Publication Date: 2022-02

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 35115730

Variant Present in the following documents:

• 41593_2021_1006_MOESM4_ESM.xlsx, sheet 9

View BVdb publication page

---

Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

---

Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism.

International Journal Of Clinical Pharmacology And Therapeutics

Akiyoshi, Takeshi T; Naitou, Rina R; Imaoka, Ayuko A; Miyazaki, Mitsue M; Guengerich, F Peter FP; Nakamura, Katsunori K; Yamamoto, Koujiro K; Ohtani, Hisakazu H

Publication Date: 2021-12

Variant appearance in text: CYP3A4: Gly56Asp

PubMed Link: 34542401

Variant Present in the following documents:

• Main text
• intjclinpharmacol-59-12-745.pdf

View BVdb publication page

---

Biomarkers for Antiplatelet Therapies in Acute Ischemic Stroke: A Clinical Review.

Frontiers In Neurology

Alhazzani, Adel A; Venkatachalapathy, Poongothai P; Padhilahouse, Sruthi S; Sellappan, Mohan M; Munisamy, Murali M; Sekaran, Mangaiyarkarasi M; Kumar, Amit A

Publication Date: 2021

Variant appearance in text: rs56324128

PubMed Link: 34177775

Variant Present in the following documents:

• Main text
• fneur-12-667234.pdf

View BVdb publication page

---

Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function.

Clinical And Translational Science

Fohner, Alison E AE; Dalton, Rachel R; Skagen, Kasse K; Jackson, Konner K; Claw, Katrina G KG; Hopkins, Scarlett E SE; Robinson, Renee R; Khan, Burhan A BA; Prasad, Bhagwat B; Schuetz, Erin G EG; Nickerson, Deborah A DA; Thornton, Timothy A TA; Dillard, Denise A DA; Boyer, Bert B BB; Thummel, Kenneth E KE; Woodahl, Erica L EL

Publication Date: 2021-07

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 33503331

Variant Present in the following documents:

• Main text
• CTS-14-1292.pdf

View BVdb publication page

---

Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

---

Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro.

Frontiers In Pharmacology

Zhou, Xiao-Yang XY; Hu, Xiao-Xia XX; Wang, Chen-Chen CC; Lu, Xiang-Ran XR; Chen, Zhe Z; Liu, Qian Q; Hu, Guo-Xin GX; Cai, Jian-Ping JP

Publication Date: 2019

Variant appearance in text: CYP3A4: G56D

PubMed Link: 31214030

Variant Present in the following documents:

• Main text
• fphar-10-00591.pdf

View BVdb publication page

---

Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related.

Frontiers In Genetics

Guttman, Yelena Y; Nudel, Adi A; Kerem, Zohar Z

Publication Date: 2019

Variant appearance in text: rs56324128

PubMed Link: 30941162

Variant Present in the following documents:

• Table_2.xlsx, sheet 8
• Table_2.xlsx, sheet 3
• Table_2.xlsx, sheet 5
• Table_2.xlsx, sheet 7

View BVdb publication page

---

Pharmacogenomic considerations for antiplatelet agents: the era of precision medicine in stroke prevention and neurointerventional practice.

Cold Spring Harbor Molecular Case Studies

Bonney, Phillip A PA; Yim, Benjamin B; Brinjikji, Waleed W; Walcott, Brian P BP

Publication Date: 2019-04

Variant appearance in text: rs56324128

PubMed Link: 30936195

Variant Present in the following documents:

• Main text
• MCS003731Bon.pdf

View BVdb publication page

---

Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

Obstetrics And Gynecology

Lazorwitz, Aaron A; Aquilante, Christina L CL; Oreschak, Kris K; Sheeder, Jeanelle J; Guiahi, Maryam M; Teal, Stephanie S

Publication Date: 2019-04

Variant appearance in text: rs56324128

PubMed Link: 30870275

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution.

Scientific Reports

Arendse, Lauren B LB; Blackburn, Jonathan M JM

Publication Date: 2018-08-08

Variant appearance in text: CYP3A4: G56D

PubMed Link: 30089838

Variant Present in the following documents:

• Main text
• 41598_2018_30195_MOESM1_ESM.pdf
• 41598_2018_Article_30195.pdf

View BVdb publication page

---

Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins.

Drugs

Danielak, Dorota D; Karaźniewicz-Łada, Marta M; Główka, Franciszek F

Publication Date: 2018-07

Variant appearance in text: rs56324128

PubMed Link: 30003466

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ticagrelor - toward more efficient platelet inhibition and beyond.

Therapeutics And Clinical Risk Management

Kubisa, Michał J MJ; Jezewski, Mateusz P MP; Gasecka, Aleksandra A; Siller-Matula, Jolanta M JM; Postuła, Marek M

Publication Date: 2018

Variant appearance in text: rs56324128

PubMed Link: 29398917

Variant Present in the following documents:

• Main text
• tcrm-14-129.pdf

View BVdb publication page

---

Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs56324128

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

---

Effect of CYP3A4 and CYP3A5 Polymorphisms on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects.

Frontiers In Pharmacology

Liu, Shuaibing S; Shi, Xiangfen X; Tian, Xin X; Zhang, Xiaojian X; Sun, Zhiyong Z; Miao, Liyan L

Publication Date: 2017

Variant appearance in text: rs56324128

PubMed Link: 28408884

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics

Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM

Publication Date: 2017-10

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 28378927

Variant Present in the following documents:

• Main text
• CPT-102-688.pdf

View BVdb publication page

---

Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

View BVdb publication page

---

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.

Nature Communications

Cereda, Matteo M; Gambardella, Gennaro G; Benedetti, Lorena L; Iannelli, Fabio F; Patel, Dominic D; Basso, Gianluca G; Guerra, Rosalinda F RF; Mourikis, Thanos P TP; Puccio, Ignazio I; Sinha, Shruti S; Laghi, Luigi L; Spencer, Jo J; Rodriguez-Justo, Manuel M; Ciccarelli, Francesca D FD

Publication Date: 2016-07-05

Variant appearance in text: CYP3A4: G56D

PubMed Link: 27377421

Variant Present in the following documents:

• ncomms12072-s6.xlsx, sheet 1

View BVdb publication page

---

Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs56324128

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

View BVdb publication page

---

GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: CYP3A4: G56D

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

View BVdb publication page

---

The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.

Expert Opinion On Drug Metabolism & Toxicology

Yang, Yao Y; Lewis, Joshua P JP; Hulot, Jean-Sébastien JS; Scott, Stuart A SA

Publication Date: 2015

Variant appearance in text: rs56324128

PubMed Link: 26173871

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs56324128

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

---

The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs56324128

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

View BVdb publication page

---

The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.

Journal Of Personalized Medicine

Wang, Danxin D; Sadee, Wolfgang W

Publication Date: 2012-10-29

Variant appearance in text: CYP3A4: G56D; rs56324128

PubMed Link: 24466438

Variant Present in the following documents:

• Main text
• jpm-02-00175.pdf

View BVdb publication page

---

Integrated analysis of germline and somatic variants in ovarian cancer.

Nature Communications

Kanchi, Krishna L KL; Johnson, Kimberly J KJ; Lu, Charles C; McLellan, Michael D MD; Leiserson, Mark D M MD; Wendl, Michael C MC; Zhang, Qunyuan Q; Koboldt, Daniel C DC; Xie, Mingchao M; Kandoth, Cyriac C; McMichael, Joshua F JF; Wyczalkowski, Matthew A MA; Larson, David E DE; Schmidt, Heather K HK; Miller, Christopher A CA; Fulton, Robert S RS; Spellman, Paul T PT; Mardis, Elaine R ER; Druley, Todd E TE; Graubert, Timothy A TA; Goodfellow, Paul J PJ; Raphael, Benjamin J BJ; Wilson, Richard K RK; Ding, Li L

Publication Date: 2014

Variant appearance in text: CYP3A4: G56D

PubMed Link: 24448499

Variant Present in the following documents:

• NIHMS551112-supplement-7.xlsx, sheet 1

View BVdb publication page

---

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics

Klein, Kathrin K; Zanger, Ulrich M UM

Publication Date: 2013

Variant appearance in text: rs56324128

PubMed Link: 23444277

Variant Present in the following documents:

• Main text
• fgene-04-00012.pdf

View BVdb publication page

---

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals

Akiyoshi, Takeshi T; Saito, Takashi T; Murase, Saori S; Miyazaki, Mitsue M; Murayama, Norie N; Yamazaki, Hiroshi H; Guengerich, F Peter FP; Nakamura, Katsunori K; Yamamoto, Koujirou K; Ohtani, Hisakazu H

Publication Date: 2011-04

Variant appearance in text: CYP3A4: G56D

PubMed Link: 21212239

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

Journal Of Clinical Pharmacology

Lee, Su-Jun SJ; Jusko, William J WJ; Salaita, Christine G CG; Calis, Karim A KA; Jann, Michael W MW; Spratlin, Vicky E VE; Goldstein, Joyce A JA; Hon, Yuen Yi YY

Publication Date: 2006-05

Variant appearance in text: CYP3A4: Gly56Asp

PubMed Link: 16638735

Variant Present in the following documents:

• Main text

View BVdb publication page

---