Development and validation of a multivariable genotype-informed gestational diabetes prediction algorithm for clinical use in the Mexican population: insights into susceptibility mechanisms.
Bmj Open Diabetes Research & Care
Zulueta, Mirella M; Gallardo-Rincón, Héctor H; Martinez-Juarez, Luis Alberto LA; Lomelin-Gascon, Julieta J; Ortega-Montiel, Janinne J; Montoya, Alejandra A; Mendizabal, Leire L; Arregi, Maddi M; Martinez-Martinez, María de Los Angeles MLA; Camarillo Romero, Eneida Del Socorro EDS; Mendieta Zerón, Hugo H; Garduño García, José de Jesús JJ; Simón, Laureano L; Tapia-Conyer, Roberto R
Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population.
Genes
Binjawhar, Dalal N DN; Ansari, Mohammed G A MGA; Sabico, Shaun S; Hussain, Syed Danish SD; Alenad, Amal M AM; Alokail, Majed S MS; Al-Masri, Abeer A AA; Al-Daghri, Nasser M NM
The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population.
Diabetologia
Wedekind, Lauren E LE; Mahajan, Anubha A; Hsueh, Wen-Chi WC; Chen, Peng P; Olaiya, Muideen T MT; Kobes, Sayuko S; Sinha, Madhumita M; Baier, Leslie J LJ; Knowler, William C WC; McCarthy, Mark I MI; Hanson, Robert L RL
Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet.
Frontiers In Endocrinology
Ramos-Levi, Ana A; Barabash, Ana A; Valerio, Johanna J; García de la Torre, Nuria N; Mendizabal, Leire L; Zulueta, Mirella M; de Miguel, Maria Paz MP; Diaz, Angel A; Duran, Alejandra A; Familiar, Cristina C; Jimenez, Inés I; Del Valle, Laura L; Melero, Veronica V; Moraga, Inmaculada I; Herraiz, Miguel A MA; Torrejon, María José MJ; Arregi, Maddi M; Simón, Laureano L; Rubio, Miguel A MA; Calle-Pascual, Alfonso L AL
Beneficial effects of mifepristone treatment in breast cancer patients selected by the progesterone receptor isoform ratio: Results from the MIPRA trial.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Elía, Andrés A; Saldain, Leo L; Vanzulli, Silvia I SI; Helguero, Luisa A LA; Lamb, Caroline A CA; Fabris, Victoria V; Pataccini, Gabriela G; Martínez-Vazquez, Paula P; Burruchaga, Javier J; Caillet-Bois, Ines I; Spengler, Eunice E; Acosta Haab, Gabriela G; Liguori, Marcos M; Castets, Alejandra A; Lovisi, Silvia S; Abascal, María F MF; Novaro, Virginia V; Sánchez, Jana J; Muñoz, Javier J; Belizán, Jose M JM; Abba, Martín C MC; Gass, Hugo H; Rojas, Paola P; Lanari, Claudia C
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.
Communications Biology
DiCorpo, Daniel D; Gaynor, Sheila M SM; Russell, Emily M EM; Westerman, Kenneth E KE; Raffield, Laura M LM; Majarian, Timothy D TD; Wu, Peitao P; Sarnowski, Chloé C; Highland, Heather M HM; Jackson, Anne A; Hasbani, Natalie R NR; de Vries, Paul S PS; Brody, Jennifer A JA; Hidalgo, Bertha B; Guo, Xiuqing X; Perry, James A JA; O'Connell, Jeffrey R JR; Lent, Samantha S; Montasser, May E ME; Cade, Brian E BE; Jain, Deepti D; Wang, Heming H; D'Oliveira Albanus, Ricardo R; Varshney, Arushi A; Yanek, Lisa R LR; Lange, Leslie L; Palmer, Nicholette D ND; Almeida, Marcio M; Peralta, Juan M JM; Aslibekyan, Stella S; Baldridge, Abigail S AS; Bertoni, Alain G AG; Bielak, Lawrence F LF; Chen, Chung-Shiuan CS; Chen, Yii-Der Ida YI; Choi, Won Jung WJ; Goodarzi, Mark O MO; Floyd, James S JS; Irvin, Marguerite R MR; Kalyani, Rita R RR; Kelly, Tanika N TN; Lee, Seonwook S; Liu, Ching-Ti CT; Loesch, Douglas D; Manson, JoAnn E JE; Minster, Ryan L RL; Naseri, Take T; Pankow, James S JS; Rasmussen-Torvik, Laura J LJ; Reiner, Alexander P AP; Reupena, Muagututi'a Sefuiva MS; Selvin, Elizabeth E; Smith, Jennifer A JA; Weeks, Daniel E DE; Xu, Huichun H; Yao, Jie J; Zhao, Wei W; Parker, Stephen S; Alonso, Alvaro A; Arnett, Donna K DK; Blangero, John J; Boerwinkle, Eric E; Correa, Adolfo A; Cupples, L Adrienne LA; Curran, Joanne E JE; Duggirala, Ravindranath R; He, Jiang J; Heckbert, Susan R SR; Kardia, Sharon L R SLR; Kim, Ryan W RW; Kooperberg, Charles C; Liu, Simin S; Mathias, Rasika A RA; McGarvey, Stephen T ST; Mitchell, Braxton D BD; Morrison, Alanna C AC; Peyser, Patricia A PA; Psaty, Bruce M BM; Redline, Susan S; Shuldiner, Alan R AR; Taylor, Kent D KD; Vasan, Ramachandran S RS; Viaud-Martinez, Karine A KA; Florez, Jose C JC; Wilson, James G JG; Sladek, Robert R; Rich, Stephen S SS; Rotter, Jerome I JI; Lin, Xihong X; Dupuis, Josée J; Meigs, James B JB; Wessel, Jennifer J; Manning, Alisa K AK
Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.
Plos One
Chen, Guanjie G; Shriner, Daniel D; Zhang, Jianhua J; Zhou, Jie J; Adikaram, Poorni P; Doumatey, Ayo P AP; Bentley, Amy R AR; Adeyemo, Adebowale A; Rotimi, Charles N CN
Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus.
Frontiers In Physiology
Ortega-Contreras, B B; Armella, A A; Appel, J J; Mennickent, D D; Araya, J J; González, M M; Castro, E E; Obregón, A M AM; Lamperti, L L; Gutiérrez, J J; Guzmán-Gutiérrez, E E
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.
Journal Of The National Cancer Institute
Murphy, Neil N; Song, Mingyang M; Papadimitriou, Nikos N; Carreras-Torres, Robert R; Langenberg, Claudia C; Martin, Richard M RM; Tsilidis, Konstantinos K KK; Barroso, Inês I; Chen, Ji J; Frayling, Timothy M TM; Bull, Caroline J CJ; Vincent, Emma E EE; Cotterchio, Michelle M; Gruber, Stephen B SB; Pai, Rish K RK; Newcomb, Polly A PA; Perez-Cornago, Aurora A; van Duijnhoven, Franzel J B FJB; Van Guelpen, Bethany B; Vodicka, Pavel P; Wolk, Alicja A; Wu, Anna H AH; Peters, Ulrike U; Chan, Andrew T AT; Gunter, Marc J MJ
TIGER: The gene expression regulatory variation landscape of human pancreatic islets.
Cell Reports
Alonso, Lorena L; Piron, Anthony A; Morán, Ignasi I; Guindo-Martínez, Marta M; Bonàs-Guarch, Sílvia S; Atla, Goutham G; Miguel-Escalada, Irene I; Royo, Romina R; Puiggròs, Montserrat M; Garcia-Hurtado, Xavier X; Suleiman, Mara M; Marselli, Lorella L; Esguerra, Jonathan L S JLS; Turatsinze, Jean-Valéry JV; Torres, Jason M JM; Nylander, Vibe V; Chen, Ji J; Eliasson, Lena L; Defrance, Matthieu M; Amela, Ramon R; , ; Mulder, Hindrik H; Gloyn, Anna L AL; Groop, Leif L; Marchetti, Piero P; Eizirik, Decio L DL; Ferrer, Jorge J; Mercader, Josep M JM; Cnop, Miriam M; Torrents, David D
Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation.
Nature Communications
Khetan, Shubham S; Kales, Susan S; Kursawe, Romy R; Jillette, Alexandria A; Ulirsch, Jacob C JC; Reilly, Steven K SK; Ucar, Duygu D; Tewhey, Ryan R; Stitzel, Michael L ML
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.
Diabetes
Slieker, Roderick C RC; Donnelly, Louise A LA; Fitipaldi, Hugo H; Bouland, Gerard A GA; Giordano, Giuseppe N GN; Åkerlund, Mikael M; Gerl, Mathias J MJ; Ahlqvist, Emma E; Ali, Ashfaq A; Dragan, Iulian I; Elders, Petra P; Festa, Andreas A; Hansen, Michael K MK; van der Heijden, Amber A AA; Mansour Aly, Dina D; Kim, Min M; Kuznetsov, Dmitry D; Mehl, Florence F; Klose, Christian C; Simons, Kai K; Pavo, Imre I; Pullen, Timothy J TJ; Suvitaival, Tommi T; Wretlind, Asger A; Rossing, Peter P; Lyssenko, Valeriya V; Legido Quigley, Cristina C; Groop, Leif L; Thorens, Bernard B; Franks, Paul W PW; Ibberson, Mark M; Rutter, Guy A GA; Beulens, Joline W J JWJ; 't Hart, Leen M LM; Pearson, Ewan R ER
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.
Diabetes
Slieker, Roderick C RC; Donnelly, Louise A LA; Fitipaldi, Hugo H; Bouland, Gerard A GA; Giordano, Giuseppe N GN; Åkerlund, Mikael M; Gerl, Mathias J MJ; Ahlqvist, Emma E; Ali, Ashfaq A; Dragan, Iulian I; Elders, Petra P; Festa, Andreas A; Hansen, Michael K MK; van der Heijden, Amber A AA; Mansour Aly, Dina D; Kim, Min M; Kuznetsov, Dmitry D; Mehl, Florence F; Klose, Christian C; Simons, Kai K; Pavo, Imre I; Pullen, Timothy J TJ; Suvitaival, Tommi T; Wretlind, Asger A; Rossing, Peter P; Lyssenko, Valeriya V; Legido Quigley, Cristina C; Groop, Leif L; Thorens, Bernard B; Franks, Paul W PW; Ibberson, Mark M; Rutter, Guy A GA; Beulens, Joline W J JWJ; 't Hart, Leen M LM; Pearson, Ewan R ER
Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors -results of the Heinz Nixdorf Recall Study.
Naunyn-Schmiedeberg'S Archives Of Pharmacology
Pechlivanis, Sonali S; Jung, Dominik D; Moebus, Susanne S; Lehmann, Nils N; Mahabadi, Amir A AA; Hoffmann, Per P; Erbel, Raimund R; Nöthen, Markus M MM; Bachmann, Hagen S HS
PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records.
Journal Of The American Medical Informatics Association : Jamia
Zheng, Neil S NS; Feng, QiPing Q; Kerchberger, V Eric VE; Zhao, Juan J; Edwards, Todd L TL; Cox, Nancy J NJ; Stein, C Michael CM; Roden, Dan M DM; Denny, Joshua C JC; Wei, Wei-Qi WQ
Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations.
Bmj Open Diabetes Research & Care
Li, Mengying M; Rahman, Mohammad L ML; Wu, Jing J; Ding, Ming M; Chavarro, Jorge E JE; Lin, Yuan Y; Ley, Sylvia H SH; Bao, Wei W; Grunnet, Louise G LG; Hinkle, Stefanie N SN; Thuesen, Anne Cathrine B ACB; Yeung, Edwina E; Gore-Langton, Robert E RE; Sherman, Seth S; Hjort, Line L; Kampmann, Freja Bach FB; Bjerregaard, Anne Ahrendt AA; Damm, Peter P; Tekola-Ayele, Fasil F; Liu, Aiyi A; Mills, James L JL; Vaag, Allan A; Olsen, Sjurdur F SF; Hu, Frank B FB; Zhang, Cuilin C
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Nature Genetics
Dwivedi, Om Prakash OP; Lehtovirta, Mikko M; Hastoy, Benoit B; Chandra, Vikash V; Krentz, Nicole A J NAJ; Kleiner, Sandra S; Jain, Deepak D; Richard, Ann-Marie AM; Abaitua, Fernando F; Beer, Nicola L NL; Grotz, Antje A; Prasad, Rashmi B RB; Hansson, Ola O; Ahlqvist, Emma E; Krus, Ulrika U; Artner, Isabella I; Suoranta, Anu A; Gomez, Daniel D; Baras, Aris A; Champon, Benoite B; Payne, Anthony J AJ; Moralli, Daniela D; Thomsen, Soren K SK; Kramer, Philipp P; Spiliotis, Ioannis I; Ramracheya, Reshma R; Chabosseau, Pauline P; Theodoulou, Andria A; Cheung, Rebecca R; van de Bunt, Martijn M; Flannick, Jason J; Trombetta, Maddalena M; Bonora, Enzo E; Wolheim, Claes B CB; Sarelin, Leena L; Bonadonna, Riccardo C RC; Rorsman, Patrik P; Davies, Benjamin B; Brosnan, Julia J; McCarthy, Mark I MI; Otonkoski, Timo T; Lagerstedt, Jens O JO; Rutter, Guy A GA; Gromada, Jesper J; Gloyn, Anna L AL; Tuomi, Tiinamaija T; Groop, Leif L
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.
Bmj (Clinical Research Ed.)
Merino, Jordi J; Guasch-Ferré, Marta M; Ellervik, Christina C; Dashti, Hassan S HS; Sharp, Stephen J SJ; Wu, Peitao P; Overvad, Kim K; Sarnowski, Chloé C; Kuokkanen, Mikko M; Lemaitre, Rozenn N RN; Justice, Anne E AE; Ericson, Ulrika U; Braun, Kim V E KVE; Mahendran, Yuvaraj Y; Frazier-Wood, Alexis C AC; Sun, Dianjianyi D; Chu, Audrey Y AY; Tanaka, Toshiko T; Luan, Jian'an J; Hong, Jaeyoung J; Tjønneland, Anne A; Ding, Ming M; Lundqvist, Annamari A; Mukamal, Kenneth K; Rohde, Rebecca R; Schulz, Christina-Alexandra CA; Franco, Oscar H OH; Grarup, Niels N; Chen, Yii-Der Ida YI; Bazzano, Lydia L; Franks, Paul W PW; Buring, Julie E JE; Langenberg, Claudia C; Liu, Ching-Ti CT; Hansen, Torben T; Jensen, Majken K MK; Sääksjärvi, Katri K; Psaty, Bruce M BM; Young, Kristin L KL; Hindy, George G; Sandholt, Camilla Helene CH; Ridker, Paul M PM; Ordovas, Jose M JM; Meigs, James B JB; Pedersen, Oluf O; Kraft, Peter P; Perola, Markus M; North, Kari E KE; Orho-Melander, Marju M; Voortman, Trudy T; Toft, Ulla U; Rotter, Jerome I JI; Qi, Lu L; Forouhi, Nita G NG; Mozaffarian, Dariush D; Sørensen, Thorkild I A TIA; Stampfer, Meir J MJ; Männistö, Satu S; Selvin, Elizabeth E; Imamura, Fumiaki F; Salomaa, Veikko V; Hu, Frank B FB; Wareham, Nick J NJ; Dupuis, Josée J; Smith, Caren E CE; Kilpeläinen, Tuomas O TO; Chasman, Daniel I DI; Florez, Jose C JC
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
Nature Communications
Adeyemo, Adebowale A AA; Zaghloul, Norann A NA; Chen, Guanjie G; Doumatey, Ayo P AP; Leitch, Carmen C CC; Hostelley, Timothy L TL; Nesmith, Jessica E JE; Zhou, Jie J; Bentley, Amy R AR; Shriner, Daniel D; Fasanmade, Olufemi O; Okafor, Godfrey G; Eghan, Benjamin B; Agyenim-Boateng, Kofi K; Chandrasekharappa, Settara S; Adeleye, Jokotade J; Balogun, William W; Owusu, Samuel S; Amoah, Albert A; Acheampong, Joseph J; Johnson, Thomas T; Oli, Johnnie J; Adebamowo, Clement C; , ; Collins, Francis F; Dunston, Georgia G; Rotimi, Charles N CN
Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk.
Scientific Reports
Christodoulou, Maria-Ioanna MI; Avgeris, Margaritis M; Kokkinopoulou, Ioanna I; Maratou, Eirini E; Mitrou, Panayota P; Kontos, Christos K CK; Pappas, Efthimios E; Boutati, Eleni E; Scorilas, Andreas A; Fragoulis, Emmanuel G EG
A likely pathogenic variant putatively affecting splicing of PIGA identified in a multiple congenital anomalies hypotonia-seizures syndrome 2 (MCAHS2) family pedigree via whole-exome sequencing.
Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.
Diabetologia
Li, Sherly X SX; Imamura, Fumiaki F; Schulze, Matthias B MB; Zheng, Jusheng J; Ye, Zheng Z; Agudo, Antonio A; Ardanaz, Eva E; Aune, Dagfinn D; Boeing, Heiner H; Dorronsoro, Miren M; Dow, Courtney C; Fagherazzi, Guy G; Grioni, Sara S; Gunter, Marc J MJ; Huerta, José María JM; Ibsen, Daniel B DB; Jakobsen, Marianne Uhre MU; Kaaks, Rudolf R; Key, Timothy J TJ; Khaw, Kay-Tee KT; Kyrø, Cecilie C; Mancini, Francesca Romana FR; Molina-Portillo, Elena E; Murphy, Neil N; Nilsson, Peter M PM; Onland-Moret, N Charlotte NC; Palli, Domenico D; Panico, Salvatore S; Poveda, Alaitz A; Quirós, J Ramón JR; Ricceri, Fulvio F; Sluijs, Ivonne I; Spijkerman, Annemieke M W AMW; Tjonneland, Anne A; Tumino, Rosario R; Winkvist, Anna A; Langenberg, Claudia C; Sharp, Stephen J SJ; Riboli, Elio E; Scott, Robert A RA; Forouhi, Nita G NG; Wareham, Nicholas J NJ
Influence of genetic ancestry and socioeconomic status on type 2 diabetes in the diverse Colombian populations of Chocó and Antioquia.
Scientific Reports
Chande, Aroon T AT; Rowell, Jessica J; Rishishwar, Lavanya L; Conley, Andrew B AB; Norris, Emily T ET; Valderrama-Aguirre, Augusto A; Medina-Rivas, Miguel A MA; Jordan, I King IK
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Diabetes
Wood, Andrew R AR; Jonsson, Anna A; Jackson, Anne U AU; Wang, Nan N; van Leewen, Nienke N; Palmer, Nicholette D ND; Kobes, Sayuko S; Deelen, Joris J; Boquete-Vilarino, Lorena L; Paananen, Jussi J; Stančáková, Alena A; Boomsma, Dorret I DI; de Geus, Eco J C EJC; Eekhoff, Elisabeth M W EMW; Fritsche, Andreas A; Kramer, Mark M; Nijpels, Giel G; Simonis-Bik, Annemarie A; van Haeften, Timon W TW; Mahajan, Anubha A; Boehnke, Michael M; Bergman, Richard N RN; Tuomilehto, Jaakko J; Collins, Francis S FS; Mohlke, Karen L KL; Banasik, Karina K; Groves, Christopher J CJ; McCarthy, Mark I MI; , ; Pearson, Ewan R ER; Natali, Andrea A; Mari, Andrea A; Buchanan, Thomas A TA; Taylor, Kent D KD; Xiang, Anny H AH; Gjesing, Anette P AP; Grarup, Niels N; Eiberg, Hans H; Pedersen, Oluf O; Chen, Yii-Derr YD; Laakso, Markku M; Norris, Jill M JM; Smith, Ulf U; Wagenknecht, Lynne E LE; Baier, Leslie L; Bowden, Donald W DW; Hansen, Torben T; Walker, Mark M; Watanabe, Richard M RM; 't Hart, Leen M LM; Hanson, Robert L RL; Frayling, Timothy M TM
Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores.
Nutrients
Corella, Dolores D; Coltell, Oscar O; Sorlí, Jose V JV; Estruch, Ramón R; Quiles, Laura L; Martínez-González, Miguel Ángel MÁ; Salas-Salvadó, Jordi J; Castañer, Olga O; Arós, Fernando F; Ortega-Calvo, Manuel M; Serra-Majem, Lluís L; Gómez-Gracia, Enrique E; Portolés, Olga O; Fiol, Miquel M; Díez Espino, Javier J; Basora, Josep J; Fitó, Montserrat M; Ros, Emilio E; Ordovás, José M JM
A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.
Nature Communications
Ahmad, Omar S OS; Morris, John A JA; Mujammami, Muhammad M; Forgetta, Vincenzo V; Leong, Aaron A; Li, Rui R; Turgeon, Maxime M; Greenwood, Celia M T CM; Thanassoulis, George G; Meigs, James B JB; Sladek, Robert R; Richards, J Brent JB