TG c.826_828delinsGAC ;(p.L276D)

Variant ID: 8-133894794-CTG-GAC

NM_003235.4(TG):c.826_828delinsGAC;(p.L276D)

This variant was identified in 8 publications

View GRCh38 version.




Publications:


S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation.

Life Science Alliance
Yu, Tao T; Li, Xi X; Luo, Qianqian Q; Liu, Huajing H; Jin, Jing J; Li, Shengjie S; He, Jun J
Publication Date: 2023-04

Variant appearance in text: TG: L276D
PubMed Link: 36690443
Variant Present in the following documents:
  • LSA-2022-01623.pdf
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Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.

Cell Reports
Baraniak, James H JH; Zhou, Yandong Y; Nwokonko, Robert M RM; Jennette, Michelle R MR; Kazzaz, Sarah A SA; Stenson, Jazmin M JM; Whitsell, Abigale L AL; Wang, Youjun Y; Trebak, Mohamed M; Gill, Donald L DL
Publication Date: 2021-06-29

Variant appearance in text: TG: L276D
PubMed Link: 34192542
Variant Present in the following documents:
  • Main text
  • nihms-1720097.pdf
  • NIHMS1720097-supplement-1.pdf
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Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.

Cell Research
Palty, Raz R; Stanley, Cherise C; Isacoff, Ehud Y EY
Publication Date: 2015-08

Variant appearance in text: TG: L276D
PubMed Link: 26138675
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structural and functional mechanisms of CRAC channel regulation.

Journal Of Molecular Biology
Shim, Ann Hye-Ryong AH; Tirado-Lee, Leidamarie L; Prakriya, Murali M
Publication Date: 2015-01-16

Variant appearance in text: TG: L276D
PubMed Link: 25284754
Variant Present in the following documents:
  • Main text
View BVdb publication page



The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels.

The Journal Of Physiology
McNally, Beth A BA; Somasundaram, Agila A; Jairaman, Amit A; Yamashita, Megumi M; Prakriya, Murali M
Publication Date: 2013-06-01

Variant appearance in text: TG: L276D
PubMed Link: 23613525
Variant Present in the following documents:
  • Main text
View BVdb publication page



Store-operated calcium channels: new perspectives on mechanism and function.

Cold Spring Harbor Perspectives In Biology
Lewis, Richard S RS
Publication Date: 2011-12-01

Variant appearance in text: TG: L276D
PubMed Link: 21791698
Variant Present in the following documents:
  • Main text
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Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate.

The Journal Of Biological Chemistry
Yamashita, Megumi M; Somasundaram, Agila A; Prakriya, Murali M
Publication Date: 2011-03-18

Variant appearance in text: TG: L276D
PubMed Link: 21193399
Variant Present in the following documents:
  • Main text
View BVdb publication page



STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy.

The Journal Of Physiology
Navarro-Borelly, Laura L; Somasundaram, Agila A; Yamashita, Megumi M; Ren, Dongjun D; Miller, Richard J RJ; Prakriya, Murali M
Publication Date: 2008-11-15

Variant appearance in text: TG: L276D
PubMed Link: 18832420
Variant Present in the following documents:
  • Main text
View BVdb publication page