Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Communications Biology
Xu, Mingguo M; Bermea, Kevin C KC; Ayati, Marzieh M; Kim, Han Byeol HB; Yang, Xiaomei X; Medina, Andres A; Fu, Zongming Z; Heravi, Amir A; Zhang, Xinyu X; Na, Chan Hyun CH; Everett, Allen D AD; Gabrielson, Kathleen K; Foster, D Brian DB; Paolocci, Nazareno N; Murphy, Anne M AM; Ramirez-Correa, Genaro A GA
Permethrin resistance in Aedes aegypti: Genomic variants that confer knockdown resistance, recovery, and death.
Plos Genetics
Saavedra-Rodriguez, Karla K; Campbell, Corey L CL; Lozano, Saul S; Penilla-Navarro, Patricia P; Lopez-Solis, Alma A; Solis-Santoyo, Francisco F; Rodriguez, Americo D AD; Perera, Rushika R; Black Iv, William C WC
Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response.
Frontiers In Physiology
Chowdhury, Shamim A K SAK; Warren, Chad M CM; Simon, Jillian N JN; Ryba, David M DM; Batra, Ashley A; Varga, Peter P; Kranias, Evangelia G EG; Tardiff, Jil C JC; Solaro, R John RJ; Wolska, Beata M BM
Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis.
Nature Communications
Zhang, Qing-Jun QJ; Tran, Tram Anh T TAT; Wang, Ming M; Ranek, Mark J MJ; Kokkonen-Simon, Kristen M KM; Gao, Jason J; Luo, Xiang X; Tan, Wei W; Kyrychenko, Viktoriia V; Liao, Lan L; Xu, Jianming J; Hill, Joseph A JA; Olson, Eric N EN; Kass, David A DA; Martinez, Elisabeth D ED; Liu, Zhi-Ping ZP
Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Lowey, Susan S; Bretton, Vera V; Joel, Peteranne B PB; Trybus, Kathleen M KM; Gulick, James J; Robbins, Jeffrey J; Kalganov, Albert A; Cornachione, Anabelle S AS; Rassier, Dilson E DE
A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.
Cell
Davis, Jennifer J; Davis, L Craig LC; Correll, Robert N RN; Makarewich, Catherine A CA; Schwanekamp, Jennifer A JA; Moussavi-Harami, Farid F; Wang, Dan D; York, Allen J AJ; Wu, Haodi H; Houser, Steven R SR; Seidman, Christine E CE; Seidman, Jonathan G JG; Regnier, Michael M; Metzger, Joseph M JM; Wu, Joseph C JC; Molkentin, Jeffery D JD
Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.
Journal Of The American Heart Association
Hernandez-Anzaldo, Samuel S; Berry, Evan E; Brglez, Vesna V; Leung, Dickson D; Yun, Tae Jin TJ; Lee, Jun Seong JS; Filep, Janos G JG; Kassiri, Zamaneh Z; Cheong, Cheolho C; Lambeau, Gérard G; Lehner, Richard R; Fernandez-Patron, Carlos C
Recurrent inactivating RASA2 mutations in melanoma.
Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.
Journal Of Molecular And Cellular Cardiology
Gaffin, Robert D RD; Peña, James R JR; Alves, Marco S L MS; Dias, Fernando A L FA; Chowdhury, Shamim A K SA; Heinrich, Lynley S LS; Goldspink, Paul H PH; Kranias, Evangelia G EG; Wieczorek, David F DF; Wolska, Beata M BM
Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.
The Journal Of Biological Chemistry
Lowey, Susan S; Lesko, Leanne M LM; Rovner, Arthur S AS; Hodges, Alex R AR; White, Sheryl L SL; Low, Robert B RB; Rincon, Mercedes M; Gulick, James J; Robbins, Jeffrey J