Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.
The Febs Journal
Fells, James I JI; Lee, Sue Chin SC; Norman, Derek D DD; Tsukahara, Ryoko R; Kirby, Jason R JR; Nelson, Sandra S; Seibel, William W; Papoian, Ruben R; Patil, Renukadevi R; Miller, Duane D DD; Parrill, Abby L AL; Pham, Truc-Chi TC; Baker, Daniel L DL; Bittman, Robert R; Tigyi, Gabor G
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Molecular Pharmacology
Fells, James I JI; Lee, Sue Chin SC; Fujiwara, Yuko Y; Norman, Derek D DD; Lim, Keng Gat KG; Tsukahara, Ryoko R; Liu, Jianxiong J; Patil, Renukadevi R; Miller, Duane D DD; Kirby, R Jason RJ; Nelson, Sandra S; Seibel, William W; Papoian, Ruben R; Parrill, Abby L AL; Baker, Daniel L DL; Bittman, Robert R; Tigyi, Gabor G