Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis.
Jhep Reports : Innovation In Hepatology
Schmalz, Franziska F; Fischer, Janett J; Innes, Hamish H; Buch, Stephan S; Möller, Christine C; Matz-Soja, Madlen M; von Schönfels, Witigo W; Krämer, Benjamin B; Langhans, Bettina B; Klüners, Alexandra A; Soyka, Michael M; Stickel, Felix F; Nattermann, Jacob J; Strassburg, Christian P CP; Berg, Thomas T; Lutz, Philipp P; Nischalke, Hans Dieter HD
Biochemical, Clinical, and Genetic Characteristics of Mexican Patients with Primary Hypertriglyceridemia, Including the First Case of Hyperchylomicronemia Syndrome Due to GPIHBP1 Deficiency.
International Journal Of Molecular Sciences
Rodríguez-Gutiérrez, Perla Graciela PG; Colima-Fausto, Ana Gabriela AG; Zepeda-Olmos, Paola Montserrat PM; Hernández-Flores, Teresita de Jesús TJ; González-García, Juan Ramón JR; Magaña-Torres, María Teresa MT
Publication Date: 2022-12-27
Variant appearance in text: LPL: 1421C>G; S474*; rs328
Kiani, Aysha Karim AK; Bonetti, Gabriele G; Donato, Kevin K; Kaftalli, Jurgen J; Herbst, Karen L KL; Stuppia, Liborio L; Fioretti, Francesco F; Nodari, Savina S; Perrone, Marco M; Chiurazzi, Pietro P; Bellinato, Francesco F; Gisondi, Paolo P; Bertelli, Matteo M
Expanding the genetic spectrum for Chinese familial hypercholesterolemia population with six genetic mutations identified using a next-generation sequencing-based laboratory-developed screening test.
Outcomes of Genetic Testing-Based Cardiac Rehabilitation Program in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention.
Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials.
Bmc Cardiovascular Disorders
Roa-Díaz, Zayne M ZM; Teuscher, Julian J; Gamba, Magda M; Bundo, Marvin M; Grisotto, Giorgia G; Wehrli, Faina F; Gamboa, Edna E; Rojas, Lyda Z LZ; Gómez-Ochoa, Sergio A SA; Verhoog, Sanne S; Vargas, Manuel Frias MF; Minder, Beatrice B; Franco, Oscar H OH; Dehghan, Abbas A; Pazoki, Raha R; Marques-Vidal, Pedro P; Muka, Taulant T
The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents.
International Journal Of Molecular Sciences
Giuliani, Angelica A; Montesanto, Alberto A; Matacchione, Giulia G; Graciotti, Laura L; Ramini, Deborah D; Protic, Olga O; Galeazzi, Roberta R; Antonicelli, Roberto R; Tortato, Elena E; Bonfigli, Anna Rita AR; Sabbatinelli, Jacopo J; Olivieri, Fabiola F
Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses.
Journal Of Lipid Research
Ibi, Dorina D; Boot, Manon M; Dollé, Martijn E T MET; Jukema, J Wouter JW; Rosendaal, Frits R FR; Christodoulides, Constantinos C; Neville, Matt J MJ; Koivula, Robert R; Rensen, Patrick C N PCN; Karpe, Fredrik F; Noordam, Raymond R; Willems van Dijk, Ko K
Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake.
Nature Communications
Zimoń, Magdalena M; Huang, Yunfeng Y; Trasta, Anthi A; Halavatyi, Aliaksandr A; Liu, Jimmy Z JZ; Chen, Chia-Yen CY; Blattmann, Peter P; Klaus, Bernd B; Whelan, Christopher D CD; Sexton, David D; John, Sally S; Huber, Wolfgang W; Tsai, Ellen A EA; Pepperkok, Rainer R; Runz, Heiko H
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.
Science Immunology
Asano, Takaki T; Boisson, Bertrand B; Onodi, Fanny F; Matuozzo, Daniela D; Moncada-Velez, Marcela M; Maglorius Renkilaraj, Majistor Raj Luxman MRL; Zhang, Peng P; Meertens, Laurent L; Bolze, Alexandre A; Materna, Marie M; Korniotis, Sarantis S; Gervais, Adrian A; Talouarn, Estelle E; Bigio, Benedetta B; Seeleuthner, Yoann Y; Bilguvar, Kaya K; Zhang, Yu Y; Neehus, Anna-Lena AL; Ogishi, Masato M; Pelham, Simon J SJ; Le Voyer, Tom T; Rosain, Jérémie J; Philippot, Quentin Q; Soler-Palacín, Pere P; Colobran, Roger R; Martin-Nalda, Andrea A; Rivière, Jacques G JG; Tandjaoui-Lambiotte, Yacine Y; Chaïbi, Khalil K; Shahrooei, Mohammad M; Darazam, Ilad Alavi IA; Olyaei, Nasrin Alipour NA; Mansouri, Davood D; Hatipoğlu, Nevin N; Palabiyik, Figen F; Ozcelik, Tayfun T; Novelli, Giuseppe G; Novelli, Antonio A; Casari, Giorgio G; Aiuti, Alessandro A; Carrera, Paola P; Bondesan, Simone S; Barzaghi, Federica F; Rovere-Querini, Patrizia P; Tresoldi, Cristina C; Franco, Jose Luis JL; Rojas, Julian J; Reyes, Luis Felipe LF; Bustos, Ingrid G IG; Arias, Andres Augusto AA; Morelle, Guillaume G; Christèle, Kyheng K; Troya, Jesús J; Planas-Serra, Laura L; Schlüter, Agatha A; Gut, Marta M; Pujol, Aurora A; Allende, Luis M LM; Rodriguez-Gallego, Carlos C; Flores, Carlos C; Cabrera-Marante, Oscar O; Pleguezuelo, Daniel E DE; de Diego, Rebeca Pérez RP; Keles, Sevgi S; Aytekin, Gokhan G; Akcan, Ozge Metin OM; Bryceson, Yenan T YT; Bergman, Peter P; Brodin, Petter P; Smole, Daniel D; Smith, C I Edvard CIE; Norlin, Anna-Carin AC; Campbell, Tessa M TM; Covill, Laura E LE; Hammarström, Lennart L; Pan-Hammarström, Qiang Q; Abolhassani, Hassan H; Mane, Shrikant S; Marr, Nico N; Ata, Manar M; Al Ali, Fatima F; Khan, Taushif T; Spaan, András N AN; Dalgard, Clifton L CL; Bonfanti, Paolo P; Biondi, Andrea A; Tubiana, Sarah S; Burdet, Charles C; Nussbaum, Robert R; Kahn-Kirby, Amanda A; Snow, Andrew L AL; , ; , ; , ; , ; , ; , ; , ; , ; , ; Bustamante, Jacinta J; Puel, Anne A; Boisson-Dupuis, Stéphanie S; Zhang, Shen-Ying SY; Béziat, Vivien V; Lifton, Richard P RP; Bastard, Paul P; Notarangelo, Luigi D LD; Abel, Laurent L; Su, Helen C HC; Jouanguy, Emmanuelle E; Amara, Ali A; Soumelis, Vassili V; Cobat, Aurélie A; Zhang, Qian Q; Casanova, Jean-Laurent JL
GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity.
Frontiers In Cell And Developmental Biology
Kristensen, Kristian Kølby KK; Leth-Espensen, Katrine Zinck KZ; Kumari, Anni A; Grønnemose, Anne Louise AL; Lund-Winther, Anne-Marie AM; Young, Stephen G SG; Ploug, Michael M
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Candidate Gene Analysis Reveals Strong Association of CETP Variants With High Density Lipoprotein Cholesterol and PCSK9 Variants With Low Density Lipoprotein Cholesterol in Ghanaian Adults: An AWI-Gen Sub-Study.
Frontiers In Genetics
Agongo, Godfred G; Amenga-Etego, Lucas L; Nonterah, Engelbert A EA; Debpuur, Cornelius C; Choudhury, Ananyo A; Bentley, Amy R AR; Oduro, Abraham R AR; Rotimi, Charles N CN; Crowther, Nigel J NJ; Ramsay, Michèle M; , ; H Africa,
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.
Nature Genetics
Vujkovic, Marijana M; Keaton, Jacob M JM; Lynch, Julie A JA; Miller, Donald R DR; Zhou, Jin J; Tcheandjieu, Catherine C; Huffman, Jennifer E JE; Assimes, Themistocles L TL; Lorenz, Kimberly K; Zhu, Xiang X; Hilliard, Austin T AT; Judy, Renae L RL; Huang, Jie J; Lee, Kyung M KM; Klarin, Derek D; Pyarajan, Saiju S; Danesh, John J; Melander, Olle O; Rasheed, Asif A; Mallick, Nadeem H NH; Hameed, Shahid S; Qureshi, Irshad H IH; Afzal, Muhammad Naeem MN; Malik, Uzma U; Jalal, Anjum A; Abbas, Shahid S; Sheng, Xin X; Gao, Long L; Kaestner, Klaus H KH; Susztak, Katalin K; Sun, Yan V YV; DuVall, Scott L SL; Cho, Kelly K; Lee, Jennifer S JS; Gaziano, J Michael JM; Phillips, Lawrence S LS; Meigs, James B JB; Reaven, Peter D PD; Wilson, Peter W PW; Edwards, Todd L TL; Rader, Daniel J DJ; Damrauer, Scott M SM; O'Donnell, Christopher J CJ; Tsao, Philip S PS; , ; , ; , ; Chang, Kyong-Mi KM; Voight, Benjamin F BF; Saleheen, Danish D
Xanthomas Can Be Misdiagnosed and Mistreated in Homozygous Familial Hypercholesterolemia Patients: A Call for Increased Awareness Among Dermatologists and Health Care Practitioners.
Global Heart
Alnouri, Fahad F; Al-Allaf, Faisal A FA; Athar, Mohammad M; Abduljaleel, Zainularifeen Z; Alabdullah, Moheeb M; Alammari, Dalal D; Alanazi, Menwar M; Alkaf, Fahmi F; Allehyani, Abeer A; Alotaiby, Mohammad A MA; Alshehri, Abdullah A; Bouazzaoui, Abdellatif A; Karrar, Hussam H; Taher, Mohiuddin M MM
Publication Date: 2020-02-28
Variant appearance in text: LPL: 1421C>G; S474*; rs328
Verification of Underlying Genetic Cause in a Cohort of Russian Patients with Familial Hypercholesterolemia Using Targeted Next Generation Sequencing.
Journal Of Cardiovascular Development And Disease
Semenova, Anna E AE; Sergienko, Igor V IV; García-Giustiniani, Diego D; Monserrat, Lorenzo L; Popova, Anna B AB; Nozadze, Diana N DN; Ezhov, Marat V MV
Identification of a novel LPL nonsense variant and further insights into the complex etiology and expression of hypertriglyceridemia-induced acute pancreatitis.
Lipids In Health And Disease
Li, Xiao-Yao XY; Pu, Na N; Chen, Wei-Wei WW; Shi, Xiao-Lei XL; Zhang, Guo-Fu GF; Ke, Lu L; Ye, Bo B; Tong, Zhi-Hui ZH; Wang, Yu-Hui YH; Liu, George G; Chen, Jian-Min JM; Yang, Qi Q; Li, Wei-Qin WQ; Li, Jie-Shou JS