Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells.
Npj Systems Biology And Applications
Immanuel, Selva Rupa Christinal SRC; Ghanate, Avinash D AD; Parmar, Dharmeshkumar S DS; Yadav, Ritu R; Uthup, Riya R; Panchagnula, Venkateswarlu V; Raghunathan, Anu A
Genetic risk factors predict disease progression in Crohn's disease patients of the Swiss inflammatory bowel disease cohort.
Therapeutic Advances In Gastroenterology
Ditrich, Felicitas F; Blümel, Sena S; Biedermann, Luc L; Fournier, Nicolas N; Rossel, Jean-Benoit JB; Ellinghaus, David D; Franke, Andre A; Stange, Eduard F EF; Rogler, Gerhard G; Scharl, Michael M; ,
Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Gut
Hu, Shixian S; Vich Vila, Arnau A; Gacesa, Ranko R; Collij, Valerie V; Stevens, Christine C; Fu, Jack M JM; Wong, Isaac I; Talkowski, Michael E ME; Rivas, Manuel A MA; Imhann, Floris F; Bolte, Laura L; van Dullemen, Hendrik H; Dijkstra, Gerard G; Visschedijk, Marijn C MC; Festen, Eleonora A EA; Xavier, Ramnik J RJ; Fu, Jingyuan J; Daly, Mark J MJ; Wijmenga, Cisca C; Zhernakova, Alexandra A; Kurilshikov, Alexander A; Weersma, Rinse K RK
Polymorphisms of the TNF Gene and Three Susceptibility Loci Are Associated with Crohn's Disease and Perianal Fistula Crohn's Disease: A Study among the Han Population from South China.
Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Zhang, Min M; Wang, Xiaoyan X; Jiang, Xiaodong X; Yang, Xiangling X; Wen, Chuangyu C; Zhi, Min M; Gao, Xiang X; Hu, Pinjin P; Liu, Huanliang H
Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.
Plos Genetics
Richard, Arianne C AC; Peters, James E JE; Savinykh, Natalia N; Lee, James C JC; Hawley, Eric T ET; Meylan, Françoise F; Siegel, Richard M RM; Lyons, Paul A PA; Smith, Kenneth G C KGC
Genetic Risk for Inflammatory Bowel Disease Is a Determinant of Crohn's Disease Development in Chronic Granulomatous Disease.
Inflammatory Bowel Diseases
Huang, Chengrui C; De Ravin, Suk See SS; Paul, Adam R AR; Heller, Theo T; Ho, Nancy N; Wu Datta, Lisa L; Zerbe, Christa S CS; Marciano, Beatriz E BE; Kuhns, Douglas B DB; Kader, Howard A HA; Holland, Steven M SM; Malech, Harry L HL; Brant, Steven R SR; ,
Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci.
Clinical And Translational Gastroenterology
Di Narzo, Antonio F AF; Peters, Lauren A LA; Argmann, Carmen C; Stojmirovic, Aleksandar A; Perrigoue, Jacqueline J; Li, Katherine K; Telesco, Shannon S; Kidd, Brian B; Walker, Jennifer J; Dudley, Joel J; Cho, Judy J; Schadt, Eric E EE; Kasarskis, Andrew A; Curran, Mark M; Dobrin, Radu R; Hao, Ke K
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
Nature Medicine
Li, Yun R YR; Li, Jin J; Zhao, Sihai D SD; Bradfield, Jonathan P JP; Mentch, Frank D FD; Maggadottir, S Melkorka SM; Hou, Cuiping C; Abrams, Debra J DJ; Chang, Diana D; Gao, Feng F; Guo, Yiran Y; Wei, Zhi Z; Connolly, John J JJ; Cardinale, Christopher J CJ; Bakay, Marina M; Glessner, Joseph T JT; Li, Dong D; Kao, Charlly C; Thomas, Kelly A KA; Qiu, Haijun H; Chiavacci, Rosetta M RM; Kim, Cecilia E CE; Wang, Fengxiang F; Snyder, James J; Richie, Marylyn D MD; Flatø, Berit B; Førre, Øystein Ø; Denson, Lee A LA; Thompson, Susan D SD; Becker, Mara L ML; Guthery, Stephen L SL; Latiano, Anna A; Perez, Elena E; Resnick, Elena E; Russell, Richard K RK; Wilson, David C DC; Silverberg, Mark S MS; Annese, Vito V; Lie, Benedicte A BA; Punaro, Marilynn M; Dubinsky, Marla C MC; Monos, Dimitri S DS; Strisciuglio, Caterina C; Staiano, Annamaria A; Miele, Erasmo E; Kugathasan, Subra S; Ellis, Justine A JA; Munro, Jane E JE; Sullivan, Kathleen E KE; Wise, Carol A CA; Chapel, Helen H; Cunningham-Rundles, Charlotte C; Grant, Struan F A SF; Orange, Jordan S JS; Sleiman, Patrick M A PM; Behrens, Edward M EM; Griffiths, Anne M AM; Satsangi, Jack J; Finkel, Terri H TH; Keinan, Alon A; Prak, Eline T Luning ET; Polychronakos, Constantin C; Baldassano, Robert N RN; Li, Hongzhe H; Keating, Brendan J BJ; Hakonarson, Hakon H
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Nature Genetics
Liu, Jimmy Z JZ; van Sommeren, Suzanne S; Huang, Hailiang H; Ng, Siew C SC; Alberts, Rudi R; Takahashi, Atsushi A; Ripke, Stephan S; Lee, James C JC; Jostins, Luke L; Shah, Tejas T; Abedian, Shifteh S; Cheon, Jae Hee JH; Cho, Judy J; Dayani, Naser E NE; Franke, Lude L; Fuyuno, Yuta Y; Hart, Ailsa A; Juyal, Ramesh C RC; Juyal, Garima G; Kim, Won Ho WH; Morris, Andrew P AP; Poustchi, Hossein H; Newman, William G WG; Midha, Vandana V; Orchard, Timothy R TR; Vahedi, Homayon H; Sood, Ajit A; Sung, Joseph Y JY; Malekzadeh, Reza R; Westra, Harm-Jan HJ; Yamazaki, Keiko K; Yang, Suk-Kyun SK; , ; , ; Barrett, Jeffrey C JC; Alizadeh, Behrooz Z BZ; Parkes, Miles M; Bk, Thelma T; Daly, Mark J MJ; Kubo, Michiaki M; Anderson, Carl A CA; Weersma, Rinse K RK
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
Nature Genetics
Kiryluk, Krzysztof K; Li, Yifu Y; Scolari, Francesco F; Sanna-Cherchi, Simone S; Choi, Murim M; Verbitsky, Miguel M; Fasel, David D; Lata, Sneh S; Prakash, Sindhuri S; Shapiro, Samantha S; Fischman, Clara C; Snyder, Holly J HJ; Appel, Gerald G; Izzi, Claudia C; Viola, Battista Fabio BF; Dallera, Nadia N; Del Vecchio, Lucia L; Barlassina, Cristina C; Salvi, Erika E; Bertinetto, Francesca Eleonora FE; Amoroso, Antonio A; Savoldi, Silvana S; Rocchietti, Marcella M; Amore, Alessandro A; Peruzzi, Licia L; Coppo, Rosanna R; Salvadori, Maurizio M; Ravani, Pietro P; Magistroni, Riccardo R; Ghiggeri, Gian Marco GM; Caridi, Gianluca G; Bodria, Monica M; Lugani, Francesca F; Allegri, Landino L; Delsante, Marco M; Maiorana, Mariarosa M; Magnano, Andrea A; Frasca, Giovanni G; Boer, Emanuela E; Boscutti, Giuliano G; Ponticelli, Claudio C; Mignani, Renzo R; Marcantoni, Carmelita C; Di Landro, Domenico D; Santoro, Domenico D; Pani, Antonello A; Polci, Rosaria R; Feriozzi, Sandro S; Chicca, Silvana S; Galliani, Marco M; Gigante, Maddalena M; Gesualdo, Loreto L; Zamboli, Pasquale P; Battaglia, Giovanni Giorgio GG; Garozzo, Maurizio M; Maixnerová, Dita D; Tesar, Vladimir V; Eitner, Frank F; Rauen, Thomas T; Floege, Jürgen J; Kovacs, Tibor T; Nagy, Judit J; Mucha, Krzysztof K; Pączek, Leszek L; Zaniew, Marcin M; Mizerska-Wasiak, Małgorzata M; Roszkowska-Blaim, Maria M; Pawlaczyk, Krzysztof K; Gale, Daniel D; Barratt, Jonathan J; Thibaudin, Lise L; Berthoux, Francois F; Canaud, Guillaume G; Boland, Anne A; Metzger, Marie M; Panzer, Ulf U; Suzuki, Hitoshi H; Goto, Shin S; Narita, Ichiei I; Caliskan, Yasar Y; Xie, Jingyuan J; Hou, Ping P; Chen, Nan N; Zhang, Hong H; Wyatt, Robert J RJ; Novak, Jan J; Julian, Bruce A BA; Feehally, John J; Stengel, Benedicte B; Cusi, Daniele D; Lifton, Richard P RP; Gharavi, Ali G AG
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
Science (New York, N.Y.)
Lee, Mark N MN; Ye, Chun C; Villani, Alexandra-Chloé AC; Raj, Towfique T; Li, Weibo W; Eisenhaure, Thomas M TM; Imboywa, Selina H SH; Chipendo, Portia I PI; Ran, F Ann FA; Slowikowski, Kamil K; Ward, Lucas D LD; Raddassi, Khadir K; McCabe, Cristin C; Lee, Michelle H MH; Frohlich, Irene Y IY; Hafler, David A DA; Kellis, Manolis M; Raychaudhuri, Soumya S; Zhang, Feng F; Stranger, Barbara E BE; Benoist, Christophe O CO; De Jager, Philip L PL; Regev, Aviv A; Hacohen, Nir N
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Nature
Jostins, Luke L; Ripke, Stephan S; Weersma, Rinse K RK; Duerr, Richard H RH; McGovern, Dermot P DP; Hui, Ken Y KY; Lee, James C JC; Schumm, L Philip LP; Sharma, Yashoda Y; Anderson, Carl A CA; Essers, Jonah J; Mitrovic, Mitja M; Ning, Kaida K; Cleynen, Isabelle I; Theatre, Emilie E; Spain, Sarah L SL; Raychaudhuri, Soumya S; Goyette, Philippe P; Wei, Zhi Z; Abraham, Clara C; Achkar, Jean-Paul JP; Ahmad, Tariq T; Amininejad, Leila L; Ananthakrishnan, Ashwin N AN; Andersen, Vibeke V; Andrews, Jane M JM; Baidoo, Leonard L; Balschun, Tobias T; Bampton, Peter A PA; Bitton, Alain A; Boucher, Gabrielle G; Brand, Stephan S; Büning, Carsten C; Cohain, Ariella A; Cichon, Sven S; D'Amato, Mauro M; De Jong, Dirk D; Devaney, Kathy L KL; Dubinsky, Marla M; Edwards, Cathryn C; Ellinghaus, David D; Ferguson, Lynnette R LR; Franchimont, Denis D; Fransen, Karin K; Gearry, Richard R; Georges, Michel M; Gieger, Christian C; Glas, Jürgen J; Haritunians, Talin T; Hart, Ailsa A; Hawkey, Chris C; Hedl, Matija M; Hu, Xinli X; Karlsen, Tom H TH; Kupcinskas, Limas L; Kugathasan, Subra S; Latiano, Anna A; Laukens, Debby D; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mahy, Gillian G; Mansfield, John J; Morgan, Angharad R AR; Mowat, Craig C; Newman, William W; Palmieri, Orazio O; Ponsioen, Cyriel Y CY; Potocnik, Uros U; Prescott, Natalie J NJ; Regueiro, Miguel M; Rotter, Jerome I JI; Russell, Richard K RK; Sanderson, Jeremy D JD; Sans, Miquel M; Satsangi, Jack J; Schreiber, Stefan S; Simms, Lisa A LA; Sventoraityte, Jurgita J; Targan, Stephan R SR; Taylor, Kent D KD; Tremelling, Mark M; Verspaget, Hein W HW; De Vos, Martine M; Wijmenga, Cisca C; Wilson, David C DC; Winkelmann, Juliane J; Xavier, Ramnik J RJ; Zeissig, Sebastian S; Zhang, Bin B; Zhang, Clarence K CK; Zhao, Hongyu H; , ; Silverberg, Mark S MS; Annese, Vito V; Hakonarson, Hakon H; Brant, Steven R SR; Radford-Smith, Graham G; Mathew, Christopher G CG; Rioux, John D JD; Schadt, Eric E EE; Daly, Mark J MJ; Franke, Andre A; Parkes, Miles M; Vermeire, Severine S; Barrett, Jeffrey C JC; Cho, Judy H JH
Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.
Plos One
Fransen, Karin K; Mitrovic, Mitja M; van Diemen, Cleo C CC; Thelma, B K BK; Sood, Ajit A; Franke, Andre A; Schreiber, Stefan S; Midha, Vandana V; Juyal, Garima G; Potocnik, Uros U; Fu, Jingyuan J; Nolte, Ilja I; Weersma, Rinse K RK
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Nature Genetics
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