Publications:

---

Flow cytometric reporter assays provide robust functional analysis of signaling complexes.

The Journal Of Biological Chemistry

Muusse, Timothy W TW; Lee, Morris Y L MYL; Kim, Hyoyoung H; Parat, Marie-Odile MO; Nanson, Jeffrey D JD; Kobe, Bostjan B; Vajjhala, Parimala R PR; Stacey, Katryn J KJ

Publication Date: 2022-11-02

Variant appearance in text: TLR4: R196A

PubMed Link: 36334634

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

---

Structural Evolution of TIR-Domain Signalosomes.

Frontiers In Immunology

Nimma, Surekha S; Gu, Weixi W; Maruta, Natsumi N; Li, Yan Y; Pan, Mengqi M; Saikot, Forhad Karim FK; Lim, Bryan Y J BYJ; McGuinness, Helen Ying HY; Zaoti, Zannati Ferdous ZF; Li, Sulin S; Desa, Sneha S; Manik, Mohammad Kawsar MK; Nanson, Jeffrey D JD; Kobe, Bostjan B

Publication Date: 2021

Variant appearance in text: TLR4: R196A

PubMed Link: 34868065

Variant Present in the following documents:

• Main text
• fimmu-12-784484.pdf

View BVdb publication page

---

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.

Nature Communications

Clabbers, Max T B MTB; Holmes, Susannah S; Muusse, Timothy W TW; Vajjhala, Parimala R PR; Thygesen, Sara J SJ; Malde, Alpeshkumar K AK; Hunter, Dominic J B DJB; Croll, Tristan I TI; Flueckiger, Leonie L; Nanson, Jeffrey D JD; Rahaman, Md Habibur MH; Aquila, Andrew A; Hunter, Mark S MS; Liang, Mengning M; Yoon, Chun Hong CH; Zhao, Jingjing J; Zatsepin, Nadia A NA; Abbey, Brian B; Sierecki, Emma E; Gambin, Yann Y; Stacey, Katryn J KJ; Darmanin, Connie C; Kobe, Bostjan B; Xu, Hongyi H; Ve, Thomas T

Publication Date: 2021-05-10

Variant appearance in text: TLR4: R196A

PubMed Link: 33972532

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88.

Scientific Reports

Dishon, Shira S; Schumacher, Adi A; Fanous, Joseph J; Talhami, Alaa A; Kassis, Ibrahim I; Karussis, Dimitrios D; Gilon, Chaim C; Hoffman, Amnon A; Nussbaum, Gabriel G

Publication Date: 2018-06-21

Variant appearance in text: TLR4: R196A

PubMed Link: 29930295

Variant Present in the following documents:

• Main text
• 41598_2018_Article_27773.pdf

View BVdb publication page

---

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Nature Structural & Molecular Biology

Ve, Thomas T; Vajjhala, Parimala R PR; Hedger, Andrew A; Croll, Tristan T; DiMaio, Frank F; Horsefield, Shane S; Yu, Xiong X; Lavrencic, Peter P; Hassan, Zahid Z; Morgan, Garry P GP; Mansell, Ashley A; Mobli, Mehdi M; O'Carroll, Ailis A; Chauvin, Brieuc B; Gambin, Yann Y; Sierecki, Emma E; Landsberg, Michael J MJ; Stacey, Katryn J KJ; Egelman, Edward H EH; Kobe, Bostjan B

Publication Date: 2017-09

Variant appearance in text: TLR4: R196A

PubMed Link: 28759049

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage.

Journal Of The American Heart Association

Zhong, Qi Q; Zhou, Kai K; Liang, Qiao-Li QL; Lin, Sen S; Wang, Yan-Chun YC; Xiong, Xiao-Yi XY; Meng, Zhao-You ZY; Zhao, Ting T; Zhu, Wen-Yao WY; Yang, Yuan-Rui YR; Liao, Mao-Fan MF; Gong, Qiu-Wen QW; Liu, Liang L; Xiong, Ao A; Hao, Junwei J; Wang, Jian J; Yang, Qing-Wu QW

Publication Date: 2016-10-11

Variant appearance in text: TLR4: R196A

PubMed Link: 27729335

Variant Present in the following documents:

• Main text
• JAH3-5-e004340.pdf

View BVdb publication page

---

Characterization and structure of the vaccinia virus NF-κB antagonist A46.

The Journal Of Biological Chemistry

Fedosyuk, Sofiya S; Grishkovskaya, Irina I; de Almeida Ribeiro, Euripedes E; Skern, Tim T

Publication Date: 2014-02-07

Variant appearance in text: TLR4: R196A

PubMed Link: 24356965

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).

The Journal Of Biological Chemistry

Bovijn, Celia C; Desmet, Anne-Sophie AS; Uyttendaele, Isabel I; Van Acker, Tim T; Tavernier, Jan J; Peelman, Frank F

Publication Date: 2013-04-26

Variant appearance in text: TLR4: R196A

PubMed Link: 23460645

Variant Present in the following documents:

• Main text

View BVdb publication page

---

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

Plos One

Ohnishi, Hidenori H; Tochio, Hidehito H; Kato, Zenichiro Z; Kawamoto, Norio N; Kimura, Takeshi T; Kubota, Kazuo K; Yamamoto, Takahiro T; Funasaka, Tatsuyoshi T; Nakano, Hiroshi H; Wong, Richard W RW; Shirakawa, Masahiro M; Kondo, Naomi N

Publication Date: 2012

Variant appearance in text: TLR4: R196A

PubMed Link: 22685567

Variant Present in the following documents:

• Main text
• pone.0038423.pdf

View BVdb publication page

---

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ohnishi, Hidenori H; Tochio, Hidehito H; Kato, Zenichiro Z; Orii, Kenji E KE; Li, Ailian A; Kimura, Takeshi T; Hiroaki, Hidekazu H; Kondo, Naomi N; Shirakawa, Masahiro M

Publication Date: 2009-06-23

Variant appearance in text: TLR4: R196A

PubMed Link: 19506249

Variant Present in the following documents:

• Main text

View BVdb publication page

---