Genetic analysis of over half a million people characterises C-reactive protein loci.
Nature Communications
Said, Saredo S; Pazoki, Raha R; Karhunen, Ville V; Võsa, Urmo U; Ligthart, Symen S; Bodinier, Barbara B; Koskeridis, Fotios F; Welsh, Paul P; Alizadeh, Behrooz Z BZ; Chasman, Daniel I DI; Sattar, Naveed N; Chadeau-Hyam, Marc M; Evangelou, Evangelos E; Jarvelin, Marjo-Riitta MR; Elliott, Paul P; Tzoulaki, Ioanna I; Dehghan, Abbas A
ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia.
Blood
Karnes, Jason H JH; Rollin, Jerome J; Giles, Jason B JB; Martinez, Kiana L KL; Steiner, Heidi E HE; Shaffer, Christian M CM; Momozawa, Yukihide Y; Inai, Chihiro C; Bombin, Andrei A; Shi, Mingjian M; Mosley, Jonathan D JD; Stanaway, Ian I; Selleng, Kathleen K; Thiele, Thomas T; Mushiroda, Taisei T; Pouplard, Claire C; Heddle, Nancy M NM; Kubo, Michiaki M; Phillips, Elizabeth J EJ; Warkentin, Theodore E TE; Gruel, Yves Y; Greinacher, Andreas A; Roden, Dan M DM
Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis.
Aging
Ni, Xiaolin X; Bai, Chen C; Nie, Chao C; Qi, Liping L; Liu, Yifang Y; Yuan, Huiping H; Zhu, Xiaoquan X; Sun, Liang L; Zhou, Qi Q; Li, Yan Y; Zhen, Hefu H; Su, Huabing H; Li, Rongqiao R; Lan, Rushu R; Pang, Guofang G; Lv, Yuan Y; Zhang, Wei W; Yang, Fan F; Yao, Yao Y; Chen, Chen C; Wang, Zhaoping Z; Gao, Danni D; Zhang, Nan N; Zhang, Shenqi S; Zhang, Li L; Wu, Zhu Z; Hu, Caiyou C; Zeng, Yi Y; Yang, Ze Z
Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis.
Aging
Ni, Xiaolin X; Bai, Chen C; Nie, Chao C; Qi, Liping L; Liu, Yifang Y; Yuan, Huiping H; Zhu, Xiaoquan X; Sun, Liang L; Zhou, Qi Q; Li, Yan Y; Zhen, Hefu H; Su, Huabing H; Li, Rongqiao R; Lan, Rushu R; Pang, Guofang G; Lv, Yuan Y; Zhang, Wei W; Yang, Fan F; Yao, Yao Y; Chen, Chen C; Wang, Zhaoping Z; Gao, Danni D; Zhang, Nan N; Zhang, Shenqi S; Zhang, Li L; Wu, Zhu Z; Hu, Caiyou C; Zeng, Yi Y; Yang, Ze Z
Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.
American Journal Of Cancer Research
Jung, Su Yon SY; Yu, Herbert H; Pellegrini, Matteo M; Papp, Jeanette C JC; Sobel, Eric M EM; Zhang, Zuo-Feng ZF
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Brain, Behavior, And Immunity
Russell, Abigail Emma AE; Ford, Tamsin T; Gunnell, David D; Heron, Jon J; Joinson, Carol C; Moran, Paul P; Relton, Caroline C; Suderman, Matthew M; Hemani, Gibran G; Mars, Becky B
Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study.
International Journal Of Cardiology
Yuan, Shuai S; Lin, Ang A; He, Qi-Qiang QQ; Burgess, Stephen S; Larsson, Susanna C SC
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study.
Plos One
Best, Lyle G LG; Balakrishnan, Poojitha P; Cole, Shelley A SA; Haack, Karin K; Kocarnik, Jonathan M JM; Pankratz, Nathan N; Anderson, Matthew Z MZ; Franceschini, Nora N; Howard, Barbara V BV; Lee, Elisa T ET; North, Kari E KE; Umans, Jason G JG; Yracheta, Joseph M JM; Navas-Acien, Ana A; Voruganti, V Saroja VS
Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes.
International Journal Of Molecular Sciences
Pujol-Moix, Núria N; Martinez-Perez, Angel A; Sabater-Lleal, Maria M; Llobet, Dolors D; Vilalta, Noèlia N; Hamsten, Anders A; Souto, Joan Carles JC; Soria, José Manuel JM
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
American Journal Of Human Genetics
Ligthart, Symen S; Vaez, Ahmad A; Võsa, Urmo U; Stathopoulou, Maria G MG; de Vries, Paul S PS; Prins, Bram P BP; Van der Most, Peter J PJ; Tanaka, Toshiko T; Naderi, Elnaz E; Rose, Lynda M LM; Wu, Ying Y; Karlsson, Robert R; Barbalic, Maja M; Lin, Honghuang H; Pool, René R; Zhu, Gu G; Macé, Aurélien A; Sidore, Carlo C; Trompet, Stella S; Mangino, Massimo M; Sabater-Lleal, Maria M; Kemp, John P JP; Abbasi, Ali A; Kacprowski, Tim T; Verweij, Niek N; Smith, Albert V AV; Huang, Tao T; Marzi, Carola C; Feitosa, Mary F MF; Lohman, Kurt K KK; Kleber, Marcus E ME; Milaneschi, Yuri Y; Mueller, Christian C; Huq, Mahmudul M; Vlachopoulou, Efthymia E; Lyytikäinen, Leo-Pekka LP; Oldmeadow, Christopher C; Deelen, Joris J; Perola, Markus M; Zhao, Jing Hua JH; Feenstra, Bjarke B; , ; Amini, Marzyeh M; , ; Lahti, Jari J; Schraut, Katharina E KE; Fornage, Myriam M; Suktitipat, Bhoom B; Chen, Wei-Min WM; Li, Xiaohui X; Nutile, Teresa T; Malerba, Giovanni G; Luan, Jian'an J; Bak, Tom T; Schork, Nicholas N; Del Greco M, Fabiola F; Thiering, Elisabeth E; Mahajan, Anubha A; Marioni, Riccardo E RE; Mihailov, Evelin E; Eriksson, Joel J; Ozel, Ayse Bilge AB; Zhang, Weihua W; Nethander, Maria M; Cheng, Yu-Ching YC; Aslibekyan, Stella S; Ang, Wei W; Gandin, Ilaria I; Yengo, Loïc L; Portas, Laura L; Kooperberg, Charles C; Hofer, Edith E; Rajan, Kumar B KB; Schurmann, Claudia C; den Hollander, Wouter W; Ahluwalia, Tarunveer S TS; Zhao, Jing J; Draisma, Harmen H M HHM; Ford, Ian I; Timpson, Nicholas N; Teumer, Alexander A; Huang, Hongyan H; Wahl, Simone S; Liu, YongMei Y; Huang, Jie J; Uh, Hae-Won HW; Geller, Frank F; Joshi, Peter K PK; Yanek, Lisa R LR; Trabetti, Elisabetta E; Lehne, Benjamin B; Vozzi, Diego D; Verbanck, Marie M; Biino, Ginevra G; Saba, Yasaman Y; Meulenbelt, Ingrid I; O'Connell, Jeff R JR; Laakso, Markku M; Giulianini, Franco F; Magnusson, Patrik K E PKE; Ballantyne, Christie M CM; Hottenga, Jouke Jan JJ; Montgomery, Grant W GW; Rivadineira, Fernando F; Rueedi, Rico R; Steri, Maristella M; Herzig, Karl-Heinz KH; Stott, David J DJ; Menni, Cristina C; Frånberg, Mattias M; St Pourcain, Beate B; Felix, Stephan B SB; Pers, Tune H TH; Bakker, Stephan J L SJL; Kraft, Peter P; Peters, Annette A; Vaidya, Dhananjay D; Delgado, Graciela G; Smit, Johannes H JH; Großmann, Vera V; Sinisalo, Juha J; Seppälä, Ilkka I; Williams, Stephen R SR; Holliday, Elizabeth G EG; Moed, Matthijs M; Langenberg, Claudia C; Räikkönen, Katri K; Ding, Jingzhong J; Campbell, Harry H; Sale, Michele M MM; Chen, Yii-Der I YI; James, Alan L AL; Ruggiero, Daniela D; Soranzo, Nicole N; Hartman, Catharina A CA; Smith, Erin N EN; Berenson, Gerald S GS; Fuchsberger, Christian C; Hernandez, Dena D; Tiesler, Carla M T CMT; Giedraitis, Vilmantas V; Liewald, David D; Fischer, Krista K; Mellström, Dan D; Larsson, Anders A; Wang, Yunmei Y; Scott, William R WR; Lorentzon, Matthias M; Beilby, John J; Ryan, Kathleen A KA; Pennell, Craig E CE; Vuckovic, Dragana D; Balkau, Beverly B; Concas, Maria Pina MP; Schmidt, Reinhold R; Mendes de Leon, Carlos F CF; Bottinger, Erwin P EP; Kloppenburg, Margreet M; Paternoster, Lavinia L; Boehnke, Michael M; Musk, A W AW; Willemsen, Gonneke G; Evans, David M DM; Madden, Pamela A F PAF; Kähönen, Mika M; Kutalik, Zoltán Z; Zoledziewska, Magdalena M; Karhunen, Ville V; Kritchevsky, Stephen B SB; Sattar, Naveed N; Lachance, Genevieve G; Clarke, Robert R; Harris, Tamara B TB; Raitakari, Olli T OT; Attia, John R JR; van Heemst, Diana D; Kajantie, Eero E; Sorice, Rossella R; Gambaro, Giovanni G; Scott, Robert A RA; Hicks, Andrew A AA; Ferrucci, Luigi L; Standl, Marie M; Lindgren, Cecilia M CM; Starr, John M JM; Karlsson, Magnus M; Lind, Lars L; Li, Jun Z JZ; Chambers, John C JC; Mori, Trevor A TA; de Geus, Eco J C N EJCN; Heath, Andrew C AC; Martin, Nicholas G NG; Auvinen, Juha J; Buckley, Brendan M BM; de Craen, Anton J M AJM; Waldenberger, Melanie M; Strauch, Konstantin K; Meitinger, Thomas T; Scott, Rodney J RJ; McEvoy, Mark M; Beekman, Marian M; Bombieri, Cristina C; Ridker, Paul M PM; Mohlke, Karen L KL; Pedersen, Nancy L NL; Morrison, Alanna C AC; Boomsma, Dorret I DI; Whitfield, John B JB; Strachan, David P DP; Hofman, Albert A; Vollenweider, Peter P; Cucca, Francesco F; Jarvelin, Marjo-Riitta MR; Jukema, J Wouter JW; Spector, Tim D TD; Hamsten, Anders A; Zeller, Tanja T; Uitterlinden, André G AG; Nauck, Matthias M; Gudnason, Vilmundur V; Qi, Lu L; Grallert, Harald H; Borecki, Ingrid B IB; Rotter, Jerome I JI; März, Winfried W; Wild, Philipp S PS; Lokki, Marja-Liisa ML; Boyle, Michael M; Salomaa, Veikko V; Melbye, Mads M; Eriksson, Johan G JG; Wilson, James F JF; Penninx, Brenda W J H BWJH; Becker, Diane M DM; Worrall, Bradford B BB; Gibson, Greg G; Krauss, Ronald M RM; Ciullo, Marina M; Zaza, Gianluigi G; Wareham, Nicholas J NJ; Oldehinkel, Albertine J AJ; Palmer, Lyle J LJ; Murray, Sarah S SS; Pramstaller, Peter P PP; Bandinelli, Stefania S; Heinrich, Joachim J; Ingelsson, Erik E; Deary, Ian J IJ; Mägi, Reedik R; Vandenput, Liesbeth L; van der Harst, Pim P; Desch, Karl C KC; Kooner, Jaspal S JS; Ohlsson, Claes C; Hayward, Caroline C; Lehtimäki, Terho T; Shuldiner, Alan R AR; Arnett, Donna K DK; Beilin, Lawrence J LJ; Robino, Antonietta A; Froguel, Philippe P; Pirastu, Mario M; Jess, Tine T; Koenig, Wolfgang W; Loos, Ruth J F RJF; Evans, Denis A DA; Schmidt, Helena H; Smith, George Davey GD; Slagboom, P Eline PE; Eiriksdottir, Gudny G; Morris, Andrew P AP; Psaty, Bruce M BM; Tracy, Russell P RP; Nolte, Ilja M IM; Boerwinkle, Eric E; Visvikis-Siest, Sophie S; Reiner, Alex P AP; Gross, Myron M; Bis, Joshua C JC; Franke, Lude L; Franco, Oscar H OH; Benjamin, Emelia J EJ; Chasman, Daniel I DI; Dupuis, Josée J; Snieder, Harold H; Dehghan, Abbas A; Alizadeh, Behrooz Z BZ
Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome.
Plos One
Johansson, Åsa Å; Alfredsson, Jenny J; Eriksson, Niclas N; Wallentin, Lars L; Siegbahn, Agneta A
Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers.
Nature Genetics
Sidore, Carlo C; Busonero, Fabio F; Maschio, Andrea A; Porcu, Eleonora E; Naitza, Silvia S; Zoledziewska, Magdalena M; Mulas, Antonella A; Pistis, Giorgio G; Steri, Maristella M; Danjou, Fabrice F; Kwong, Alan A; Ortega Del Vecchyo, Vicente Diego VD; Chiang, Charleston W K CWK; Bragg-Gresham, Jennifer J; Pitzalis, Maristella M; Nagaraja, Ramaiah R; Tarrier, Brendan B; Brennan, Christine C; Uzzau, Sergio S; Fuchsberger, Christian C; Atzeni, Rossano R; Reinier, Frederic F; Berutti, Riccardo R; Huang, Jie J; Timpson, Nicholas J NJ; Toniolo, Daniela D; Gasparini, Paolo P; Malerba, Giovanni G; Dedoussis, George G; Zeggini, Eleftheria E; Soranzo, Nicole N; Jones, Chris C; Lyons, Robert R; Angius, Andrea A; Kang, Hyun M HM; Novembre, John J; Sanna, Serena S; Schlessinger, David D; Cucca, Francesco F; Abecasis, Gonçalo R GR
Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes.
Plos One
Almlöf, Jonas Carlsson JC; Lundmark, Per P; Lundmark, Anders A; Ge, Bing B; Pastinen, Tomi T; , ; Goodall, Alison H AH; Cambien, François F; Deloukas, Panos P; Ouwehand, Willem H WH; Syvänen, Ann-Christine AC
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
Annals Of Neurology
Williams, Frances M K FM; Carter, Angela M AM; Hysi, Pirro G PG; Surdulescu, Gabriela G; Hodgkiss, Dylan D; Soranzo, Nicole N; Traylor, Matthew M; Bevan, Steve S; Dichgans, Martin M; Rothwell, Peter M W PM; Sudlow, Cathie C; Farrall, Martin M; Silander, Kaisa K; Kaunisto, Mari M; Wagner, Peter P; Saarela, Olli O; Kuulasmaa, Kari K; Virtamo, Jarmo J; Salomaa, Veikko V; Amouyel, Philippe P; Arveiler, Dominique D; Ferrieres, Jean J; Wiklund, Per-Gunnar PG; Ikram, M Arfan MA; Hofman, Albert A; Boncoraglio, Giorgio B GB; Parati, Eugenio A EA; Helgadottir, Anna A; Gretarsdottir, Solveig S; Thorsteinsdottir, Unnur U; Thorleifsson, Gudmar G; Stefansson, Kari K; Seshadri, Sudha S; DeStefano, Anita A; Gschwendtner, Andreas A; Psaty, Bruce B; Longstreth, Will W; Mitchell, Braxton D BD; Cheng, Yu-Ching YC; Clarke, Robert R; Ferrario, Marco M; Bis, Joshua C JC; Levi, Christopher C; Attia, John J; Holliday, Elizabeth G EG; Scott, Rodney J RJ; Fornage, Myriam M; Sharma, Pankaj P; Furie, Karen L KL; Rosand, Jonathan J; Nalls, Mike M; Meschia, James J; Mosely, Thomas H TH; Evans, Alun A; Palotie, Aarno A; Markus, Hugh S HS; Grant, Peter J PJ; Spector, Tim D TD; , ; , ; , ; , ; ,
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
Plos Genetics
Naitza, Silvia S; Porcu, Eleonora E; Steri, Maristella M; Taub, Dennis D DD; Mulas, Antonella A; Xiao, Xiang X; Strait, James J; Dei, Mariano M; Lai, Sandra S; Busonero, Fabio F; Maschio, Andrea A; Usala, Gianluca G; Zoledziewska, Magdalena M; Sidore, Carlo C; Zara, Ilenia I; Pitzalis, Maristella M; Loi, Alessia A; Virdis, Francesca F; Piras, Roberta R; Deidda, Francesca F; Whalen, Michael B MB; Crisponi, Laura L; Concas, Antonio A; Podda, Carlo C; Uzzau, Sergio S; Scheet, Paul P; Longo, Dan L DL; Lakatta, Edward E; Abecasis, Gonçalo R GR; Cao, Antonio A; Schlessinger, David D; Uda, Manuela M; Sanna, Serena S; Cucca, Francesco F
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
Lancet (London, England)
Reilly, Muredach P MP; Li, Mingyao M; He, Jing J; Ferguson, Jane F JF; Stylianou, Ioannis M IM; Mehta, Nehal N NN; Burnett, Mary Susan MS; Devaney, Joseph M JM; Knouff, Christopher W CW; Thompson, John R JR; Horne, Benjamin D BD; Stewart, Alexandre F R AF; Assimes, Themistocles L TL; Wild, Philipp S PS; Allayee, Hooman H; Nitschke, Patrick Linsel PL; Patel, Riyaz S RS; , ; , ; Martinelli, Nicola N; Girelli, Domenico D; Quyyumi, Arshed A AA; Anderson, Jeffrey L JL; Erdmann, Jeanette J; Hall, Alistair S AS; Schunkert, Heribert H; Quertermous, Thomas T; Blankenberg, Stefan S; Hazen, Stanley L SL; Roberts, Robert R; Kathiresan, Sekar S; Samani, Nilesh J NJ; Epstein, Stephen E SE; Rader, Daniel J DJ