Publications:

FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity.

Blood Advances

Ettinger, Ruth A RA; Liberman, Joseph A JA; Gunasekera, Devi D; Puranik, Komal K; James, Eddie A EA; Thompson, Arthur R AR; Pratt, Kathleen P KP

Publication Date: 2018-02-27

Variant appearance in text: FVIII: M2199I

PubMed Link: 29444872

Variant Present in the following documents:

• Main text

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Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody.

Plos One

Lin, Jasper C JC; Ettinger, Ruth A RA; Schuman, Jason T JT; Zhang, Ai-Hong AH; Wamiq-Adhami, Muhammad M; Nguyen, Phuong-Cac T PC; Nakaya-Fletcher, Shelley M SM; Puranik, Komal K; Thompson, Arthur R AR; Pratt, Kathleen P KP

Publication Date: 2015

Variant appearance in text: FVIII: M2199I

PubMed Link: 25615825

Variant Present in the following documents:

• Main text
• pone.0116577.pdf

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High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.

Blood

Nguyen, Phuong-Cac T PC; Lewis, Kenneth B KB; Ettinger, Ruth A RA; Schuman, Jason T JT; Lin, Jasper C JC; Healey, John F JF; Meeks, Shannon L SL; Lollar, Pete P; Pratt, Kathleen P KP

Publication Date: 2014-04-24

Variant appearance in text: FVIII: M2199I

PubMed Link: 24591205

Variant Present in the following documents:

• Main text

View BVdb publication page