van Ree, Janine H JH; Jeganathan, Karthik B KB; Fierro Velasco, Raul O RO; Zhang, Cheng C; Can, Ismail I; Hamada, Masakazu M; Li, Hu H; Baker, Darren J DJ; van Deursen, Jan M JM
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells
Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells
Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL
Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL.
Cells
Olazábal-Morán, Manuel M; Sánchez-Ortega, Miriam M; Martínez-Muñoz, Laura L; Hernández, Carmen C; Rodríguez, Manuel S MS; Mellado, Mario M; Carrera, Ana C AC
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.
Nature Communications
Park, Hae-Eun H HH; Hwang, Wooseon W; Ham, Seokjin S; Kim, Eunah E; Altintas, Ozlem O; Park, Sangsoon S; Son, Heehwa G HG; Lee, Yujin Y; Lee, Dongyeop D; Heo, Won Do WD; Lee, Seung-Jae V SV
A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation.
Plos Genetics
Ganguly, Payel P; Madonsela, Landiso L; Chao, Jesse T JT; Loewen, Christopher J R CJR; O'Connor, Timothy P TP; Verheyen, Esther M EM; Allan, Douglas W DW
Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer.
Npj Breast Cancer
Smyth, Lillian M LM; Batist, Gerald G; Meric-Bernstam, Funda F; Kabos, Peter P; Spanggaard, Iben I; Lluch, Ana A; Jhaveri, Komal K; Varga, Andrea A; Wong, Andrea A; Schram, Alison M AM; Ambrose, Helen H; Carr, T Hedley TH; de Bruin, Elza C EC; Salinas-Souza, Carolina C; Foxley, Andrew A; Hauser, Joana J; Lindemann, Justin P O JPO; Maudsley, Rhiannon R; McEwen, Robert R; Moschetta, Michele M; Nikolaou, Myria M; Schiavon, Gaia G; Razavi, Pedram P; Banerji, Udai U; Baselga, José J; Hyman, David M DM; Chandarlapaty, Sarat S
Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.
Nature Communications
Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A
Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.
Embo Reports
Nitzsche, Anja A; Pietilä, Riikka R; Love, Dominic T DT; Testini, Chiara C; Ninchoji, Takeshi T; Smith, Ross O RO; Ekvärn, Elisabet E; Larsson, Jimmy J; Roche, Francis P FP; Egaña, Isabel I; Jauhiainen, Suvi S; Berger, Philipp P; Claesson-Welsh, Lena L; Hellström, Mats M
Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer.
The Oncologist
Huang, Richard S P RSP; Li, Xinyan X; Haberberger, James J; Sokol, Ethan E; Severson, Eric E; Duncan, Daniel L DL; Hemmerich, Amanda A; Edgerly, Claire C; Williams, Erik E; Elvin, Julia J; Vergilio, Jo-Anne JA; Killian, Jonathan Keith JK; Lin, Douglas D; Hiemenz, Matthew M; Xiao, Jinpeng J; McEwan, Deborah D; Holmes, Oliver O; Danziger, Natalie N; Erlich, Rachel R; Frampton, Garrett G; Cohen, Michael B MB; McGregor, Kimberly K; Reddy, Prasanth P; Cardeiro, Dawn D; Anhorn, Rachel R; Venstrom, Jeffrey J; Alexander, Brian B; Brown, Charlotte C; Pusztai, Lajos L; Ross, Jeffrey S JS; Ramkissoon, Shakti H SH