Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
Nature Communications
Yang, Yandan Y; Bolomsky, Arnold A; Oellerich, Thomas T; Chen, Ping P; Ceribelli, Michele M; Häupl, Björn B; Wright, George W GW; Phelan, James D JD; Huang, Da Wei DW; Lord, James W JW; Van Winkle, Callie K CK; Yu, Xin X; Wisniewski, Jan J; Wang, James Q JQ; Tosto, Frances A FA; Beck, Erin E; Wilson, Kelli K; McKnight, Crystal C; Travers, Jameson J; Klumpp-Thomas, Carleen C; Smith, Grace A GA; Pittaluga, Stefania S; Maric, Irina I; Kazandjian, Dickran D; Thomas, Craig J CJ; Young, Ryan M RM
Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies.
Journal Of Cancer Research And Clinical Oncology
Kleo, Karsten K; Jovanovic, Vladimir M VM; Arndold, Alexander A; Lehmann, Annika A; Lammert, Hedwig H; Berg, Erika E; Harloff, Hannah H; Treese, Christoph C; Hummel, Michael M; Daum, Severin S
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Castel, Pau P; Dharmaiah, Srisathiyanarayanan S; Sale, Matthew J MJ; Messing, Simon S; Rizzuto, Gabrielle G; Cuevas-Navarro, Antonio A; Cheng, Alice A; Trnka, Michael J MJ; Urisman, Anatoly A; Esposito, Dominic D; Simanshu, Dhirendra K DK; McCormick, Frank F
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Nature Communications
Giubilaro, Jenna J; Schuetz, Doris A DA; Stepniewski, Tomasz M TM; Namkung, Yoon Y; Khoury, Etienne E; Lara-Márquez, Mónica M; Campbell, Shirley S; Beautrait, Alexandre A; Armando, Sylvain S; Radresa, Olivier O; Duchaine, Jean J; Lamarche-Vane, Nathalie N; Claing, Audrey A; Selent, Jana J; Bouvier, Michel M; Marinier, Anne A; Laporte, Stéphane A SA
Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition.
Nature Communications
Yao, Zhong Z; Aboualizadeh, Farzaneh F; Kroll, Jason J; Akula, Indira I; Snider, Jamie J; Lyakisheva, Anna A; Tang, Priscilla P; Kotlyar, Max M; Jurisica, Igor I; Boxem, Mike M; Stagljar, Igor I
Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells.
Cancers
Meinohl, Christopher C; Barnard, Sarah J SJ; Fritz-Wolf, Karin K; Unger, Monika M; Porr, Andreea A; Heipel, Marisa M; Wirth, Stefanie S; Madlung, Johannes J; Nordheim, Alfred A; Menke, Andre A; Becker, Katja K; Giehl, Klaudia K
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nature Communications
Bery, Nicolas N; Legg, Sandrine S; Debreczeni, Judit J; Breed, Jason J; Embrey, Kevin K; Stubbs, Christopher C; Kolasinska-Zwierz, Paulina P; Barrett, Nathalie N; Marwood, Rose R; Watson, Jo J; Tart, Jon J; Overman, Ross R; Miller, Ami A; Phillips, Christopher C; Minter, Ralph R; Rabbitts, Terence H TH
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Elife
Bery, Nicolas N; Cruz-Migoni, Abimael A; Bataille, Carole Jr CJ; Quevedo, Camilo E CE; Tulmin, Hanna H; Miller, Ami A; Russell, Angela A; Phillips, Simon Ev SE; Carr, Stephen B SB; Rabbitts, Terence H TH
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
Leukemia
Rothenberg-Thurley, Maja M; Amler, Susanne S; Goerlich, Dennis D; Köhnke, Thomas T; Konstandin, Nikola P NP; Schneider, Stephanie S; Sauerland, Maria C MC; Herold, Tobias T; Hubmann, Max M; Ksienzyk, Bianka B; Zellmeier, Evelyn E; Bohlander, Stefan K SK; Subklewe, Marion M; Faldum, Andreas A; Hiddemann, Wolfgang W; Braess, Jan J; Spiekermann, Karsten K; Metzeler, Klaus H KH
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Embo Molecular Medicine
Baietti, Maria Francesca MF; Simicek, Michal M; Abbasi Asbagh, Layka L; Radaelli, Enrico E; Lievens, Sam S; Crowther, Jonathan J; Steklov, Mikhail M; Aushev, Vasily N VN; Martínez García, David D; Tavernier, Jan J; Sablina, Anna A AA
Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.
Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.
Genome Medicine
Alakus, Hakan H; Babicky, Michele L ML; Ghosh, Pradipta P; Yost, Shawn S; Jepsen, Kristen K; Dai, Yang Y; Arias, Angelo A; Samuels, Michael L ML; Mose, Evangeline S ES; Schwab, Richard B RB; Peterson, Michael R MR; Lowy, Andrew M AM; Frazer, Kelly A KA; Harismendy, Olivier O
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.
Science Signaling
Zhang, Weiying W; Nandakumar, Nivedita N; Shi, Yuhao Y; Manzano, Mark M; Smith, Alias A; Graham, Garrett G; Gupta, Swati S; Vietsch, Eveline E EE; Laughlin, Sean Z SZ; Wadhwa, Mandheer M; Chetram, Mahandranauth M; Joshi, Mrinmayi M; Wang, Fen F; Kallakury, Bhaskar B; Toretsky, Jeffrey J; Wellstein, Anton A; Yi, Chunling C
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Nature Chemical Biology
Lavoie, Hugo H; Thevakumaran, Neroshan N; Gavory, Gwenaëlle G; Li, John J JJ; Padeganeh, Abbas A; Guiral, Sébastien S; Duchaine, Jean J; Mao, Daniel Y L DY; Bouvier, Michel M; Sicheri, Frank F; Therrien, Marc M
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Science Signaling
Sasaki, Atsuo T AT; Carracedo, Arkaitz A; Locasale, Jason W JW; Anastasiou, Dimitrios D; Takeuchi, Koh K; Kahoud, Emily Rose ER; Haviv, Sasson S; Asara, John M JM; Pandolfi, Pier Paolo PP; Cantley, Lewis C LC
Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands.
Neoplasia (New York, N.Y.)
Tetsu, Osamu O; Phuchareon, Janyaporn J; Chou, Annie A; Cox, Darren P DP; Eisele, David W DW; Jordan, Richard C K RC