Publications:

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: G13E

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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Characteristics and Treatment Outcomes in Advanced-Stage Non-Small Cell Lung Cancer Patients with a KRAS G12C Mutation: A Real-World Study.

Journal Of Clinical Medicine

Illini, Oliver O; Fabikan, Hannah H; Hochmair, Maximilian Johannes MJ; Weinlinger, Christoph C; Krenbek, Dagmar D; Brcic, Luka L; Setinek, Ulrike U; Terbuch, Angelika A; Absenger, Gudrun G; Konjić, Selma S; Valipour, Arschang A

Publication Date: 2022-07-15

Variant appearance in text: KRAS: G13E

PubMed Link: 35887862

Variant Present in the following documents:

• jcm-11-04098.pdf

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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Feng, Siyu S; Callow, Marinella G MG; Fortin, Jean-Philippe JP; Khan, Zia Z; Bray, David D; Costa, Mike M; Shi, Zhen Z; Wang, Weiru W; Evangelista, Marie M

Publication Date: 2022-05-03

Variant appearance in text: KRAS: G13E

PubMed Link: 35471904

Variant Present in the following documents:

• pnas.202120512.pdf

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Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

International Journal Of Molecular Medicine

Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R

Publication Date: 2022-05

Variant appearance in text: KRAS: Gly13Glu

PubMed Link: 35244186

Variant Present in the following documents:

• Supplementary_Data3.xlsx, sheet 1
• Supplementary_Data2.xlsx, sheet 1

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Alternative polyadenylation is a determinant of oncogenic Ras function.

Science Advances

Subramanian, Aishwarya A; Hall, Mathew M; Hou, Huayun H; Mufteev, Marat M; Yu, Bin B; Yuki, Kyoko E KE; Nishimura, Haruka H; Sathaseevan, Anson A; Lant, Benjamin B; Zhai, Beibei B; Ellis, James J; Wilson, Michael D MD; Daugaard, Mads M; Derry, W Brent WB

Publication Date: 2021-12-17

Variant appearance in text: KRAS: G13E

PubMed Link: 34919436

Variant Present in the following documents:

• sciadv.abh0562.pdf

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Alternative polyadenylation is a determinant of oncogenic Ras function.

Science Advances

Subramanian, Aishwarya A; Hall, Mathew M; Hou, Huayun H; Mufteev, Marat M; Yu, Bin B; Yuki, Kyoko E KE; Nishimura, Haruka H; Sathaseevan, Anson A; Lant, Benjamin B; Zhai, Beibei B; Ellis, James J; Wilson, Michael D MD; Daugaard, Mads M; Derry, W Brent WB

Publication Date: 2021-12-17

Variant appearance in text: KRAS: G13E

PubMed Link: 34919436

Variant Present in the following documents:

• sciadv.abh0562.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: G13E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.

Nature Communications

Cook, Joshua H JH; Melloni, Giorgio E M GEM; Gulhan, Doga C DC; Park, Peter J PJ; Haigis, Kevin M KM

Publication Date: 2021-03-22

Variant appearance in text: KRAS: G13E

PubMed Link: 33753749

Variant Present in the following documents:

• 41467_2021_22125_MOESM4_ESM.xlsx, sheet 4

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: KRAS: G13E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Role of next generation sequencing-based liquid biopsy in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: impact of STK11, KRAS and TP53 mutations and co-mutations on outcome.

Translational Lung Cancer Research

Pavan, Alberto A; Bragadin, Andrea Boscolo AB; Calvetti, Lorenzo L; Ferro, Alessandra A; Zulato, Elisabetta E; Attili, Ilaria I; Nardo, Giorgia G; Dal Maso, Alessandro A; Frega, Stefano S; Menin, Andrea Giovanni AG; Fassan, Matteo M; Calabrese, Fiorella F; Pasello, Giulia G; Guarneri, Valentina V; Aprile, Giuseppe G; Conte, PierFranco P; Rosell, Rafael R; Indraccolo, Stefano S; Bonanno, Laura L

Publication Date: 2021-01

Variant appearance in text: KRAS: G13E

PubMed Link: 33569305

Variant Present in the following documents:

• tlcr-10-01-202-supplementary.pdf

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Targeted RNA sequencing with touch imprint cytology samples for non-small cell lung cancer patients.

Thoracic Cancer

Seto, Katsutoshi K; Masago, Katsuhiro K; Fujita, Shiro S; Haneda, Masataka M; Horio, Yoshitsugu Y; Hida, Toyoaki T; Kuroda, Hiroaki H; Hosoda, Waki W; Okubo, Ken-Ichi KI

Publication Date: 2020-07

Variant appearance in text: KRAS: Gly13Glu

PubMed Link: 32372482

Variant Present in the following documents:

• Main text
• TCA-11-1827.pdf

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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer

Mack, Philip C PC; Banks, Kimberly C KC; Espenschied, Carin R CR; Burich, Rebekah A RA; Zill, Oliver A OA; Lee, Christine E CE; Riess, Jonathan W JW; Mortimer, Stefanie A SA; Talasaz, AmirAli A; Lanman, Richard B RB; Gandara, David R DR

Publication Date: 2020-07-15

Variant appearance in text: KRAS: G13E

PubMed Link: 32365229

Variant Present in the following documents:

• Main text

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: G13E

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine

Wang, Haiyun H; Lv, Qi Q; Xu, Yue Y; Cai, Zhaoqing Z; Zheng, Jie J; Cheng, Xiaojie X; Dai, Yao Y; Jänne, Pasi A PA; Ambrogio, Chiara C; Köhler, Jens J

Publication Date: 2019-11

Variant appearance in text: KRAS: G13E

PubMed Link: 31668570

Variant Present in the following documents:

• Main text
• main.pdf

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Mutation profiling of cancer drivers in Brazilian colorectal cancer.

Scientific Reports

Dos Santos, Wellington W; Sobanski, Thais T; de Carvalho, Ana Carolina AC; Evangelista, Adriane Feijó AF; Matsushita, Marcus M; Berardinelli, Gustavo Nóriz GN; de Oliveira, Marco Antonio MA; Reis, Rui Manuel RM; Guimarães, Denise Peixoto DP

Publication Date: 2019-09-23

Variant appearance in text: KRAS: Gly13Glu

PubMed Link: 31548566

Variant Present in the following documents:

• 41598_2019_49611_MOESM1_ESM.pdf

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Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations.

Scientific Reports

Leal, Letícia Ferro LF; de Paula, Flávia Escremim FE; De Marchi, Pedro P; de Souza Viana, Luciano L; Pinto, Gustavo Dix Junqueira GDJ; Carlos, Carolina Dias CD; Berardinelli, Gustavo Noriz GN; Miziara, José Elias JE; da Silva, Carlos Maciel CM; Silva, Eduardo Caetano Albino ECA; Pereira, Rui R; de Oliveira, Marco Antonio MA; Scapulatempo-Neto, Cristovam C; Reis, Rui Manuel RM

Publication Date: 2019-03-01

Variant appearance in text: KRAS: Gly13Glu

PubMed Link: 30824880

Variant Present in the following documents:

• Main text
• 41598_2019_39965_MOESM1_ESM.pdf
• 41598_2019_Article_39965.pdf

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Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.

Genome Medicine

Li, Shuyu D SD; Ma, Meng M; Li, Hui H; Waluszko, Aneta A; Sidorenko, Tatyana T; Schadt, Eric E EE; Zhang, David Y DY; Chen, Rong R; Ye, Fei F

Publication Date: 2017-10-30

Variant appearance in text: KRAS: G13E

PubMed Link: 29082853

Variant Present in the following documents:

• 13073_2017_478_MOESM1_ESM.xlsx, sheet 2

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: KRAS: G13E

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Circulating and tissue biomarkers in early-stage non-small cell lung cancer.

Ecancermedicalscience

Fumagalli, Caterina C; Bianchi, Fabrizio F; Raviele, Paola Rafaniello PR; Vacirca, Davide D; Bertalot, Giovanni G; Rampinelli, Cristiano C; Lazzeroni, Matteo M; Bonanni, Bernardo B; Veronesi, Giulia G; Fusco, Nicola N; Barberis, Massimo M; Guerini-Rocco, Elena E

Publication Date: 2017

Variant appearance in text: KRAS: G13E

PubMed Link: 28194229

Variant Present in the following documents:

• Main text
• can-11-717.pdf

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: KRAS: G13E

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.

Plos One

Solassol, Jérôme J; Vendrell, Julie J; Märkl, Bruno B; Haas, Christian C; Bellosillo, Beatriz B; Montagut, Clara C; Smith, Matthew M; O'Sullivan, Brendan B; D'Haene, Nicky N; Le Mercier, Marie M; Grauslund, Morten M; Melchior, Linea Cecilie LC; Burt, Emma E; Cotter, Finbarr F; Stieber, Daniel D; Schmitt, Fernando de Lander FL; Motta, Valentina V; Lauricella, Calogero C; Colling, Richard R; Soilleux, Elizabeth E; Fassan, Matteo M; Mescoli, Claudia C; Collin, Christine C; Pagès, Jean-Christophe JC; Sillekens, Peter P

Publication Date: 2016

Variant appearance in text: KRAS: G13E

PubMed Link: 27685259

Variant Present in the following documents:

• Main text
• pone.0163444.pdf

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Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA.

Plos Genetics

Schmid, Tobias T; Snoek, L Basten LB; Fröhli, Erika E; van der Bent, M Leontien ML; Kammenga, Jan J; Hajnal, Alex A

Publication Date: 2015-05

Variant appearance in text: KRAS: G13E

PubMed Link: 25978500

Variant Present in the following documents:

• Main text
• pgen.1005236.pdf

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KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity?

British Journal Of Cancer

Lopez-Crapez, E E; Mineur, L L; Emptas, H H; Lamy, P-J PJ

Publication Date: 2010-03-16

Variant appearance in text: N/A

PubMed Link: 20160721

Variant Present in the following documents:

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High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue.

Journal Of Cellular And Molecular Medicine

Tol, Jolien J; Dijkstra, Jeroen R JR; Vink-Börger, Marianne E ME; Nagtegaal, Iris D ID; Punt, Cornelis J A CJ; Van Krieken, Johan H J M JH; Ligtenberg, Marjolijn J L MJ

Publication Date: 2010-08

Variant appearance in text: KRAS: 38_39delinsAG

PubMed Link: 19453520

Variant Present in the following documents:

• Main text
• jcmm0014-2122.pdf

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