Publications:

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Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.

Nature Communications

Berko, Esther R ER; Witek, Gabriela M GM; Matkar, Smita S; Petrova, Zaritza O ZO; Wu, Megan A MA; Smith, Courtney M CM; Daniels, Alex A; Kalna, Joshua J; Kennedy, Annie A; Gostuski, Ivan I; Casey, Colleen C; Krytska, Kateryna K; Gerelus, Mark M; Pavlick, Dean D; Ghazarian, Susan S; Park, Julie R JR; Marachelian, Araz A; Maris, John M JM; Goldsmith, Kelly C KC; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP

Publication Date: 2023-05-05

Variant appearance in text: ALK: R1192P

PubMed Link: 37147298

Variant Present in the following documents:

• 41467_2023_38195_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Case report: Epithelioid inflammatory myofibroblastic sarcoma treated with an ALK TKI ensartinib.

Frontiers In Oncology

Li, Mengmeng M; Xing, Ruyue R; Huang, Jiuyan J; Shi, Chao C; Wei, Chunhua C; Wang, Huijuan H

Publication Date: 2023

Variant appearance in text: ALK: R1192P

PubMed Link: 37035183

Variant Present in the following documents:

• Main text
• fonc-13-1084456.pdf

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Classical ALK G1202R resistance mutation was identified in a lung adenocarcinoma patient with rare LOC388942-ALK fusion after sequential treatment with ALK-TKIs and anlotinib: a case report.

Annals Of Translational Medicine

Zhai, Xiaoqian X; Liu, Yanyang Y; Liang, Zuoyu Z; Wang, Weiya W; Qin, Tian T; Liu, Stephen V SV; Um, Sang-Won SW; Luo, Feng F; Liu, Jiewei J

Publication Date: 2022-11

Variant appearance in text: ALK: R1192P

PubMed Link: 36467355

Variant Present in the following documents:

• Main text
• atm-10-21-1180.pdf

View BVdb publication page

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Mutational Profile and Potential Molecular Therapeutic Targets of Pheochromocytoma.

Frontiers In Endocrinology

Ma, Xiaosen X; Ling, Chao C; Zhao, Meng M; Wang, Fen F; Cui, Yunying Y; Wen, Jin J; Ji, Zhigang Z; Zhang, Caili C; Chen, Shi S; Tong, Anli A; Li, Yuxiu Y

Publication Date: 2022

Variant appearance in text: ALK: R1192P

PubMed Link: 35966080

Variant Present in the following documents:

• fendo-13-921645.pdf

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Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications

Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L

Publication Date: 2022-03-10

Variant appearance in text: ALK: 3575G>C; R1192P

PubMed Link: 35273153

Variant Present in the following documents:

• 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

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Durable Clinical Response to ALK Tyrosine Kinase Inhibitors in Epithelioid Inflammatory Myofibroblastic Sarcoma Harboring PRRC2B-ALK Rearrangement: A Case Report.

Frontiers In Oncology

Wang, Zhan Z; Geng, Yan Y; Yuan, Ling-Yan LY; Wang, Miao-Miao MM; Ye, Chen-Yang CY; Sun, Li L; Dai, Wei-Ping WP; Zang, Yuan-Sheng YS

Publication Date: 2022

Variant appearance in text: ALK: R1192P

PubMed Link: 35237506

Variant Present in the following documents:

• Main text
• fonc-12-761558.pdf

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: ALK: R1192P

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: ALK: Arg1192Pro

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Therapeutic advances in non-small cell lung cancer: Focus on clinical development of targeted therapy and immunotherapy.

Medcomm

Cheng, Yuan Y; Zhang, Tao T; Xu, Qing Q

Publication Date: 2021-12

Variant appearance in text: ALK: R1192P

PubMed Link: 34977873

Variant Present in the following documents:

• MCO2-2-692.pdf

View BVdb publication page

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: R1192P

PubMed Link: 34885113

Variant Present in the following documents:

• Main text

View BVdb publication page

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: R1192P

PubMed Link: 34885113

Variant Present in the following documents:

• Main text

View BVdb publication page

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Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis.

Npj Precision Oncology

Angeles, Arlou Kristina AK; Christopoulos, Petros P; Yuan, Zhao Z; Bauer, Simone S; Janke, Florian F; Ogrodnik, Simon John SJ; Reck, Martin M; Schlesner, Matthias M; Meister, Michael M; Schneider, Marc A MA; Dietz, Steffen S; Stenzinger, Albrecht A; Thomas, Michael M; Sültmann, Holger H

Publication Date: 2021-12-07

Variant appearance in text: ALK: 3575G>C; R1192P

PubMed Link: 34876698

Variant Present in the following documents:

• 41698_2021_239_MOESM1_ESM.pdf

View BVdb publication page

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Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer.

International Journal Of Molecular Sciences

Wulf, Anna M AM; Moreno, Marcela M MM; Paka, Chloé C; Rampasekova, Alexandra A; Liu, Karen J KJ

Publication Date: 2021-10-29

Variant appearance in text: ALK: R1192P

PubMed Link: 34769149

Variant Present in the following documents:

• Main text
• ijms-22-11718.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ALK: R1192P

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Therapeutic Targeting of the Anaplastic Lymphoma Kinase (ALK) in Neuroblastoma-A Comprehensive Update.

Pharmaceutics

Brenner, Annette K AK; Gunnes, Maria W MW

Publication Date: 2021-09-08

Variant appearance in text: ALK: R1192P

PubMed Link: 34575503

Variant Present in the following documents:

• Main text
• pharmaceutics-13-01427.pdf

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Sustained response to brigatinib in a patient with refractory metastatic pheochromocytoma harboring R1192P anaplastic lymphoma kinase mutation: a case report from the Austrian Group Medical Tumor Therapy next-generation sequencing registry and discussion of the literature.

Esmo Open

Heregger, R R; Huemer, F F; Hutarew, G G; Hecht, S S; Cheveresan, L L; Kotzot, D D; Schamschula, E E; Rinnerthaler, G G; Melchardt, T T; Weiss, L L; Greil, R R

Publication Date: 2021-08

Variant appearance in text: ALK: 3575G>C; R1192P

PubMed Link: 34371380

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed ALK F1174L-mutated neuroblastoma.

Cold Spring Harbor Molecular Case Studies

Liu, Tingting T; Merguerian, Matthew D MD; Rowe, Steven P SP; Pratilas, Christine A CA; Chen, Allen R AR; Ladle, Brian H BH

Publication Date: 2021-08

Variant appearance in text: ALK: R1192P

PubMed Link: 34210658

Variant Present in the following documents:

• Main text
• MCS006064Liu.pdf

View BVdb publication page

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Genetics of congenital solid tumors.

Romanian Journal Of Morphology And Embryology = Revue Roumaine De Morphologie Et Embryologie

Jurcă, Maria Claudia MC; Ivaşcu, Marius Evelin ME; Jurcă, Aurora Alexandra AA; Kozma, Kinga K; Magyar, Ioan I; Şandor, Mircea Ioan MI; Jurcă, Alexandru Daniel AD; Zaha, Dana Carmen DC; Albu, Cristina Crenguţa CC; Pantiş, Carmen C; Bembea, Marius M; Petcheşi, Codruţa Diana CD

Publication Date: 2020

Variant appearance in text: ALK: R1192P

PubMed Link: 34171053

Variant Present in the following documents:

• Main text

View BVdb publication page

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A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.

Journal Of Experimental & Clinical Cancer Research : Cr

Mlakar, Vid V; Morel, Edouard E; Mlakar, Simona Jurkovic SJ; Ansari, Marc M; Gumy-Pause, Fabienne F

Publication Date: 2021-06-08

Variant appearance in text: ALK: R1192P

PubMed Link: 34103089

Variant Present in the following documents:

• Main text
• 13046_2021_Article_1967.pdf

View BVdb publication page

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Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2021-03-09

Variant appearance in text: ALK: R1192P

PubMed Link: 33674381

Variant Present in the following documents:

• Main text
• pnas.202019132.pdf

View BVdb publication page

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Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Fois, Sara S SS; Paliogiannis, Panagiotis P; Zinellu, Angelo A; Fois, Alessandro G AG; Cossu, Antonio A; Palmieri, Giuseppe G

Publication Date: 2021-01-09

Variant appearance in text: ALK: R1192P

PubMed Link: 33435440

Variant Present in the following documents:

• Main text
• ijms-22-00612.pdf

View BVdb publication page

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Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA.

Ebiomedicine

Dietz, Steffen S; Christopoulos, Petros P; Yuan, Zhao Z; Angeles, Arlou Kristina AK; Gu, Lisa L; Volckmar, Anna-Lena AL; Ogrodnik, Simon J SJ; Janke, Florian F; Fratte, Chiara Dalle CD; Zemojtel, Tomasz T; Schneider, Marc A MA; Kazdal, Daniel D; Endris, Volker V; Meister, Michael M; Muley, Thomas T; Cecchin, Erika E; Reck, Martin M; Schlesner, Matthias M; Thomas, Michael M; Stenzinger, Albrecht A; Sültmann, Holger H

Publication Date: 2020-12

Variant appearance in text: ALK: 3575G>C; Arg1192Pro

PubMed Link: 33161228

Variant Present in the following documents:

• mmc1.pdf

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: ALK: R1192P

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Nervous system: Embryonal tumors: Neuroblastoma.

Atlas Of Genetics And Cytogenetics In Oncology And Haematology

Pudela, Caileigh C; Balyasny, Skye S; Applebaum, Mark A MA

Publication Date: 2020-07

Variant appearance in text: ALK: R1192P

PubMed Link: 32296467

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: ALK: R1192P

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.

Thoracic Cancer

Takahashi, Ken K; Seto, Yosuke Y; Okada, Koutaroh K; Uematsu, Shinya S; Uchibori, Ken K; Tsukahara, Mika M; Oh-Hara, Tomoko T; Fujita, Naoya N; Yanagitani, Noriko N; Nishio, Makoto M; Okubo, Kenichi K; Katayama, Ryohei R

Publication Date: 2020-03

Variant appearance in text: ALK: R1192P

PubMed Link: 31943796

Variant Present in the following documents:

• Main text
• TCA-11-581.pdf

View BVdb publication page

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Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells.

Scientific Reports

Cervantes-Madrid, Diana D; Szydzik, Joanna J; Lind, Dan Emil DE; Borenäs, Marcus M; Bemark, Mats M; Cui, Jean J; Palmer, Ruth Helen RH; Hallberg, Bengt B

Publication Date: 2019-12-18

Variant appearance in text: ALK: R1192P

PubMed Link: 31852910

Variant Present in the following documents:

• Main text
• 41598_2019_Article_55060.pdf

View BVdb publication page

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Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells.

Frontiers In Oncology

Alam, Muhammad Wasi MW; Borenäs, Marcus M; Lind, Dan E DE; Cervantes-Madrid, Diana D; Umapathy, Ganesh G; Palmer, Ruth H RH; Hallberg, Bengt B

Publication Date: 2019

Variant appearance in text: ALK: R1192P

PubMed Link: 31334113

Variant Present in the following documents:

• Main text
• fonc-09-00579.pdf

View BVdb publication page

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Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular And Molecular Life Sciences : Cmls

Jordan, E Joseph EJ; Patil, Keshav K; Suresh, Krishna K; Park, Jin H JH; Mosse, Yael P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2019-07

Variant appearance in text: ALK: R1192P

PubMed Link: 30982079

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeting anaplastic lymphoma kinase in neuroblastoma.

Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica

Umapathy, Ganesh G; Mendoza-Garcia, Patricia P; Hallberg, Bengt B; Palmer, Ruth H RH

Publication Date: 2019-05

Variant appearance in text: ALK: R1192P

PubMed Link: 30803032

Variant Present in the following documents:

• Main text

View BVdb publication page

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Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data.

Npj Precision Oncology

Patterson, Sara E SE; Statz, Cara M CM; Yin, Taofei T; Mockus, Susan M SM

Publication Date: 2019

Variant appearance in text: ALK: R1192P

PubMed Link: 30675517

Variant Present in the following documents:

• Main text
• 41698_2018_Article_73.pdf

View BVdb publication page

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Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma.

Drug Design, Development And Therapy

Pacenta, Holly L HL; Macy, Margaret E ME

Publication Date: 2018

Variant appearance in text: ALK: R1192P

PubMed Link: 30425456

Variant Present in the following documents:

• Main text
• dddt-12-3549.pdf

View BVdb publication page

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Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces.

International Journal Of Molecular Sciences

Huang, Hao H

Publication Date: 2018-11-02

Variant appearance in text: ALK: R1192P

PubMed Link: 30400214

Variant Present in the following documents:

• Main text

View BVdb publication page

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Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.

Acs Medicinal Chemistry Letters

Johnson, Ted W TW; Bolanos, Ben B; Brooun, Alexei A; Gallego, Rebecca A RA; Gehlhaar, Dan D; Jalaie, Mehran M; McTigue, Michele M; Timofeevski, Sergei S

Publication Date: 2018-09-13

Variant appearance in text: ALK: R1192P

PubMed Link: 30258533

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Predisposition to Neuroblastoma.

Children (Basel, Switzerland)

Barr, Erin K EK; Applebaum, Mark A MA

Publication Date: 2018-08-31

Variant appearance in text: ALK: R1192P

PubMed Link: 30200332

Variant Present in the following documents:

• Main text
• children-05-00119.pdf

View BVdb publication page

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: ALK: R1192P

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 3

View BVdb publication page

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Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.

Scientific Reports

Li, Jianzong J; Huang, Yue Y; Wu, Miaomiao M; Wu, Chuanfang C; Li, Xin X; Bao, Jinku J

Publication Date: 2018-07-13

Variant appearance in text: ALK: R1192P

PubMed Link: 30006516

Variant Present in the following documents:

• 41598_2018_28752_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib.

Cold Spring Harbor Molecular Case Studies

Guan, Jikui J; Fransson, Susanne S; Siaw, Joachim Tetteh JT; Treis, Diana D; Van den Eynden, Jimmy J; Chand, Damini D; Umapathy, Ganesh G; Ruuth, Kristina K; Svenberg, Petter P; Wessman, Sandra S; Shamikh, Alia A; Jacobsson, Hans H; Gordon, Lena L; Stenman, Jakob J; Svensson, Pär-Johan PJ; Hansson, Magnus M; Larsson, Erik E; Martinsson, Tommy T; Palmer, Ruth H RH; Kogner, Per P; Hallberg, Bengt B

Publication Date: 2018-08

Variant appearance in text: ALK: R1192P

PubMed Link: 29907598

Variant Present in the following documents:

• Main text
• MCS002550Gua.pdf

View BVdb publication page

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Genetic susceptibility to neuroblastoma: current knowledge and future directions.

Cell And Tissue Research

Ritenour, Laura E LE; Randall, Michael P MP; Bosse, Kristopher R KR; Diskin, Sharon J SJ

Publication Date: 2018-05

Variant appearance in text: ALK: R1192P

PubMed Link: 29589100

Variant Present in the following documents:

• Main text

View BVdb publication page

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Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

Oncotarget

Gudernova, Iva I; Balek, Lukas L; Varecha, Miroslav M; Kucerova, Jana Fialova JF; Kunova Bosakova, Michaela M; Fafilek, Bohumil B; Palusova, Veronika V; Uldrijan, Stjepan S; Trantirek, Lukas L; Krejci, Pavel P

Publication Date: 2017-12-12

Variant appearance in text: ALK: R1192P

PubMed Link: 29312610

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis.

Oncotarget

Uryu, Kumiko K; Nishimura, Riki R; Kataoka, Keisuke K; Sato, Yusuke Y; Nakazawa, Atsuko A; Suzuki, Hiromichi H; Yoshida, Kenichi K; Seki, Masafumi M; Hiwatari, Mitsuteru M; Isobe, Tomoya T; Shiraishi, Yuichi Y; Chiba, Kenichi K; Tanaka, Hiroko H; Miyano, Satoru S; Koh, Katsuyoshi K; Hanada, Ryoji R; Oka, Akira A; Hayashi, Yasuhide Y; Ohira, Miki M; Kamijo, Takehiko T; Nagase, Hiroki H; Takimoto, Tetsuya T; Tajiri, Tatsuro T; Nakagawara, Akira A; Ogawa, Seishi S; Takita, Junko J

Publication Date: 2017-12-08

Variant appearance in text: ALK: R1192P

PubMed Link: 29296183

Variant Present in the following documents:

• oncotarget-08-107513-s001.pdf

View BVdb publication page

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The role of anaplastic lymphoma kinase in pediatric cancers.

Cancer Science

Takita, Junko J

Publication Date: 2017-10

Variant appearance in text: ALK: R1192P

PubMed Link: 28756644

Variant Present in the following documents:

• Main text
• CAS-108-1913.pdf

View BVdb publication page

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Retinoblastoma and Neuroblastoma Predisposition and Surveillance.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Kamihara, Junne J; Bourdeaut, Franck F; Foulkes, William D WD; Molenaar, Jan J JJ; Mossé, Yaël P YP; Nakagawara, Akira A; Parareda, Andreu A; Scollon, Sarah R SR; Schneider, Kami Wolfe KW; Skalet, Alison H AH; States, Lisa J LJ; Walsh, Michael F MF; Diller, Lisa R LR; Brodeur, Garrett M GM

Publication Date: 2017-07-01

Variant appearance in text: ALK: R1192P

PubMed Link: 28674118

Variant Present in the following documents:

• Main text

View BVdb publication page

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Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S

Publication Date: 2017-10

Variant appearance in text: ALK: 3575G>C; Arg1192Pro

PubMed Link: 28569743

Variant Present in the following documents:

• gim201760x7.xlsx, sheet 2

View BVdb publication page

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ALK: a tyrosine kinase target for cancer therapy.

Cold Spring Harbor Molecular Case Studies

Holla, Vijaykumar R VR; Elamin, Yasir Y YY; Bailey, Ann Marie AM; Johnson, Amber M AM; Litzenburger, Beate C BC; Khotskaya, Yekaterina B YB; Sanchez, Nora S NS; Zeng, Jia J; Shufean, Md Abu MA; Shaw, Kenna R KR; Mendelsohn, John J; Mills, Gordon B GB; Meric-Bernstam, Funda F; Simon, George R GR

Publication Date: 2017-01

Variant appearance in text: ALK: R1192P

PubMed Link: 28050598

Variant Present in the following documents:

• Main text
• HollaMCS001115.pdf

View BVdb publication page

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The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN.

Disease Models & Mechanisms

Guan, J J; Tucker, E R ER; Wan, H H; Chand, D D; Danielson, L S LS; Ruuth, K K; El Wakil, A A; Witek, B B; Jamin, Y Y; Umapathy, G G; Robinson, S P SP; Johnson, T W TW; Smeal, T T; Martinsson, T T; Chesler, L L; Palmer, R H RH; Hallberg, B B

Publication Date: 2016-09-01

Variant appearance in text: ALK: R1192P

PubMed Link: 27483357

Variant Present in the following documents:

• Main text

View BVdb publication page

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Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice.

Oncotarget

Siaw, Joachim T JT; Wan, Haiying H; Pfeifer, Kathrin K; Rivera, Victor M VM; Guan, Jikui J; Palmer, Ruth H RH; Hallberg, Bengt B

Publication Date: 2016-05-17

Variant appearance in text: ALK: R1192P

PubMed Link: 27049722

Variant Present in the following documents:

• Main text
• oncotarget-07-29011.pdf

View BVdb publication page

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