Publications:

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Sustained Improvement in the Management of Patients with Non-Small-Cell Lung Cancer (NSCLC) Harboring ALK Translocation: Where Are We Running?

Current Oncology (Toronto, Ont.)

Spitaleri, Gianluca G; Trillo Aliaga, Pamela P; Attili, Ilaria I; Del Signore, Ester E; Corvaja, Carla C; Corti, Chiara C; Crimini, Edoardo E; Passaro, Antonio A; de Marinis, Filippo F

Publication Date: 2023-05-16

Variant appearance in text: ALK: I1171S

PubMed Link: 37232842

Variant Present in the following documents:

• Main text
• curroncol-30-00384.pdf

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Biology and impact of lineage plasticity in ALK-positive NSCLC: a narrative review.

Translational Lung Cancer Research

Meador, Catherine B CB; Piotrowska, Zofia Z

Publication Date: 2023-04-28

Variant appearance in text: ALK: I1171S

PubMed Link: 37197622

Variant Present in the following documents:

• tlcr-12-04-837.pdf

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Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.

Nature Communications

Berko, Esther R ER; Witek, Gabriela M GM; Matkar, Smita S; Petrova, Zaritza O ZO; Wu, Megan A MA; Smith, Courtney M CM; Daniels, Alex A; Kalna, Joshua J; Kennedy, Annie A; Gostuski, Ivan I; Casey, Colleen C; Krytska, Kateryna K; Gerelus, Mark M; Pavlick, Dean D; Ghazarian, Susan S; Park, Julie R JR; Marachelian, Araz A; Maris, John M JM; Goldsmith, Kelly C KC; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP

Publication Date: 2023-05-05

Variant appearance in text: ALK: I1171S

PubMed Link: 37147298

Variant Present in the following documents:

• Main text
• 41467_2023_Article_38195.pdf

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Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report.

Frontiers In Pharmacology

Zhao, Jiuzhou J; Li, Xiang X; Fan, Ruizhe R; Qin, Yaping Y; Wang, Zhizhong Z; Wang, Bo B; Li, Shaomei S; Fan, Jianfeng J; Wu, Xinxin X; Liu, Hongxia H; Guan, Yuping Y; Liang, Yinfeng Y; Zhang, Xiao X; Guo, Yongjun Y

Publication Date: 2022

Variant appearance in text: ALK: I1171S

PubMed Link: 36506539

Variant Present in the following documents:

• fphar-13-1060460.pdf

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Secondary mutant ALK-I1171s in pituitary metastases from a patient with ALK fusion-positive advanced lung adenocarcinoma: A case report and literature review.

Frontiers In Oncology

Han, Dan D; Zhao, Kewei K; Yang, Qin Q; Zhang, Liling L; Fei, Shihong S

Publication Date: 2022

Variant appearance in text: ALK: Ile1171Ser

PubMed Link: 36324562

Variant Present in the following documents:

• Main text
• fonc-12-1016320.pdf

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Histone deacetylases modulate resistance to the therapy in lung cancer.

Frontiers In Genetics

Contreras-Sanzón, Estefanía E; Prado-Garcia, Heriberto H; Romero-Garcia, Susana S; Nuñez-Corona, David D; Ortiz-Quintero, Blanca B; Luna-Rivero, Cesar C; Martínez-Cruz, Victor V; Carlos-Reyes, Ángeles Á

Publication Date: 2022

Variant appearance in text: ALK: I1171S

PubMed Link: 36263432

Variant Present in the following documents:

• fgene-13-960263.pdf

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Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer.

Cancers

Papageorgiou, Savvas S; Pashley, Sarah L SL; O'Regan, Laura L; Khan, Sam S; Bayliss, Richard R; Fry, Andrew M AM

Publication Date: 2022-07-15

Variant appearance in text: ALK: I1171S

PubMed Link: 35884511

Variant Present in the following documents:

• Main text
• cancers-14-03452.pdf

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: ALK: I1171S

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

View BVdb publication page

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Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?

Biochemical Society Transactions

Shevchenko, Ekaterina E; Pantsar, Tatu T

Publication Date: 2022-02-28

Variant appearance in text: ALK: I1171S

PubMed Link: 35226061

Variant Present in the following documents:

• Main text
• BST-50-633.pdf

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Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma.

Frontiers In Oncology

Wang, Yuan Y; He, Jing J; Xu, Manyu M; Xue, Qingfeng Q; Zhu, Cindy C; Liu, Juan J; Zhang, Yaping Y; Shi, Wenyu W

Publication Date: 2022

Variant appearance in text: ALK: I1171S

PubMed Link: 35211406

Variant Present in the following documents:

• Main text
• fonc-12-815654.pdf

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Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open

Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K

Publication Date: 2022-02

Variant appearance in text: ALK: I1171S

PubMed Link: 35123209

Variant Present in the following documents:

• main.pdf

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Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open

Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K

Publication Date: 2022-02-02

Variant appearance in text: ALK: I1171S

PubMed Link: 35123209

Variant Present in the following documents:

• main.pdf

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Prospective analysis of liquid biopsies of advanced non-small cell lung cancer patients after progression to targeted therapies using GeneReader NGS platform.

Translational Cancer Research

Mayo de Las Casas, Clara C; Garzón-Ibañez, Mónica M; Jordana-Ariza, Núria N; Viteri-Ramírez, Santiago S; Moya-Horno, Irene I; Karachaliou, Niki N; Yeste, Zaira Z; Campos, Raquel R; Villatoro, Sergi S; Balada-Bel, Ariadna A; García-Peláez, Beatriz B; Reguart, Noemí N; Teixidó, Cristina C; Jantús, Eloisa E; Calabuig, Silvia S; Aguado, Cristina C; Giménez-Capitán, Ana A; Román-Lladó, Ruth R; Pérez-Rosado, Ana A; Catalán, Maria José MJ; Bertrán-Alamillo, Jordi J; García-Román, Silvia S; Rodriguez, Sonia S; Alonso, Lidia L; Aldeguer, Erika E; Martínez-Bueno, Alejandro A; González-Cao, Maria M; Aguilar Hernandez, Andrés A; Garcia-Mosquera, Juan J; de Los Llanos Gil, Maria M; Fernandez, Manuel M; Rosell, Rafael R; Molina-Vila, Miguel Ángel MÁ

Publication Date: 2019-01

Variant appearance in text: ALK: I1171S

PubMed Link: 35117060

Variant Present in the following documents:

• tcr-08-S1-S3.pdf

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Utility of the Ba/F3 cell system for exploring on-target mechanisms of resistance to targeted therapies for lung cancer.

Cancer Science

Koga, Takamasa T; Suda, Kenichi K; Mitsudomi, Tetsuya T

Publication Date: 2022-03

Variant appearance in text: ALK: I1171S

PubMed Link: 34997674

Variant Present in the following documents:

• CAS-113-815-s001.pdf
• CAS-113-815.pdf

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: I1171S

PubMed Link: 34885113

Variant Present in the following documents:

• Main text
• cancers-13-06003.pdf

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: I1171S

PubMed Link: 34885113

Variant Present in the following documents:

• Main text
• cancers-13-06003.pdf

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New Advances in Liquid Biopsy Technologies for Anaplastic Lymphoma Kinase (ALK)-Positive Cancer.

Cancers

Villa, Matteo M; Sharma, Geeta G GG; Manfroni, Chiara C; Cortinovis, Diego D; Mologni, Luca L

Publication Date: 2021-10-14

Variant appearance in text: ALK: I1171S

PubMed Link: 34680298

Variant Present in the following documents:

• Main text

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The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology

Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F

Publication Date: 2021

Variant appearance in text: ALK: I1171S

PubMed Link: 34660278

Variant Present in the following documents:

• Main text
• fonc-11-713530.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ALK: I1171S

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review.

Jto Clinical And Research Reports

Zhu, Viola W VW; Nagasaka, Misako M; Madison, Russell R; Schrock, Alexa B AB; Cui, Jean J; Ou, Sai-Hong Ignatius SI

Publication Date: 2021-01

Variant appearance in text: ALK: I1171S

PubMed Link: 34589977

Variant Present in the following documents:

• Main text
• main.pdf

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A patient with ALK-positive lung adenocarcinoma who survived alectinib-refractory postoperative recurrence for 4 years by switching to ceritinib.

Thoracic Cancer

Matsumura, Yuki Y; Inomata, Sho S; Yamaguchi, Hikaru H; Mine, Hayato H; Takagi, Hironori H; Watanabe, Masayuki M; Ozaki, Yuki Y; Yamaura, Takumi T; Fukuhara, Mitsuro M; Muto, Satoshi S; Okabe, Naoyuki N; Hasegawa, Takeo T; Shio, Yutaka Y; Suzuki, Hiroyuki H

Publication Date: 2021-08

Variant appearance in text: ALK: I1171S

PubMed Link: 34159737

Variant Present in the following documents:

• TCA-12-2225.pdf

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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations.

Molecular Cancer Therapeutics

Murray, Brion W BW; Zhai, Dayong D; Deng, Wei W; Zhang, Xin X; Ung, Jane J; Nguyen, Vivian V; Zhang, Han H; Barrera, Maria M; Parra, Ana A; Cowell, Jessica J; Lee, Dong J DJ; Aloysius, Herve H; Rogers, Evan E

Publication Date: 2021-09

Variant appearance in text: ALK: I1171S

PubMed Link: 34158340

Variant Present in the following documents:

• Main text
• 1499.pdf

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Sensitivity, specificity, and accuracy of a liquid biopsy approach utilizing molecular amplification pools.

Scientific Reports

Garcia, Jessica J; Kamps-Hughes, Nick N; Geiguer, Florence F; Couraud, Sébastien S; Sarver, Brice B; Payen, Léa L; Ionescu-Zanetti, Cristian C

Publication Date: 2021-05-24

Variant appearance in text: ALK: I1171S

PubMed Link: 34031447

Variant Present in the following documents:

• 41598_2021_89592_MOESM1_ESM.xlsx, sheet 4

View BVdb publication page

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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer.

Nature Communications

Mizuta, Hayato H; Okada, Koutaroh K; Araki, Mitsugu M; Adachi, Jun J; Takemoto, Ai A; Kutkowska, Justyna J; Maruyama, Kohei K; Yanagitani, Noriko N; Oh-Hara, Tomoko T; Watanabe, Kana K; Tamai, Keiichi K; Friboulet, Luc L; Katayama, Kazuhiro K; Ma, Biao B; Sasakura, Yoko Y; Sagae, Yukari Y; Kukimoto-Niino, Mutsuko M; Shirouzu, Mikako M; Takagi, Satoshi S; Simizu, Siro S; Nishio, Makoto M; Okuno, Yasushi Y; Fujita, Naoya N; Katayama, Ryohei R

Publication Date: 2021-02-24

Variant appearance in text: ALK: I1171S

PubMed Link: 33627640

Variant Present in the following documents:

• Main text

View BVdb publication page

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Current Knowledge about Mechanisms of Drug Resistance against ALK Inhibitors in Non-Small Cell Lung Cancer.

Cancers

Smolle, Elisabeth E; Taucher, Valentin V; Lindenmann, Joerg J; Jost, Philipp J PJ; Pichler, Martin M

Publication Date: 2021-02-09

Variant appearance in text: ALK: I1171S

PubMed Link: 33572278

Variant Present in the following documents:

• cancers-13-00699.pdf

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Therapeutic Sequencing in ALK+ NSCLC.

Pharmaceuticals (Basel, Switzerland)

Elsayed, Mei M; Christopoulos, Petros P

Publication Date: 2021-01-21

Variant appearance in text: ALK: I1171S

PubMed Link: 33494549

Variant Present in the following documents:

• Main text

View BVdb publication page

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Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won.

Translational Lung Cancer Research

Tabbò, Fabrizio F; Reale, Maria Lucia ML; Bironzo, Paolo P; Scagliotti, Giorgio V GV

Publication Date: 2020-12

Variant appearance in text: ALK: I1171S

PubMed Link: 33489817

Variant Present in the following documents:

• Main text
• tlcr-09-06-2545.pdf

View BVdb publication page

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Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

Cells

Hofman, Paul P

Publication Date: 2021-01-15

Variant appearance in text: ALK: I1171S

PubMed Link: 33467720

Variant Present in the following documents:

• Main text
• cells-10-00168.pdf

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: ALK: 3512T>G; I1171S

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
• 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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[Advances in Drug Resistance Mechanisms and Prognostic Markers of Targeted Therapy in ALK-positive Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Shasha S; Shi, Yuankai Y; Han, Xiaohong X

Publication Date: 2020-11-20

Variant appearance in text: ALK: I1171S

PubMed Link: 33203201

Variant Present in the following documents:

• Main text
• zgfazz-23-11-1014.pdf

View BVdb publication page

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: ALK: I1171S

PubMed Link: 33133066

Variant Present in the following documents:

• Table_6.xlsx, sheet 9
• Table_1.xlsx, sheet 4
• Table_1.xlsx, sheet 8
• Table_2.xlsx, sheet 7
• Table_2.xlsx, sheet 1
• Table_6.xlsx, sheet 4
• Table_2.xlsx, sheet 2

View BVdb publication page

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Real-World Treatment Patterns and Survival Outcome in Advanced Anaplastic Lymphoma Kinase (ALK) Rearranged Non-Small-Cell Lung Cancer Patients.

Frontiers In Oncology

Britschgi, Christian C; Addeo, Alfredo A; Rechsteiner, Markus M; Delaloye, Raphaël R; Früh, Martin M; Metro, Giulio G; Banini, Marco M; Gautschi, Oliver O; Rothschild, Sacha I SI; Wild, Peter J PJ; Banna, Giuseppe L GL; Curioni-Fontecedro, Alessandra A

Publication Date: 2020

Variant appearance in text: ALK: Ile1171Ser

PubMed Link: 32974130

Variant Present in the following documents:

• Main text
• fonc-10-01299.pdf

View BVdb publication page

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: ALK: I1171S

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy

Chan, Hiu Ting HT; Chin, Yoon Ming YM; Low, Siew-Kee SK

Publication Date: 2019-06

Variant appearance in text: ALK: I1171S

PubMed Link: 32700193

Variant Present in the following documents:

• Main text
• 40487_2018_Article_90.pdf

View BVdb publication page

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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

Cancers

Hamid, Abdulaziz B AB; Petreaca, Ruben C RC

Publication Date: 2020-04-09

Variant appearance in text: ALK: I1171S

PubMed Link: 32283832

Variant Present in the following documents:

• Main text
• cancers-12-00927-s001.pdf
• cancers-12-00927.pdf

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: ALK: I1171S

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.

Thoracic Cancer

Takahashi, Ken K; Seto, Yosuke Y; Okada, Koutaroh K; Uematsu, Shinya S; Uchibori, Ken K; Tsukahara, Mika M; Oh-Hara, Tomoko T; Fujita, Naoya N; Yanagitani, Noriko N; Nishio, Makoto M; Okubo, Kenichi K; Katayama, Ryohei R

Publication Date: 2020-03

Variant appearance in text: ALK: I1171S

PubMed Link: 31943796

Variant Present in the following documents:

• Main text
• TCA-11-581.pdf

View BVdb publication page

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Treatment with Next-Generation ALK Inhibitors Fuels Plasma ALK Mutation Diversity.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Dagogo-Jack, Ibiayi I; Rooney, Marguerite M; Lin, Jessica J JJ; Nagy, Rebecca J RJ; Yeap, Beow Y BY; Hubbeling, Harper H; Chin, Emily E; Ackil, Jennifer J; Farago, Anna F AF; Hata, Aaron N AN; Lennerz, Jochen K JK; Gainor, Justin F JF; Lanman, Richard B RB; Shaw, Alice T AT

Publication Date: 2019-11-15

Variant appearance in text: ALK: I1171S

PubMed Link: 31358542

Variant Present in the following documents:

• Main text

View BVdb publication page

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Profile of alectinib for the treatment of ALK-positive non-small cell lung cancer (NSCLC): patient selection and perspectives.

Oncotargets And Therapy

Karachaliou, Niki N; Fernandez Bruno, Manuel M; Bracht, Jillian Wilhelmina Paulina JWP; Rosell, Rafael R

Publication Date: 2019

Variant appearance in text: ALK: I1171S

PubMed Link: 31354290

Variant Present in the following documents:

• Main text
• ott-12-4567.pdf

View BVdb publication page

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